Gene InR (Fruit Fly)

InR

Species: Fruit Fly
Alias: DIHR, Dir-b, Dir-a, dInR, inr, insulin/insulin-like growth factor receptor, lethal(3)93Dj, Inr, l(3)93Dj, DIR, DILR, CG18402, er10, DIRbeta, Inr-alpha, insulin receptor homolog, dInr, dIRH, insulin receptor, dIR, l(3)05545, dInsR, IR, InR, DInr, DIRH, Inr-beta, l(3)er10, SFO164, INR, insulin/insulin-like growth fact, dir, dinr
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 93E4,

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
InR.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 280 Kinase domain by global Sugen HMM Fasta, JSON
InR.AA Protein Various 2141 None Fasta, JSON

Protein domain

Protein domains of InR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Furin-like InR.AA Furin-like 117-129 30 5.97818 0.45 Pfam 171-182 (182) Show / Hide 
Range on Protein: 117-129
Range on HMM: 171-182/182
Sequence Identity: 30% (4 aa)

VKCSGHQCSNECD
..|.|  |  .| 
EPCEGP-CPKVCY
Recep_L_domain InR.AA Recep_L_domain 356-465 40 2.6e-46 157.42 Pfam 1-121 (121) Show / Hide 
Range on Protein: 356-465
Range on HMM: 1-121/121
Sequence Identity: 40% (50 aa)

NCTVIEGFLLIDLINDASPLNR---SFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFD--GYALVVYSNFD--LMDLGLHKLRSITR--GGVR
|||||.| | | ....   |..   .||...|.|.|..|||. ..... . |||| .|||..||.   |||..|.| .  | .|....|. |||  |||.
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGGVY

IEKNH--KLCYDRT-IDWLEIL
|..|.  |||| .| |.| .|.
IHNNPHPKLCYTHTEIMWWMIY
Furin-like InR.AA Furin-like 509-648 29 2.6e-54 178.68 Pfam 1-182 (182) Show / Hide 
Range on Protein: 509-648
Range on HMM: 1-182/182
Sequence Identity: 29% (55 aa)

NASCQ--------LHN---------NRRL-CWNSK--LCQ----TKCPEKCRN-NCI--DEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCP
| .|.         ..         ...  ||...   ||    ..|||.| . .|   ... ||.. |||||    |....|..||....|..|.|.||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGC-TGPNNDTDCVACRHFYHNGTCVDQCP

K----------------GYYQF-DSRCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKS--ENKRMCEPCPGGKCDKECS
.                |.||| ..||||..|| .|  ..... .  ...||.|...|| ||..    |..|||||  |.|.|.|.
PMMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKL--SHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCE-GPCPKVCY
FU InR.AA FU 542-586 28 3.8e-09 37.65 SMART 1-48 (48) Show / Hide 
Range on Protein: 542-586
Range on HMM: 1-48/48
Sequence Identity: 28% (14 aa)

EHTC--CSQDCLGGCVIDKNGNESCISCRNVSFN---NICMDSCPKGYYQ
...|  |.  |..||.  .  ...|.||..  .    ..|...|| ||| 
DGVCKPCHPECATGCWGPG--PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain InR.AA Recep_L_domain 663-782 34 1.5e-38 131.35 Pfam 1-121 (121) Show / Hide 
Range on Protein: 663-782
Range on HMM: 1-121/121
Sequence Identity: 34% (44 aa)

GCTIITGTEPLTISIKRESGAHVMDELKY---GLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRD--LDELWGPNQTVFIR
.||.| |   |.|.. .|..      |..    .. ...|  .|... || ||.|.||..|..| |.. .. |.||||..||..  | ||| .| .. .|
NCTVIYG--NLEITWRDEHNE-----LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITR

K-GGVFFHFNP--KLCVSTINQLLPMLA
| |||..|.||  ||| ...... .|. 
KNGGVYIHNNPHPKLCYTHTEIMWWMIY
FN3 InR.AA FN3 805-910 10 0.017838 12.46 SMART 1-69 (69) Show / Hide 
Range on Protein: 805-910
Range on HMM: 1-69/69
Sequence Identity: 10% (13 aa)

GTAVLN---VTLQSVGAN------SAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIP
  .. |   ... .|...      |. |  . .                         | |.                               ....| |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK-PP-----------------------IVGYR------------------------------YTVTGLKP

Y----TNYSYYVRTM----AISS
.    |.|.. ||      | ..
GQYPWTEYEFRVRAVNGNDAGEG
FN3 InR.AA FN3 926-1172 4 0.000886 19.8 SMART 1-69 (69) Show / Hide 
Range on Protein: 926-1172
Range on HMM: 1-69/69
Sequence Identity: 4% (12 aa)

PGRPSK---VVATAISDS------KINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKT
|| |.    ...|.....       ....|.   .|    ..|                                                         
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK---PP---IVGYR--------------------------------------------------------

SSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKD
                                                                                                    
----------------------------------------------------------------------------------------------------

DENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHF----TRYAIFVVACRE--EIPS
                               .... |.      |.| . |.|  .    ..
-------------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 InR.AA FN3 1205-1289 20 0.000249 21.63 SMART 1-69 (69) Show / Hide 
Range on Protein: 1205-1289
Range on HMM: 1-69/69
Sequence Identity: 20% (21 aa)

MDLKVD---LEHANNTESP------VRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIK-LNEG-----LYSFRVRANSI--AG
 .   .   |.  . |...      |...|.||      ||.|.                           | .. | .|      |.||||| .   ||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR---------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAG

YG
.|
EG
Kinase InR.AA InsR 1368-1649 65 9.3e-219 733.03 In-house 1-278 (278) Show / Hide 
Range on Protein: 1368-1649
Range on HMM: 1-278/278
Sequence Identity: 65% (186 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDR--ECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRP
|......||||||||||||.|...|....|  .||||||||||..|||..||.||||||||...||||||||||||||..||||.|..||||||||..||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

EERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESL
||..       |..|...|...|......|||.||.|||||||||||||||||.|||||..|.|||||||||||||||.||||||.||.||||||.||||
EEEF-------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESL

RDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV-IDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEP
.|||....|||.|||||||||.||..||||||||||||.|. .||.|...|||||.....||..||......||.|||||.||  
KDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase InR.AA Pkinase_Tyr 1368-1647 42 4.4e-148 502.15 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1368-1647
Range on HMM: 1-270/270
Sequence Identity: 42% (124 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRE--RTNFLSEASVMKEF-DTYHVVRLLGVCS-RGQP--ALVVMELMKKGDLKSYLR
|. .  ||.|.||.||.|..|   | . . ..|.|...|.|....  |  |..||..||.. .  ..|||.|||. .|.|   ..|||.|..|||..|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYY-RKGTKGLLPVRWM
.||                   . ||.|  .. ||...||.||.||..|...|||||||||.|.....|||.|||..||||..||| ||...| ||..||
KHR------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM

PPESLRDGVYSSASDVFSFGVVLWEMATLAAQP-YQGLSNEQVLRYV-IDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYL
.||....|.....||| ||||..||. |. .|| |.|.|||.|..|.  ||. |..|||||| ...||..|||.  . ||.| .|.  |
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase InR.AA TyrKc 1368-1647 37 1.9e-133 450.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 1368-1647
Range on HMM: 1-280/280
Sequence Identity: 37% (117 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEF--DTYHVVRLLGVCSRG-------QPALVVMELMKKGDLKS
|  .  || | || ||.|..|        ...|.|...|.|    |  |..||..|...  .  ..|||.|||. .       .| ..|||.|..||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYET-------DYYRK--
|||.|||.                      .     .... ||.||.||. |...|||||||||.|....||||.|||..||||.        |||||  
YLRKHRPK---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE

--GTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQG-----LSNEQVLRYVIDGGVMERPEN--------CPDFLHKLMQRCWHHRS
  |.|..||.|||.||....|.....|||.||||..||. |. .||| |     .||..|..|| .|. |..|.|        ||| ....|..|||.  
HKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

SARPSFLDIIAYL
. ||.| .|. ..
EDRPTFSEIHECF
Kinase InR.AA TK 1368-1647 24 9.79999999999e-115 386.24 In-house 1-486 (486) Show / Hide 
Range on Protein: 1368-1647
Range on HMM: 1-486/486
Sequence Identity: 24% (121 aa)

IIQLAPLGQGSFG---MVYEGILKSFPPNGVDR--------------------ECAIKTVNE--NATDRERTN-----------FLSEASVMKEFD----
|. .  ||.| ||   .||.|.... .|.. .|                    ..|.|.. |  .....|.             ||.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-TYHVVRLLGVCSRG------------QPALVVMELMKKGD----LKSYLRAHRPEERDEAMMTYLNRIGV-----------------------------
   ..|||.|||..|            .| ..|||.|..||    |..|||..||....|.   . .. ..                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----TGNVQPPTYGRIYQ-------------------MAIEIADGMAYLAAK------KFVHRDLAARNCMVADDLT-----------VKIGDFGMT--
         .| |    .|                   |.  ||.||.||..|      .|||||||||||.|.....           .||.|||..  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------RDIYE------------------------TDYYRKGTKGLLPVRWMPPESLRDGV---------YSSASDVFSFGVVLWEMATLAAQPYQG-LS
      ||||.                        .||||. ..| ||.|||.||.|.|.|         ....|||.||||..||. |....|| | .|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------EQVLRYVIDG--------------GVMERPENCP--------------DFLHKLMQRCWHHRSSARPSFLDIIAYL
|         ..|..|. .|                |..|..||              .... |||.|||.  . ||.| ..  .|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase InR.AA UTK 1368-1647 35 4.3e-100 338.82 In-house 1-296 (296) Show / Hide 
Range on Protein: 1368-1647
Range on HMM: 1-296/296
Sequence Identity: 35% (110 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVN-ENATDRERT---NFLSEAS---VMKEFD-TYHVVRLLGVCSRGQPALVVMELMKKGDLKSY
......|||| ||.|... ..  .. . .  .|.|. . . .. .|..    |. ||    .|| |.  ..|.||.|||....| ..|.|.|..||| ||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQ---MAIEIADGMAYLAAKKFVHRDLAARNCMVADD-------LTVKIGDFG---MTRDIY----
|| |||. .                 ..|.. .  |   ||  ||.||.||. ..||||||||||| |...       ...||.|||   |.|...    
LRRHRPTPP-----------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHF

-----ETDYYRKGTKGLLPVRWMPPESLRDG-VYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGG--VMERPENCPDFLHKLMQRCWHHRS
     |..||..   . .|.||| ||.| ..  ....|||.|||||.||. | ...|| |.||.||.  | .||   |..|. ||. . .||.||||   
SNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDP

SARPSFLDIIAYL
. ||.| |. . .
QERPDFEDLVQQM
Kinase InR.AA TK-Unique 1368-1647 36 6.5e-96 324.94 In-house 1-294 (294) Show / Hide 
Range on Protein: 1368-1647
Range on HMM: 1-294/294
Sequence Identity: 36% (109 aa)

IIQLAPLGQGSFGMVYEGILKSFP-PNGVDRECAIKTVNENATDRERTNFLSEASVMKEFD-TYHVVRLLGVCSRGQ-PALVVMELMKKGDLKSYLRAHR
.  .  .|.|.|| |. | ..... ... ..  |.|....|||| .. .||.|...||| .   ..|..||.| . . | . .|| . .|.| .|||  |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PEERDEAMMTYLNRI------GVTGNVQPPTYGRIYQMAIEIADGMAYLAA--KKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY-ETDYYRKGTKGLL
|. |.    || |          . .  | .... |. |..|| ||.|||   ||.|||||.|||.....|...||.||||.||.| ...| .....| .
PAMRQHQ--TYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

PVRWMPPESLR--DGVY-SSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENC-PDFLHKLMQRCWHHRSSARPSFLDIIAYL
|.|||.||||.  .|.| .. ||| ||||..||..|| |.|| |........ . ||  |..||.| .. ...||..||..  . |||| .|.  |
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase InR.AA Trk 1368-1647 39 3.8e-90 305.78 In-house 1-275 (275) Show / Hide 
Range on Protein: 1368-1647
Range on HMM: 1-275/275
Sequence Identity: 39% (112 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEE
|.    || | || |. .  .  .|.      |.||  . |..  |. |  || .. . .  |.|.. |||  ..| | | | || |||. |||.| |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKD-ASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

RDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYE-TDYYRKGTKGLLPVRWMPPESLR
  . .. |  |.  .    | | . .   | .|| || |.|   |||||.|.|||.|...| |||||||| ||.|. ||||| | .. ||.|||||||  
--MCYAQYQPRQAPG----PLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIM

DGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGV-MERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYL
   ..  ||| |||||.||  |   ||. .|||  |  ..  | . .|||. ||  . ..|  ||.     | .  || . .
YRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase InR.AA Musk 1368-1647 37 2.1e-86 285.49 In-house 1-282 (282) Show / Hide 
Range on Protein: 1368-1647
Range on HMM: 1-282/282
Sequence Identity: 37% (106 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEE
||    .|.| || |.        |   .   |.|   ..| .     |  ||  | |||   .|.|||||  |.|    .| | .|||  .|..  |  
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

RDEAMMTYLN---RIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPES
   .    .    ..   |  |  .| .  .|| .|| |||||  ..||||||| |||.. .   ||| |||. | ||  |||.       |.|||||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQL-CMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPES

LRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYL
. .  .. .||| ..||.|||.   | ||| |.. | |. |. .| ..  |||||  ...|| |||  . . ||.| .|   .
IWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase InR.AA FGFR 1372-1647 36 7.7e-82 278.19 In-house 5-293 (293) Show / Hide 
Range on Protein: 1372-1647
Range on HMM: 5-293/293
Sequence Identity: 36% (107 aa)

APLGQGSFGMVYEGILKSFPPN--GVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYH-VVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEER
..|| | || |  .  |  ...        |.| . .|.||..     ||  .||       ...|||.|. . |  |. |. ..| |. .|||.|| ..
KMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARRPPGM

DEAMMTY--LNRIGVTGNVQP--------PTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVR
|    .   ..        |.         |     ..|  .| || ||| .| .||||||||  | ||   || |||  ||| ..||||| | | ||. 
DYKKDSQEYTDYK-PRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIK

WMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYL
|| ||.| | || . ||| |.|| |||  |.  ||| .    |.   | . |  ||.|.||.  .  .|  |||  ...||.|  .. ||
WMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase InR.AA Met 1497-1641 40 4.6e-68 222.15 In-house 110-271 (271) Show / Hide 
Range on Protein: 1497-1641
Range on HMM: 110-271/271
Sequence Identity: 40% (65 aa)

AIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDI-YETDYYRKGTKGL---LPVRWMPPESLR--------DGV-YSSASDVFSFGVVL
.  .| || |.|..||||||||.||||   ..|||..|||  ||. |.. ||    .     |||.||.||.|.        .   ....||| |||||.
CHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWSFGVVM

WEMATLAAQPYQGLSN-EQVLRYVIDG--GVMERPENCPDFLH-KLMQRCWHHRSSARPSFL
||  | .| ||   .|   .. .   |      .|| ||| |   .|..|||    .||.| 
WELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase InR.AA CTKB 1492-1640 47 1e-65 224.67 In-house 110-260 (269) Show / Hide 
Range on Protein: 1492-1640
Range on HMM: 110-260/269
Sequence Identity: 47% (72 aa)

RIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAA
|.  ||  .||||||.| |. ||||||||||.| ..  | |||||. ||.|   ||       ||.||| |||. ||||...||| |.|.|.||. | | 
RLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWSYGIVIWEIMTFAK

QPYQG-LSNEQVLRYVIDG-GVMERPENCPDFLHKLMQRCWHHRSSARPSF
 || . ..|  |   . |.   | .|. ||| .  || .||      |.||
MPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISF
Kinase InR.AA ALK 1495-1649 44 3.6e-60 206.22 In-house 115-273 (273) Show / Hide 
Range on Protein: 1495-1649
Range on HMM: 115-273/273
Sequence Identity: 44% (70 aa)

QMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLT---VKIGDFGMTRDI-YETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLA
| .  .| |  ||  ..|.||| |||||          .||.|||| ||| | .|||||| . ..|| ||||| . ||.. | .|| |||| .||   | 
QCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDVWSFGVLCWEIFSLG

AQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEP
  || | .|..|.  |  || |. | |||    ..|  || |    ||.| .|.  .. 
YMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase InR.AA S_TKc 1368-1647 19 1.6e-32 115.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 1368-1647
Range on HMM: 1-231/231
Sequence Identity: 19% (57 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKK--GDLKSYLRAHRP
   | ..|.|.|| || .. |.      .|..||| ..         ....| ...|. .  ..|.|..|.   .   .|||..    |||..|.. ...
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

EE----RDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMP
.      .| .  .                    .. .|.....|.  ....||||   | .. .  ..||.|||. | .         |       .|.
HGLRFPFPE-HARF--------------------YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMA

PESLRDGVYSS-ASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIA---------YL
|| |    |.  ..|. |.|..|.||..    |..   ..|..  .|           |.... ....|..   . ||.  .. .         ..
PEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase InR.AA ALK 1368-1467 38 2.1e-24 81.18 In-house 1-100 (273) Show / Hide 
Range on Protein: 1368-1467
Range on HMM: 1-100/273
Sequence Identity: 38% (38 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEE
|  .  ||.| || ||.|  .  |   |    |.||  | .   .   |. || .|  |.   |||..|.| . || ..| |.|  ||.||.||  ||..
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP
Kinase InR.AA Met 1369-1461 37 1.8e-19 60.25 In-house 1-95 (271) Show / Hide 
Range on Protein: 1369-1461
Range on HMM: 1-95/271
Sequence Identity: 37% (37 aa)

IQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVN-ENATDRER-TNFLSEASVMKEFDTYHVVRLLGVC--SRG-QPALVVMELMKKGDLKSYLR
  . ..||| || || | .   .. |    ||.|. . | .|| .   .|| |. .||.||  .|  |.|.|  . |  | .|| . ||.||||.. |
HFDDVIGQGHFGCVYHGMYH--DNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMP-WVVLPYMKHGDLKTFIR
Kinase InR.AA CTKB 1368-1465 43 1.6e-17 59.11 In-house 1-98 (269) Show / Hide 
Range on Protein: 1368-1465
Range on HMM: 1-98/269
Sequence Identity: 43% (43 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTN-FLSEASVMKEFDT-YHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRP
|.    || | ||.|| |  |   |       ||| . . .   | || |. |  .|.  |    .|||||.| |  | |.|.||| |||||  ||  ||
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVTPVAIKMLQDSSS--EATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRP
Kinase InR.AA Pkinase 1499-1647 18 1.5e-16 59.61 Pfam 116-293 (293) Show / Hide 
Range on Protein: 1499-1647
Range on HMM: 116-293/293
Sequence Identity: 18% (34 aa)

EIADGMAYLAAKKFVHRDLAARNCMVADDLTV----KIGDFGMTRDI-YETDYYRKGTKGLLPVRWMPPESLR-DGVYSSASDVFSFGVVLWEMATLAAQ
.|. |..|. .....||||   |... .. ..    ||.|||  . . |  .   ..  | .  ..|.|| .| .  |....|..|.|..|.||..    
QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRP

PYQGL------SNEQVLRYVIDGGVMERPE--------------------NCPDFLHKLMQRCWHHRSSARPSFLDIIAY--L
|..|       .  |... . .. ...  .                    | .. . ... .|..   . ||.. .|     .
PFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase InR.AA Pkinase 1368-1465 24 1e-10 39.01 Pfam 1-102 (293) Show / Hide 
Range on Protein: 1368-1465
Range on HMM: 1-102/293
Sequence Identity: 24% (26 aa)

IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDR--ERTNFL-SEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKG----DLKSYL
.  . ..|.|||| ||... |. .      . |.|...   ..   ..|... ||...||...  ..|||.... ...   .|||.. .|    ||..|.
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R--AHRP
.  .|..
STWRHGC