Gene Gprk1 (Fruit Fly)

Gprk1

Species: Fruit Fly
Alias: Gprk1, GPRK1, CT4320, Gprk-1, SFO219
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 41B3--C2,

Classification

Group: AGC
Family: GRK
Subfamily: BARK

Sequence

Name Sequence Type Origin Length Description Download
Gprk1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
Gprk1.AA Protein Various 700 None Fasta, JSON

Protein domain

Protein domains of Gprk1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS Gprk1.AA RGS 54-175 25 8e-33 116.28 SMART 1-121 (121) Show / Hide 
Range on Protein: 54-175
Range on HMM: 1-121/121
Sequence Identity: 25% (31 aa)

NFHKNF-NEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLS-HTYEYSKHAVASVQKYLLKNEVPVDLFEPYLE
.||. . |   |...|..|...  .|... |.|.. .. |.|.|  .||...||.||| .|... .. |  ....| .. .|..| .  .. |.|.....
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMED-EERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN--PHPDCFDEAQR

EIFTQLKGKPFKKFLESDKFTRFC
.... ........||.||...|..
HVYQLMEKDSYPRFLRSDYYKRYL
RGS Gprk1.AA RGS 54-174 23 6.9e-24 80.79 Pfam 1-124 (124) Show / Hide 
Range on Protein: 54-174
Range on HMM: 1-124/124
Sequence Identity: 23% (29 aa)

NFHKNFNEVL-GYLLFKDFCENDSEEPIQQLKFFEQIKLFEKT--ECYDERKKM-ARDIYDNFIMEEMLSHTYEYSKHAVASVQKYLLKNEVPVDLFEPY
.||. .|.   | .||..|.|.   |.   ..| . .. |.|.  .. ...... ||.||...|...  ..    ...... .|..| ....  |.|...
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

LEEIFTQLKGKPFKKFLESDKFTRF
 ..|.| ...... .||.||.. ||
QRHIYTLMEKDSYPRFLKSDYYQRF
Kinase Gprk1.AA BARK 191-454 88 9.60000000001e-228 762.88 In-house 1-264 (264) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-264/264
Sequence Identity: 88% (234 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGIF
|||||||||||||||||||||||||||||||||||||||||||.||||||.||..||||.||||||||||||||||||||||||||||||||||||||.|
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVF

SEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS
||.||.|||||.||||||||.|..|||||||||||||||||.|||||||||||||||||||||||||||||||.|||.|||.|||||.||||||||.|||
SEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLRGHS

PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFF
|||||||||| |||.||||||||||.||| |...|||.||||||||||||||.||.|||.|.||
PFRQHKTKDKHEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase Gprk1.AA GRK 191-454 57 1.4e-214 683.2 In-house 1-272 (272) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-272/272
Sequence Identity: 57% (156 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGI-
|...|..|.||||||..|....||||||.|||||||||...||..||||...|. |... ||||||||.||..|.|.||.....|||||||||....|  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSR-DCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNN

---FSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKK--PHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYK
   |.|..|.|||||...||||||.|.||||||||.|||||..||.|||||||||......  .|..||||||||||||.....||...||.|.|||.|.
EPGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYE

LLKGHSPFRQHKTKDKL-EIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGN--GADEVKMHNFF
...|||||||||.|.|  |.|.......|..|..|| |.|...|||||.|...||||.|.  ||.|||.|.||
MIEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase Gprk1.AA AGC 191-454 28 6.1e-153 398.68 In-house 1-395 (395) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-395/395
Sequence Identity: 28% (115 aa)

FSVHRIIGRGGFGEVYGCRKA------DTGKMYAMKCLDKKR-IKMKQ--GEMLALNE------------RNMLQAVS--------TGIDCPFIVC-MTY
| ....||.|.||.|| .||       ||||.||||.|.||. |..|.   .  ...|            ||.|. ..        .  ..||||  . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKS--HHPFIVKILHY

AFHTPDK--LCFILDLMN---------GG-DLHYHLS---QHGIFSEDEMKFYAAE-------VILGLEHMHK-RCIVYRD-LKPANILLDENGHIRISD
.|...|.  |.|....|.         || .|..||    . |.|.|.. .|||||       ..|.||..|. . |..|| ||| ||||||.|||...|
SFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTD

LGLACDFSK----------------------------------------------------KKPHASVG--THGYMAPEVLSKGTSYDSCADWFS--FGC
 ||.. . .                                                    .. .  .|  |. |||||.|     |.  .|| |  .||
FGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGC

MLYKLLKGHSPFRQH-------------KTKDKLEIDKMTLTMNVELP----------ESFSLELKNLLEMLLQRDVSKRLGCMGN-----GADEVKMHN
..| .| |..||. .             .. .| ........ .|..|          ..|| |.|.|...||..| .|||||.||     ||.|.| | 
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

FF
.|
WF
Kinase Gprk1.AA GRK 191-454 47 4.6e-104 352.03 In-house 1-265 (265) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-265/265
Sequence Identity: 47% (128 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--
|   |. | ||||||  |    |||||| | |.||||| ..|| .||||   |. |.     .|.| . ||. | | || .. .|||||| .|.   |  
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVH----SRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGEN

-IFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKKP-HASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLL
  |.|    |||||...|||| |.. |||||.|| |||||. |||||||||||      ..    ||| |||||||.     |.   ||...|| .|   
PGFDEERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNER-YTFSPDWWGLGCLIYEMI

KGHSPFRQHKTK-DKLEIDKMTLTMNVELP-ESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFF
 |.||||| | |  . |.|. ..   .. . | || | | . .|||. | ..|||| . |.|||. | ||
EGRSPFRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase Gprk1.AA Pkinase 191-454 29 7e-91 313.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLAL-NERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGG----DLHYHLS
. ..|.||.|.||.|| |.. .|||..|.|...|...|... . ... .|  ... ..    .|.|| . ..|...|..........||    ||. ..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--QHGIF--SEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHI----RISDLGLAC---DFSKKKPHASVGTHGYMAPEVLSKGTSYDSCAD
  .|| |  ||.| |||. ... |||..|.. |..|||||.|||.|.||||    .|.| |||.     ..  ..  .|| .||||||. .|. |.. .|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

WFSFGCMLYKLLKGHSPFRQH----KTKDKLEIDKMTLTMNVELPESFS---------------------LELKNLLEMLLQRDVSKRLGCMGNGADEVK
..|.||.|| .| |. ||..|    .  |.... ....   .. ... .                      |.| ... .|..| .||..     |....
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQIL

MHNFF
 | .|
QHPWF
Kinase Gprk1.AA S_TKc 191-454 32 2.4e-90 307.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNG--GDLHYHLSQHG
. ..|.||.|.||.|| ||. .||. .|.|...            ...|...|.      ..|.|| . ..|.. |.|........|  |||. .. ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

I------FSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDS-CADWFSFGCM
       |.| . .||.......||..|.. |..|||||.||||||  || |.| |||. .     .  .||  |||||||    .|.   .|| |.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

LYKLLKGHSPFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADE--VKMHNFF
|| .| |  ||.     ... ..|.            | |.|.... .||.| .||...    .||  .|.| .|
LYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Gprk1.AA RSK 194-454 37 8.6e-89 301.29 In-house 1-278 (278) Show / Hide 
Range on Protein: 194-454
Range on HMM: 1-278/278
Sequence Identity: 37% (106 aa)

HRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQG-EMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGI
..  |.||.|.|. |||    |||. |||| |.|. |. .|     .. ||| |...     .||||   |||.|..||  |.....||.| .||.....
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQ---HPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKH

---FSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDE---NGHIRISDLGLACDF--S-KKKPHASVGTHGYMAPEVLS---KGTSYDSCADWFS
   ||||| .||.||..| .||.|.. |..||||| |||.|.   .|||...| |... |  . ... .  ..|. |||||.|    ..  .|  .||.|
FGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWS

FGCMLYKLLKGHSPFRQHKTK-DKLEIDKMTLTMN--VELP--ESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFF
.|. .| .| |..||..   . .. || |  .. .  ...|  .. | | |.|. ..|.|| .|||||  ..|.|.| | .|
LGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Gprk1.AA Akt 191-454 40 1.1e-84 270.63 In-house 1-264 (264) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-264/264
Sequence Identity: 40% (109 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMY-AMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGI
| . ...|.| || |. ..| ||.|.| ||| | |..| .|     .. |||.|| .     .|||| . |.| |.|||.|..| .|||.| |||.. ..
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN----HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRR

FSEDEMKFYAAEVILGLEHMHKRCIVYRD-LKPANILLDENGHIRISDLGLAC-D-FSK-KKPHASVGTHGYMAPEVLSKGTSYDSCADWFS-FGCMLYK
||||. .||.||.||..|| |.. |.||| ||| |||.|..|||.. | ||.  .  .   |     ||  |.|||.|.. . .. ..|| . .|| .| 
FSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG-NGHTKAVDWWGSLGCVMYE

LLKGHSPFRQHKTKDKLEIDKMTLTMNVELP--ESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFF
.. |  ||  .. .|. .  |  .. .|. |  . .| | |.|.. ||..| .||||   |.|.|.| | .|
MMCGRPPF--YN-QDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase Gprk1.AA AktR 191-454 36 2e-83 283.44 In-house 1-268 (268) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-268/268
Sequence Identity: 36% (101 aa)

FSVHRIIGRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGI
| |....|.|.||.|| ..|  |..|.|||| ..|| |. .. .  ...||| ...    .. |||| . |.| | .|| ||.. . ||.| .||.. . 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMC---CNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK

FSEDEMKFYAAEVILGLEHMHKR-CIVYRDLKPANILLDENGHIRISDLGLAC-DFSK-K--KPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYK
|||.. .||.|...|.||. |..  |.|||||| ||||||.||..|.| ||.   | . .  | .  .||. |||||.. |   ..  .|| .||. .| 
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYE

LLKGHSPFRQHKTKDKLEIDKMTLTMNVELPES--FSLELKNLLE-MLLQRDVSKRLGCMGNGADEVKMHNFF
.. |. || .........  . . . ... |..  || ..|.|..  ||...  ||||   ||..|.|.| .|
MVTGCPPFYHKNQNQMFQK-IKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase Gprk1.AA SGK 191-454 35 7.8e-83 255.56 In-house 1-283 (283) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-283/283
Sequence Identity: 35% (103 aa)

FSVHRIIGRGGFGEVYGCRKADT------------------GKMYAMKCLDKKRIK-------MKQGEMLALNER-NMLQAVSTGIDCPFIVCMTYAFHT
|    .|| |.||.||  .. |.                  .|.|||| | |. |         |  . . . || . |. ..     ||||   ||| |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMK----HPFIVNLHYAFQT

PDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLAC-DFSKKKPHASV-GTHGYMAPEV
..|| | .| .|||.. |||   ..|.||. .|||||... ||. |.  |.|||||| |||||  ||... | ||.  .  ...   .  ||  |.||||
KWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEV

LSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFF
| | . .|   ||.. || || .. |  ||     ..| .     .     .| ..| . . |.. |||.|..||||   ... |.| | ||
LRKQP-HDRTVDWWCLGCVLYEMMYGLPPFYS---RNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase Gprk1.AA RSK 191-454 38 1.5e-73 250.7 In-house 1-271 (271) Show / Hide 
Range on Protein: 191-454
Range on HMM: 1-271/271
Sequence Identity: 38% (109 aa)

FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQ
. .|. ||.| |..|| |.|    ||.. |||| ..|. .. | .    . .||..|  .    . ||||   |.| .  |.  |.|.| ||||  .|. 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYG----HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLK

HGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDEN----GHIRISDLGLACDFSKKKPHASVG-------THGYMAPEVLSKGTSYDSCADW
 . |||.| |||.||. | .|. |.  ||.|||||.|||.|.     |||.| |.|.|     |.  .  |       |  |||||||..   .|  .||
QKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFA-----KQLRDENGMLMTFCYTANYMAPEVLKR-QGHDQACDW

FSFGCMLYKLLKGHSPFRQHKTKDKLE--IDKMTLTM---NVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFF
.|||  .|  | |. || |.|..| ..  | .  | |   .   ... | | | || |.| ||  .|||.  ||. ..| | .|
WSFGVLMYEMLTGCTPF-QNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase Gprk1.AA RSK-Unclassified 191-348 40 1.4e-54 169.63 In-house 1-157 (283) Show / Hide 
Range on Protein: 191-348
Range on HMM: 1-157/283
Sequence Identity: 40% (65 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLS--QHG
| .|| ||.| ||.||  || || ..|||| | |...  ..    .. |.| . |..   . |||| . ..| | |.|  ...   |||.  ||      
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIM-ATT---NHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEK

IFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDF-SKKKP
 |.||. .|||.||.. ||..||| ..|||||| ||.|.  ||.. .| .|  .    |||
CFCEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKP
Kinase Gprk1.AA RSK-Unclassified 352-454 33 3.2e-23 69.36 In-house 183-283 (283) Show / Hide 
Range on Protein: 352-454
Range on HMM: 183-283/283
Sequence Identity: 33% (35 aa)

VGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDKLEIDKMTLTMNVELP--ESFSLELKNLLEMLLQRDVSKRLGCMGNG-ADEV
.||  |.|||.. ..       ||.  | ..| .| |  |.   .   | |. .  .. .| .|  .  | . . |.  ||||  .||||| . | ||..
CGTEEYLAPEMI-RRCGHTKAVDWWTLGIVMYEMLFGCPPY---YGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGC-KMGDADDI

KMHNFF
| | ||
KRHPFF
Kinase Gprk1.AA TyrKc 191-448 18 1.2e-12 -18.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 191-448
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGI--DCPFIVCMTYAFHTP-------DKLCFILDLMNGGDLH
 .  ...|.| ||||| ..      . | |.| .        ..  ..| ...      .  . | ||..  .  ..       . |. .. .| .|||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCK----LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

YHLSQHGI-FSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKK------KPHASV----GTHG-----YMAPEVLSK
 .|  |.  .. ...  ..  .  | |. |..... |||   |.|..||....||| ||. |   .      |   ..    |...      ||||.. .
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

GTSYDSCADWFSFGCMLYKLL-KGHSPFRQ-----HKTKDKLEIDKMTLTMNVELPES--------FSLELKNLLEMLLQRDVSKRLGCMGNGADEV
   . .  | .||| ... ..  | .|         . .. .|  |    |  . |..         . |. .. ..  ..| ..|  .. .  .. 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM--PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-TFSEIHECF
Kinase Gprk1.AA S_TK_X 455-531 22 1.7e-08 35.51 SMART 1-79 (79) Show / Hide 
Range on Protein: 455-531
Range on HMM: 1-79/79
Sequence Identity: 22% (20 aa)

CGIDWHQVYI--QKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQEV--------SETVFDTVN
 |||| ..|   ....|| .|.  ||.| ...|.. ||.| |..          ..... ..|.. .|.             |. |.
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase Gprk1.AA Pkinase_Tyr 267-340 25 0.001157 13.03 Pfam 81-158 (270) Show / Hide 
Range on Protein: 267-340
Range on HMM: 81-158/270
Sequence Identity: 25% (20 aa)

KLCFILDLMNGGDLHYHLSQH----GIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLA
... .. .| .|||. .| .|    . ..  ..  .....  |.|. . . .. |||   |.|..||....|.| |||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase Gprk1.AA Pkinase_Tyr 191-206 43 0.899233 3.24 Pfam 1-16 (270) Show / Hide 
Range on Protein: 191-206
Range on HMM: 1-16/270
Sequence Identity: 43% (7 aa)

FSVHRIIGRGGFGEVY
 .  . .|.| |||||
ITFGKKLGEGAFGEVY
PH Gprk1.AA PH 558-657 19 2.5e-12 47.12 Pfam 1-92 (92) Show / Hide 
Range on Protein: 558-657
Range on HMM: 1-92/92
Sequence Identity: 19% (19 aa)

CILHGYIKKLGGSFASLWQTKYAKLYPNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEWSSSLRSAHK
.|..|...|.|  . . |.  .. | .|.| .. ... ..   | .. . ..  .    |...|.|||. |.    ....  ..|  ...| ....||..
VIKEGWLHKKG--KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDC-QVTKVPDN-KRPHCFQIRT-DR---RTYYFQAESEEEMNDWMQAIQSACR
PH Gprk1.AA PH 558-659 13 2.8e-09 38.05 SMART 1-82 (82) Show / Hide 
Range on Protein: 558-659
Range on HMM: 1-82/82
Sequence Identity: 13% (14 aa)

CILHGYIKKLGGSFASLWQTKYAKLYPNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEWSSSLRSAHK
 |..|...|..      |. ... |....| .. ..   . . |... ..    .        |..|.  |.    ....  ..|  ..|| .....| .
VIKEGWLYKKS---K-RWKKRWFVLFNDCLYYYKDK--KPKGSIPLSDCTVRE-P--------CFEIHH-DR----TYYFQCESEEEMQEWMQAIQKAIH

IS
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