Gene CG10738 (Fruit Fly)

CG10738

Species: Fruit Fly
Alias: CG10738, GYC, SFO186
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 70B1--2,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
CG10738.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
CG10738.AA Protein Various 1172 None Fasta, JSON

Protein domain

Protein domains of CG10738.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor CG10738.AA ANF_receptor 64-423 18 3e-35 125.48 Pfam 1-364 (364) Show / Hide 
Range on Protein: 64-423
Range on HMM: 1-364/364
Sequence Identity: 18% (72 aa)

TISGAISLAVEEVNAGRL-RDRGHSLQFVVAETY---GEEVVSIRQTAALWTQQVAAYIGPQETC--VHEGRMAAAFNLPMISYYCTHRDPSN--KADFP
   .|. .|.|..|| .   ..|..|.... ..             .  .. ..|.| |||. ..     .|.|...|.||||. ||    ..  |  .|
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

TFARTRPPDTQI-SKSVVALLLA-FNWTQVSFLYLDDASGQYQPV---AETILSTLTDAGVSIRDIRTWNTIYHHGFMDN----PFEALVEQ-TYANTRI
.|.|| |.||.  .. .|...   |.|..|...| ||.  ... .   .|.. ..| ..|. .  .     ..   . ..     ..  . . .. ..|.
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYA----YVSMVIPWDDDFMDYLKKIKDIIKMKARV

YLILGHYYEH----VGLMVSLQRRGILSKGDYFVVGIDI--EQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVP-TASVSFATFANEVNKYMERPPF
... ... .       .|   ...|.  .|.|  ...|.  . ||   .     .   .   . ...|... ||. . . | .|  |  ...|       
IVMCCYPDDMGLLQRQIMQQAHELGM-MSGGYVWIYTDWWMHSYDMQ-W-----WYDDDMDNDKFREAMKGVLGFTMHP-SPEFQEFMQRWKK-------

NFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGS---------AIVAAIKG-SRYRSAMGYHVYIDENGDAAGNYTVLARGS
          .  .... |||.||||.||| || ..| ...   ||.         ... ...   ..  ..|  .. |..|. .. . ..    
----------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase CG10738.AA RGC 583-834 41 1.3e-135 456.87 In-house 1-300 (300) Show / Hide 
Range on Protein: 583-834
Range on HMM: 1-300/300
Sequence Identity: 41% (124 aa)

KGQLYAIKKVRKK----SVDITREMKKELKLLRDARHDNICAFIGACTDPP------NICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIY
.|.. .|||. ..    ..|.||.|..|||..|...|||.. |||.|.|||      |.||..|||.||||.|||||.|.|.|.||..|.. ||..|  |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHDSPIRFHGALCTSNCLVDSRWVVKLTDFGL-----FAFKQGIEDS--------STDMQHMSAKCLKLLYRAPELLRQGPSSLVMG--------TQRGD
||.||||.|| |. .||.||||||||.|||||       ||.|...         ...... .... |.|..|||.||. ...  .|        ||.||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

AYSFGILLYEMHVRRG-----PF----GETGLTPMQCLQKVLQPQD--YLNPYRPSLQPLET-----AFDCVSECLRECWAERPEDRPD-FKTIRTKLRP
 ||||| .||. .|.|     ||    ||. |.||.....|. |      .|.|||... |.     . .|. ...|.||||.||.||| |..||..|. 
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CG10738.AA RGC 583-834 41 1.3e-135 456.87 In-house 1-300 (300) Show / Hide 
Range on Protein: 583-834
Range on HMM: 1-300/300
Sequence Identity: 41% (124 aa)

KGQLYAIKKVRKK----SVDITREMKKELKLLRDARHDNICAFIGACTDPP------NICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIY
.|.. .|||. ..    ..|.||.|..|||..|...|||.. |||.|.|||      |.||..|||.||||.|||||.|.|.|.||..|.. ||..|  |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHDSPIRFHGALCTSNCLVDSRWVVKLTDFGL-----FAFKQGIEDS--------STDMQHMSAKCLKLLYRAPELLRQGPSSLVMG--------TQRGD
||.||||.|| |. .||.||||||||.|||||       ||.|...         ...... .... |.|..|||.||. ...  .|        ||.||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

AYSFGILLYEMHVRRG-----PF----GETGLTPMQCLQKVLQPQD--YLNPYRPSLQPLET-----AFDCVSECLRECWAERPEDRPD-FKTIRTKLRP
 ||||| .||. .|.|     ||    ||. |.||.....|. |      .|.|||... |.     . .|. ...|.||||.||.||| |..||..|. 
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CG10738.AA TKL 580-832 22 2.7e-43 150.18 In-house 12-364 (364) Show / Hide 
Range on Protein: 580-832
Range on HMM: 12-364/364
Sequence Identity: 22% (80 aa)

GLYKG----------QLYAIKKVRKKSVD---------------------------ITREMKKELKLLRDARHDNICAFIGACTDPPN------------
| ..|          .  |.|| .....|                           .  . ..|.....  ||.||. |.|.|..||.            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ICIISEYCTRGS-LKDILENEDVKLDNMFIASMVADIIRGVIYLHD-------SPIRFHGALCTSNCLVDSRWV--------------VKLTDFGLFAF
 .||. ||| .|| | ...           . ... || ||. |||         |   |  | ..|.|||. |               .|..||||  |
QLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

KQ---GIEDSSTDMQ----------HMSAKCLKLLYRAPELLRQG--PSSLV---------MGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQ-----
..   . .|..|.|.          . . .|  . . |||.||.    .. |           ... | |||||.|.|.  |. |. . .  ||.     
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPF

CLQKVLQPQDYLNPYRPSL-------QPLETAFDCVSECLRECWAERPEDRPDFKTIRTKL
 .  ..  .. | | .|.        .| ... . ... . .||.. ||.|| |..|  .|
EEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CG10738.AA DRK 588-778 36 2.3e-37 124.15 In-house 26-209 (258) Show / Hide 
Range on Protein: 588-778
Range on HMM: 26-209/258
Sequence Identity: 36% (71 aa)

AIKKVRKKSVD---ITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDS-PIRFHGA
|.|.     ..   .  |...|  |.   || ||| |.|.|. || |||. ||  ||||  || .| ...|   . .|  |. .|.|||| . ||  |  
AVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRD

LCTSNCLVDSRWVVKLTDFGLFA-FKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQ
| . | |||  | ||  ||||   ||. ...  . |      |      ||| ||  .      |   | |||.| | |.  |  |.   |  ..|
LKSHNLLVDEHWQVKVADFGLSTRFKK-HKQHKFAMTMCGTPC----WTAPEVLRNQRY-----TEKADVYSFAIVLWECVTRQDPY--FGMPTFQ
Kinase CG10738.AA TKL-Unique 580-762 31 2.6e-34 118.44 In-house 16-221 (290) Show / Hide 
Range on Protein: 580-762
Range on HMM: 16-221/290
Sequence Identity: 31% (66 aa)

GLYKGQLYAIKKVRK---KSVDITREMKKELKLLRDAR-HDNICAFIGACT----DPPNICIISEYCTRGSLKDILE---------NEDVKLDNMFIASM
| ..|  .|||.  .   .| ....| ..|....   . |.||  ..|.|.    .||| ||..||| .||| | |          |.  ||..  . .|
GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM

VADIIRGVIYLHDSP--IRFHGALCTSNCLVDSR-----WVVKLTDFGLFAFKQGIEDSSTDMQH---MSAKCLKLLYRAPELLRQGPSSLVMGTQRGDA
. || .| .||| .   |  |..| .|| |||..     | .|. ||||  |.  | .... .      . .|  ....|||.||.      . ..  | 
AIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF---CQYSEKSDV

YSFGILLYEM
||||| |.|.
YSFGIVLWEI
Kinase CG10738.AA Dicty4 588-762 32 1.1e-27 89.5 In-house 26-210 (277) Show / Hide 
Range on Protein: 588-762
Range on HMM: 26-210/277
Sequence Identity: 32% (63 aa)

AIKKV--RKKS--VDITREMKKELKLLRDARHDNICAFIGACT----DPPNICIISEYCTRGSLKDILEN------EDVKLDNMFIAS---MVADIIRGV
|.||   ..     ..  | .|| ...   || ||| | ||||     |. .|| .||. .|.|  .| .      . .|||   | .   |  |. ||.
AVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGM

IYLHD-SPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEM
..||   |.  |  | ..| |||  |.|| .|||| . .. .|| ..    ... |   .. ||| ..  |      ..  | |||||.|.|.
NWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDN---QMTACGTPCWMAPEVMMHQPY-----NEKADVYSFGIVLWEI
Kinase CG10738.AA MLK 580-783 23 2.1e-24 81.67 In-house 18-249 (291) Show / Hide 
Range on Protein: 580-783
Range on HMM: 18-249/291
Sequence Identity: 23% (58 aa)

GLYKGQL-----YAIKKVR-KKSVDITRE------MKKELKLLRDARHDN----ICAFIGACTDPPN-ICIISEYCTRGSLKDILENED-----------
| .....      |.|.||  .  |. ..      ...| ..||  .| |    |..| |.|..||.  ||..|||  ||| ..| ...           
GRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK

--VKLDNMFIASMVADIIRGVIYLHD-SP---IRFHGALCTSNCLVDS------RWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQG
  .  |  ....   .. ||. |||   |   |...  |  .| |.|         ..| .|||.. ... ..  ..    |  ..  . ..||| . | 
NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRD--LKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TN----MMSNAGTYAWMAPEVIQQF

PSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKV
... .  .   | .|.|..|.||. |. |.   .. ||... .|
RCEKY--SEKCDVWSWGVVLWEMLTREVPYK-QHYDPMAIAWWV
Kinase CG10738.AA TK 582-704 14 4.5e-21 66.71 In-house 19-297 (486) Show / Hide 
Range on Protein: 582-704
Range on HMM: 19-297/486
Sequence Identity: 14% (41 aa)

YKGQLY-------------------------------AIKKVRKKSVDITREMKK-----------------ELKLLRD--ARHDNICAFIGACTDP---
|||...                               |.| ..... .  .|..                  |.|...    .|.||  ..|.||..   
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

---------PNICIISEYCTRGS----LKDILENEDVK--------------------------------------------------------------
         . ..|. ||.  |.    |.| | . . |                                                              
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLL

-------------LDNMFIASMVADIIRGVIYLHDSPIR-----FHGALCTSNCLVDSRWV-----------VKLTDFGL
             |.      | ..| .|  |||. ...      |. |.. ||||... |           .|..||||
QMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL
Kinase CG10738.AA Pkinase_Tyr 582-704 28 2e-19 66.38 Pfam 16-157 (270) Show / Hide 
Range on Protein: 582-704
Range on HMM: 16-157/270
Sequence Identity: 28% (41 aa)

YKGQLY----------AIKKVRKKSVDI---TREMKKELKLLRDA-RHDNICAFIGACT--DPP-NICIISEYCTRGSLKDILENE---DVKLDNMFIAS
||| ..          |.|... .. .     ... .|.|...   .|.||  ..|.||  . | .|.|. ||.  |.|.| | .    . .|.   . .
YKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQ

MVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGL
| ..| .|  ||.. ..  |  |.. ||||..  ||| .||||
MCWQIAKGMEYLESKNC-IHRDLAARNCLVTENNVVKICDFGL
Kinase CG10738.AA Pkinase 584-675 20 9.5e-18 63.83 Pfam 24-126 (293) Show / Hide 
Range on Protein: 584-675
Range on HMM: 24-126/293
Sequence Identity: 20% (21 aa)

GQLYAIKKVRKKSVDITREMKK----ELKLLRDARHDNICAFIGACTDPPNICIISEYCTRG----SLKDILE-NEDVKL--DNMFIASMVADIIRGVIY
|...|.|...|.. .   .. .    |.....  .|.||. ......|...|... |||  |    .|.|...  .. ..  .   . ...  |.||. |
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY

LHD
.|.
CHS
Kinase CG10738.AA RAF 604-770 26 1.6e-16 53.04 In-house 44-218 (275) Show / Hide 
Range on Protein: 604-770
Range on HMM: 44-218/275
Sequence Identity: 26% (47 aa)

KKELKLLRDARHDNICAFIGACTDP--PNICIISEYCT-RGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLT
|.|   ..  ||.||  | |.|..|  |.. |.   |  . ... |.. ...|.|   .      |. |. |||   |  |. | . | . ..  ||..|
KNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMNWTIQIAQQICQGMDYLHAKNI-IHRDLKSKNIFLHNGKVVVIT

DFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQG-PSSLVMG------TQRGDAYSFGILLYEMHVRRGPFG
|||||  | . . . .  |.      .... |||..|.  |   .        ..  | |.||. .||.. .. |..
DFGLFTVK-RCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDVYAFGTVWYELMAGEWPYQ
S_TKc CG10738.AA S_TKc 573-836 19 1.8e-16 62.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 573-836
Range on HMM: 1-231/231
Sequence Identity: 19% (57 aa)

TTIFTPIG------------LYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTR--GSLKDILENEDVK-----
 .|  .||               |...|||...       . ...|...|.  .|.||. ..... |  ..... |||    |.|.|....   .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAY
..   ...... |.... |.|.     |  |  .| |.|.  ..|..|||| ..              .  |  . |.|||.|         |. . | .
FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-------GYGKCKCDWW

SFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRT-----KLRPLR
|.|..|||| ... ||     .... ..|..                    . . . .| |.   ||.||    . .     |. |  
SCGCILYEMLCGYPPFP----QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG10738.AA TK-Unique 588-704 22 3.6e-16 52.37 In-house 33-179 (294) Show / Hide 
Range on Protein: 588-704
Range on HMM: 33-179/294
Sequence Identity: 22% (34 aa)

AIKKVRKKSVDITR--EMKKELKLLRDAR-HDNICAFIGACTDPP-NICIISEYCTRGSLKDILE----------------------NEDVK---LDNMF
.. | .|.... |.  ...||.....    | ||  ..|.||..  . .|| ||| .|.| . |                       ....    ..  .
VAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKD

IASMVADIIRGVIYLHD--SPIRFHGALCTSNCLVDSRWVVKLTDFGL
 ..   .| .|  ||.     | .|. ||..|.|. .. |.|..|||.
LYHFAWQIACGMEYLASQRKKI-VHRDLCARNVLLTEDKVCKICDFGM
TyrKc CG10738.AA TyrKc 573-832 25 4.2e-14 5.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 573-832
Range on HMM: 1-280/280
Sequence Identity: 25% (77 aa)

TTIFTPIG------LYKGQLY---AIKKVRKKSVDITREMKKELKLLRDA--RHDNICAFIGACTDP-------PNICIISEYCTRGSLKDILENEDVKL
 |    .|       |||...   |.|.... .    ... .|.....    .|.|| ...|.||..       . ..|. ||.  |.||| | .   ||
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

DNMFIASMVADIIRGVIYLHDSPI--RFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDS-----STDMQHMSA-KCLK--LLYR--APELLRQGPSS
 .    |.  .| .|  |||. ..  |    | . ||||... .|| .||||      |.|      |.|. ...  |. |  | .|  ||| .      
CMKDLLSFCWQIACGMEYLHSKNCIHRD---LAARNCLVGENHTVKISDFGL---SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

LVMGTQRGDAYSFGILLYEMHVRRGPFGETG-----LTPMQCLQKVLQPQDYLNPYRPSLQPL------ETAFDCVSECLRECWAERPEDRPDFKTIRTK
  . |   | .|||....|.   .|     |     ... . ...| |       ||.   |        .. | . .  ..||.| ||||| |..|. .
YGKFTTKSDVWSFGVCMWEI-FTYGQQPYPGMIQQMMSNQEVIEYVKQG------YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase CG10738.AA TK 747-832 21 8.8e-10 28.18 In-house 372-486 (486) Show / Hide 
Range on Protein: 747-832
Range on HMM: 372-486/486
Sequence Identity: 21% (25 aa)

TQRGDAYSFGILLYEMHVRR-GPFG--ETG---------LTPMQCLQK---------------VLQPQDYLNP----YRPSLQPLETAFDCVSECLRECW
|   | .|||.|..|.  .  .|..   .             |..|..                 .||  . |    ||  . | ... . . . ...||
TTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCW

AERPEDRPDFKTIRTKL
.. |||||.|.... .|
HYDPEDRPTFSQLHEQL
Kinase CG10738.AA TK-Unique 811-832 40 3.5e-07 20.93 In-house 273-294 (294) Show / Hide 
Range on Protein: 811-832
Range on HMM: 273-294/294
Sequence Identity: 40% (9 aa)

LRECWAERPEDRPDFKTIRTKL
...|| . ||.||.| .|. .|
MKSCWQWEPEERPSFRQIKHRL
Kinase CG10738.AA Pkinase_Tyr 811-832 45 5.5e-07 24.29 Pfam 249-270 (270) Show / Hide 
Range on Protein: 811-832
Range on HMM: 249-270/270
Sequence Identity: 45% (10 aa)

LRECWAERPEDRPDFKTIRTKL
...||.. ||||| |. |. .|
MKQCWHYDPEDRPTFSEIHEQL
Kinase CG10738.AA TKL-Unique 811-832 36 1e-06 19.51 In-house 269-290 (290) Show / Hide 
Range on Protein: 811-832
Range on HMM: 269-290/290
Sequence Identity: 36% (8 aa)

LRECWAERPEDRPDFKTIRTKL
...||.  |..|| | .|...|
IQQCWHHDPSQRPSFDEIIHRL
Kinase CG10738.AA MLK 811-832 36 1e-06 18.92 In-house 270-291 (291) Show / Hide 
Range on Protein: 811-832
Range on HMM: 270-291/291
Sequence Identity: 36% (8 aa)

LRECWAERPEDRPDFKTIRTKL
. .|| . |..||.|. | ..|
MKQCWNQDPHKRPSFRQIVQHL
Kinase CG10738.AA Pkinase 687-819 21 8e-06 21.62 Pfam 137-282 (293) Show / Hide 
Range on Protein: 687-819
Range on HMM: 137-282/293
Sequence Identity: 21% (34 aa)

SNCLVDSRWVV----KLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGET----GLTPMQ
.|.|.|.. ..    |..|||| ....  . ... |..    |  . |.|||..|    .  . ... | .|.|..||||  .| || .     ....||
ENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTF---CGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQ

CLQKVLQPQDYLNPYRPSLQPL----------------ETAFDCVSECLRECWAERP
.......|.   . . ..  ..                |.. | .. ||. . ..||
MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase CG10738.AA RAF 807-832 42 1.5e-05 14.98 In-house 250-275 (275) Show / Hide 
Range on Protein: 807-832
Range on HMM: 250-275/275
Sequence Identity: 42% (11 aa)

VSECLRECWAERPEDRPDFKTIRTKL
..| | |||.  ||.|| |  |  ..
MKELLMECWSYQPEERPSFQQIMKMI
Kinase CG10738.AA DRK 811-834 29 0.020526 4.03 In-house 235-258 (258) Show / Hide 
Range on Protein: 811-834
Range on HMM: 235-258/258
Sequence Identity: 29% (7 aa)

LRECWAERPEDRPDFKTIRTKLRP
. .|| | |  || .  .   |  
MNDCWNEDPQHRPSMQECLERLEA
Kinase CG10738.AA TK-Unique 732-762 37 0.11929 1.61 In-house 204-232 (294) Show / Hide 
Range on Protein: 732-762
Range on HMM: 204-232/294
Sequence Identity: 37% (12 aa)

APELLRQGPSSLVMG-TQRGDAYSFGILLYEM
||| |.       |  | ..| .|||.|..|.
APESLKCY---HGMYHTTKSDVWSFGVLMWEI
Kinase CG10738.AA Pkinase_Tyr 753-762 50 6.241465 0.39 Pfam 198-207 (270) Show / Hide 
Range on Protein: 753-762
Range on HMM: 198-207/270
Sequence Identity: 50% (5 aa)

YSFGILLYEM
.|||.|..|.
WSFGVLMWEI
CYCc CG10738.AA CYCc 871-1065 47 6.4e-108 365.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 871-1065
Range on HMM: 1-231/231
Sequence Identity: 47% (110 aa)

EEKKKTDALLHEMLPRCVADQLKKG-HKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYD-----VYKVETIGDAYMVVSGL
.||.|.| ||..|||| ||.||| | |.|.|..|. |.|.|.||||||.....|||.|||..|||.||.||.||....     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PLRNGD-------------------LHAAEIATMSLHLLSAVSEFKIRHR----PTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGV
| ||..                    || .|| ..|. .... .|...|.    | | | .|||||.|||..||||..|||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PLKIHCSWQCRQLL-------DRLGGYHFAE
| .||.| .  ..|        | |...| .
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc CG10738.AA Guanylate_cyc 898-1084 42 4.3e-89 307.09 Pfam 1-214 (214) Show / Hide 
Range on Protein: 898-1084
Range on HMM: 1-214/214
Sequence Identity: 42% (92 aa)

VDPEHYEQVSIYFSDIVGFTAMSAECT----PLQVVDFLNDLYTCFDSIIGHY--DVYKVETIGDAYMVVSGLPLR-----NGDLHAAEIATMSLHLLSA
| .. |..|.|.|.|||||||....|.    |.|.|..|||.|||||......  ..|||.||||.||.||||| .     ..  ||. .| |.| .. .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VSEFKIRHRPTNR-----LLLRIGIHSGPVCAGVVG--LKMPRYCLFGDTVNTASRMESSGVPL--KIHCSWQCRQLLDRLGGYHFA----ERGVISMKG
.... . | . ..     . .|||||.|||.|||.|  ..|||||..|||||.|||||| |||.  ||| |    ..| ..... |     .|| |..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGDQ---RTYWLLG
|| .    ||.| |
KGKMGEMETYFLHG
HNOBA CG10738.AA HNOBA 869-892 62 3e-09 35.01 Pfam 211-234 (234) Show / Hide 
Range on Protein: 869-892
Range on HMM: 211-234/234
Sequence Identity: 62% (15 aa)

LQEEKKKTDALLHEMLPRCVADQL
| |||||||.||..|.|. ||..|
LEEEKKKTDDLLYSMFPKSVANRL