Gene LIMK1 (Fruit Fly)

LIMK1

Species: Fruit Fly
Alias: LIM-kinase1, dLIMK, LIMK1, DLIMK, limk, CG1848, DLIMK1, LIM-DOMAIN KINASE, SFO075, LIM-kinase
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 11B2,

Classification

Group: TKL
Family: LISK
Subfamily: LIMK

Sequence

Name Sequence Type Origin Length Description Download
LIMK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 286 Kinase domain by global Sugen HMM Fasta, JSON
LIMK1.AA Protein Various 1257 None Fasta, JSON

Protein domain

Protein domains of LIMK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LIM LIMK1.AA LIM 32-86 29 3.8e-15 57.58 SMART 1-52 (52) Show / Hide 
Range on Protein: 32-86
Range on HMM: 1-52/52
Sequence Identity: 29% (16 aa)

LCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCRED
 ||.|. .. .   . .. |.|. || .||.|..|. .| . ..|..| .||. .
KCARCNKPIYG---DQVMRAMGKHWHPECFCCCHCNKPLGGTFYEKDGKPYCKHC
LIM LIMK1.AA LIM 33-91 31 6.4e-15 55.73 Pfam 1-60 (60) Show / Hide 
Range on Protein: 33-91
Range on HMM: 1-60/60
Sequence Identity: 31% (20 aa)

CAHCRGQLLPHPEEPIVM-ALGQQWHCDCFRCSVCEGHLHNW--YFEREG-LLYCREDYYGRF
|| | ..     .  .|| |..  || .||.|..|  .| ..  ..|..| .|||. .|. .|
CAGCNKPIY---DRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF
LIM LIMK1.AA LIM 95-152 35 7.5e-18 66.11 Pfam 1-60 (60) Show / Hide 
Range on Protein: 95-152
Range on HMM: 1-60/60
Sequence Identity: 35% (21 aa)

CQQCMAVITGPVMV--AGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRS
|. |   |.. ..|  | ....|||||||. |. ....| .. ... .|||| .|| |. 
CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF
LIM LIMK1.AA LIM 94-147 36 3.1e-11 44.55 SMART 1-52 (52) Show / Hide 
Range on Protein: 94-147
Range on HMM: 1-52/52
Sequence Identity: 36% (20 aa)

ACQQCMAVITG-PVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQC
 |  |   |.|  ||.|.....|||||||. |.  .|.   .  ..  |.||  |
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGG---TFYEKDGKPYCKHC
PDZ LIMK1.AA PDZ 233-271 22 6.5e-09 33.1 Pfam 47-86 (86) Show / Hide 
Range on Protein: 233-271
Range on HMM: 47-86/86
Sequence Identity: 22% (9 aa)

LHIGDRILEVNGTPVSDSSVEQIDKLIRSNEK-MLQLTVE
.|.||.|...||..... ..... ..|..  .  ..||..
IHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
Kinase LIMK1.AA LIMK 401-686 72 3.3e-254 850.81 In-house 1-287 (287) Show / Hide 
Range on Protein: 401-686
Range on HMM: 1-287/287
Sequence Identity: 72% (209 aa)

LVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRV
|..||.||.||||...||||||.|||||.|||||.|||.||.|.|||.|.|.|||.|||||||||||||.|.|||||..|||||..|||..|..||.|||
LIHGEVLGKGFFGQAIKVTHRQTGEVMVMKELHRCDEETQRTFLKEVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQPFPWQQRV

RLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMA
|.||||||||||||||.||||||||.||||||||||.||||||||.....|..|.||||||||||||.|.||.|..||...|||.|..||||||||||||
RFARDIACGMSYLHSMCIIHRDLNSHNCLVREDRSVVVADFGLARLMIDERKQSCNMTPGGYGSGANMDNPMEPKRTLHKPKSRDRKKRYTVVGNPYWMA

PEMMKGLKYDEKLDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFC-AQCPEPFVKVAFVCCDLNPDMRPCFETLHVWL
||||.|..||||.|||||||..|||||||.|.||.|||..||.||||||.||.| .|||.||....|.|||..|||||||..||.||
PEMMNGKSYDEKVDVFSFGIVMCEIIGRVYACPDCMPRTMDFGLNQQEFWEKCCPDQCPPPFFPIMFMCCDMDPDMRPCFDKLHQWL
Kinase LIMK1.AA LISK 406-686 47 4.8e-189 619.63 In-house 1-296 (296) Show / Hide 
Range on Protein: 406-686
Range on HMM: 1-296/296
Sequence Identity: 47% (141 aa)

KLGEGFFGKVFKVTHRQSGEVMVLKELHR-----ADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYK-DKKLHMVTEYVAGGCLKELIHDPAQ---VLPW
..|.||||||.|.||||.|.||..|..||      |.|.|.....||.....|.|.....|.||.|. |..||.||||. ||.|.....|...   .|||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

PQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVR----EDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTV
||||..|.|||||||||||||||||||.|.|||||    ......|.|||.|| .| .. ...||....... ...|..|............||..|.|.
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESD-PCMDNDMPMKRKIPKKCMNQRKRRMTI

VGNPYWMAPEMMKGLKYDEKLDVFSFGIMLCEIIGRVEADPDFMPRNS--DFSLNQQEFREKFCAQ-CPEPFVKVAFVCCDLNPDMRPCFETLHVWL
.|.||||||||..| .|||. |||||||.|||||.||.||||..||..  || |...||..|.|   ||.||....| ||...|..||.|.... ||
CGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LIMK1.AA TESK 405-688 44 3.5e-110 349.25 In-house 1-292 (292) Show / Hide 
Range on Protein: 405-688
Range on HMM: 1-292/292
Sequence Identity: 44% (131 aa)

EKLGEGFFGKVFKVTHRQSGEVMVLKELH-RADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLA
||.| |||  |.||.||.|| |||||    .     . | ..||  .  | |  .|.| ||  .. .|| .|||. |||| .|  |   .|.|.|...||
EKIGSGFFSEVYKVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLA

RDIACGMSYLHSMNIIHRDLNSMNCLVR--EDR--SVIVADFGLA-----RSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSR---QRRQRYT
 ||| ||||||| .. |||| | |||||  ...  . .|.|||||          |  |    .|      |    ||     | .  .     |...  
YDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPM-----LEKIPVYCMDSRKEKMA

VVGNPYWMAPEMMKGLKYDEKLDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQR
||| ||||||| ..| .|||| ||||||| ||||| |..|||| |||  .| |  | |.|.    ||||| ..|| || ..|  || |. .   |. 
VVGSPYWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPRTEKFGLDYQAFKEMCPMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHLEW
Kinase LIMK1.AA TKL 407-686 24 3.6e-87 295.89 In-house 1-364 (364) Show / Hide 
Range on Protein: 407-686
Range on HMM: 1-364/364
Sequence Identity: 24% (95 aa)

LGEGFFGKVFKVTHRQ--------SGEVMVLKELHR---------------------------ADEEAQRNFIKEVAVLRLLDHRHVLKFIG--------
.|.|.||.|.| ..|.        .|.... | ...                             . ..  ...|. ... |.| ....|.|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VLYK----DKKLHMVTEYVAGGC-LKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMN--------IIHRDLNSMNCLVREDRS--------------
 | ..    ...|..|.||. ||. |  |.        |.||.|.|.|||.||.||||||        ||||||.| |.|| |.                
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

VIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGL----------------KYDEKLDVFSFG
. ..||||.|...     . .|| ...  .|       .      .. ..| ...|..|.|.|||||...|                 .|.|| ||.|||
CKICDFGLSRFMSQSGNMNDTMTTMME--SA-------E------HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

IMLCEIIG--RVEADPDFMPRN------SDFSLNQQEFREKFC-------------AQCPEPFVKVAFVCCDLNPDMRPCFETLHVWL
|.|.||.   |...|...||.        .|... ....   .              .||... | .  |.| .|. || |...  .|
IVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LIMK1.AA LISK-DD1 446-686 29 9.9e-63 214.72 In-house 44-290 (290) Show / Hide 
Range on Protein: 446-686
Range on HMM: 44-290/290
Sequence Identity: 29% (84 aa)

EVAVLRL---LDHRHVLKFIGVLYK-------------DKKLHMVTEYVAGGCLKELIHD-P-----------AQVLPWPQRVRLARDIACGMSYLHSMN
|...|.    . |  . .|||. ..             .  |. |||.. || | ... . |              .||. ||..|.||||.|.|||| |
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

IIHRDLNSMNCLVRED----RSVIVADFGLARSVDAP---RLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYD
|||||| | | || |     .   | |||.|| ..     .                                  .  ..| .| . |||||.  |..||
IIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQ----------------------------------NNRHMTICGTDNWMAPEVILGMSYD

EKLDVFSFGIMLCEIIGRVEADPDFMPRN--SDFSLNQQEFRE-KFCAQ--CPEPFVKVAFVCCDLNPDMRPCFETLHVWL
.  ||||||. | |.| |.  |... .|.  ..| ..| |||  |  .   ||..| .... ||  .|. || | .    |
WSCDVFSFGMVLLELITRKKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL
Kinase LIMK1.AA TK 401-686 15 5.7e-56 185.76 In-house 1-486 (486) Show / Hide 
Range on Protein: 401-686
Range on HMM: 1-486/486
Sequence Identity: 15% (80 aa)

LVIGEKLGEGFFG---KVFKVTHRQSG----------------------------EVMVLKELHRADEEAQRN--------------FIKEVAVLR--LL
...|.||||| ||   .|.| . |. .                             | .||| . ...|...               .  | ....  |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHRHVLKFIGVLYKDKK------------LHMVTEYVAGGC----LKELIHDPAQV--------------------------------------------
.| ......||  ...             . .|.||...|.    |..  ..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPWPQRVRLARDIACGMSYLHSM------NIIHRDLNSMNCLVREDRS-----------VIVADFGLAR
                               |. .|..  ...|||||.||||.      |..||||   |||| |.             . .|||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

---SVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPY----------------------------WMAPEMMKGLK------
                                     ...  .... |.......                            ||||| ... .      
QGSG--------------------------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEK

---YDEKLDVFSFGIMLCEIIGRVEADPDF-MPR--------NSDFSLNQQEF--------------REKFC-AQCP--------------EPFVKVAFV
   . .| ||.|||... ||  . .. .   |.         | ..  . ..                .. . ..||              | .  .   
YGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQ

CCDLNPDMRPCFETLHVWL
|....|. || |..||  |
CWHYDPEDRPTFSQLHEQL
Kinase LIMK1.AA TKL-Unique 403-626 28 2.4e-53 183.53 In-house 1-222 (290) Show / Hide 
Range on Protein: 403-626
Range on HMM: 1-222/290
Sequence Identity: 28% (70 aa)

IGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQ--RNFIKEVAVLRLLD-HRHVLKFIGVLY----KDKKLHMVTEYVAGGCLKELIH-------
...|.||| .|.|.|...|..   .. ...  .| . .  ..|..|| ..  |. |  .....|.      . ... .|.||. || | ...|       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--DPAQVLPWPQRVRLARDIACGMSYLHSMN--IIHRDLNSMNCLVRED-----RSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLR
   .   |.. |||..|.||| || |||. .  |||||| | | || ..      .. ..||||... .     . |.  |.                  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR-----------------

RSKSRQRRQRYTVVGNPYWMAPEMMKG--LKYDEKLDVFSFGIMLCEII
           |..|.. |||||....   .|.|| ||.||||.| ||.
---------NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase LIMK1.AA S_TKc 401-686 23 8.7e-49 169.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 401-686
Range on HMM: 1-231/231
Sequence Identity: 23% (72 aa)

LVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAG--GCLKELIHDPAQV-----
  |..|.|.| ||||.|..|. .|... .|...       .....|...|.  .| .. |...| .  ..|.||.||. |  | |...|..         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVV
.|  .  .... |.|.. |.||..||||||   | |. |   . ..|||||| .                                          .|..
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------TTFC

GNPYWMAPEMMKGLKYDE-KLDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETL--------HV
| |..||||..   .|.  | |. |.|..| | . .    |           ..|.  .| .   ....      |.. .|. ||  | |        | 
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHP

WL
|.
WF
Kinase LIMK1.AA Pkinase_Tyr 401-547 32 3.6e-47 160.36 Pfam 1-161 (270) Show / Hide 
Range on Protein: 401-547
Range on HMM: 1-161/270
Sequence Identity: 32% (53 aa)

LVIGEKLGEGFFGKVFKVTHR----QSGEVMVLKEL-HRADEEA--QRNFIKEVAVLRLL-DHRHVLKFIGVLY-KDKK--LHMVTEYVAGGCLKELIHD
...|.||||| ||.|.| | .    . .     | | . |..|.  .. |..|..... | .| ......|| . ...   . .|.||...|.|..  ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P---AQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSV
.    | |. .. .  ...||.||.||.|.|.|||||   |||| |.. | ..|||||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase LIMK1.AA Pkinase 401-622 24 4.3e-47 167.55 Pfam 1-202 (293) Show / Hide 
Range on Protein: 401-622
Range on HMM: 1-202/293
Sequence Identity: 24% (58 aa)

LVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEA--QRNFIK--EVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGG----CLKELIH-DPA
..||.|.|.| ||.|.| .|. .|.. ..|.. . .|.   ... ..  |..... |.| ........ . .....||.||. ||     |...|. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QVL--PWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSV----IVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQ
 ..  .. .  . .. |..|. |.|||.|||||| . |.|. ..  .     ..|||||. .|                                     
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------------------------------Y-N

RRQRYTVVGNPYWMAPEMMK-GLKYDEKLDVFSFGIML
 .  .|..| |..||||  . | .|. | |..|.|..|
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL
Kinase LIMK1.AA STE 401-626 21 1.6e-44 154.26 In-house 1-262 (359) Show / Hide 
Range on Protein: 401-626
Range on HMM: 1-262/359
Sequence Identity: 21% (64 aa)

LVIGEKLGEGFFGKVFKVTHR------QSGEV---------MVLKELHRADE-----------------EAQRNFIKEVAVLRLLD--HRHVLKFIGVLY
. . ||.|.| ||.|.|  ..      ..|||         |  |...  ..                 | . ...||. ... ..  | .. |..|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------KKLHMVTEYVAGGCLKELIH---DPAQVLP----------WPQRVRLARDIACG-MSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLAR
|.        .|... ||..||.| ..|.    . . |.           .|  . .|.|  | ..||||..|||||. . | |.     |  .|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

SVDA------------PRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKG------LKYDEKLDVFSFGIMLCEII
...                                            . . .  .|.|.|| | |||||....       .||.| |. |.|....| .
QLTDSMANIQSNNIIDC------------------------------I-ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase LIMK1.AA TyrKc 401-686 25 1.9e-43 151.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 401-686
Range on HMM: 1-280/280
Sequence Identity: 25% (82 aa)

LVIGEKLGEGFFGKVFKVTHRQSGEVMVL-KELHRADEEAQRNFIKEVAVLRLL--DHRHVLKFIGVLYKD-------KKLHMVTEYVAGGCLKELIHDP
.. |.|||||.||.|.| | .    ..|  | |.      .. |..|  ... |  .| ......||  ..       . | .|.||...|.||. ....
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

AQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSV---DAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRR
   |.... .  . .|||||.||||.|.|||||   |||| |.. | ..||||.| .   |.                                    . 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---------------------------------ESK

QRYTV----VGNP----YWMAPEMMKGLKYDEKLDVFSFGIMLCEIIGRVEADPDF-----MPRNSDFSLNQQEFREKFCAQ--------CPEPFVKVAF
. |..     |.      ||||| ..  |. .| ||.|||... ||  . .  .       |.    . . .| .| .  .         ||.   ..  
DYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK

VCCDLNPDMRPCFETLHVWL
 |.. .|..||.|...|  .
QCWHEDPEDRPTFSEIHECF
Kinase LIMK1.AA MLK 401-547 28 3.8e-34 115.91 In-house 1-183 (291) Show / Hide 
Range on Protein: 401-547
Range on HMM: 1-183/291
Sequence Identity: 28% (53 aa)

LVIGEKLGEGFFGKVFKVTHRQSG----EVMVLKELHRA-----DEEAQRNFIKEVAVLRLLDHRH----VLKFIGVLYKD-KKLHMVTEYVAGGCLKEL
. . |..|.| ||||.| . |       .| | .  .|.      .. |..| .|.  || |.|.     . .| ||  .. ...  |.||..||.| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IHD----PA---------QVLPWPQRVRLARDIACGMSYLHSMN---IIHRDLNSMNCLVRE------DRSVIVADFGLARSV
.|.    ..          | .  . .. | ..| ||.|||||    ||||||.| | |. |      .. . ..|||..|..
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW
Kinase LIMK1.AA Dicty5 443-549 35 5e-29 97.04 In-house 43-156 (260) Show / Hide 
Range on Protein: 443-549
Range on HMM: 43-156/260
Sequence Identity: 35% (41 aa)

FIKEVAVLRLLD--HRHVLKFIGVLYKDKKL-HMVTEYVAGGCLKELIHDPAQ----VLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRS
| .||... . .  |  . .. |   ...|    ||||.  | | ..  |        . ..|.. .| ||| .| .||||||||||| ||| |. |.  
FYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWK

VIVADFGLARSVDA
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IKIIDFGTSRFVDN
Kinase LIMK1.AA Dicty5 583-631 44 1.5e-14 46.45 In-house 151-202 (260) Show / Hide 
Range on Protein: 583-631
Range on HMM: 151-202/260
Sequence Identity: 44% (23 aa)

SR--QRRQRYTV-VGNPYWMAPEMMKGLKYDEKLDVFSFGIMLCEIIGRVEA
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SRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEP
Kinase LIMK1.AA MLK 594-628 44 3.1e-11 35.33 In-house 195-232 (291) Show / Hide 
Range on Protein: 594-628
Range on HMM: 195-232/291
Sequence Identity: 44% (17 aa)

GNPYWMAPEMM---KGLKYDEKLDVFSFGIMLCEIIGR
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GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase LIMK1.AA Pkinase_Tyr 598-626 48 0.000671 13.83 Pfam 180-208 (270) Show / Hide 
Range on Protein: 598-626
Range on HMM: 180-208/270
Sequence Identity: 48% (14 aa)

WMAPEMMKGLKYDEKLDVFSFGIMLCEII
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WMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase LIMK1.AA Pkinase_Tyr 668-686 36 0.07519 6.89 Pfam 252-270 (270) Show / Hide 
Range on Protein: 668-686
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CCDLNPDMRPCFETLHVWL
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CWHYDPEDRPTFSEIHEQL