Gene slpr (Fruit Fly)

slpr

Species: Fruit Fly
Alias: dMLK, SFO137, dMLK2, Mlk2, Mixed lineage protein kinase 2, slipper, MLK2, slpr, CG2272
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 7D17,

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
slpr.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
slpr.AA Protein Various 1020 None Fasta, JSON

Protein domain

Protein domains of slpr.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 slpr.AA SH3 46-106 39 2.1e-19 71.7 SMART 1-58 (58) Show / Hide 
Range on Protein: 46-106
Range on HMM: 1-58/58
Sequence Identity: 39% (25 aa)

SLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIG--DKVGVFPKDFVTDED
    |||||.||..|||....|.|. ||. |     | ||| |...   ..| ||. .|.  |
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 slpr.AA SH3_1 49-99 35 3.3e-15 54.28 Pfam 1-49 (49) Show / Hide 
Range on Protein: 49-99
Range on HMM: 1-49/49
Sequence Identity: 35% (19 aa)

TALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGD--KVGVFPK
.|||||.||..|||....|.|. |.. . .     .||.|.  .  ..| || 
VALYDYQAQQPDELSFKKGDIIHVIEKSDD----WDWWKGRCNNTGQEGWFPS
SH3_2 slpr.AA SH3_2 47-102 20 3.7e-08 31.47 Pfam 1-65 (68) Show / Hide 
Range on Protein: 47-102
Range on HMM: 1-65/68
Sequence Identity: 20% (14 aa)

LWTALYDYDA-QGEDE-----LTLRRGEIVVVL---STDSEVSGDVGWWTG-KI--GDKV--GVFPKDFV
.  .. ||.. ....|     |....|....|.   ..|..     .|| .     | ..  |.|| ..|
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-----NWWWCWETIWGGRRMRGWFPSQWV
Kinase slpr.AA MLK 129-386 65 9.20000000001e-192 639.38 In-house 1-280 (280) Show / Hide 
Range on Protein: 129-386
Range on HMM: 1-280/280
Sequence Identity: 65% (184 aa)

LDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRM---RDNVLQEAKLFWALKHENIAALRGVCLN-TKLCLVMEYARGGSLNRILAGK-IPPD
|.|||.||.|||.||.|....|||||.|...|..|.|||..   ...| |||.|||.|||.||.|||||||. ..|||||||.|||||||..||| |||.
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGKRIPPH

VLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIE-----------------GNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISV
||||||.||||||||||||||..||||||||||.||.|.|.                 ......|.|||||||||||...|.|||||||||||.||||..
VLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKE

STYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL
||.||.|||||||||||||.|||.||.|.|||.||||||.|.||||||.||||.|..||..||..||||||.|.|||.||
STWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase slpr.AA MLK 129-386 42 5.6e-148 497.9 In-house 1-291 (291) Show / Hide 
Range on Protein: 129-386
Range on HMM: 1-291/291
Sequence Identity: 42% (126 aa)

LDIKEVIGSGGFCKVHRGYYDGEE-----VAIKIAHQTGEDDMQRM---RDNVLQEAKLFWALKHEN----IAALRGVCLNT-K-LCLVMEYARGGSLNR
....|.||||.|.||..|.. ...     ||.|..... . |....   .... .|..... |.|.|    | ...||||.. . .|.||||..||||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ILAGK----------------IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNT-Q-RMSAAGTY
.|.|.                ...|...||| |.||||.|||..||. ||||||||.|.||.| |.. .....||||.|||..|..... . .||.||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

AWMPPEVI---SVSTYSKFSDVWSYGVLLWELITGETPYK-GFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL
||| ||||     ..||. .||||.||.|||..|.|.||| . ||. .|..||.| |..|||.|||| |  ||| ||..|||||| |..|...|
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase slpr.AA TKL 135-386 28 2.9e-102 346.03 In-house 1-364 (364) Show / Hide 
Range on Protein: 135-386
Range on HMM: 1-364/364
Sequence Identity: 28% (104 aa)

IGSGGFCKVHRGYYDG----------EEVAIKIAHQTG-----------------------EDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTK--
||||||..|..|.. |          ..||.|. ...                        ... ...|.   .|...   |.|.||  . |.|.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVMEYARGGS-LNRILAGKIPPDVLVNWAIQIARGMNYLHNEAP-----MSIIHRDLKSSNVLIYEAIEG------NHLQQKTLKI
            ||.||||. ||| |....     ......||..|||||||||.. |     . ||||||||.|.|. |  .       |.  . ..||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

TDFGLAREM---------------------YNTQRMSAAGTYAWMPPEVISVS----------------TYSKFSDVWSYGVLLWELITGETPYKGFDPL
.||||.|.|                     .....|.  ||..||.|||.  .                .||. .||.|.|..|||..|...||..... 
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

SVA---------YGVAVNTLTLPIP------------KTCPETWGALMKSCWQTDPHKRPGFKEILKQL
..          ..|... | .|||            ..||. .  ||. ||..||.||| |.||||.|
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase slpr.AA TyrKc 129-386 29 3.5e-75 256.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 129-386
Range on HMM: 1-280/280
Sequence Identity: 29% (89 aa)

LDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWAL--KHENIAALRGVCLN--------TKLCLVMEYARGGSLNRIL--
.  ....|.| |..|..| .. ..||.|  .          |   ..||..   |  .|.|| .| |||.           |..||||. .|.|.  |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

-AGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNT---------QRM----SAA--GTYAWMP
  .|.... |.....|||.||.|||      .|||||   |.|. |          | ||.||||.|. |.           |.    ..     . ||.
HRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKG----FDPLSVAYGVAVNTLTLPIPKT--------CPETWGALMKSCWQTDPHKRPGFKEILKQL
||.|  ....  |||||.||..||. | |..|| |    . . . ..    .   .|.|.         ||.    .||.||. ||..|| |.|| ...
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase slpr.AA Pkinase_Tyr 129-386 33 1.6e-74 252.99 Pfam 1-270 (270) Show / Hide 
Range on Protein: 129-386
Range on HMM: 1-270/270
Sequence Identity: 33% (95 aa)

LDIKEVIGSGGFCKVHRGYYD------GEEVAIKIAHQTGEDDMQRM--RDNVLQEAKLFWAL-KHENIAALRGVCL-----NTKLCLVMEYARGGSLNR
. . ...|.| | .|..|...      . .||.|.  .   . |..   |.  ..|||.   | .|.||  | |||.     | ....||||. .|.|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLD

ILAGK------IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREM----YN-TQRMSAAGTYAWMPPEV
 |  .      ...  |.....|||.||.||..   . .|||||   |.|. |        ... ||.|||||| .    |  ..| ..     ||.||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

ISVSTYSKFSDVWSYGVLLWELIT-GETP-YKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL
|. . ..  |||||.|||.||..| ||.| |.| ..  |   .. .   .|.|. ||.    |||.||. || .|| |.||. ||
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase slpr.AA TKL-Unique 131-386 33 1.1e-71 244.5 In-house 1-290 (290) Show / Hide 
Range on Protein: 131-386
Range on HMM: 1-290/290
Sequence Identity: 33% (100 aa)

IKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALK-HENIAALRGVCL-----NTKLCLVMEYARGGSLNRILA-------
. ..||.||...| .| . |..||||. |   ||   .|...   | ..   |. |.||  . |.|      . ..|.||||  ||||.  |.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

-----GKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAA-----------GTYAWMPP
      |... . |. ||.||.||.|||.. |  ||||||||||.|. ..   . ..    || ||||..   .  .|..            |.. ||.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWN---IKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

EVISV--STYSKFSDVWSYGVLLWELITGET------PYKGFDPLSVAYGVAV--NTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL
||..   ..||. |||.|.|. |||..|..       ||.|.|. ...  |..    . .|||  ||.    |.. ||  || .|| | ||.. |
EVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase slpr.AA LZK 131-386 40 6.8e-70 234.83 In-house 1-241 (241) Show / Hide 
Range on Protein: 131-386
Range on HMM: 1-241/241
Sequence Identity: 40% (106 aa)

IKEV--IGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKL-CLVMEYARGGSLNRIL--AGKIPPDVL
|.|   .|||    | || . .|.||.|   .  | |   .|            |||.|| ...|||      | .|||   | |  .|    .|.|  .
ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETDIKHLR-----------KLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLM

VNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNT--QRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLW
|.|  ||| ||.|||      |||||||| |.||         ..  .|| |||  ... .    .|| .|| ||| ||||     |   |.||.|| ||
VDWSKQIAQGMHYLHQHK---IIHRDLKSPNILI--------SHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLW

ELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL
|. |.|.|||  |   . .||  | | ||.| ||||    ||| ||.  |  || |. ||  .
EMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase slpr.AA TK 129-386 17 1.8e-67 225.0 In-house 1-486 (486) Show / Hide 
Range on Protein: 129-386
Range on HMM: 1-486/486
Sequence Identity: 17% (88 aa)

LDIKEVIGSGGFC---KVHRGYYDG---------------------------EEVAIKIAHQTGEDDMQRMRD-------------NVLQEAKLFW--AL
. . ...|.| |.   .|..| . |                           ..||.|. . . ........|             . ..|.|..   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHENIAALRGVCLNTK-------------LCLVMEYARGGS----LNRILAGK-----------------------------------------------
.|.||  | |||.  .             ...||||. .|.    |   |  .                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IPPDVLVNWAIQIARGMNYLHNE--APM--SIIHRDLKSSNVLIYEAIEGNHLQQK--------TLKIT
                               ...  |. .. |||.|| |||      .   ..||||   |.|.     |.... |        . ||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLV-----GENNVCKWHFDGCGPVCKIA

DFG--------LAREMYNTQRMSAAGTYA----------------------------WMPPEVIS---------VSTYSKFSDVWSYGVLLWELIT-G-E
|||        |||..|. .   ....|                             ||.||..            ...  |||||.|||.||. | | |
DFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQE

TPYKGFDP--------LSVAYGVAVN--------------TLTLPIPKTCP--------------ETWGALMKSCWQTDPHKRPGFKEILKQL
..| | .         .   .   ..               . .| |. ||              | .  ||..||. || .|| |.....||
PYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase slpr.AA Pkinase 129-386 27 1.9e-65 228.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 129-386
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

LDIKEVIGSGGFCKVHRGYYDGEE--VAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGG----SLNRILA----
. |...||||.| .| ...  |..  ||.||    .|.. .....  |.|...   |.|.||  |....  ......||||..||    .| ...     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKI--PPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAR---EMYNTQRMSAAGTYAWMPPEVIS-VSTYSK
|..  ..... ... ||.||..|.|..   .|||||||..|.|| .  . .     ..||.|||||.   .  |.  .. .||. .|.||||   . |..
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

FSDVWSYGVLLWELITGETPYKGF------DPLSVAYGVAVNTLTLPIPKTCP-------------------ETWGALMKSCWQTDPHKRPGFKEILKQ-
 .|.||.|..|.|...|..|..|       |.. . . .    |  ..|..|.                   |.   ..|.|.. ||.|||....||.  
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
Kinase slpr.AA S_TKc 129-395 28 2.7e-63 217.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 129-395
Range on HMM: 1-231/231
Sequence Identity: 28% (79 aa)

LDIKEVIGSGGFCKVHRGYY--DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARG--GSLNRILAGK-----
 .| ..||.|.| ||....   .|..||||| .           .....| ..    .|.||  | .|. ...|..||||. |  |.| ...  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSK-FSDV
   .|. .   .. ||.....|.|.   . ||||||| .|.|. |          ..||.||||||..     ..  ||  .|.|||.    |.|  .|.
RFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDW

WSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFT
|| |..|.|...|..|.     . . . . .           || .  ... |.| || |||.  |.|.  . |.|  . 
WSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase slpr.AA Dicty4 129-388 33 3.3e-63 209.7 In-house 1-277 (277) Show / Hide 
Range on Protein: 129-388
Range on HMM: 1-277/277
Sequence Identity: 33% (96 aa)

LDIKEVIGSGGFCKVHRGYYDGEEVAIKIA--HQTG--EDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL----NT-KLCLVMEYARGGSLNRILAG-
..| . ||.|.| .|..|   | |||.|..  |...  |. ..  |    .|...   . | ||  . | |.    .  |.| |.||   |.| ..|   
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFR----KEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDK

------KIPPD-VLVNW----AIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAR----EMYNTQ-RMSAAGTYAWMPPE
      .|..|  |.      |. .|||||.||.  |  ||||||||.| |. .         .. |..||||..    .  ...  |.|.|| .|| ||
PSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK--------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE

VISVSTYSKFSDVWSYGVLLWELITGETPYK--GFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQ--LES
|     |   .|| |.| .|||. |.. ||   . ..  .. .|.   | .|||. ||  | .|.. || .|| .|| |.||...  ||.
VMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase slpr.AA LRRK 129-388 27 9.4e-59 201.5 In-house 1-351 (351) Show / Hide 
Range on Protein: 129-388
Range on HMM: 1-351/351
Sequence Identity: 27% (96 aa)

LDIKEVIGSGGFC-KVHRGYYDG----------------------------EEVAIKIAHQTG------------------------------EDDMQRM
| | | ||.|||  .|.|. . |                            ..||||. . ..                              ..|. | 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

RDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILA---G--------KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVL
     .|. .   |.| ||  | |.|..  ||.|||||. |.|.. |             .|.. ..   |.|||.||.|||.  |. |||||||| |.|
FREFRHEVWIMSHLNHPNIVSLKGFCIHP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPP-IIHRDLKSPNIL

IYEAIEGN----HLQQKTLKITDFGLAR--EMYNTQ-RMSAAGTYAWMPPEVISV---STYSKFSDVWSYGVLLWELITGE-TPYKGFD-P--LSVAYGV
. .  ...      .. . || |||. |    . .  ..   |.  || ||..     ..|.  .|. |.|..||||.|..  |. ..| .  ..  . .
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQI

AV---NTLTLPIPKT-CPE-----TWGALMKSCWQTDPHKRPGFKEILKQLES
     . |  .|| . ||.        .|...|||.|| ||| | .|.|.|..
EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase slpr.AA Dicty4-Unclassified 129-386 31 1e-57 196.26 In-house 1-263 (263) Show / Hide 
Range on Protein: 129-386
Range on HMM: 1-263/263
Sequence Identity: 31% (86 aa)

LDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQ-RMRDNVLQEAKLFWALKHENIAALRGVCLNT-----KLCLVMEYARGGSLNRILA-----
. |   || | | |||.|   | .||.|.    . .     | .. . |  .   . | |   ..| |.|       .| |||    | |  .       
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNE-NKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

--GKIPPDV--LVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAG-TYAWMPPEVISVSTYSKF
    |  |    .  |. ||.|| .||      .||||.||||.|.              || |||..|.  ... | . . | .|  ||.     |   
QQQPIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFN--------IKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQK

SDVWSYGVLLWELITGETPYKGFD-PLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL
|||.||...|.||.||. || .   .. .|  |.   |   ||  |.  |  | | ||  || ||| . .| . |
SDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase slpr.AA TK-Unique 129-386 29 2.1e-55 189.46 In-house 1-294 (294) Show / Hide 
Range on Protein: 129-386
Range on HMM: 1-294/294
Sequence Identity: 29% (91 aa)

LDIKEVIGSGGFCKVHRGYYDG----EEVAIKIAHQTGEDDMQRM-RDNVLQEAKLFWALK-HENIAALRGVCL-NT-KLCLVMEYARGGSLNRILA---
| ...|||.| |  |.|| . |    ..  ...|. . .|. .   ... |.|......|. |.||  . |.|  ..   ...|||...|.|   |    
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GK-------------------------IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYN-----T
..                         | |  |...|.|||.||.||.   .. |.|||| ..|||. |         |..||.|||.||. |.     .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLAS-QRKKIVHRDLCARNVLLTE--------DKVCKICDFGMARDVYTNGVYSM

QRMSAAGTYAWMPPEVIS--VSTY-SKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTC-PETWGALMKSCWQTDPHKRPGFKEI
.. .    ..||.||...    .| .  |||||.|||.||. | |..|| | .. ..   .  .  ..| |. | ...   ||||||| .|..|| | .|
MCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIR-DGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQI

LKQL
...|
KHRL