Gene PEK (Fruit Fly)

PEK

Species: Fruit Fly
Alias: CG2087, SFO131, EIF2-like, DPERK, PEK, DmPEK
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 83A4,

Classification

Group: Other
Family: PEK
Subfamily: PEK

Sequence

Name Sequence Type Origin Length Description Download
PEK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
PEK.AA Protein Various 1162 None Fasta, JSON

Protein domain

Protein domains of PEK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ PEK.AA PQQ 73-111 33 1.2e-05 22.07 Pfam 1-37 (37) Show / Hide 
Range on Protein: 73-111
Range on HMM: 1-37/37
Sequence Identity: 33% (13 aa)

RLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSI
. .|. | ||.. |||..  ||..|...|||..   .  
GDVYVHTWDGYIYALDADT-GKVKWKFKTGPPDWW-PMT
PQQ PEK.AA PQQ 67-100 38 0.002981 18.05 SMART 1-33 (33) Show / Hide 
Range on Protein: 67-100
Range on HMM: 1-33/33
Sequence Identity: 38% (13 aa)

ERRVARRLLYISTLDGRLSALDIAKSGKLRWSVP
  .|.  ..|..| ||.| |||  |.||..|...
PVVVWDGTVYVGTYDGYLYALDA-KTGKVLWTYK
PQQ PEK.AA PQQ 231-262 18 0.12274 9.35 SMART 1-33 (33) Show / Hide 
Range on Protein: 231-262
Range on HMM: 1-33/33
Sequence Identity: 18% (6 aa)

DPLLDD-VIIVRRQTQTVRAVESRTGVERWNFS
 ....| ...| ..  ...|. ..|| ..|.. 
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ PEK.AA PQQ 235-273 20 0.386442 6.99 Pfam 1-37 (37) Show / Hide 
Range on Protein: 235-273
Range on HMM: 1-37/37
Sequence Identity: 20% (8 aa)

DDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRP
.||..      ...|.  .|| ..| | .|..       
GDVYVH-TWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ PEK.AA PQQ 313-329 29 4.184582 3.54 Pfam 22-37 (37) Show / Hide 
Range on Protein: 313-329
Range on HMM: 22-37/37
Sequence Identity: 29% (5 aa)

MLWKYKFDHPIVSAWNT
..||.| ..|... . |
VKWKFKTGPPDWW-PMT
Kinase PEK.AA PEK 642-1123 22 5.70000000001e-152 511.16 In-house 1-655 (655) Show / Hide 
Range on Protein: 642-1123
Range on HMM: 1-655/655
Sequence Identity: 22% (163 aa)

FELMQCLGRGGF-GVVFEAKNKLDENRYAIKRITLPNKE----------------SSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLL
|| .||||.||| |.|....||||...||||||.|..|.                .....||||..|||...|.|||||...| |.|. .||...| ...
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

AHE----LSTSIQIETPDDSTMPSLTEQLKEKRQQQLLSWVSDAA------------------------NSTACSHDFHLPGESS---------------
  .     ...  . ..   . |.  |   .   .| ..  |.                          ... .. .. . ..||               
LDSSTDWPNGKH-KSKDYNFH-PFEKEW-DD-EEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTE

-----------------------------------------------LKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQ-----
                                                ..... .. ... .....| ... .  .. .|..| ||..| . .|      
NENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDS

---------------------GDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQ
                        ...|..| |  ...   . .| |. . .   |..|                                         
KNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNN-NKNKFKQMHNTKQ-----------------------------------------

PTPSSATILNGTVAKPSKVYLYIQMQLCRKESLRDWLRDNR-------------------------------------------SETRAAHIGDIFHQIV
                .. ||||||..|.|..||||...|.                                           ... . .. .||.||.
---------------YQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQIL

DAVDYVHLKGLIHRDLKPSNIFFSQDGQ-----IKIGDFGLVTDMA--------------------DIPNLVAKCGDQSGLPSCAR--------------
....|.| .|.|||||||||||...|||     .|||||||.|...                     . |. ... .|. .|....              
EGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTS

--------HTQQVGTHLYMSPEQLLGQ-----HYDYKVDIYSLGLIFFELHVYFSTEM-ERIKTLRSLRD------GQYP-KDFAVNYPQQYDLLQQMLS
        ||..|||.|||||||| ||     ||. |||.||||.||||....|.|.| ||.|||..|||      |..| |.|...||.|.|..|.|||
MFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLS

AQPEQRPQTKQLKSQLRN
 .|.|||...|. ...  
HDPQQRPSAQQILQHEFF
Kinase PEK.AA PEK 803-1123 27 1.7e-127 428.46 In-house 256-758 (758) Show / Hide 
Range on Protein: 803-1123
Range on HMM: 256-758/758
Sequence Identity: 27% (137 aa)

SESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFD----LKNINYSQHQLVSNSFQIESVR---PKSSGSDDANDDNKARRKPL-TL
||||.  .  .. || .     .   ..  ...  .  ....|. . |    .|      . . . |   ....     ....|.  .|||    .. | 
SESQFMPSEFSGTDDEEQSWMDSNNDTMYNAQQKCMTKCFGHHKHMMDFSKDNKEEHTFFDCPSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTK

ALAQNHNNNQNGSQPTPSSATILNGT--------------------VAKPS----KVYLYIQMQLCRKESLRDWLRD--NRSETRAAHIGDIFHQIVDAV
 . |..  ||  .|. .||.   ...                    ..| .    ..|.||||||||||.|.||.|.  ........|....||||...|
QHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNNKNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGV

DYVHLKGLIHRDLKPSNIFFSQDGQ------------------------IKIGDFGLVTDM---------------------------------------
.|.|.||.|||||||||||||.|.|                        |||||||||||.                                       
NYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQ

--------------------------------------------------------------------ADIPNLVAKCGDQSGLPSCARHTQQVGTHLYM
                                                                    ..|......|..|...|||.|||.||||||||
QQQQQQQQQQQQQQQQQQQQQQQQQQQQTTITTISVSPSKPSSISTPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYM

SPEQLLGQ----------------HYDYKVDIYSLGLIFFELHVY-FSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQ
||||. .|                .|..||||||||||||||... |||.||||.|...||.||.||.|...|||.|...|||.|..|..||...|....
SPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMH

LRN
.  
DFF
Kinase PEK.AA PEK 642-724 35 4.6e-58 192.03 In-house 1-156 (758) Show / Hide 
Range on Protein: 642-724
Range on HMM: 1-156/758
Sequence Identity: 35% (55 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPN--------KESSRQRVLREARTLASCEHHNIVRYFHSWTETP----------------------
||..||||.|||||||.||||.|.|.|||||||.||        .||.|..|.||.||||...||||||||..|.|||                      
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

-------------------------------------------PTGWQEEEDRKLL
                                           |..|||..| ...
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENEDDNPCNRFVNKIPKKWQEKMDKCWN
Kinase PEK.AA GCN2 928-1117 36 1.5e-53 184.19 In-house 281-505 (511) Show / Hide 
Range on Protein: 928-1117
Range on HMM: 281-505/511
Sequence Identity: 36% (82 aa)

YLYIQMQLCRKESLRDWLRDNRSETRAAH-IGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTD----------------------
||||||  | . .||. . || . ...   .  .| ||.....|.| .| |||||||||||. ..|..|||||||.|                       
YLYIQMEYCEGKTLRQYI-DNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHW

--MADIPNLVAKCGDQSGLPSCA------RHTQQVGTHLYMSPEQLLGQHYDYKVDIYSL-GLIFFELHVY-FSTEMERIKTLRSLRDGQYPKDFA----
   ..|    ..   ||. ..         ||  ||| .||.|||.   ||. |||.||| |.||||.  . |.|.|||...|. ||. . |.||     
AIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVD

VNYPQQYDLLQQMLSAQPEQRPQTKQL
. .. |.|.....|.  | .|| ..||
NHHKDQQDMIRWCLNHDPQKRPSAQQL
Kinase PEK.AA STE 642-1063 13 2.1e-43 150.49 In-house 1-261 (359) Show / Hide 
Range on Protein: 642-1063
Range on HMM: 1-261/359
Sequence Identity: 13% (64 aa)

FELMQCLGRGGFGVVFEAKNKL---------------DENRYAIKRITLPNKE----------------SSRQRVLREARTLASCE--HHNIVRYFHSWT
.|.....|.|.||.|. |.|.                  ...|||.. | |..                . .|..|.| ...  |   | |||.|. .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSA
   .                                                                                                
KEGHN-----------------------------------------------------------------------------------------------

ALRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQ
                                                                                                    
----------------------------------------------------------------------------------------------------

PTPSSATILNGTVAKPSKVYLYIQMQLCRKESLRDWLR------DNRSETR-------AAHIGDIFHQIVDA-VDYVHLKGLIHRDLKPSNIFFSQDGQI
              . .. .|.| | ..   ||.| ..      .. .  |          |. | .||. .  .| | .. ||||.||.||..     .
--------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----V

KIGDFGLVTDMAD-------------IPNLVAKCGDQSGLPSCA-RHTQQVGTHLYMSPEQLLG------QHYDYKVDIYSLGLIFFEL
|. |||. . ..|             |              ... . .  |||  .|.|| ...      ..||.|.||.|||.   |.
KLCDFGVCGQLTDSMANIQSNNIIDCI-------------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase PEK.AA Ciliate-E2-Unclassified 642-1063 12 2.4e-41 141.18 In-house 1-263 (352) Show / Hide 
Range on Protein: 642-1063
Range on HMM: 1-263/352
Sequence Identity: 12% (61 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRV------LREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIE
... ...|.||||.|.....| .   |... .   ... ... .      ..|. .. . .. ...|                                 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-K-------------------------------

TPDDSTMPSLTEQLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKR
                                                                                                    
----------------------------------------------------------------------------------------------------

HRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSAT--------------ILNGTV
                                                                                              |..   
------------------------------------------------------------------------------YNKIMQQILLNHPHPFIVKMFY

AKPSKVYLYIQMQLCRKESLRDWLRD------------------NRSETRAAHIG---DIFHQIVDAVDYVHLKG-LIHRDLKPSNIFFSQDG---QIKI
.. .| ..|| |..|.  .|......                  .. . ..|  .   ..| ||... .| | |.  ||||.||.||.|...|   .|||
CFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKI

GDFGLVTDMADIPN-----LVAKCGDQSGLPSCARHTQQVGTHLYM----SPEQLLGQHYD----YKVDIYSLGLIFFEL
 |||.     . .|     .      . . ..  . ....||  ||    .|| | ||.||    ||.||.||| |..|.
IDFGISKKYQQNNNCDTNQQ-----QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase PEK.AA S_TKc 642-1125 12 1.3e-40 142.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 642-1125
Range on HMM: 1-231/231
Sequence Identity: 12% (64 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDST
.|... .|.|.||.|. ...| .  ..|||.|                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

MPSLTEQLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVS
                                                                                                    
----------------------------------------------------------------------------------------------------

IDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRK--E
                                                       ...  .        |   ...   .      .||. | .|     
-----------------------------------------------------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLG

SLRDWLRDNRSE-----TRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQVGTH
.|.| .......         |.  ...||..|..| | .| |||||||.||....  .|||.|||| . .                      | ..|| 
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTP

LYMSPEQLLGQHYDY-KVDIYSLGLIFFELHV---YFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKS-----QLRNIL
 ||.|| |   .|.. |.|..|.| |..|. .    |.   .  .... ..            |.  |.....|   ||.||   ..        .   .
WYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PEK.AA Ciliate-E2 928-1118 24 2.5e-37 125.66 In-house 108-360 (365) Show / Hide 
Range on Protein: 928-1118
Range on HMM: 108-360/365
Sequence Identity: 24% (66 aa)

YLYIQMQLCRKESLRDWLRDN---RSETRA-------AHIGDIFHQIVD---------------AVDYVHLKG-LIHRDLKPSNIFFSQDGQIKIGDFGL
..|. | .|   .|.|....|   | . .         .|..|. ||..               |. | | |.  ||||.||.||.|     ||| ||||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGL

VTDMADI---------PNLVAKCG-DQSGLPSCARHTQ---------QVGTHLYMSPEQLLGQH---------YDYKVDIYSLGLIFFELHVY---FSTE
 ..  |           ..    . | |. |.. .  |         ..||  ||.|| | |.          ||||.||.||| |..|.      |   
SKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD--QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---

MERIKTLRSLR------------DGQYPK--DFAVNYPQQYDLLQQ----MLSAQPEQRPQ-TKQLK
 ....    ..            . | .|  ..    ..  ||...    ||  .||.|..  .|..
-QQQIKQCKIDFPCPEWQKDTQCI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase PEK.AA Pkinase 928-1063 29 6.9e-37 131.52 Pfam 74-205 (293) Show / Hide 
Range on Protein: 928-1063
Range on HMM: 74-205/293
Sequence Identity: 29% (44 aa)

YLYIQMQLCRKE----SLRDWLR-DNRSET--RAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQI----KIGDFGLVTDMADIPNLVAKCG
..|. | .|..     .| |... ...        .. ... ||. ...| | .| |||||||.||.....|.|    ||.||||   .           
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------

DQSGLPSCARHTQQVGTHLYMSPEQLL-GQHYDYKVDIYSLGLIFFEL
    . .    |  .||  ||.|| .. ||.|..|||..|.|.|..|.
----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase PEK.AA PKR 929-1003 53 1.5e-25 88.38 In-house 96-171 (272) Show / Hide 
Range on Protein: 929-1003
Range on HMM: 96-171/272
Sequence Identity: 53% (41 aa)

LYIQMQLCRKESLRDWLRD-NRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVT
|.|||  | |  |  |.|. . .    . | |.. |||  |||.| |.||||||||||||   . .||||||||||
LFIQMEFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVT
Kinase PEK.AA HRI 1027-1122 45 3.1e-23 78.33 In-house 517-613 (613) Show / Hide 
Range on Protein: 1027-1122
Range on HMM: 517-613/613
Sequence Identity: 45% (44 aa)

HTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQ-LKSQLR
||  ||| .| ||||| |  || | | ||.|.| |||   | ||||| . |  .| || |       | |   .| .      |||   | |.| | 
HTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase PEK.AA GCN2 642-828 20 1.3e-22 75.71 In-house 1-219 (511) Show / Hide 
Range on Protein: 642-828
Range on HMM: 1-219/511
Sequence Identity: 20% (44 aa)

FELMQCLGRGGFGVVFE-AKNKLDENRYAIKRITLP-NKESSRQR--VLREARTLASCEHHNIVRYFHSWTE--TPPTGWQEEEDRKLLAHELSTSIQIE
||  .|||.|||| |   ..|..|.. ||||.. .. .... . .   .||. .|... | ..|||. .| |   .|.  . ..|. . . . | .  . 
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

TPDDSTMPSLTEQLKE--KRQQQLLSWVSDAANSTACSHDFHLPGESS------------------------LKNIREEYDYDEEEDSLIEFRSESQSAA
.  .. ||.  .|  |    . .  .  |.  |. . . .     |..                        ..  ..    .|  |   .   .  |  
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWDIESNN

LRAEEEDDTDDDYEEDEEQ
 | .|.|| ... |....|
VRDMESDDNEWEQEQQNNQ
Kinase PEK.AA PEK-Unclassified 1028-1121 31 1.7e-22 74.93 In-house 731-835 (835) Show / Hide 
Range on Protein: 1028-1121
Range on HMM: 731-835/835
Sequence Identity: 31% (33 aa)

TQQVGTHLYMSPEQL-----------LGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQ
|  .|| .| |.||.            .  |. . ||||.| |||..   . | ||| ||.  .. |  || |   .|   ....  ||  | .||   .
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSK

LKSQL
.   |
IEQTL
Kinase PEK.AA WEE 929-1063 27 3.4e-22 71.3 In-house 80-229 (297) Show / Hide 
Range on Protein: 929-1063
Range on HMM: 80-229/297
Sequence Identity: 27% (46 aa)

LYIQMQLCRKES--LRDWLRDNRSETR---AAHIGDIFHQIVDAVDYVHLK-GLIHRDLKPSNIFFSQDG--------------------QIKIGDFGLV
.|||| .|.. |  | .|. .. .. .    . | .|. .|. .. ..| . |..| |.||.|||.| ..                     .||||||.|
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV

TDMADIPNLVAKCGDQSGLPSCARHTQQV---GTHLYMSPEQLLG--QHYDY-KVDIYSLGLIFFEL
|||                    ..  ..   |   ||.|| | |  .. .  | ||.|||. ..||
TDMNS-----------------NNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYEL
Kinase PEK.AA WEE 642-710 33 9.8e-22 69.74 In-house 1-77 (297) Show / Hide 
Range on Protein: 642-710
Range on HMM: 1-77/297
Sequence Identity: 33% (26 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRI-TLPNKESSRQRVLREARTLASCE------HH-NIVRYFHSWTET
|.  | .|.| || |. .....| . ||||..   ....|.|.| |||.. ...        || .||||. .| |.
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEED
Kinase PEK.AA HRI 642-709 42 1.3e-21 72.47 In-house 1-69 (613) Show / Hide 
Range on Protein: 642-709
Range on HMM: 1-69/613
Sequence Identity: 42% (29 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPN-KESSRQRVLREARTLASCEHHNIVRYFHSWTE
||    .|.||.| |.  ..|||   ||||.|     .  | ....|| ..||  .|||||||  .| |
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase PEK.AA PKR 1028-1121 45 6.7e-21 71.47 In-house 181-272 (272) Show / Hide 
Range on Protein: 1028-1121
Range on HMM: 181-272/272
Sequence Identity: 45% (43 aa)

TQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQL
| . ||  ||||||.  |||   |||| ||||  ||     ||.|.||   .|||| .  |   |  .   |||..|| .|. ||.|  .   |
TRRKGTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDN--KEKTLLQKLLSKKPKDRPNTSEILRTL
Kinase PEK.AA PEK-Unclassified 642-731 32 7.9e-21 68.97 In-house 1-97 (835) Show / Hide 
Range on Protein: 642-731
Range on HMM: 1-97/835
Sequence Identity: 32% (32 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLP------NKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGW-QEEEDRKLLAHELSTS
|  .| .|.|||..|.   .|.|.  ||.|.| .              . ..|.| .|   | ||.||.||| |       |  |. |    ||| |
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEIKKNSQKQEEQKRQTLELSSS
Kinase PEK.AA HRI 928-1001 43 2.6e-20 67.79 In-house 393-483 (613) Show / Hide 
Range on Protein: 928-1001
Range on HMM: 393-483/613
Sequence Identity: 43% (40 aa)

YLYIQMQLCRKESLRDWL--RDNR-----SETR-----AA--HIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQ----IKIGDFGL
.|.||||||   ||.||.  |  |     .||      |    |  || |||  . |.| .. .|||.|| ||| .   |    .|||||||
MLHIQMQLC-ELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGL
Kinase PEK.AA Pkinase 642-709 23 4.8e-16 57.83 Pfam 1-71 (293) Show / Hide 
Range on Protein: 642-709
Range on HMM: 1-71/293
Sequence Identity: 23% (17 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLR---EARTLASCEHHNIVRYFHSWTE
... ...|.|.||.|.....| .. ..|.|.| .....|. .. .|   |.. .... | ||||.......
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED
Kinase PEK.AA PEK-Unclassified 959-1003 51 1.9e-14 46.03 In-house 617-663 (835) Show / Hide 
Range on Protein: 959-1003
Range on HMM: 617-663/835
Sequence Identity: 51% (24 aa)

DIFHQIVDAVDYVHLKG-LIHRDLKPSNIFFSQD-GQIKIGDFGLVT
.|  ||. |  ..|  . ..|||.|| |||  |   ||||||||||.
EITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVK
Kinase PEK.AA PKR 642-707 40 4.3e-13 43.12 In-house 1-61 (272) Show / Hide 
Range on Protein: 642-707
Range on HMM: 1-61/272
Sequence Identity: 40% (27 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSW
|. .  .| |||| || || ..|  ||.|||.   | |    .  .| . ||  .| |||.|   |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKY-NNE----KAEHEVQALAKLDHVNIVHYHSCW
Kinase PEK.AA TyrKc 642-1121 12 6e-11 -45.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 642-1121
Range on HMM: 1-280/280
Sequence Identity: 12% (64 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASC--EHHNIVRYFHSWTE--------TPPTGWQEEEDRKLLAHELSTS
 .| . ||.| ||.|.... |      |.| .        |.  .|||| . .   .| |||| .   |.         |.    |      ..   .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME------YMPHGDLK

IQIETPDDSTMPSLTEQLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQGD
  .  . .                                                                                            
DYLRKHRPK-------------------------------------------------------------------------------------------

HEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYI
                                                                                                    
----------------------------------------------------------------------------------------------------

QMQLCRKESLRDWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQV
                       ..  .. .|| .  .| | |..|||||   |.  . ....||.||||  |  |         ||.|    ...   .
--------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDD--------DQQG----ESKDYYR

-----GTH--L---YMSPEQLLGQHYDYKVDIYSLGLIFFEL----HVYFSTE----MERIKTLRSLRDGQYPKDFAVNY--------PQQYDLLQQMLS
     |..  |    |.|| .    .  | |..| |   .|.        . .    |. .  .. ...| ...  . .|        .  |.. .|   
KKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

AQPEQRPQTKQLKSQL
..||.||  .......
EDPEDRPTFSEIHECF
Kinase PEK.AA Ciliate-E2 642-681 25 3.7e-09 27.57 In-house 1-38 (365) Show / Hide 
Range on Protein: 642-681
Range on HMM: 1-38/365
Sequence Identity: 25% (10 aa)

FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESS
... ...|.|.||.|...|.... ...|||.|.  .. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QR
Kinase PEK.AA Pkinase_Tyr 642-703 25 8.6e-08 27.02 Pfam 1-69 (270) Show / Hide 
Range on Protein: 642-703
Range on HMM: 1-69/270
Sequence Identity: 25% (18 aa)

FELMQCLGRGGFGVVFEAKNK----LDENRYAIKRITLPNKESS---RQRVLREARTLASC-EHHNIVRY
 .... ||.| ||.|.... |     ..   |.| .  ..  ..   |.  .|||... .   |.||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase PEK.AA Pkinase_Tyr 928-1001 29 0.01501 9.26 Pfam 81-157 (270) Show / Hide 
Range on Protein: 928-1001
Range on HMM: 81-157/270
Sequence Identity: 29% (23 aa)

YLYIQMQLCRKESLRDWLRDN---RSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGL
..|| | .. . .|.| ||..   .      .. .. .|| .. .| . |..|||||   |.  . ....||.||||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase PEK.AA Ciliate-E2-Unclassified 1098-1118 42 0.093803 1.89 In-house 327-347 (352) Show / Hide 
Range on Protein: 1098-1118
Range on HMM: 327-347/352
Sequence Identity: 42% (9 aa)

DLLQQMLSAQPEQRPQTKQLK
||||.||  .|..|.. .|..
DLLQKMLKKNPNKRITFEQIL
Kinase PEK.AA Pkinase_Tyr 1097-1121 40 5.301997 0.63 Pfam 246-270 (270) Show / Hide 
Range on Protein: 1097-1121
Range on HMM: 246-270/270
Sequence Identity: 40% (10 aa)

YDLLQQMLSAQPEQRPQTKQLKSQL
|||..|   ..||.||  ... .||
YDLMKQCWHYDPEDRPTFSEIHEQL