Gene Pkc98E (Fruit Fly)

Pkc98E

Species: Fruit Fly
Alias: Pkc3, PKC d98F, SFO210, nPKC, 98F, PKC-brain, Dpkc3, PKC, dPKC98F, CG1954, Nc98F, Neural-conserved-at-98F, Pkc98E, PKC 98F
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 98F6,

Classification

Group: AGC
Family: PKC
Subfamily: PKCh

Sequence

Name Sequence Type Origin Length Description Download
Pkc98E.AA Protein Various 739 None Fasta, JSON
Pkc98E.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Pkc98E.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD Pkc98E.AA C2_PKD 3-172 41 3.1e-94 319.39 In-house 1-183 (183) Show / Hide 
Range on Protein: 3-172
Range on HMM: 1-183/183
Sequence Identity: 41% (76 aa)

TGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESH----FDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDFVANC
.|......|.|.||.|..||..|||||||.||...||||....|||.|    ....|...|||.|.||..|.|.|.....|.....|.|..||...||.|
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

IISFEDLMQSE---TAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTV---AVNKEFK-ERAGFNRRRG-AMR-RRVH
....||.....   ......|.|||||||.||.|...|.....|......|.|   ...|||| .|.||||||| ||| ...|
TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C2 Pkc98E.AA C2 6-99 25 1.5e-15 55.52 Pfam 1-90 (90) Show / Hide 
Range on Protein: 6-99
Range on HMM: 1-90/90
Sequence Identity: 25% (26 aa)

LQIKVCEASGLRPTDFQKRHNLTFGKLADEQ-LIDPYVSIDVDESHF----DRATTRPKTFDPVWNEQFVHD--VTNVSN-INLTVFHDAALPPDDFVAN
|...|.|| .|.|.|.            |   ..|||| . ..  .      .  . ..|..|||||.|. |  . .. . . .||...  .  |||.  
LRVHVIEARNLPPMDW------------DKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQ

CI
|.
CC
C2 Pkc98E.AA C2 5-114 17 5.2e-15 57.12 SMART 1-92 (92) Show / Hide 
Range on Protein: 5-114
Range on HMM: 1-92/92
Sequence Identity: 17% (23 aa)

KLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTF---DPVWNE---QFVHDVTNVSNINLTVFHDAALPPDDFVANC
.| ... || .|.                     |||| .        .  . ..|     |||||   .|. ||.. . . ..|...      ||.  |
TLTVHIIEARNLP---------------------DPYVKVY-------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH------DFIGHC

IIS--------------FEDLMQSETAVQD
.|.              ..|.. ..   . 
CIPPNNPHWHQWDGCIHLSDIL-GYRH-WW
C1_1 Pkc98E.AA C1_1 177-229 41 1.5e-22 86.07 Pfam 1-55 (55) Show / Hide 
Range on Protein: 177-229
Range on HMM: 1-55/55
Sequence Identity: 41% (23 aa)

HKFMAT-FLRQPTFCSHCREFIWG-IGKQGYQCQVCTLVVHKKCHLSVVSKCPGM
|..... ...|||||.||.||.|| .|.||..||.| ...|..||  |...|.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 Pkc98E.AA C1 177-226 37 4.2e-18 67.38 SMART 1-61 (61) Show / Hide 
Range on Protein: 177-226
Range on HMM: 1-61/61
Sequence Identity: 37% (23 aa)

HKFMATFLRQPTFCSHCREFIWGIGKQ-----GYQCQVCTLVVHKKCHLSVVS-------KC
|.....   .||.|.|||..|||. ||     ||.|..| ...|||||  | .        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 Pkc98E.AA C1_3 200-219 28 0.302341 4.67 Pfam 10-30 (30) Show / Hide 
Range on Protein: 200-219
Range on HMM: 10-30/30
Sequence Identity: 28% (6 aa)

IGK-QGYQCQVCTLVVHKKCH
|.   .| |  |  ..|..| 
IYRDPFYHCMQCDFMLHEDCA
C1_1 Pkc98E.AA C1_1 252-304 43 1.3e-23 89.58 Pfam 1-55 (55) Show / Hide 
Range on Protein: 252-304
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HRFVVH-SYKRFTFCDHCGSLLYG-LIKQGLQCETCGMNVHKRCQKNVANTCGIN
|..|.| ..|. |||.|||....| |..||..|..|..|.|.||...|.. || |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 Pkc98E.AA C1 252-301 25 4.2e-18 67.39 SMART 1-61 (61) Show / Hide 
Range on Protein: 252-301
Range on HMM: 1-61/61
Sequence Identity: 25% (16 aa)

HRFVVHSYKRFTFCDHCGSLLYGLIKQ-----GLQCETCGMNVHKRCQKNVAN-------TC
|... ... . |.|.||.....|. ||     |..|. |....||.|...|..       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 Pkc98E.AA C1_3 263-294 25 0.022686 7.53 Pfam 1-30 (30) Show / Hide 
Range on Protein: 263-294
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQ
 .|. ||  .|.    .  | .|  ..|..| 
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
Kinase Pkc98E.AA PKC 408-665 75 2.3e-220 721.25 In-house 1-262 (262) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-262/262
Sequence Identity: 75% (198 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEAS
|||.|||||||||||||||.|||||.|||||||||.|||||||.|||||||.||||..|||||.||.||||.|||||||||||||||||.||..|||. .
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF
.|.|||||...||||||..|.|||||||||.|||.|||.|.||||||||...||. |.||||||||||||||..||||.||||||.|||||||||||.||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

EADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDE----NEIRKHPFF
....|||||.|||||...||.|||.|||||.|||.|||||.||||. ..    ..||.||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase Pkc98E.AA Eta 408-665 83 1e-212 712.94 In-house 1-261 (261) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-261/261
Sequence Identity: 83% (218 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEAS
|||||||||||||||||||.|||||.|||||||||.|||||||.|||||||||.||..|||||.||.||||.||||||||||||||||||||.||.|...
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF
||.|||||||.||.|||.||||||||||||||||.||||||||||||||||||||.||||||||||||||||.|.|||.||||||.||||||||.|||||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

EADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCT---GDENEIRKHPFF
||||||.||.||.||||||||||..|||||||.|.||||..||||.   |.|..||.||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase Pkc98E.AA AGC 408-665 36 2.9e-203 531.81 In-house 1-395 (395) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-395/395
Sequence Identity: 36% (145 aa)

FNFIKVLGKGSFGKVMLAEKK------GTDEIYAIKVLKKDA-IIQDD--DVDCTMTE------------KRILALAAN---------HPFLTA-LHSCF
|.|.||.||||||||.|..||      .|...||.|||||.  |....  .|..||||            ..||... .         |||..  ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPDR--LFFVME----YVN-----GG-DLMFQIQ---KARRFEASRAAFYAAE-------VTLALQFLHT-HGVIYRD-LKLDNILLDQEGHCKLADFG
|..|.  |.||||    |||     || .|....|   | .||. .|| |||||       ..|||..||  .|.|.|| ||..|||||..||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGIMNG--------------------------------------------------MLTTTFCG--TPDYIAPEILKEQEYGASVDWWA--LGVLMY
.||||...|                                                   .|.||||  ||.|.|||||    || ..|||.  ||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMAGQPPFEADN----------EDELFDSIM------HDDVLYP----------VWLSREAVSILKGFLTKNPEQRLGCTGD------ENEIRKHPFF
||..|.||| .||          ..|.|..||      ...| .|          .|.| ||....|..|.|.||.|||| |.       .||..||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Pkc98E.AA Alpha 408-665 68 7e-183 613.85 In-house 1-259 (259) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-259/259
Sequence Identity: 68% (177 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEAS
|||..||||||||||||||.||||| ||||.|||| |||||||.|||.|||.|||    |||...||||||.|||.||||||||||||..||.  .|  .
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF
 |.|||||.  .| |||. |.|||||||||..|| ||| |.||||||||.....  | |||||||||||||   | || |||||| |||.||||||||||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

EADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGD-ENEIRKHPFF
. . ||||| .||   | ||  .|.|||.| ||||||.| .||||..| | .||.||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase Pkc98E.AA Akt 408-665 50 1.3e-150 484.77 In-house 1-264 (264) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-264/264
Sequence Identity: 50% (135 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIY-AIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEA
|.|.|||||||||||.|..|| |...| |.|||||| ||| . |  |.||..||    ||||.. ||  |||.|.|.|||.|.|||.| . .|..|||  
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQ-HCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

SRAAFYAAEVTLALQFLHTHGVIYRD-LKLDNILLDQEGHCKLADFGMCKEG-IMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWA-LGVLMYEMMAG
.|| ||.||. ||...|| ...|||| ||. |||.|..|| .|.|||.|||. | ..  |.|||||| |.|||||. . .. .||||. ||..||||| |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QPPFEADNEDELFDSIMHDDVLYP--VWLSREAVSILKGFLTKNPEQRLG-CTGDENEIRKHPFF
.||| ... ...|. |.  .| .|   |.| |. ....| |.|.|..|||   .| .||. ||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase Pkc98E.AA Delta 408-665 60 2.9e-146 492.19 In-house 1-259 (259) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-259/259
Sequence Identity: 60% (157 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEAS
|.| ||||||||||||||| ||... |||| |||| ...||||.||| |.|.||||..||||. |   ||| . |||||||.||||||. ||. .||. .
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF
|| |||.|. ..|||||..|.|||||||||.|||..|| |.|||||||| ..    . |||||||||||||.| | | .|||||. |||||||. || ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

EADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC-TGDENEIRKHPFF
. ..|||||.||..|   ||.|...|| ..||. . ..||.|||     . .||.|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase Pkc98E.AA SGK 408-665 44 8.4e-138 428.36 In-house 1-283 (283) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-283/283
Sequence Identity: 44% (126 aa)

FNFIKVLGKGSFGKVMLAEKKGT------------------DEIYAIKVLKKDAII-------QDDDVDCTMTEK-RILALAANHPFLTALHSCFQTPDR
| |.||.||||||||.....|..                  | .||.|||.|..||       .   .  .|.|.  || .  .|||.  ||  |||.. 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKN-MKHPFIVNLHYAFQTKWK

LFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKE
|.|||.|||||.. . .|....|  .|| |||||. .||  ||   .|||||| .||||| .|||.| ||| |||||     |.|||||| | |||.|. 
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

QEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEIRKHPFF
|... .|||| || ..|||| | |||.  |  ...| |.. .   |   | .| ....| |.|.|..|||   |  ||..||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase Pkc98E.AA Iota 408-665 55 1e-130 437.85 In-house 1-271 (271) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-271/271
Sequence Identity: 55% (150 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEAS
|. |.|.|.||. ||...| | |. |||.||.||. . .|.|.|   ||| .   |.|||||  |||||||. |||||.|.|||||||| .|. |.    
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

RAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF
 | ||.||. |||.||| .|.|||||||||.|||.||| || |.||||||| .| .| |||||| |||||||. ..|| |||||||||||.|||||  ||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

---------EADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDE----NEIRKHPFF
         .   || ||  |.   .  |  ||  | ..||||| |.|..||||  .      .|..||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase Pkc98E.AA PKN 408-665 54 4e-119 402.06 In-house 1-260 (260) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-260/260
Sequence Identity: 54% (142 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALA--ANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFE
| .| |||.| ||||.|.. |.|.|.||||.|||  |.  |.|.  |.||||.. .  . ||||  |..|||| .  .|||||. ||||| .| .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHED-VFS

ASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQP
  || |||| | | ||.|| | .|||||||||.|||.||. |.||||.||||.  |  | ||||||...|||.| .. |   |||| ||||.|||. | .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTG-DENEIRKHPFF
||  |.|.|.||.|. ||| || .|| ||..|..  | ||||.||| .  |  .|...|||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase Pkc98E.AA AktR 408-665 42 2.4e-115 389.49 In-house 1-268 (268) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-268/268
Sequence Identity: 42% (115 aa)

FNFIKVLGKGSFGKVMLAEKK-GTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEA
| ..|.|||| ||||.|..||  ....||.|..||  ||.    . | ||. |..  .||||.  || |||| . |||.|||. ||.| . ..| ..|. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SRAAFYAAEVTLALQFLHTH-GVIYRDLKLDNILLDQEGHCKLADFGMCK-EGIM-NGMLTTTFCGTPDYIAPEILKE-QEYGASVDWWALGVLMYEMMA
..| ||.|.. |||..|| |  .|||||| .|||||..|| |..|||. | ...| .  ....||||| |.|||.... . .. ||||||.|.. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQPPFEADNEDELFDSIMHDD---VLYPVWLSREAVSILK-GFLTKNPEQRLG-CTGDENEIRKHPFF
|.|||...|  ..|..|   .   . ||. .| .. .... . | |||..|||  . .  ||..||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase Pkc98E.AA S_TKc 408-665 36 4.8e-106 359.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNG--GDLMFQIQKARR--
. .....|||.||||... .|.|..|.|||..|          . .. | .||    .||..  |. .||. |.|..||||..|  |||.  |.| .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGA-SVDWWALGVLMY
    |   .|.||.... .||...| ||.|.|||| .|||||.  | |..|||....        |||||||.|.|||.|    ||  ..|||..|...|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDEN---EIRKHPFF
||..|.|||.  .....|. |.          |.|| ..... |.|.||.|...    .   .|..||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Pkc98E.AA Pkinase 408-665 30 1.9e-87 301.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 408-665
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTM-TEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGG----DLMFQIQ--K
. .....|.||||.| .. .||| .|.|.|..||. .  . |.  .  .| .|..   |||.   |. .|...|.. .||||..||    ||.  |.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

ARRF--EASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHC----KLADFGMCKEG-IMNGMLTTTFCGTPDYIAPEILK-EQEYGASVDWWA
 ..|  .   . ||. ..  .|...| .|.|.||||..|||.|..||.    |..||| .|   . |.  .|||||||.|.|||...  |.|| .||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLMYEMMAGQPPFEAD------NEDELFDSIMHDDVLYPVWLS---------------------REAVSILKGFLTKNPEQRLGCTGDENEIRKHPFF
.|...|||. |.|||  .      ....... ||. .. .. . .                     .|. ...|. |.|.|..|..      .| .||.|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase Pkc98E.AA S_TK_X 666-729 36 1.7e-27 98.6 SMART 1-79 (79) Show / Hide 
Range on Protein: 666-729
Range on HMM: 1-79/79
Sequence Identity: 36% (29 aa)

AKLDWKELEK--RNIKPPFRPKMK----NPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDE---------FAGFSFVN
...||. |..  ..|.|||.|| |    .|.|..||| |||.|.|.|||.   ......|.|         |.||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase Pkc98E.AA Pkinase_Tyr 408-608 24 1.8e-17 59.79 Pfam 1-217 (270) Show / Hide 
Range on Protein: 408-608
Range on HMM: 1-217/270
Sequence Identity: 24% (54 aa)

FNFIKVLGKGSFGKVMLAEKK----GTDEIYAIKVLKKDAIIQD---DDVDCTMTEKRILALAANHPFLTALHSCFQ-TPDR--LFFVMEYVNGGDLMFQ
  |.|.||.|.||.|.... |    .|.   |.|.|| .|  ..   .|    | | .|.    .|| .  |. .     .   .. ||||. .|||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF---MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IQK----ARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEG-------IMNGMLTTTFCGTPDYIAPEILKEQEYGA
 .|     ...  ..   .....  ....|. .. | |||   |.|.. ....| .|||...          . |        .    ||| ... ..  
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTT

SVDWWALGVLMYEMMA-GQPP-FE
  | |. ||||.|..  |. | ..
KSDVWSFGVLMWEIFTYGEQPTYP
Kinase Pkc98E.AA Pkinase_C 685-731 42 3.4e-17 63.73 Pfam 1-46 (46) Show / Hide 
Range on Protein: 685-731
Range on HMM: 1-46/46
Sequence Identity: 42% (20 aa)

KMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPK
. |.|.|. ||| |||.|.|..||  ..  . ..|..| ||..|||.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase Pkc98E.AA TyrKc 408-659 21 5.4e-16 35.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 408-659
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALA-ANHPFLTALHSCFQTP-------DRLFFVMEYVNGGDLMFQIQ
  ..|.|| | ||.|.... |   .  |.|.||.||      .   | | ||.     .|| . .|. .  ..       . |. ||||. .|||   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KARR-FEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMN-------GMLTTTFCGTPD------YIAPEILKEQEYG
| |. .  .    ..  .    ..|| ...| |||   |.|.. ....| .|||.....           . ...  .  .        ||| ... .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

ASVDWWALGVLMYEMMA-GQPPFEA-----DNEDELFDSIMHDDVLYPVWL---------SREAVSILKGFLTKNPEQRLGCTGDENEI
   | |. ||.|.|..  ||.| .       . .|..  ... . . .            . |  .| |     .||.|   .    ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF