Gene Pkg21D (Fruit Fly)

Pkg21D

Species: Fruit Fly
Alias: Pkg21D, PKG 21D, cGMP, SFO203, dg1, PKG, Pkg1, DG1, CG3324, Dg1
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 21D3,

Classification

Group: AGC
Family: PKG

Sequence

Name Sequence Type Origin Length Description Download
Pkg21D.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
Pkg21D.AA Protein Various 768 None Fasta, JSON

Protein domain

Protein domains of Pkg21D.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP Pkg21D.AA cNMP 185-299 28 3.7e-27 97.46 SMART 1-123 (123) Show / Hide 
Range on Protein: 185-299
Range on HMM: 1-123/123
Sequence Identity: 28% (35 aa)

FLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQ---------GKVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVL
..||.|... |||.|.|......||| ..|.|..| |.|.  .|.. |...         ..... .|.|  |||||.| . .|||..| ..| ...| .
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

DRRVFQQIMMCTGLQRIENSVNFL
|.. |.|.... ..  ...  ...
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding Pkg21D.AA cNMP_binding 203-285 24 3.5e-16 58.19 Pfam 1-87 (91) Show / Hide 
Range on Protein: 203-285
Range on HMM: 1-87/91
Sequence Identity: 24% (22 aa)

SKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLD-----KMGAGKAFGELAILYNC-TRTASIRVLSEAARVWVLDRRVFQQIMM
 .....||.....|. . |.|.   |.. | . ..  .      .|.|  |||.|...|. .|||....  . ...|...| .|.|.|.
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVA-LTDCECWRIPREDFRQLMQ
CNMP Pkg21D.AA cNMP 304-428 31 1.3e-33 118.9 SMART 1-123 (123) Show / Hide 
Range on Protein: 304-428
Range on HMM: 1-123/123
Sequence Identity: 31% (40 aa)

LLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQK--LTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTL
.. ||.|..|....|..|...|.||.||.||| .||.|..|..| |||...   .. . .|.....|..||.||| ||.    |... .|. . .|| |.
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL----RRPRTAAARACCECCTI

DRDSFKRLIGDLCELKEKDYGDESRKL
.|..|..... | . ... | .  . .
WRIDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding Pkg21D.AA cNMP_binding 322-415 30 8e-22 77.57 Pfam 1-91 (91) Show / Hide 
Range on Protein: 322-415
Range on HMM: 1-91/91
Sequence Identity: 30% (29 aa)

LEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINED-KRTANIIALSPGVECLTLDRDSFKRLIGDLCE
.. |..|..|..|| ..|.|... .| |.|..           |..|..||.||| ||.... .|||...|    .||. ..|..|..|. .  |
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQ--ILGFLGPGDFFGEMALFTNQNPRTATVVA-LTDCECWRIPREDFRQLMQQHPE
Kinase Pkg21D.AA PKG 457-717 71 3.1e-220 737.92 In-house 1-260 (260) Show / Hide 
Range on Protein: 457-717
Range on HMM: 1-260/260
Sequence Identity: 71% (187 aa)

LEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFED
|....|||.|||||||||...||. ...|||||.||||||||.|.|||.||..||...|..||.||||||||.||||||.|||||||.||.|||||.|.|
LKIIATLGVGGFGRVELVQYNHQK-SRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDD

NAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPF
....|...||..||.|||...||||||||||||||.|||.|.|||||||.||...||||||||||||||||||||||||.|||||||||..|||.|.|||
KTTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPF

SAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF
|..|||.|||.|||||||..||..|.|||...||.||||.|.||||||..||.||||||||
SGSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase Pkg21D.AA AGC 457-717 27 4.7e-157 409.55 In-house 1-395 (395) Show / Hide 
Range on Protein: 457-717
Range on HMM: 1-395/395
Sequence Identity: 27% (111 aa)

LEVVSTLGIGGFGRVELVKAHHQ----DRVDIFALKCLKKRH-IVDTK--QEEHIFSE------------RHIMLSSR----------SPFICR-LYRTF
 |.. ..| |.||.| ||.  .     |  ...|.|.|||.| ||..|  ..||. .|            |.|.   .          .|||.. |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RDEKY--VYMLLEACM---------GG-EIWTMLR---DRGSFEDNAAQFIIGC-------VLQAFEYLHA-RGIIYRD-LKPENLMLDERGYVKIVDFG
 |...  .|...| .          || | ...|.   ..|.|. ..|.|.. .       .. |.||||  .|||.|| |||||..|||.|..|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKQIGTSS---------------------------------------------------KTWTFCG--TPEYVAPEIILNKGHDRAVDYWA--LGILIH
..|.. ..                                                    .||||||  ||||.||||.    ...|.|.|.  ||.|. 
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLNGTPPFSAP----------DPMQTYNLILKGI----DMIAFP----------KHISRWAVQLIKRLCRDVPSERLGYQTG-----GIQDIKKHKWF
|.| | |||..           .||.....|..|.    . . ||          ...|  |. |||.|.   |..|||.. .     |...||.|.||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Pkg21D.AA PKA 457-717 47 3.2e-118 399.07 In-house 1-263 (263) Show / Hide 
Range on Protein: 457-717
Range on HMM: 1-263/263
Sequence Identity: 47% (127 aa)

LEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICR-LYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFE
 | . ||| | ||||.|..  |    ...|.|.|||. ||..||.||. .|..|... ..||| . .| || |..| ||..| . |||. . || .|.| 
FEIIQTLGTGSFGRVMLCRHKHSG--NYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFS

DNAAQFIIG-CVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNK-GHDRAVDYWALGILIHELLNGT
   |.|..   .  |.||||.  ||||||||||...|..|..|| |||||| . .   ||| |||||| |||||..| || ..|| ||||||| |.| | 
NPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGY

PPFSAP--DPMQTYNLILKGIDMIAFPKHISRWA---VQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF
|||..   ||||.|. |..|   | || |..  |     |||.|    ...|.| . .|..|||.||||
PPFYDHNRDPMQIYEKICNGK--IKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase Pkg21D.AA Pkinase 457-717 32 5.6e-102 349.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 457-717
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

LEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIF-SERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGG----EIWTMLR--
.......| |.||.|   |.||..  .|.|.|..||||. . |...|.  || .||.. ..|.|.|||..|.|....|| .| |.||    . .....  
YHIGRKIGSGSFGCV--YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

DRGSF--EDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYV----KIVDFGFAKQ--IGTSSKTWTFCGTPEYVAPEIIL-NKGHDRAVDYW
..|.|  ... ..|..  .|.. ||.|..|||.|||||||...|..|..    || |||.|||  .  .| ..||||||.|.|||.|. .......|| |
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGILIHELLNGTPPFSAP------DPMQTYNLILKGIDMIAFPKHIS-------------------RWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHK
..|....|.|.| |||.        |.|| ...|.... .  .|. .|                   ... ..||....  |..|..     ...|..|.
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHP

WF
||
WF
Kinase Pkg21D.AA Ciliate-E2b 457-717 33 2.8e-94 286.87 In-house 1-272 (272) Show / Hide 
Range on Protein: 457-717
Range on HMM: 1-272/272
Sequence Identity: 33% (94 aa)

LEVVSTLGIGGFGRVELVKA-HHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRG--S
....  || | || | ||..  ....  ..|.|| .|  |. .  | |. .|  ...    ||| ...|.|.|....|...| | |.|. ...|. |   
MIYIKKLGFGQFGSVYLVWNTKNTKQ--YYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLL

FEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSK----TWTFCGTPEYVAPEIIL-----NKGHDRAVDYWALGI
.  . .||.|. .. ..|||| ..|||||.|||| |.|. ||.|..|.| || . ...     | | .|||.| |||||      .||   .|| |..||
LSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGI

LIHELLNGTPPFS--APDPMQTYNLILKGIDMIAFPKHISRWAV--QLIKRLCRDVPSERLGYQTGGIQDIKKHKWF
   |.. | .|.   . || . |  |.|. | | || ...      .|. ..   .|  |||   | ..  | |.||
CLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG---GSYSWLKSHPWF
Kinase Pkg21D.AA AktR 458-717 40 3.1e-92 312.72 In-house 2-268 (268) Show / Hide 
Range on Protein: 458-717
Range on HMM: 2-268/268
Sequence Identity: 40% (109 aa)

EVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIML-SSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFED
.|   || |.||.| ||.    |  ...|.| .|| .|.. .|..|.  || ||   .. ||| .|. .| .... . ..| | |||. ..|. .. |. 
HVYKCLGKGAFGKVYLVQKKR-DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NAAQFIIGCVLQAFEYLHAR-GIIYRDLKPENLMLDERGYVKIVDFGFAK-QIG--TSSKTWTFCGTPEYVAPEIILN-KGHDRAVDYWALGILIHELLN
. |.|..  .| |.|||| .  ||||||||||..||| |.|||.||| .| |.    . |. .|||||||.|||.|.. |||...||.||.||.| |.. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GTPPFSAPDPMQTYNLILKGIDM-IAFPKH--ISRWAVQLIK-RLCRDVPSERLGYQTGGIQDIKKHKWF
| ||| . .  |....... | . . ||..  .|  .  ||. .|  . | .||||.. |...||.|.||
GCPPFYHKN--QNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase Pkg21D.AA RSK 460-717 37 3.4e-89 302.62 In-house 1-278 (278) Show / Hide 
Range on Protein: 460-717
Range on HMM: 1-278/278
Sequence Identity: 37% (103 aa)

VSTLGIGGFGRVELVKAH-HQDRVDIFALKCLKKRHIVDTKQ-EEHIFSERHIMLSSR-SPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGS---
.. || ||.| | |..   | |   |.| | |||. || ..   .| . || |.. .. .|||..|. .|..|...|. .| |.|||  | |. ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDE---RGYVKIVDFGFAKQ--IGTSSKTWTFCGTPEYVAPEIIL----NKGHDRAVDYWALGI
|  . |.|..  .  | |.|| .|||.||||||| ..|.   .| .|..||||.||  .  ...| |||.| ||.|||..     ..|||.|.|.| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIHELLNGTPPFSA---PDPMQTYNLILKGIDMIAFP--KHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF
|..|.| | ||| .    .. .. . |.||     .|  . .|. |  ||...    |. |||.  .....||.|.||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Pkg21D.AA S_TKc 457-717 32 4.3e-86 293.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 457-717
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

LEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMG--GEIWTMLRDRGS-
 |.. ..| |.||.| ... ..     |.|.|..|          ||| .|. |. . . |.|..|| .|.| ...|| .| | |  |.  .....||. 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDR-AVDYWALGILIH
     |    |.|..  ...| ||.| .|||.|||||||..|||   .|| |||.|.|.       ||||||.|.|||..   |... ..| |..|... 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGI--QDIKKHKWF
|.| | |||.  ........|.            |. | ..|.....  |..|..        .|||.| ||
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Pkg21D.AA Akt 458-717 38 5.8e-84 268.28 In-house 2-264 (264) Show / Hide 
Range on Protein: 458-717
Range on HMM: 2-264/264
Sequence Identity: 38% (102 aa)

EVVSTLGIGGFGRVELVKAHHQDRVDIF-ALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFED
...  || | ||.| |||    ..  .. |.| |||..|.. .| ||.. || |    ..|||  |.  | .... |. .. | |||. . |. .. |  
DFLKVLGKGSFGKVFLVKKKDTQK--WYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

NAAQFIIGCVLQAFEYLHARGIIYRD-LKPENLMLDERGYVKIVDFGFAKQI-GTS-SKTWTFCGTPEYVAPEIILNKGHDRAVDYWA-LGILIHELLNG
. | | .  .  | |.|| ..||||| |||||...|. |.... ||| .|..  .   || |||||||| ||||....||..||| |. ||... |.. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

TPPFSAPDPMQTYNLILKGIDMIAFP--KHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF
 ||| . |  | . .|. .   . ||  . ||  .  ||..|.   |..|||.  ...|.|| | ||
RPPFYNQDHHQMFKKIKNQ--PVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase Pkg21D.AA SGK 458-717 34 6.8e-80 246.32 In-house 2-283 (283) Show / Hide 
Range on Protein: 458-717
Range on HMM: 2-283/283
Sequence Identity: 34% (100 aa)

EVVSTLGIGGFGRVELVKAHHQDR------------------VDIFALKCLKKRHIV-------DTKQEEHIFSER-HIMLSSRSPFICRLYRTFRDEKY
.  ...| |.||.| .||  | |                    ...|.| |.| ||.         |.. || .||  |.   ..|||  |   |  ...
DFLKVIGKGSFGKVYQVK--HKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWK

VYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAK-QIGTSSKTWTFCGTPEYVAPEIILN
 |. ..   |||    |. ...|    | |    .  | ||||   ||||||||||..||  |.... ||| .| .| |. .| |||||||| |||... 
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

KGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF
..|||.|| | ||..  |.. | |||   .  | |  |...   . .|. .|  |  ||. |    |..|||   .... ||.| .|
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQ--PLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFME-IKNHPFF
Kinase Pkg21D.AA Ciliate-E2 457-717 23 1.1e-77 264.42 In-house 1-365 (365) Show / Hide 
Range on Protein: 457-717
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

LEVVSTLGIGGFG-----RVELVKAHH----------------QDRVDIFALKCLKKRHIVDTKQEEHIF----------SERHIMLSSRSPFICRLYRT
 ...  .| |.||     .| .|.                   .. . |.|.|..||. |  .|||.||.           |. |. .  .|.|...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FR--DEKYVYMLLEACMGGEIWTMLRDR-----------GSFEDNAAQ---------------FIIGCVLQAFEYLHARG-IIYRDLKPENLMLDERGYV
|   |....|. .| | ||. .  ....           ..| .. ..               |.|.|...|.|||| .. ||.||.||||...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIVDFGFAKQIGTS--------------------------------SKTWTFCGTPEYVAPEIILNKG---------HDRAVDYWALGILIHELLNGTPP
||.|||..|.. ..                                  ..|.||||.|.||||. .|.         .| ..|.|.||....|.| | ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FSAPDPMQTYNLILKGIDMIAFP------------------KHISRWAVQLIKR----LCRDVPSERLGYQTGGIQDIKKHKWF
|          .. .    | ||                  |..|  . .|||.    .    |..|..    |...|..|.||
F----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase Pkg21D.AA p70 458-717 35 1.8e-75 257.04 In-house 2-299 (299) Show / Hide 
Range on Protein: 458-717
Range on HMM: 2-299/299
Sequence Identity: 35% (105 aa)

EVVSTLGIGGFGRVELVKAHH-QDRVDIFALKCLKKRHIV----DTKQEE----------------------HIFSERHIMLSSRSPFICRLYRTFRDEK
| .  || ||.| | .|.    .|   |.| | |.|. ||    ||                            | || |  .  .|||| |   | .. 
ELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTNG

YVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAK-QIGTSSK----------TWTFCGT
  | .||   ||| .. |   | .  . |.|    .  | |.|| .||||||||||| ||...| |.  |||  | .|  ...          |.|||||
KLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGT

PEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF
.|| ||||.. .||..|||.|.||.|.   | | ||| .  . .| . ||||   .. |   .  .  |||.|    |..|.|   . ..||..|..|
IEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase Pkg21D.AA S_TK_X 718-768 25 3.9e-11 44.23 SMART 1-79 (79) Show / Hide 
Range on Protein: 718-768
Range on HMM: 1-79/79
Sequence Identity: 25% (20 aa)

LGFDWDGLAS--QLLIPPFVRPIA----HPTDVRYFD-RFPC-----DLNEP----------------PDELSGWDADF
 |.|||.| .  . . |||. .|     .|||...||  |.      .  .|                ||.  |....|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase Pkg21D.AA TyrKc 457-711 20 7.4e-11 -47.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 457-711
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

LEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSS--RSPFICRLYRTFRDE-------KYVYMLLEACMGGEIWTM
..   .|| | ||.| . ..         | |.||. .      .| . .|  || .   . | | |||   ...       . .....| . .|     
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRDRGSFEDNAAQFIIGC--VLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTS-----SKTWTFC----GTPE-----YVAPEIILNK
||...    . ....  |  . .  |||| ...| |||   | ...|.. ||| ||| .. |.       ||         |.         ||| |  .
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GHDRAVDYWALGILIHELL-NGTPPFSA-----PDPMQTYNLILKGIDMIAFPK-------HISRWAVQLIKRLCRDVPSERLGYQTGGIQDI
    . | |. |... |.. .| .| .       .. . .... .|  |   |        . .    |..|. ..  |..|   ..  ....
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF