Gene CG4549 (Fruit Fly)

CG4549

Species: Fruit Fly
Alias: FRAP-related, SFO293, CG4555, CG4549
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 6D3--4,

Classification

Group: Atypical
Family: PIKK
Subfamily: SMG1

Sequence

Name Sequence Type Origin Length Description Download
CG4549.AA Protein Various 3218 None Fasta, JSON
CG4549.kin_dom Protein Kinase Domain None 12 None Fasta, JSON

Protein domain

Protein domains of CG4549.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT CG4549.AA HEAT 1648-1678 32 5e-06 24.78 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1648-1678
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

IIPQLFSRLNHHEPYVRKSVCDLLCRLAKSR
|.| |.. ||. .. ||...|  |..|..  
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Kinase CG4549.AA PIKK 1893-2186 37 2.6e-102 346.23 In-house 1-290 (290) Show / Hide 
Range on Protein: 1893-2186
Range on HMM: 1-290/290
Sequence Identity: 37% (110 aa)

YIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALY
.| .   .| |...|.||||  . |..|  | .|.|| |||..|.|.||.... | . . ..       . . .|||||.....||| |||. .. ...|
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPEC-QKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIY

KKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQ-WPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMS
|.|.|.    .. .  .|  | . .    .  ..|    || ||. .. .| || .. ..|. |..| || |......|  . ....|  .  .. |   
KQWCQKK---HIRHEQEAQMNYQTCMYRDWLKQMS--YYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYA

VMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFE-KGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAF
||.| ||..||||||..|..|.  .|.|||||...||| ....|. |||||||||.|.| |||..|.||.||  || |...||. ||||.|..|.|
VMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase CG4549.AA SMG1 1901-2138 50 1e-95 317.6 In-house 1-242 (242) Show / Hide 
Range on Protein: 1901-2138
Range on HMM: 1-242/242
Sequence Identity: 50% (124 aa)

VCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMAC--RSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQR
. .|||||||||. | || |. | .||||.||||||||||||||| | . |   | . |    . | |||| |||  |||| |||| ||.| |||.||||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETP---RFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQR

RSQVAGNAGAGAVAN------VPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSV
   .       .         |||   .|.| |. | |    . .   || ||. |.  ||.||   || .|||.|||       ||      . |   |
EAALQAQKAQDSYQTPQNPGIVPRP-SELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAV

MSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPE
|||.||.||||||||||||| .  |..|||||..|||||. |..||
MSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase CG4549.AA PI3_PI4_kinase 1922-2196 21 3.2e-55 194.56 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1922-2196
Range on HMM: 1-300/300
Sequence Identity: 21% (73 aa)

RYTFLFKGMEDLH--LDERIMQFL------------------SISNAIMACRSDAPGNGCYR----AHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQ
 | |.||| .||.   |.|.||..                  . .   . ..     ... |    ...|..||.||..|.| ||. .|.   . ...  
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

RRSQVAGN---------AGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNA-AEWRQSVRRFV
...  . |         ...   .                                 .   ..| .. .  || . | ...| . ..|  || .. ..||
KCKHKHFNKEHKMWMKMWPDWWHLM--------------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFV

RCMSVMSMIGYVIGLGDRHLDNVLI--NLGSGDIVHIDYNVCFE--KGRTLRIPEKVPFRLTQ------NLVQAM------GITGIEGPFRLGCEYVLKV
| . .|....|..|.||||.|| ..  . ..| ..|||.. ||.  |. ..  ||.||||.|.      ..| ||      . .| .| ||  |. .. .
RSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRA

MRKERETLLTLL-------EAFVYDPLVDWTT
.|.  . ...||       |..|.|.|..|. 
LRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase CG4549.AA ATM 2086-2197 54 1.1e-48 153.41 In-house 140-251 (304) Show / Hide 
Range on Protein: 2086-2197
Range on HMM: 140-251/304
Sequence Identity: 54% (61 aa)

FVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEA
. | .   |..||..||||||  |.|||  | ..||||  | ||.|. |  || ||||||  .|  |||||.|| ||  ||  . |||   |||||. | 
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEV

FVYDPLVDWTTN
 .|||| ||| |
LLYDPLFDWTMN
Kinase CG4549.AA FRAP 2058-2196 45 6.8e-44 152.15 In-house 112-251 (251) Show / Hide 
Range on Protein: 2058-2196
Range on HMM: 112-251/251
Sequence Identity: 45% (63 aa)

QETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKG-RTLRIPEKVPFRLTQNLVQAMGITG
. |  . |.. ||    |   | .    . | . .|||.||..||||||. |....  .| |||||.  |||   |  ..|||.|||||  || || ..|
NNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACG

IEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTT
||| .|  || |.||.| ..| ..  |||||||||  |  
IEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase CG4549.AA ATR 2078-2186 43 8.3e-42 139.99 In-house 159-267 (267) Show / Hide 
Range on Protein: 2078-2186
Range on HMM: 159-267/267
Sequence Identity: 43% (47 aa)

EWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERE
.|  |   ..| . |..|.||.||||||| ||.||.   |..||.|||. | .|... .|| ||||||.|.| .||  . .| ||  || ....||..|.
QWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRD

TLLTLLEAF
 .. ....|
DIMSVWDCF
Kinase CG4549.AA PI3Kc 1924-2257 18 6.7e-40 139.8 SMART 1-336 (336) Show / Hide 
Range on Protein: 1924-2257
Range on HMM: 1-336/336
Sequence Identity: 18% (73 aa)

TFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYK---KWQQ-----------------------
 ..||. .||. |.|.||.... | | .  . . .  .. .  |..||.||..|.| ||  ....  . |   ||.                        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLH-MRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY

------------------RRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEW
                  ....    ..  . .. |. . | |...                                                    .|
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN----------------------------------------------EDW

RQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIP-----EKVPFRLTQNLVQAMG----ITGIEGPFRLGCEYVLK
......|.| . ...|..|. |.||||.|| ..   .| ..|||.. .|..|...  .     |.||||||...| .||    ..| .| ||  |. ...
WEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYR

VMRKERETLLTLLEAFVYDPL-VDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDLKYHKKD----KNKGKPLDSDVKR-QPFLSKLGML
.|||.......|.|..||||.  .|. .   .   . |........       | . .   . ..    |  .. ..|  .| . .. .. ..
AMRKHSNLIMNLFEMMVYDPIMPCWRMM---EKDIKYLRQRFRLDH-------LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase CG4549.AA DNAPK 2085-2196 34 1.1e-22 79.19 In-house 189-301 (301) Show / Hide 
Range on Protein: 2085-2196
Range on HMM: 189-301/301
Sequence Identity: 34% (40 aa)

RFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFE-KGRTLRIPEKVPFRLTQ---NLVQAMGITGIEGPFRLGCEYVLKVMRKERETLL
.|.|   |    ... | |||||.| ..|   |||. ||.   |   .  | .||  |||||    ||   |.|.||   ..      .. .||.|  |.
HFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGI---MYQIMIHSMMAFRKDRNILT

TLLEAFVYDPLVDWTT
   . |. ||..||  
NFCDVFINDPSFDWKN
Kinase CG4549.AA ATR 1892-1983 32 6.6e-13 39.89 In-house 1-91 (267) Show / Hide 
Range on Protein: 1892-1983
Range on HMM: 1-91/267
Sequence Identity: 32% (30 aa)

VYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVD
 ||   .  | .| .  ||||... ||.|. |  . |  .||  | | |.| .. | .     .    . |    |.||||  |...| ||.
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEE-RRRFYHMRTYAVIPLNDQCCIIEWVN
Kinase CG4549.AA FRAP 1923-1982 38 2.1e-11 38.3 In-house 2-60 (251) Show / Hide 
Range on Protein: 1923-1982
Range on HMM: 2-60/251
Sequence Identity: 38% (23 aa)

YTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWV
| || || ||.  |||.||   . | ...   ..   .      ||.|||  ..||| ||
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKN-LSIQRYSIIPLSMNTGLIGWV
Kinase CG4549.AA DNAPK 1891-1983 30 2.2e-08 26.41 In-house 1-92 (301) Show / Hide 
Range on Protein: 1891-1983
Range on HMM: 1-92/301
Sequence Identity: 30% (28 aa)

QVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVD
 | |   .  | |.    .||..   |       |..|| ||| .| || |   . | |..  . .          |..||.    ||| |||
HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDP-QCQQRELQLRTYNIIPMTNRLGLIEWVD
FATC CG4549.AA FATC 3186-3218 48 9.2e-14 47.11 Pfam 1-33 (33) Show / Hide 
Range on Protein: 3186-3218
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

QRSTVAEQVDYVIREACNPENLAVLYEGWTPWV
.  .| .|||  |.|| .||||...| || ||.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW