Gene Nek2 (Fruit Fly)

Nek2

Species: Fruit Fly
Alias: NEK2, SFO136, DmNek2, Nek2, CG17256
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 7C1,

Classification

Group: Other
Family: NEK
Subfamily: NEK2

Sequence

Name Sequence Type Origin Length Description Download
Nek2.AA Protein Various 735 None Fasta, JSON
Nek2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Nek2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Nek2.AA NEK2 19-281 49 2e-206 692.05 In-house 1-319 (319) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-319/319
Sequence Identity: 49% (158 aa)

YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQR
||||...||||||.|.|||.||.|....||...|....|..|..||||...||||.|||||.||.....|.....|||||.|.||||.|.....|..||.
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FEEPYIWRVLFQLCRALQVCHN----------------KIPN-GTILHRDIKPANIFLDAAGN-------------------------------------
.||..|||..||||.|||.|||                .|.. .|||||||||||||||...|                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFML
  .|||||||||||..|.|||..|||||.|||||...|.||..|||.|.||||.||||||.|||......||.|||.||.|.|||..||..|.|||.||.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

AVDHEQRPGIEVIIRHPLV
.|||..||.||.|..||..
NVDHYHRPSIEEILQHPQI
Kinase Nek2.AA NEK 19-281 39 5.2e-140 471.43 In-house 1-286 (286) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-286/286
Sequence Identity: 39% (113 aa)

YEVLAVMGNGSFGTCYKVRDKSTGEL-----FAWKGMNYDELDEAKCDALV-SEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCA-GGDLAQI---
||.. . |.||||..||||.||.|       ..|| .|.....| . .... .|. .|.||.||||| || . . ..  . .|||| |  ||||.|    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

VQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG--TILHRDIKPANIFLDAAGN----AKLGDFGLARMLRRDQSFAAS-FVGTPHYMSPELVKGR
 .. . ... ||| .||....|.| ||. .|... ..   ||||||||.||||.. .|    .|.||||....| .....| . .||||.|||||.....
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

KYDRKSDVWAVGCLVYEMCAL--RPPFRGR--AFDQLSEKIAQG-EFSRIPAI--YSTDLQEIIAFMLAVDHEQRPGIEVIIRHPLV
.|. |||.|..||..||||.|  ..||..    . .|  || .| ....||    ||.|||..| .|| .|.|||| .. |. .|..
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Nek2.AA S_TKc 19-281 33 2.2e-86 294.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAG--GDLAQIVQRARSQR
||.| . | |.||..||.|.|.||...| | ..         . . .||..|.. .|||||..| . ..   ...|.|||.| |  ||| .. .. ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

QR--FEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDR-KSDVWAVG
 |  | |  ..... |.|.||. ||.   .  |.|||.||.||.||   . |..|||||| |        .|.|||.||.||..   .|.. |.|.|..|
LRFPFPE-HARFYMYQICCALEYCHS---H-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIR-------HPLV
|..|||.. .|||.    ... .||            | .. ..|  .| .| |.||..  . .       || .
CILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Nek2.AA Pkinase 19-281 30 4.2e-81 280.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVS--EISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGG----DLAQIVQRA
|... . | ||||..|| ..|.||...| | ..... .. |. ...   ||.... |.|||||..|.   .   ...|.|||.| ||    ||. .... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

RSQRQRF--EEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNA----KLGDFGLARML-RRDQSFAASFVGTPHYMSPELVK-GRKYD
 ... .|  .|  . ... |..|.|. ||..     |.|||.||.||..|  |.     |..|||||. .    .| . .|.|||.||.||... |..|.
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RKSDVWAVGCLVYEMCALRPPFRGR------AFDQLSEKIAQGEFSRI-PAIYS-------------------TDLQEIIAFMLAVDHEQRPGIEVIIRH
.|.|.|..||..|||.  ||||.|.        .|. ..| ......  |  .|                    .....|  .|..| ..||..| |  |
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PLV
| .
PWF
Kinase Nek2.AA NEK8 19-281 34 3.4e-77 219.9 In-house 1-278 (278) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-278/278
Sequence Identity: 34% (99 aa)

YEVLAVMGNGSFGTCYKVRDKSTG--ELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR
||   | | |.|| |   | |. .   |  ||  |  ...|   ..  .||.||  ||||||. || |    | ..  |.|| . || |.|. |. .   
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFM--EDNTLMIEMEYADGGTLYQMIQH-QQNK

QRFEEP----------------YIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAA-GNAKLGDFGLARMLRRDQSFAAS--FVGTPHYMSPEL
  .||                 .|  ..|| | |.   | .     |||||.|..|||.. . .  |.||||..  .  . . . .   |||| |||||.
LFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQH----NILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEM

VKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQG-EFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHPLV
..|..|. |||.||.||  |||| |.  | .     |  || |. ..  |.  || ..   .   |..| ||||    |   ||.
CEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase Nek2.AA NEK1 19-281 35 3.4e-73 249.49 In-house 1-276 (276) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-276/276
Sequence Identity: 35% (99 aa)

YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQR
|... . | ||||  ..|..|. | ... |  |  .  |    . . |  .|. . |||||.|.   . .     ||||| | ||||.|  .|.. . . 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLD--AAG---------------NAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGR
| |. |     |.| ||.  | .     |||||||. ||||     |                .|||||| ||||    ..|   .||| | |||.   .
FSEDQIMHWFCQICLALNHIHDR----KILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNK

KYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHPLV
 |. |||.|. ||  || |.|  || .... .|  || || .. ||. ||..||. .. |. .. . || .  |   | .
PYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase Nek2.AA STE 19-281 23 5e-68 232.32 In-house 1-359 (359) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

YEVLAVMGNGSFGTCYKVRDK------STGEL---------FAWKGMNYDELD---------------EAKCDALVSEISVLRQLQ--HPNIVQYYHHLV
.| . . |.|.||| || ...      .|||.         .| | ||... .               . . . .  ||.......  |||||.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NREAK-----SVYIVMECCAGGDLAQIVQRA-RSQR---------QRFEEPYIWRVLFQLCRA-LQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDF
.   .     ...|.|| ..|| | .|...    ..         .||.|. | ....|.... |.  |..     | |||||||||.|     .|| ||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLCDF

GLARMLRRD----------------QSFAASFVGTPHYMSPELVKG------RKYDRKSDVWAVGCLVYEMCALRPPFRG-RAFDQLSEKIAQ-------
|..  |  .                |.   .||||| .|.|| ...       .||.|.|.| .||.. ||.  .||.     .  . ...         
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

-------GEFSRIP-------------------AIYSTDLQEIIAFMLAVDHEQRPGIEVIIR--HPLV
       |.  ..|                     .| .... |.  |  | ..||  .  ..  || .
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Nek2.AA CAMK 24-281 21 7.4e-64 204.37 In-house 1-425 (425) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-425/425
Sequence Identity: 21% (94 aa)

VMGNGSFGTCYKVRDKSTG------------ELFAWKGMNYDELD--------------------------EAKCDALVSEISVLRQLQ-------HPNI
. | ||||. .....|.|.            . .| | .. . |.                          . ... . .||.....||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYYHHLVNRE-----------------AKSVYIVM---ECCAGG----D-LAQIVQR-----------ARSQRQRFEEPYIWRVLFQLCRALQVCHNKI
.. |..  ...                  | .|.||   | | ||    | .  ||..              .| ||.|    |.  |.| |.. ||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS--

PNGTILHRDIKPANIFLDAA-----------------GNAKLGDFGLARMLRRDQS-----------------------FAASFVGTPHYMS-PELVKG-
 .. | |||.|| || ||                   .| |. |||.|........                           |.|||.||. ||...| 
-HN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK

-------------RKYDRKSDVWAVGCLVYEMCALRPPFRGR-------------AFDQLSEKIAQGEFSRIPAIYST----------------------
             . |..|.|.|..|.. | |   .|||.|                 .| ||| .|... .|   |.                      
GHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVS

-DLQEIIAFMLAVDHEQRPGIEVIIRHPLV
 . .  |  || || |.|. || . .|| .
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Nek2.AA NEK4 19-281 36 2.5e-61 210.06 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-257/257
Sequence Identity: 36% (97 aa)

YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQR
|. . | |.||.|  . || .  .  .  | |.  . .  .  |   |. .| ||.|||||.|       . .  ||||  | |||| .  .. .   | 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKN--QF

FEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYE
 ||  .     |   |||  | |     ||||| |  ||||      |.||||..| |     .|   .||| |||||.   | || |||.|. || |||
LEEYQVVEWFVQIAMALQYMHEK----HILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYE

MCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHPLV
|  |.  |  .  . |  .| ||    .|  ||.|||...  ||    ..|| |  |.. | .
MITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase Nek2.AA NEK6 19-272 36 1.1e-60 198.39 In-house 1-252 (252) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-252/252
Sequence Identity: 36% (95 aa)

YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDA-LVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQ
...   .| | |   |. .    .   | | .   |. .||  .  . || .|.||.|||...||   .  |   . ||.|    ||......  . |. 
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFI--ENNELNIVLELADAGDMSRMIKHFKKQKR

RFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVY
   |  ||.   |||.||.  | |     ..||||||||.|. | |  |||| || |    .   | | |||| ||||| ..   |  |||.|..|||.|
LIPERTIWKYFVQLCSALEHMHSK----RVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLY

EMCALRPPFRGRAFD--QLSEKIAQGEFSRIPA-IYSTDLQEIIAFMLAVDHEQRPGI
|| ||  || |       | .|| | ..  .|| .||..|.. .....  | |.|| |
EMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase Nek2.AA ULK 19-281 26 3.3e-58 199.69 In-house 1-329 (329) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-329/329
Sequence Identity: 26% (88 aa)

YEVLAVMGNGSFGTCYKVRDKST----GELFAWKGMNYDELDEAK--------CDALVSEISVLRQL--------QHPNIVQYYHHLVNREAKSVYIVME
|..  . | ||||. || |.| |    .|..| | .  ..... .         . | .|| ....|        .|||||..|. . .   . .||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

CCAGGDLAQIVQRARS------QRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAA------------GNAKLGDFGLARMLRRD-
 | |||| |. .. .         .|..|. .  .. |.. ...  | .     | ||||||.|| ..              | .|..|||.|...  | 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH----NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

--QSFAASFV------GTPHYMSPELVKGR----KYD-RKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFS--------------RIP-----
  |  . ..|      ||| ||.|....|.    .|.  |.|.| .||. |||   .|||..  | .. ..| | ..               ..|     
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

AIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHPLV
 . | .....|  || .| ..|  .| .. ||..
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Nek2.AA ULK 19-281 26 1.5e-57 197.49 In-house 1-324 (324) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-324/324
Sequence Identity: 26% (86 aa)

YEVLAVMGNGSFG-TCYKVRDKST---GELFAWKGMNYDELDEAKCD--------ALVSEISVLRQLQ---HPN--IVQYYHHLVNREAKSVYIVMECCA
|..  . | |||| . || |.| |   ....| | .. ... . | .         | .||.....|    |||  ||..|. . .   . .||.|| | 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLAQIVQRARS-----QRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGN------------AKLGDFGLARMLR---RDQS
|||| |. .. .        .|..|. .  .. |.| ...  |..     | ||||||.|| .                 .|..|||.|...     .| 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH----NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

FAASFV------GTPHYMSPELVKGR----KYD-RKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEK--------------IAQGEF-SRIPA---IYST
   ..|      ||| ||.|....|.    .|.  |.|.| .||. |||   ..||... | .. ..              | .  .  ..|    . | 
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP

DLQEIIAFMLAVDHEQRPGIEVIIRHPLV
.....|  || .| ..|  .| |. ||..
ECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase Nek2.AA TyrKc 19-280 21 2.2e-16 42.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-280
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQL--QHPNIVQYYHHLVNR-----EAKSVYIVMECCAGGDLAQIVQR
 . . . |.| ||. || . |   .  | | .. |        .. .|......|  .|||||. |   .       ... ..|||| ...||| .  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

ARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRD-------QSFAASF-VGTP-----HYMSPELV
 | .   .  .      .| ..  .  | |     . |||.   |. ... . .| .||||.| .  |       .   ..   |.        |.||  
HRPK---LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

KGRKYDRKSDVWAVGCLVYEMCAL-RPPFRG-----RAFDQLSEKIAQGEFSRIPAI--------YSTDLQEIIAFMLAVDHEQRPGIEVIIRHPL
. .|.  |||||. | . .|.. .  .|  |        ... |.. ||.  ..|.          .... .|.    . | |.||  . | .. .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase Nek2.AA Pkinase_Tyr 61-105 36 4.3e-07 24.63 Pfam 48-94 (270) Show / Hide 
Range on Protein: 61-105
Range on HMM: 48-94/270
Sequence Identity: 36% (17 aa)

DALVSEISVLRQL-QHPNIVQYYHHLVNREAK-SVYIVMECCAGGDL
... .|.....|| .|||||..|   . ..   ..||||| ...|||
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase Nek2.AA Pkinase_Tyr 156-222 27 1e-06 23.32 Pfam 141-210 (270) Show / Hide 
Range on Protein: 156-222
Range on HMM: 141-210/270
Sequence Identity: 27% (20 aa)

NIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGT-----PHYMSPELVKGRKYDRKSDVWAVGCLVYEMCAL
|. ..  . .| .|||||| .  . .   . ...        |.||  . .|.  |||||. | | .|.. .
NCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY