Gene wts (Fruit Fly)

wts

Species: Fruit Fly
Alias: lts, CG12072, wts, large tumor suppressor, SFO214, lats, l(3)100Aa, WTS/LATS, warts/lats, lats: large tumor suppressor
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 100A5,

Classification

Group: AGC
Family: NDR
Subfamily: LATS

Sequence

Name Sequence Type Origin Length Description Download
wts.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 302 Kinase domain by global Sugen HMM Fasta, JSON
wts.AA Protein Various 1105 None Fasta, JSON

Protein domain

Protein domains of wts.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase wts.AA NDR 719-1020 54 6.1e-233 726.83 In-house 1-350 (350) Show / Hide 
Range on Protein: 719-1020
Range on HMM: 1-350/350
Sequence Identity: 54% (190 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEAD--NNWVVKLYYSFQDKDNLYFVMDYIPGGDLMS---LLIKLG
|...|.||.|||||| || | || .|.||||..||......||||||.|||||.||||  |.||||||||||||..||.||.|.||||.|.   ||.|..
FEIIKIIGKGAFGEVWLVRKKDT-GHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMD

IFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTG---------------------FRWTHNSKYYQENGNHSRQDSMEPW
||.|..||||||| .||..||||||.|||||||||.|||.||||||||||||||                     |.|||||.|||....|..||.|..|
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNW

EEYSENGPK-------------PTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLER-SGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEK
.. ..|  .              .||..|... ..|.||.|.||||.|.||||...  ||.|.||.||.|.|.||||||.|||.. .| ||..|..||..
NSNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQ

TL-----HIPPQAELSREATDLIRRLCA-SADKRLG-KS--VDEVKSHDFF
|.     |.||.|.||.|| |||||||.  .|.||| .   |||.||| ||
TWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase wts.AA AGC 719-1020 31 1.1e-184 482.66 In-house 1-395 (395) Show / Hide 
Range on Protein: 719-1020
Range on HMM: 1-395/395
Sequence Identity: 31% (134 aa)

FVKLKPIGVGAFGEVTLVSKID-----TSNHLYAMKTLRKAD-VLKRN--QVAHVKAE------------RDILAEAD----------NNWVVK-LYYSF
|  ||.|| |.||.| || | |     .....|||| |.|.. .....  .|.|...|            |.||....          . ..|| |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKDN--LYFVMDYIP--------GGDLMSLLIKLG-----IFEEELARFYIAE-------VTCAVDSVHK-MGFIHRD-IKPDNILIDRDGHIKLTDFG
||||.  |||||.|.|        ||.....|.. |     .|.|| ||||.||       ...|... |. ||.|||| .||.|||.|.||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCTG----------------FRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQ-----------RVLAHSLVG--TPNYIAPEVLE
||.                 |.| ||.|| |  .      .|.  .         . ..........           |.......|  ||.|.|||.| 
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS------NMD--T-N-------K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-

RSGYTQLCDYWS--VGVILYEMLVGQPPFLANSPL----------ETQQKVI------NWEKTL------HIPPQAELSREATDLIRRLCA-SADKRLG-
   |.. ||.||  .|...||||.|.||| ...|           |. ||..      ||. ..      ..|.. ..| || |||..|.    .|||| 
---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGC

-KS------VDEVKSHDFF
 ..      ..|.|.| .|
GGNDFGDKGAEEIKNHPWF
Kinase wts.AA MAST 719-1020 39 7.89999999999e-114 368.4 In-house 1-334 (334) Show / Hide 
Range on Protein: 719-1020
Range on HMM: 1-334/334
Sequence Identity: 39% (132 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEE
|   |||. ||.| | || ...| | ..|||...|.| ...|.| .|..||.|||...|..|||..|||| |..|..||.|  |||. |||  .| |.|.
FEFIKPISKGAYGKVYLVKHKKT-NDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEW

LARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC-TGFRWTHNSKYYQ-----------ENGNHSRQDSME-P----------WEEY
.|..||||.  ...  |..| .|||.||||.||| .||||||||||   ||.   | .| .            . |...||  . |           .. 
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQI

SENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSG-YTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKT-LHIPPQ------AE
...  .|       || |.     ...||| ||||||. . | . .  |.||.|.|.|| ||| |||   .| |. |...| .     .|.        .
QQQQEQPQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEA

LSREATDLIRRLCAS-ADKRLGKS--VDEVKSHDFF
.| || |||..| .    |||| .  .||||.| ||
MSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase wts.AA DMPK 719-865 50 2.3e-111 276.43 In-house 1-147 (270) Show / Hide 
Range on Protein: 719-865
Range on HMM: 1-147/270
Sequence Identity: 50% (75 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLG-IFEE
|  || || |.|||| .|    | |  |||| . |.. ||| ..| .. ||||.. ..  |...|.| |||...||.||.| ||||| .|. . .  ..|
FEILKVIGRGHFGEVQVVRHKQT-NDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPE

ELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
..||||.||.. |..|.|.||..||||||||.|.|| ||||| ||| |
DMARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase wts.AA RSK 722-1020 34 6.6e-95 321.61 In-house 1-278 (278) Show / Hide 
Range on Protein: 722-1020
Range on HMM: 1-278/278
Sequence Identity: 34% (110 aa)

LKPIGVGAFGEVTLVSKID--TSNHLYAMKTLRKADVLKRNQ-VAHVKAERDILAEAD-NNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGI---
||  | |..|.| |. |.    ....|||| |.|| . .|.  ..|...||.||..      .|.|.|.||... || .|.|..||.|   | | ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDR---DGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMR
| |. |.||.||...||.  |. |.||||.||.||| |    .|||||||||.|  |                                          |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF------------------------------------------R

DHQRVLAHSLVGTPNYIAPEVLE----RSGYTQLCDYWSVGVILYEMLVGQPPFLA---NSPLETQQKVINWEKTLHIPPQAELSREATDLIRR-LCASA
 ..  .... ..| .|.|||.|     ..|... ||.|| ||..||||.|.||| .   |.. |. ... . . .| .|  ..||.|| ||||. |.   
CDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDP

DKRLG---KSVDEVKSHDFF
 ||||   . ..|.|.| .|
HKRLGCGPQDAEEIKQHPWF
Kinase wts.AA S_TKc 719-1020 31 2.3e-94 320.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 719-1020
Range on HMM: 1-231/231
Sequence Identity: 31% (98 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPG--GDLMSLLIKLGI--
. .|..|| ||||.| .. ... .....|.| ..           |.. |..|| . .  ..||||..||| |.||.||.|..|  |||.... | |   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRM
    | |  ||||.... ||..  |..|.||||.||.|||.|.  |||..||||.. .                                          
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------

RDHQRVLAHSLVGTPNYIAPEVLERSGYTQ-LCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCA-SADKRLG
        ....|||.|.|||||   ||.   || ||.|.||||||.|.|||    . .. .|.               |.|| |.||...    .||..
--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPT

KSVDE----VKSHDFF
  . .    .|.| .|
AEALQDEWDIKCHPWF
Kinase wts.AA MAST 719-864 47 9.8e-80 243.13 In-house 164-311 (337) Show / Hide 
Range on Protein: 719-864
Range on HMM: 164-311/337
Sequence Identity: 47% (71 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQD--KDNLYFVMDYIPGGDLMSLLIKLG-IF
|  .|.|..||.| | || ...| | ..|||.... | ...||| .|..||.||....|..|||..||||   |. |..||.|  |||  |||  .|  .
FEFIKCISKGAYGAVYLVKHKKT-NDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCM

EEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGL
.|..|..||||   ...  |..| .|||.||||.||| .||||||||||
PEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase wts.AA CRIK 719-863 52 2.2e-72 229.96 In-house 1-145 (272) Show / Hide 
Range on Protein: 719-863
Range on HMM: 1-145/272
Sequence Identity: 52% (76 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLG-IFEE
|     || | ||.| .|    | |  |||| ..|. || . ||. .. ||||.. .   |. .| | |||.|||| .| | ||||| ||.   .  |.|
FEVKDLIGCGHFGQVQVVREKQT-NDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDE

ELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFG
..|||| || . || |.|.||..||||||.|||||| ||||| |||
NMARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFG
Kinase wts.AA Akt 719-865 51 1.7e-70 224.53 In-house 235-382 (264) Show / Hide 
Range on Protein: 719-865
Range on HMM: 235-382/264
Sequence Identity: 51% (76 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLY-AMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEE
|  || .| |.|| | || | || . .| ||| |.|   ...|||.|.|.|| ||   ... .|.|.||||..|.|||||||..||.| ..| . ..| |
FDFLKVLGKGSFGKVFLVKKKDTQK-WYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

ELARFYIAEVTCAVDSVHKMGFIHRD-IKPDNILIDRDGHIKLTDFGLC
. ||||.||. .| .  |... | ||  || |||.|.||||.|||||||
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase wts.AA Pkinase 719-1020 26 2.3e-69 241.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 719-1020
Range on HMM: 1-293/293
Sequence Identity: 26% (91 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVK-AERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGG----DLMSLLI--K
......|| |.||.| .  ...|.  ..|.|...| .  .  ...|.. .|  |... .   .|.||..|.|||..|.||.| .||    ||....   .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

LGIF--EEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHI----KLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVL
 | |  .|. ..||. .. ....  |.||.||||.||.|||||..|||    |..||||.  |.                                    
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------------------------------

ERRRMRDHQRVLAHSLVGTPNYIAPEVLE-RSGYTQLCDYWSVGVILYEMLVGQPPFLANS----PLETQQKVINWEKT--LHIPPQAELS---------
          . .....|||.|.||||.  ...|.. .| ||.|.|||||| |.|||  ..    .  .|...|.  .   || . . . |         
------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW

----------REATDLIRRLCA-SADKRLGKSVDEVKSHDFF
          .|. |.|.....    ||..   .... |..|
HFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHPWF
Kinase wts.AA GEK 719-865 52 7.1e-62 206.36 In-house 1-147 (269) Show / Hide 
Range on Protein: 719-865
Range on HMM: 1-147/269
Sequence Identity: 52% (78 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLG-IFEE
|  || || ||||||. | |.  ....|||| | | ..|||  .|  . |||.| . |. |. .| | ||| ..||.||||  ||||. || | .    |
FEILKVIGRGAFGEVAVV-KMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPE

ELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
..|||||||.  |.||||.....||||||||.|.|. |||.| ||| |
DMARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSC
Kinase wts.AA ROCK 719-865 53 1.2e-61 208.64 In-house 1-145 (263) Show / Hide 
Range on Protein: 719-865
Range on HMM: 1-145/263
Sequence Identity: 53% (78 aa)

FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEE
|  .| || |||||| || .  .|.. |||| | | ...||   |    ||||.| |  .|.|.|.| |||.  || ||||.|||||..|. .  .  | 
FHMIKVIGRGAFGEVQLV-RHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEK

LARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
 |||| .||  |.|..| |||||||.||||.|.|. ||.|| ||| |
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase wts.AA DMPK 909-1020 40 2.2e-51 124.7 In-house 149-270 (270) Show / Hide 
Range on Protein: 909-1020
Range on HMM: 149-270/270
Sequence Identity: 40% (49 aa)

RMRDHQRVLAHSLVGTPNYIAPEVL------ERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINW-EKTLHIPPQAE--LSREATDLIRRL
.|..   | . . |||| ||.||||       .. |   ||.|||||..||||.|. || | |  ||  |  |  .  |  |.. .  .| ||.|||..|
KMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQL

CASADKRLG-KSVDEVKSHDFF
  ....|||  .... | | ||
LCDREERLGRNGYEDFKCHPFF
Kinase wts.AA MAST 922-1020 43 1.1e-35 106.01 In-house 229-337 (337) Show / Hide 
Range on Protein: 922-1020
Range on HMM: 229-337/337
Sequence Identity: 43% (47 aa)

VGTPNYIAPEVLERSG-YTQLCDYWSVGVILYEMLVGQPPFLANSPLE-TQQKVINWEKTLHIPPQ------AELSREATDLIRRLCASA-DKRLGKS-V
.||| ||||||. . | | .  |.||.|.|.|| ||| ||| . .| | . |..|| .. .  |.        ..| || |||..| .    ||||   .
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

DEVKSHDFF
||.|.| ||
DEIKQHPFF
Kinase wts.AA ROCK 909-1020 42 1.7e-34 114.73 In-house 147-263 (263) Show / Hide 
Range on Protein: 909-1020
Range on HMM: 147-263/263
Sequence Identity: 42% (50 aa)

RMRDHQRVLAHSLVGTPNYIAPEVLERSG----YTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASAD
.|  .  | .   |||| ||.||||   |    | . ||.||||| .||||||. || |.|   |  |...    |. |...|.|..| |||..  . ..
KMNKNGMVRCDTAVGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDRE

KRLGK-SVDEVKSHDFF
.|||. .||..| | ||
QRLGRNGVDDIKQHKFF
Kinase wts.AA GEK 909-1020 41 8e-31 100.38 In-house 149-269 (269) Show / Hide 
Range on Protein: 909-1020
Range on HMM: 149-269/269
Sequence Identity: 41% (50 aa)

RMRDHQRVLAHSLVGTPNYIAPEVLE-----RSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAE---LSREATDLIRRLC
||..   | .   |||| ||.||.|      .  | . ||.||.||..|||| |. || |.|  ||  |..|..  ...|.| .   .| || ||||.| 
RMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLI

ASADKRLGKS-VDEVKSHDFF
 |...|||.  ... | | ||
CSQEHRLGRNGIQDFKKHPFF
Kinase wts.AA CRIK 910-1020 32 1.8e-25 77.86 In-house 150-272 (272) Show / Hide 
Range on Protein: 910-1020
Range on HMM: 150-272/272
Sequence Identity: 32% (40 aa)

MRDHQRVLAHSLVGTPNYIAPEVL--------ERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVIN------WEKTLHIPPQAELSREATDL
| .   |.. . |||| |.|||||         .. |   ||.||.|.| ||| .|. ||   .  .|  ...|        . |  |    .| ...||
MNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAYEMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDL

IRRLCASADKRLGKSVDEVKSHDFF
|. |     |||  .   .. | ||
IQSLLCNQSKRL--KYEQLCCHPFF
Kinase wts.AA Akt 918-961 44 1.9e-21 65.22 In-house 159-203 (264) Show / Hide 
Range on Protein: 918-961
Range on HMM: 159-203/264
Sequence Identity: 44% (20 aa)

AHSLVGTPNYIAPEVLERSGYTQLCDYWS-VGVILYEMLVGQPPF
. .. ||| |.|||.|.  |.|. .| |. .|...|||. |.|||
TKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase wts.AA TyrKc 719-1020 19 3.1e-11 -41.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 719-1020
Range on HMM: 1-280/280
Sequence Identity: 19% (66 aa)

FVKLKPIGVGAFGEV---TLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEA--DNNWVVKLYYSFQDK-------DNLYFVMDYIPGGDLM
 ...| .| ||||||   |.           | |.|..        ..    |  |. .   ..  .|.||    ..       . |. || | |.||| 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

SLLIKLGI-FEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQEN---GNHSRQDSMEPWEEYSENGPKP
. | | .  .  .    .   . |  .  |....||||.   |.|.......| .||||         |..  .    |                     
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL---------SRDIYDDDQQG---------------------

TVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEML-VGQPPFLA-----NSPLETQQKVINWEKTLHIPPQAE------LSR
   .    |  ..  .....      |||..  . .|   | || || ..|..  ||.|         |. |  ..| .  . . .|| ..       . 
--ESKDYYRKKEHKGGKTMLPI-RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPD

EATDLIRRLCAS-ADKRLGKSVDEVKSHDFF
|  ..... ..  ...|   |      |..|
EMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase wts.AA S_TK_X 1021-1083 23 1.2e-08 35.94 SMART 1-79 (79) Show / Hide 
Range on Protein: 1021-1083
Range on HMM: 1-79/79
Sequence Identity: 23% (21 aa)

KGIDFADMR----KQKAPYIPEIK----HPTDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRT-------------------FHGFFEFT
.|||. . .    . ..|..|.||    .|||||||||  .|.  .           ...| .                   | ||. . 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-----------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase wts.AA Pkinase_C 1038-1088 29 4e-06 25.05 Pfam 1-46 (46) Show / Hide 
Range on Protein: 1038-1088
Range on HMM: 1-46/46
Sequence Identity: 29% (15 aa)

EIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRTFHGFFEFTFRRFF
..|.||||||||| . .. . .|. ...     .... |.|   ||.....
QVKSPTDTSNFDP-EFTDEPPMDTPPDWR-MSSGDQEPFRG---FTYVNPD
Kinase wts.AA Akt 980-1020 33 5e-06 15.1 In-house 220-264 (264) Show / Hide 
Range on Protein: 980-1020
Range on HMM: 220-264/264
Sequence Identity: 33% (15 aa)

LHIPPQAELSREATDLIRRLCA-SADKRLG--KS-VDEVKSHDFF
. .|.   .| |. |||..|.    .||||  .. ..|.|.| .|
VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase wts.AA Pkinase_Tyr 835-865 35 1.8e-05 19.13 Pfam 128-158 (270) Show / Hide 
Range on Protein: 835-865
Range on HMM: 128-158/270
Sequence Identity: 35% (11 aa)

HKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
. ...||||.   |.|.......| .||||.
ESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase wts.AA Pkinase_Tyr 719-733 53 0.077263 6.85 Pfam 1-15 (270) Show / Hide 
Range on Protein: 719-733
Range on HMM: 1-15/270
Sequence Identity: 53% (8 aa)

FVKLKPIGVGAFGEV
 ...| .| ||||||
ITFGKKLGEGAFGEV
Kinase wts.AA Pkinase_Tyr 929-961 34 1.437463 2.55 Pfam 182-216 (270) Show / Hide 
Range on Protein: 929-961
Range on HMM: 182-216/270
Sequence Identity: 34% (12 aa)

APEVLERSGYTQLCDYWSVGVILYEMLV-GQPP-F
|||..  . .|   | || || ..|..  |. | .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY