Gene CG8789 (Fruit Fly)

CG8789

Species: Fruit Fly
Alias: SFO192, DLK/ZPK, CG8789
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 76B9--11,

Classification

Group: TKL
Family: MLK
Subfamily: LZK

Sequence

Name Sequence Type Origin Length Description Download
CG8789.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 240 Kinase domain by global Sugen HMM Fasta, JSON
CG8789.AA Protein Various 977 None Fasta, JSON

Protein domain

Protein domains of CG8789.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG8789.AA LZK 161-400 78 6.30000000001e-211 707.01 In-house 1-241 (241) Show / Hide 
Range on Protein: 161-400
Range on HMM: 1-241/241
Sequence Identity: 78% (189 aa)

ITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGM
|.||.|||||||||||.|...|||||||||..||||||||||||.|.|||.|||||||||..|||||.||.|.|...|.|.....|...|.|||||| ||
ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETDIKHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGM

QYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEI-STKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVG
.|||.||||||||||||||||.|.||||.|||||..|||. ||||||.||||||||||||||||||||||||.|||||||||||||||||||.|||||||
HYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVG

NNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHL
.|||.|..|||||||||||.|.||..||||||||||||.|.
SNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase CG8789.AA MLK 161-400 46 6.9e-147 494.29 In-house 1-291 (291) Show / Hide 
Range on Protein: 161-400
Range on HMM: 1-291/291
Sequence Identity: 46% (134 aa)

ITELEWLGSGAQGAVFSGRLKNET-----VAVKKVK-------------ELKETDIKHLRKLDHEN----IIKFKGVCTQSPV-FCIIMEFCPYGPLQNI
|...||.|||..|.|..|| .|..     ||||.|.             . .|....|||.|.|.|    ||.|.|||.|.|  |||.||.|..|.| |.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LKEEQ--------------VMLPSRLVSWSKQIALGMQYLHSHK---IIHRDLKSPNILIS------TNEVVKISDFGTSREWNEI-STKMSFAGTVAWM
|....              |. .. ...|..|.| ||.||||..   ||||||||.||||.       ....||.||||||.|... ...||.|||.|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEVI---RNEPCSEKVDIWSYGVVLWEMLTCEIPYK-DVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHL
|||||   |.|..|||.|.||.|||||||||.|.||| ..|..||.|.|..|.| . .||||||..| | | ||...|..|||||||..||
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase CG8789.AA TKL 167-400 27 1.2e-104 353.92 In-house 1-364 (364) Show / Hide 
Range on Protein: 167-400
Range on HMM: 1-364/364
Sequence Identity: 27% (102 aa)

LGSGAQGAVFSGRLKN----------ETVAVKKVK----------------------------------ELKETDIKHLRKLDHENIIKFKGVCTQSPV-
.|||. | |. |....          ..||||| |                                  . .|  |.....|.|.||..|.|.|...|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHK--------IIHRDLKSPNILISTNEV--------------VK
            .||.||.|| | | ..|       ......|...||.||.||||..        ||||||||.|||.  |                .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ISDFGTSREWNEIS--------------------TKMSFAGTVAWMAPEVIRNE----------------PCSEKVDIWSYGVVLWEMLTCEIPYKDVDS
|.|||.||.... .                    |.|.  || .||||||.|..                . |||.|..|.|.||||.||...||.| ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

S---------AIIWGVGNNSLKLLVP------------STCPEGFKLLVKLCWKSKPRNRPSFRQILSHL
.         .....|....|....|            ..||...| | . ||...|..|||| .||..|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CG8789.AA ZAK 161-399 42 4.8e-76 258.95 In-house 1-257 (257) Show / Hide 
Range on Protein: 161-399
Range on HMM: 1-257/257
Sequence Identity: 42% (110 aa)

ITELEWLGSGAQGAVFSGR--LKN---ETVAVKKVKEL-KETDIKHLRKLDHENIIKFKGVCTQSPV-FCIIMEFCPYGPLQNILKEE--QVML------
|   .  | |  |.|....  .      ..|||||  . ||  |  | |. | ||| | |.|   |  . |. |.   | |      .  | |       
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFKIEKEAEI--LSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGN

-PSRLVSWSKQIALGMQYLH---SHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVI-RNEPCSEKVDIWSYGVVLWEML
     . |  ||| ||.|||     ||||||||| |. |  | |.|| ||||||.     | ||. || .|||||.|   || .|  |.|||||||||||
SMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEML

TCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSH
| |.|||| .   | | .     .| .|. ||  || |   |||  |. ||..||| | 
TREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase CG8789.AA Pkinase_Tyr 161-400 33 1.9e-74 252.78 Pfam 1-270 (270) Show / Hide 
Range on Protein: 161-400
Range on HMM: 1-270/270
Sequence Identity: 33% (90 aa)

ITELEWLGSGAQGAVFSGRLK------NETVAVKKVKELKETD----------IKHLRKL-DHENIIKFKGVCT-QSPV--FCIIMEFCPYGPLQNILKE
|| .. ||.|| | |. |..|      . .||||..||    .          .| ...| .|.||... |||| |.     .|.||..|.| | . |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----EQVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREW----NE-ISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWS
    .|   ...|.... ||| ||.||.|...|||||   |.|.. | ||||.||| .|      .   ... .    . |||||.|..  ...| |.||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWS

YGVVLWEMLT-CEIP-YKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHL
.||..||..| .|.| |.... . ..  .. .   .  |  ||.    | |.||. .| .||.|..|...|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CG8789.AA TyrKc 161-400 32 2.8e-74 254.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 161-400
Range on HMM: 1-280/280
Sequence Identity: 32% (92 aa)

ITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETD-----IKHLRKL--DHENIIKFKGVCTQS-------PVFCIIMEFCPYGPLQNILKEEQV-ML
|| .. ||.|| | |. |..| ..||||..|| .        .. ..||  .|.||... |||||.       .  .|.||..|.| |.. |.. .    
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

PSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEI--------STKMSF--AGT----VAWMAPEVIRNEPCSEKVDIWS
.. |.|.. ||| ||.||||...|||||   |.|.. | .||||||| ||.. .           ...    |     . |||||.|.   ...| |.||
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

YGVVLWEMLT-CEIPYKD-----VDSSAIIWGVGNNSLKLLVPS-------TCPEGFKLLVKLCWKSKPRNRPSFRQILSHL
.||..||..| .. || .     .. . .|  | .       |.       .||.    . | ||. .| .||.|..| . .
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CG8789.AA Dicty4 161-402 32 7.4e-74 245.73 In-house 1-277 (277) Show / Hide 
Range on Protein: 161-402
Range on HMM: 1-277/277
Sequence Identity: 32% (91 aa)

ITELEWLGSGAQGAVFSGRLKNETVAVKKV---KE-LKETDIKHLRK-------LDHENIIKFKGVCT----QSPVFCIIMEFCPYGPLQNILKE-----
|.  . .|.|. | |. |. .   |||||    .. . |  .. .||       . | ||..|.| ||    ... .|| .|..| | | ..|       
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-EQVMLP-SRLVS---WSKQIALGMQYLHS--HKIIHRDLKSPNILISTNEVVKISDFGTSR---EWNEIST-KMSFAGTVAWMAPEVIRNEPCSEKVDI
 . . |. ..  .     . .|.||..||.    |||||||| |.|.. | .||..||| |.   .  . ..  |. .||..|||||| ...|  ||.| 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

WSYGVVLWEMLTCEIPYK--DVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSH--LDI
 |.| ||||.||...||     .   .. .|.|  |.. .|. ||  .| |.. ||   | .|||| .|..   |. 
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase CG8789.AA Pkinase 161-400 28 3.6e-73 254.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 161-400
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

ITELEWLGSGAQGAVFSGRLKNET--VAVKKVKELKETD-----------IKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYG----PLQNILK--EE
.. .. .|||. | |. .. |..   ||||..|  .| .           |. ...|.|.||........ ..  ...||.|. |     |  ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QVM--LPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVV----KISDFGTSRE--WNEISTKMSFAGTVAWMAPEVIR-NEPCSEKVDIWSY
 ..   .  . .. .||. |..|.||..|||||||. ||||. | ..    ||.||| ..   .   |  ..|.||  .||||||| ... . |||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLWEMLTCEIPYKDV------DSSAIIWGVGNNSLKLLVPSTCP-------------------EGFKLLVKLCWKSKPRNRPSFRQILSH--L
|..|.|||. . |...       |  ..|  ..   |.   | .|.                   | .| ..| |.. .|  ||...||| |  .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CG8789.AA TKL-Unique 164-400 30 8.8e-70 238.15 In-house 2-290 (290) Show / Hide 
Range on Protein: 164-400
Range on HMM: 2-290/290
Sequence Identity: 30% (88 aa)

LEWLGSGAQGAVFSGRLKNETVAVKKVKE-----LKETD--IKHL---RKLD-HENIIKFKGVCT----QSPVFCIIMEFCPYGPLQNILK---------
.. .|.|..|.|. |  . . ||.|. ..     .....  ....    ||. |.|| .. |.|.    . | .||.||.|| | | . |          
WNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

-EEQVMLPSRLVSWSKQIALGMQYLHSHK--IIHRDLKSPNILISTN-----EVVKISDFGTSREWNEI---STKM-------SFAGTVAWMAPEVIRN-
 ..  . ... |.  ..||.|| |||. .  ||||||||.|.|.. |       .||.|||.|.  . |   ....       .. |.  ||||||.|. 
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-EPCSEKVDIWSYGVVLWEMLTCEI------PYKDVDSSAIIWGVGN--NSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHL
 .  |||.|..|.|.||||..| .|      ||...|. ...  |     .. . .|. ||. .. | . ||.. | .|||| .|.. |
FCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase CG8789.AA S_TKc 161-402 28 2.5e-68 234.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 161-402
Range on HMM: 1-231/231
Sequence Identity: 28% (75 aa)

ITELEWLGSGAQGAVFSGRLKN--ETVAVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPY--GPLQNILKEEQV------MLPSRLV
 . |. .|.|| | |. .| |.  . ||.|..||  .  |. |.| .|.||.|...|.     ....||.|.   | |  ..|. .       . . .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

SWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSE-KVDIWSYGVVLWEMLTCEIPYKDV
.. .||.....|.|||.|||||||  |||...  ..||.||| .|.       ..| ||  .|||||.   . .  |.|.|| |..|.|||. . |.   
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

DSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILS-------HLDI
.  ...  .|            .. .| ... |..  |..||.  ..|        |  .
QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG8789.AA TK 161-400 17 5.9e-65 216.41 In-house 1-486 (486) Show / Hide 
Range on Protein: 161-400
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)

ITELEWLGSGAQG---AVFSGRLKN---------------------------ETVAVKKVKELKETDIK---------------------HLRKLD----
|| .. ||.|. |    |. |....                           ..|||| .||  ... .                      . ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HENIIKFKGVCTQS------------PVFCIIMEFCPYGP----LQNILKEEQV---------------------------------------------
 |.||... |||||.            . ..|.||..|.|     |.. |..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MLPSRLVSWSKQIALGMQYLHSH------KIIHRDLKSPNILISTNEV-----------VKISDFG---
                               . . .|. .. ||| ||.||||.      ...||||   |.|.. | |           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TSREWN--EISTKMSFAGT-------------------------VAWMAPEVIR---------NEPCSEKVDIWSYGVVLWEMLT-CEIPYKDVD
      .|. .  .  ...|  ||                         . |||||...         .  ...| |.||.||..||..| .. ||    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SS---------AIIWGVGNN--------------SLKLLVPSTCP--------------EGFKLLVKLCWKSKPRNRPSFRQILSHL
|.         . .     .               . .  |  ||              | . .| . ||. .|. ||.|.|... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CG8789.AA STE 161-402 22 4.8e-61 209.11 In-house 1-359 (359) Show / Hide 
Range on Protein: 161-402
Range on HMM: 1-359/359
Sequence Identity: 22% (81 aa)

ITELEWLGSGAQGAVFSGRLKNET-----------------VAVKKVK---------------------ELKE---TDIKHLRKLD--HENIIKFKGVCT
 . .| .|.|| | |. .. .. .                 .|.|...                     | ..    .|| ..|..  |.||.|. | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QS-------PVFCIIMEFCPYGPLQNILKEEQVMLP--------------SRLVSWSKQIALG-MQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSR
.           .|.||....| |  |.|.   ..               | .    .||  | ..|||||.|||||.|. |||.     ||..|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EWNEIST----------------KM-SFAGTVAWMAPEVIRN------EPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVG-------------
  .....                |  .|.||  |||||||..       ....|.|||| | ...||.| . |. |      ..                
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NNSLKLLV-----------------PSTCPEGFKLLVKLCWKSKPRNRPSFRQILS--HLDI
   ... .|                   |. . . ||  ...| .  |..||.  | |.  |  |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CG8789.AA TK-Unique 161-400 30 2.4e-59 203.24 In-house 1-294 (294) Show / Hide 
Range on Protein: 161-400
Range on HMM: 1-294/294
Sequence Identity: 30% (91 aa)

ITELEWLGSGAQGAVFSGRLKN--------ETVAVKKVK-ELKETD-------IKHLRKLD-HENIIKFKGVCTQSP-VFCIIMEFCPYGPLQNILK---
.. .. .|.|| | |. | ...          ||||..| .. .||       |.....|. |.||... |.|| |   ..||||.||.| ||. |.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-------------------EEQVML----PSRLVSWSKQIALGMQYLHS--HKIIHRDLKSPNILISTNEVVKISDFGTSREWNE---ISTKMS-FAGTV
                   ......    | .|... .||| ||.||.|  .||.|||| . |.|.. . |.||.||| .|. .    .|.. | .   .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

AWMAPEVIR--NEPC-SEKVDIWSYGVVLWEMLTC-EIPYKDVDSSAIIWGVGNNSLKLLVPSTC-PEGFKLLVKLCWKSKPRNRPSFRQILSHL
.|||||...   ... ..| |.||.||..||..|  . || ..... |.  .  .   ...|. | .. .  | | ||...|  |||||||.. |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase CG8789.AA MLK 283-400 50 2.6e-54 177.79 In-house 164-280 (280) Show / Hide 
Range on Protein: 283-400
Range on HMM: 164-280/280
Sequence Identity: 50% (60 aa)

NEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLC
| . || |||  ||| .   .|| ||| ||||||||.    |.  |.|||||.|||.|| | ||. .|  |. .|| .| | | .|||||| .. | . |
NKQLKITDFGLAREWHKTT-RMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDC

WKSKPRNRPSFRQILSHL
|.  |  ||.| .||  |
WNQDPHKRPKFSEILQQL
Kinase CG8789.AA MLK 161-280 37 4.7e-31 99.71 In-house 1-136 (280) Show / Hide 
Range on Protein: 161-280
Range on HMM: 1-136/280
Sequence Identity: 37% (52 aa)

ITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHL--------------RKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLP
..  | .|.|  | |. .  | | ||||  ..  | |.                   | |.|||. .||| . | .|..||.|  |.|.....      |
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK-RIPP

SRLVSWSKQIALGMQYLHSHK---IIHRDLKSPNILI
  || |  ||| ||.|||      |||||||| ||||
HVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI