phl

Species: Fruit Fly
Alias: l(1)2Fe, raf-like-oncogene-1, 11-29, l(1)raf, DRaf, l(1)ph, RAF, rafl, raf, pole-hole, D-raf1, l(1)ph: pole-hole, l(1)phl, Draf, ph: polyhomeotic, ph, CG2845, D-Raf, raf1: raf-like-oncogene-1, phl, Draf1, D-raf, Raf1, EG:BACH48C10.3, Raf, l(1)polehole, l(1)pole hole, SFO059, Draf-1, D-RAF, C110, raf1
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 3A1,

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
phl.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
phl.AA Protein Various 739 None Fasta, JSON

Protein domain

Protein domains of phl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD phl.AA RBD 141-212 36 5.4e-32 113.66 Pfam 1-77 (77) Show / Hide
Range on Protein: 141-212
Range on HMM: 1-77/77
Sequence Identity: 36% (28 aa)

ILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTH----SGRHIIPWHTDIGTLHV-EEIFVRLL
.....||||.||..|||..|....|.|||..| ..|.|..|.|....    .......|||||..|.. .|..|..|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL

RBD phl.AA RBD 141-212 34 3.1e-28 101.06 SMART 1-76 (76) Show / Hide
Range on Protein: 141-212
Range on HMM: 1-76/76
Sequence Identity: 34% (26 aa)

ILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHS----GRHIIPWHTDIGTLHVEEIFVRLL
.. . |||..|||.|.|..|....|.|||..| |.|.|..|.| ..|.    ......||..| .|. .|..|...
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR

C1_1 phl.AA C1_1 223-271 25 8.1e-15 58.05 Pfam 1-55 (55) Show / Hide
Range on Protein: 223-271
Range on HMM: 1-55/55
Sequence Identity: 25% (14 aa)

HQIIRK-TFFSLVFCEGCRRLL-----FTGFYCSQCNFRFHQRCANRVPMLCQPF
|..... .| . .||. |. ..     ..|. |..|....|.||...||..|.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN

C1 phl.AA C1 223-268 22 1.6e-11 45.52 SMART 1-61 (61) Show / Hide
Range on Protein: 223-268
Range on HMM: 1-61/61
Sequence Identity: 22% (14 aa)

HQIIRKTFFSLVFCEGCRRLLFT---------GFYCSQCNFRFHQRCANRVPM-------LC
|. ....| .  .|. || ....         |. || |....|..|. .||         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC

C1_3 phl.AA C1_3 234-261 30 1.1e-09 26.17 Pfam 1-30 (30) Show / Hide
Range on Protein: 234-261
Range on HMM: 1-30/30
Sequence Identity: 30% (9 aa)

VFCEGCRRLLF--TGFYCSQCNFRFHQRCA
 .|. | . .    ...|.||.| .|..||
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA

C1_2 phl.AA C1_2 235-261 34 0.000191 14.59 Pfam 1-32 (32) Show / Hide
Range on Protein: 235-261
Range on HMM: 1-32/32
Sequence Identity: 34% (11 aa)

FCEGCRRLLFT---GFYCSQCN--FRFHQRCA
 |. ||| .     ...|. |.  |  | |||
WCDVCRRKIDGFYWFYHCKKCCCDFTVHVRCA

Kinase phl.AA RAF 429-688 65 4e-194 635.24 In-house 1-282 (282) Show / Hide
Range on Protein: 429-688
Range on HMM: 1-282/282
Sequence Identity: 65% (185 aa)

ILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQA---FKNEVAMLKKTRHCNILLFMGCVSKPS---LAIVTQWCEGSSLYKHVHVSET--KF
. ...||||||||||||.||||.||||.|||..|.|.|.||   ||||||..|||||||||||||..|||.   .||||||||.||||.|.||.||  ||
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

KLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWS--GEKQANQPTGSILWMAPEVIR-----------MQELNPYSF
....||||.|||.||||||||||||||||||||||||||..||||||||.|.|||||  |..|..|||..||||||||||           ||. |||||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYAFGIVMYELLAECLPY-GHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLEN
|||||.||||||||.....|| .||.|.|||.||.|||.||||.|.||.|.|.|..||.|||.|.....||||...|.... 
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV

Kinase phl.AA RAF 429-686 57 1.3e-181 609.6 In-house 1-275 (275) Show / Hide
Range on Protein: 429-686
Range on HMM: 1-275/275
Sequence Identity: 57% (159 aa)

ILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSP-AQLQAFKNEVAMLKKTRHCNILLFMGCVSKP---SLAIVTQWCEGSSLYKHVHVSET-KFKLN
..|| |||.|.||||||.||||.|||||||.|.|.| .|||||||||.|.|||||.||.||||...||   ..|||||||.||.||.|.|| .| ||..|
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

TLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAK-TRWS--GEKQANQPTGSILWMAPEVIRMQ---------ELNPYSFQSDV
..|.| .|..||||||||||||||||||.|||||....|.|.||||.| | .||.  ...|..||.|.|.|||||||||.         . ||.||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
||||.|.|||.|...||.||....||..||.|| ||.|.|..|...|...|.| ..|..|.|..||.|. ...|.
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI

Kinase phl.AA TKL 435-686 26 2.7e-95 322.88 In-house 1-364 (364) Show / Hide
Range on Protein: 435-686
Range on HMM: 1-364/364
Sequence Identity: 26% (98 aa)

IGSGSFGTVYRAHWHG-----------PVAVKTLNVK------------------------TPSPAQLQAFKNEVA-MLKKTRHCNILLFMG-CVSKPS-
||||.||.||...|.|           .||||.....                         | . ... |..|.. |....|| ||..||| | . |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHA--------KNIIHRDLKSNNIFLHEDLS--------------V
            |.||...|.| ||. ..|       .. .... ...|.||.|||.        ..||||||||.||...|..               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATAKT------------------RWSGEKQANQPTGSILWMAPEVIRMQEL-------------NPYSFQSDVYAFGIVMYELLAECLPYGHI
||.||||.. ..                  . ...|. . . |.. ||||||.|.|.               .|| ..|||.||||..|.|. |.|| ..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

SNKDQI------LFMVGRG--LLRPDMS---------QVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
 . ..|      .......   ||| .          .  .|.|. .|.|..|| .. |..|| |  .|  |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase phl.AA KSR 429-686 38 2.4e-74 252.85 In-house 1-272 (272) Show / Hide
Range on Protein: 429-686
Range on HMM: 1-272/272
Sequence Identity: 38% (105 aa)

ILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVK-TPSPAQ-LQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEG-SSLYKHVHVSETKFKLNT
...|..|| | ||.|.|.|||| ||.|... .      . | .|| ||.|.|.||| || |||| |.. | ||||.  | |  .|| |.||  .|. .|.
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAK---TRWSGEKQANQPTGSILWMAPEVIRMQEL---------NPYSFQSDVY
 ..| .| .||| ||||| ||| |||| |||.     | | ||||   .       .| ..  | |    .||| ||             .|.| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AFGIVMYELLAECLPYGHISNKDQILFMVGRG-LLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
||| . ||...  .|. .     .|.. ...|  .|.....|   . . .| .   |  | | .|| |  .. ||
AFGTIWYEMICGEWPF-KYQCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML

Kinase phl.AA Pkinase 429-686 25 1.2e-73 255.74 Pfam 1-293 (293) Show / Hide
Range on Protein: 429-686
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

ILIGPRIGSGSFGTVYRAHWHGP---VAVKTLNVKTPSPAQLQAFKN--EVAMLKKTRHCNILLFMGCV-SKPSLAIVTQWCEGS----SLYKHVH-VSE
. || .|||||||.||..|..|    ||||...... .. ..|.  .  |....|. .|.||. . ... .|... .|. .|||     .|. ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKF--KLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSV----KIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDV
..|    ...... .|...|..|.|...|||||||. ||.....  .    ||.|||||  .  .     .. ..|.. .|||||||  . ..|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YAFGIVMYELLAECLPYGHI-----SNKDQILFMVGRGLLRPDMSQVRSDA----------------PQALKRLAEDCIKYTPKDRPLFRPLLNM--L
...|...||.|   .|. .       ...|........ |. | .. .|                  ....| . ..|... ||.|| .. .|.   .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase phl.AA TKL-Unique 431-686 31 3.1e-65 223.03 In-house 1-290 (290) Show / Hide
Range on Protein: 431-686
Range on HMM: 1-290/290
Sequence Identity: 31% (94 aa)

IGPRIGSGSFGTVYRAHWHG-PVAVKTLNV-KTPSPAQLQAFKNEVAMLKKTR-HCNILLFMG-CV----SKPSLAIVTQWCEGSSLYKHVH--------
..  ||.|..|.||.. |.| |||.|....   .|.  .| |.|||  .|| . | ||...|| |.    . | . ||.  |.|.|||.. |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VSETKFKLNTLIDIGRQVAQGMDYLHAKN--IIHRDLKSNNIFLHED-----LSVKIGDFGLATAKTRWSGEKQANQ-------PTGSILWMAPEVIRM
  ...|. ..  ... ...||||.||| ..  |||||||| |. . ..     ...|| ||||.. ... . ..  .        . ||..||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QELNPYSFQSDVYAFGIVMYELLAECL------PYGHISNKDQILFMVGR--GLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
 . . || .||||.||||..|..  ..      || .. . .|.. ||      .||  ..   . |. .. | ..| .  | .|| |   .. |
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIPN---HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase phl.AA Pkinase_Tyr 429-686 28 1.1e-62 212.99 Pfam 1-270 (270) Show / Hide
Range on Protein: 429-686
Range on HMM: 1-270/270
Sequence Identity: 28% (81 aa)

ILIGPRIGSGSFGTVYRAHWH-------GPVAVKTLNVKTPSPAQ--LQAFKNEVAMLKKT-RHCNILLFMGCVS--KPS--LAIVTQWCEGSSLYKHVH
| .|  .|.|.||.||...|.        |||||.|   . .. |  ...| .|....|.  .| ||. ..|...  . .  . ||.  ... .|... .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VS---ETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQAN-QPTG----SILWMAPEVIRMQELNPYS
     . .... .|... .|.|.||.||..||.|||||   |. ..|.. |||.||||| .      ..    . .|     | |||||.|.  .   ..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI----YNDDYYYRKRGGGKLPIKWMAPECINYGK---FT

FQSDVYAFGIVMYELLAEC-LP-YGHISNKDQILFMV--GRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
 .|||..||..|.|..  .  | |  .|| . . .    |. . .|.      ..|. . .|  .| .| |.||| |. ....|
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPE------NCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase phl.AA TK 429-686 17 1.3e-61 204.96 In-house 1-486 (486) Show / Hide
Range on Protein: 429-686
Range on HMM: 1-486/486
Sequence Identity: 17% (83 aa)

ILIGPRIGSGSFG---TVYRAHWHG----------------------------PVAVKTLNVK-TPSPAQLQA--------------FKNEVAMLK--KT
| .|  .|.| ||   .||.. |.|                            |||||.|  . . |... ..              . .| .|..  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHCNILLFMGCVSKPS-------------LAIVTQWCEGSS----LYKHVHVSETK--------------------------------------------
.| ||. . |.....              . ||. .... .    | .. . .  |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FKLNTLIDIGRQVAQGMDYLHAK------NIIHRDLKSNNIFLHEDLS-----------VKIGDFGLAT
                               . . .|. . .|.|.|| |||.|      |..||||   |. ..|..            .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

AKT----RWSGE-----KQANQPTGS-----------------------ILWMAPEVIRMQE------LNPYSFQSDVYAFGIVMYELLAEC-LPYGH-I
...    |  ..     .. .. ||                        | |||||... ..       . .. .|||..||..|.|..  .  ||.  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN--------KDQILFMVGRG--------------LLRPDMSQVR----------SDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
||         .... .. ||              . .|   .            . .|... .|  .| .| |.||| |. |...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase phl.AA Dicty4 429-688 34 5.3e-60 198.87 In-house 1-277 (277) Show / Hide
Range on Protein: 429-688
Range on HMM: 1-277/277
Sequence Identity: 34% (99 aa)

ILIGPRIGSGSFGTVYRAHWHG-PVAVKTL-NVKTP-SPAQLQAFKNEVAMLKKTRHCNILLFMG-CV----SKPSLAIVTQWCEGSSLYKHVHV-----
| |. |||.||||.||.. | |  |||| | | ..  . . |..|..||. ..| || ||.|||| |      .... |||  .   .||.  |      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-SETKFKLNTLID---IGRQVAQGMDYLHAKN--IIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQ-ANQPTGSILWMAPEVIRMQELNPYSFQ
 ...|  . . .    ... .|.|| .||. |  |||||||| |.   ... ||..||||.. . . .  |. .  . |. .|||||| . |   ||   
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ---PYNEK

SDVYAFGIVMYELLAECLPYG-HISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNM--LEN
.||| |||| .|.|    ||  |... .|. . |..  ||| ...   . |  .|.| ..|    |. || |   ..   || 
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPD---WCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase phl.AA S_TKc 429-690 23 3.5e-56 193.87 SMART 1-231 (231) Show / Hide
Range on Protein: 429-690
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

ILIGPRIGSGSFGTVYRAHWHG---PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEG--SSLYKHVHVSETK----
  |.  ||.|.||.||......    ||.| ..         . ...|...||| .| ||  . ..    .| .|.  |.|   .|... .   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSF-QSDVYAFGIV
 |   .   . .|......|.| ..|||||||  ||.| |   .||.|||||.           .   |.  .|||||.      .|..  .|....|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

MYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLN-----MLENML
.||.|. . |.    . .... ..|               .. .| . . | .. |..||    .|.     ..   .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase phl.AA MLK 429-686 29 8.5e-55 188.36 In-house 1-291 (291) Show / Hide
Range on Protein: 429-686
Range on HMM: 1-291/291
Sequence Identity: 29% (87 aa)

ILIGPRIGSGSFGTVYRAHWHGPV-AVKTLNVKTPSP---------AQLQAFKNEVAMLKKTRHCN----ILLFMGCVSKP-S-LAIVTQWCEGSSLYKH
|..   ||||||| |... |..    .|.. ||             .. ..|. |.  |.. .| |    |  |.|. ..| . ..||...|||.|||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

VHVSET-------------KFKLNTLIDIGRQVAQGMDYLHAKN---IIHRDLKSNNIFLHE------DLSVKIGDFGLATAKTRWSGEKQANQPTGSIL
 |  ..               ..  ....  |.|.||.|||..    |||||||| || ..|      .. .|| |||... ...   .   ... |.  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

WMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYG-HISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
|||||||   . ..||  .||. .|.|..|.|.  .||  |...   .  ..  || .|    ..|..|  .|.| ..| .  |..|| ||  .  |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPP----IPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase phl.AA STE 430-628 23 9.5e-49 168.27 In-house 1-268 (359) Show / Hide
Range on Protein: 430-628
Range on HMM: 1-268/359
Sequence Identity: 23% (65 aa)

LIG-PRIGSGSFGTVYRAHWHGP------------------VAVKTLNVKTPSP---------------AQLQAFKNEVAMLKKTR--HCNILLFMGCVS
. |  .||.|.|||||.|  | .                  .|.| .|... ..                ..| ...|. ..|| .  | ||  . ||  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KP--------SLAIVTQWCEGSSLYKHVH-VSETKFK------------LNTLIDIGRQVAQG-MDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLAT
|         .| |.  ...| || . .. . ....              . .. | ||. .| ..||| ..|||||.|. ||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

AKTR--------------WSGEKQANQPTGSILWMAPEVIRMQE---LNPYSFQSDVYAFGIVMYELLAECLPY
  |                .. .. |  .|.  |||||||. ..    ..|....|.. .|... |..  . |.
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

Kinase phl.AA TyrKc 429-686 26 1.3e-48 168.72 SMART 1-280 (280) Show / Hide
Range on Protein: 429-686
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

ILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKT--RHCNILLFMGCVSK--------PSLAIVTQWCEGSSLYKHVHVSET
|  |  .|.| ||.||...|  .||||.|.  .     ...| .|  ...|   .| ||. . |....        . | ||.  ... .| .. . .. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRW------SGEKQAN---QPT--GSILWMAPEVIRMQELNPYSF
|... .|...  |.|.||.||| ||.|||||   |. ..|.. |||.||||. . .        .  . .    .      | |||||.|     . ...
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYAFGIVMYELLAEC-LPYGH-----ISNKDQILFMVGRGLLRPDMSQVRSD-----APQALKRLAEDCIKYTPKDRPLFRPLLNML
.|||..||..|.|..  .  ||       .||.. ..  | .|  .| .  .        .|... .. ..| .. |.||| |. .   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase phl.AA LRRK 429-688 24 5.2e-47 162.51 In-house 1-351 (351) Show / Hide
Range on Protein: 429-688
Range on HMM: 1-351/351
Sequence Identity: 24% (85 aa)

ILIGPRIGSGSFG-TVYRAHWHG-----------------------------PVAVKTLNV--------------------------------KTPSPAQ
. |.. ||.|.|| .|||| | |                             .||.|..|.                                 . ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSSLYKHVH---VSE-----TKFKLNTLIDIGRQVAQGMDYLHAKN--IIHRDLKSNNIFL
.. | .||... . .| ||.  .|   .| |..|.      .||.. |    ..     .... .... |  |.| ||.||| .|  |||||||| ||.|
FREFRHEVWIMSHLNHPNIVSLKGFCIHP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

--H----------EDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQ-ELNPYSFQSDVYAFGIVMYELLAEC-LPYGHISNKDQILFMVG
  .          ..  .||.|||. .      ... |.  .| ..|||||..|   | . |. ..|.|.||....|||    .|..... .|.. .|  
WSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEE-YTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

RGL-----LRPDMS---QVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLEN
  .     |||  .   . .   .  .. | ..| .  ||.|| |   .  |. 
IEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ