Gene dnt (Fruit Fly)

dnt

Species: Fruit Fly
Alias: dnt, doughnut, CG17559, SFO114
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 37D2

Classification

Group: TK
Family: Ryk

Sequence

Name Sequence Type Origin Length Description Download
dnt.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
dnt.AA Protein Various 565 None Fasta, JSON

Protein domain

Protein domains of dnt.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
WIF dnt.AA WIF 27-163 50 3.9e-88 300.03 SMART 1-146 (146) Show / Hide 
Range on Protein: 27-163
Range on HMM: 1-146/146
Sequence Identity: 50% (73 aa)

HLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNF------IVPVPANVKDISFTWQSLAG-RGLPYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTW
|.|...|..|..||.||.||.|||||||||.||.||      ..|||||.....||||.... ....|.|||.|.||||.|.|..|..|.|..|.|.|.|
HVNMWINKHEMRRLIGVDAELYYVREGHINHYAHNFRKAQQRMYPVPANIHYMHFTWQAVGQAHYVHYFINVQSDDQEVMPMPIVNIPHQGTVPHTLQVW

SIALKCSGLKA--AEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLM
....||||...  ||..||....|..|||..|.|||.|||||||..
QVEYKCSGHRDGVAEFMVTMYVMVKYNRSTKNFTHLNFRRKKICYQ
WIF dnt.AA WIF 30-161 44 1.7e-75 259.32 Pfam 1-145 (145) Show / Hide 
Range on Protein: 30-161
Range on HMM: 1-145/145
Sequence Identity: 44% (64 aa)

VFLNPVEVMRLLGVSAEVYYVREGHINNYALN-----F------IVPVPANVKDISFTWQSLAGRGLPYSINV-VSSDQEVLPRPAINVSHSGEIPTTIQ
...|. .||.|.|||||.||...||.|.||..     |      ..|||.||....||||||. . ..|...| .||||....||..|.||.|..|....
MWINEHQVMMLIGVSAEIYYIHNGHVNHYAHDPNFSHFRKAQQRMPPVPSNVHYVNFTWQSLGKHKYHYNFQVLYSSDQQIMKRPTLNISHQGRVPHEAK

TWSIALKCSGLKAAEVDVTVSLEVVLNRSL-NNVTHLVFRRKKIC
..||.|.||| .......||.|||...||. ||.|.|.|.|||||
EFSIDLPCSGNRSGQATFTVNLEVMHRRSKPNNNTPLRFKRKKIC
Kinase dnt.AA Ryk 298-554 59 4.5e-222 709.4 In-house 1-292 (292) Show / Hide 
Range on Protein: 298-554
Range on HMM: 1-292/292
Sequence Identity: 59% (174 aa)

VRLSSLLQEGTFGRVYRGTYN------------------DTQDVLVKTVAQHASQMQVLLLLQEGMLLYGAS-HPGILSVLGVS--------IEDHTTPF
...|.|.|||||||.|.|..|                  |.|||.||||..||||||| ..|||..||||.| |..||.||.|.        ||||..||
IQYSCLVQEGTFGRIYHGIWNQVDDVNNGDVDDEEDTFCDCQDVFVKTVKDHASQMQVHCMLQESCLLYGISPHQNILPVLHVCSFGRFDRPIEDHDPPF

VLYPALNNTRNLKQFLLD-----PACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQ---LRVKLSDSSLSRDLFPSDYNCLGDSENR
|.||..||..|||||| |     |.|.....|.|.|.||.|..|...|||.|..|||||||||||||.|   |.||..||.|||||||.||.||||.|||
VCYPHMNNWGNLKQFLQDCRHDKPKCHQAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSRDLFPMDYHCLGDNENR

PVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCL
||||||||.||||..|.|||.|.|||.||||.|....||.|.|||||.|||||||||.|||||||||||.||.||...|.|||||.||..||
PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDELFTVMACCWHCMPEERPTFQQLVQCL
Kinase dnt.AA Pkinase_Tyr 298-554 30 6.3e-91 308.57 Pfam 1-270 (270) Show / Hide 
Range on Protein: 298-554
Range on HMM: 1-270/270
Sequence Identity: 30% (82 aa)

VRLSSLLQEGTFGRVYRGTYN-----DTQDVLVKTVAQHASQMQ--VLLLLQEGMLLYGA-SHPGILSVLGVSIEDHTT--PFVLYPALNNTRNLKQFLL
...   | || ||.||.||..     ....| ||.. ..|.. |     ...|  ..    .|| |.. .|| ...     ...  .   .  .|. .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-DLLDYLR

DP-ACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYN-CLGDSENRPVKWMSLEALQHKQFSEASDSWA
..    . .|. ... |. | ......|.|.. .| |.|.||| ..... || .|  |.||... ||    ...   |.|||..|..... |...|| |.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVLMWELCTSAKQP-YAEVDPFEMEHYL-KDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCL
|||||||..|  .|| |......|. .|. .||||...| |||||. ..|  ||.  |..||||......|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase dnt.AA TyrKc 298-554 29 1.6e-87 297.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 298-554
Range on HMM: 1-280/280
Sequence Identity: 29% (84 aa)

VRLSSLLQEGTFGRVYRGTYNDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGA--SHPGILSVLGVSIEDH------TTPFVLYPALNNTRNLKQFLLDP
..|   | || ||.||.||..  ..| ||..  .|    .  ...|  ..     .|| |.  .|| ...         ....     .  .||..| ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

ACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPS-------DYNCL--GDSEN--RPVKWMSLEALQHKQFS
     ... . . .. | .   ..|||....| |.|.||| ......|| ||  ||||.          ||     .....   |..||..|..... |.
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EASDSWAFGVLMWELCTSAKQPYAE-----VDPFEMEHYLKDGYRLAQPFN--------CPDELFTIMAYCWALLPAERPTFAQLQSCL
..|| |.|||.|||..|  .||| .     ....|. .|.|.|||. || |        ||||...||  ||.  |..||||... .|.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase dnt.AA TK 298-554 16 8.9e-79 263.56 In-house 1-486 (486) Show / Hide 
Range on Protein: 298-554
Range on HMM: 1-486/486
Sequence Identity: 16% (82 aa)

VRLSSLLQEGTFG---RVYRGTYNDT--------------------------QDVLVKTVAQ--HASQMQVLL--------------LLQEGMLLYG--A
..|   | || ||   .||.|....                           ..| ||..    ..||.. ..              ...| ...     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPGILSVLGVSIEDHT----------TPFVLYPALNNTRN----LKQFLLDPACART------------------------------------------
 || |.. .||. .. .           |. .   . .  .    |...| .    ..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VTTIQIVMMASQLSMALDHLHSH------GVVHKDIATRNCVIDDQLR-----------VKLSDSS---
                               .|. | . |. |.. .. .|||.      ..|| |.|.||| ......           .|..|     
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRDLFPSDYNCLGD------------------------SENRPVKWMSLEALQ---------HKQFSEASDSWAFGVLMWELCTSA-KQPYAEV
     |.||. ..|. .  .                        .   |..||. |.|.         .. |...|| |.|||||||..| . ...| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DP---------FEMEHYLKDG--------------YRLAQPFNCP--------------DELFTIMAYCWALLPAERPTFAQLQSCL
.           |.  ||..|              .|..|| .||              .|.. .|  ||.. |..||||.||...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase dnt.AA TK-Unique 298-554 24 1.3e-58 200.71 In-house 1-294 (294) Show / Hide 
Range on Protein: 298-554
Range on HMM: 1-294/294
Sequence Identity: 24% (73 aa)

VRLSSLLQEGTFGRVYRGTYND-------TQDVLVKTVAQHASQM-QVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDP
... ....|| || |.||..         .. |.||..  .|..  .  .|    |. .   || |.. ||.....   .. ... . .  ||  .|   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCG-NLQHYLRTC

ACA--RT---------------------VTTIQIVMMASQLSMALDHLHS--HGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLF-PSDYNCLGDSENRP
..|  ..                     ..  . .  | |. ... .|.|  ...||.|...||. . . ...|..|  ..||.  . .|.  . ..  |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VKWMSLEALQ--HKQF-SEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNC-PDELFTIMAYCWALLPAERPTFAQLQSCL
..||..|.|.  |... .. || |.|||||||..|  ..|| .... ...  ..||||. || .| ..|.. .| .|| . | |||.|.|. . |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase dnt.AA Met 299-548 31 1.3e-57 187.34 In-house 1-271 (271) Show / Hide 
Range on Protein: 299-548
Range on HMM: 1-271/271
Sequence Identity: 31% (85 aa)

RLSSLLQEGTFGRVYRGTYND----TQDVLVKTVA--QHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHT-TPFVLYPALNNTRNLKQFLLDPAC
 .   .  | || ||.|.| |       . .|.          ..   | ||..  . .|| .|| .|..... .  | |. |   .   ||.|  .|  
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHG-DLKTFIRNP--

ARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDL-FPSDYNCLGDSEN---RPVKWMSLEALQ---------HKQFS
 .. .  . .  . |       ..|   || | | ||| .|  ..||  |  |.||.     |    .       ||||| .| ||          .||.
QNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFT

EASDSWAFGVLMWELCTSAKQPYAEVDP-FEMEHYLKDG--YRLAQPFNCPDELF-TIMAYCWALLPAERPTFA
 .|| | |||.|||| | .  || .||. |   |.|. |   || ||  ||| |   .|  ||   |..||.| 
TKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase dnt.AA Musk 420-554 39 3e-50 164.15 In-house 148-282 (282) Show / Hide 
Range on Protein: 420-554
Range on HMM: 148-282/282
Sequence Identity: 39% (53 aa)

VHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRL
|| |.||||| | ..  || .|  |||     ||    . .  |. || .|..   ||. .|| ||.||..||.   | |||      |   | ..|..|
VHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNIL

AQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCL
. | ||| ... .|  ||  .||.|| |.|.. |.
SCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase dnt.AA UTK 298-554 25 3.4e-50 169.9 In-house 1-296 (296) Show / Hide 
Range on Protein: 298-554
Range on HMM: 1-296/296
Sequence Identity: 25% (76 aa)

VRLSSLLQEGTFGRVYRGTYND------TQDVLVKTVAQHAS---QMQ---VLLLLQE-----GMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTR
|.|. .| .| || |.......      ..|| ||.   ||.   ..     .....      ...     || .| ..||   .      .. ..   .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEP----WMIVTEYME

--NLKQFLLDPACART-----VTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQ-------LRVKLSDSS---LSRDLFP--------SDYNC
  .| ..| . . .       .|  | . ||.. . .. .|||.|.|| |.| ||| ....       . .|..|     .||..          ..| .
NGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYY

LGDSENR-PVKWMSLEALQHK-QFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDG--YRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQ
  .. .| |..||. ||| |  .|...|| |.|||..||..| ...||..    .  | . .|  ||...|  ||......|  ||.  |.|||.| .| 
MAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLV

SCL
. .
QQM
Kinase dnt.AA Axl 298-552 30 1.3e-46 161.2 In-house 1-267 (267) Show / Hide 
Range on Protein: 298-552
Range on HMM: 1-267/267
Sequence Identity: 30% (82 aa)

VRLSSLLQEGTFGRVYRGTYNDTQ----DVLVKTV-AQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHT-----TPFVLYPALNNTRNLKQFLL
. |  .| || || |  |  .        | ||.. ..  .| ..   |.|   .   .|| .. ..||.|.         | |. | .     |  |||
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHG-DLHTFLL

DPACARTVTTIQIVMMA---SQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSW
          ... |.      . . .. | ..  .|.|.| |||.. ... |   |  ||. ..  ||   |     ||||. .|.|  . .   || |
YSRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVW

AFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQS
|||| |||. |  . ||. |.  ||  || .| || || .| |||. .|  || . | .||.|..|. 
AFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase dnt.AA Abl 298-554 29 1.6e-45 149.54 In-house 1-252 (252) Show / Hide 
Range on Protein: 298-554
Range on HMM: 1-252/252
Sequence Identity: 29% (75 aa)

VRLSSLLQEGTFGRVYRGTYNDTQD-VLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACARTVT
. .   |  | .| || | .   .  | |||.   .  |.|   |.|  ..    || .  .|||    .  || .        || ..| . .  ....
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDT--MEVHEFLKEAAIMKEMKHPNLVQLLGVCT--REPPFYIITEFMCYGNLLDYLRE-CDREELP

TIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTS
 . .. ||.|.. ... | ..  .|.|.| |||.. ..  ||. |  |.| .   |          |.||   |.| ...||  || ||||||.||. | 
AVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLAR-MMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATY

AKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCL
   ||  .|  .. | | .|||. .|  ||.. . .|  ||   ...||.|...   .
GMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase dnt.AA Frk 298-558 29 1.2e-42 145.44 In-house 1-260 (260) Show / Hide 
Range on Protein: 298-558
Range on HMM: 1-260/260
Sequence Identity: 29% (79 aa)

VRLSSLLQEGTFGRVYRGTYNDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLL-DPACARTVT
..|   |  | || |. | .| |  | |||.   .  |    .|.|  ..    || ....  |   .   |  .   |     |...|       | . 
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTL--KPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEE--PIYIITELMRHGSLQEYLQAINDKGRQCQ

TIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDY--NCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELC
  |.| || |.   .  | |.  .|.|.| || ...... .|. |  | | |   .            |.||   || . ..|.  || |.||.|. |. 
MQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEII

TSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFY
|  . ||. .   |. . .. |||. || ||| .|. ||  ||   | .||||  ||  | ...
TYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase dnt.AA Src 298-554 30 1.5e-42 142.32 In-house 1-255 (255) Show / Hide 
Range on Protein: 298-554
Range on HMM: 1-255/255
Sequence Identity: 30% (80 aa)

VRLSSLLQEGTFGRVYRGTYNDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLL-DPACARTVT
..|   | .| || |. |..|.. .| |||  .    |..  .|||  ..   .|. ... . |  ..   |.     . .  .| ..|  |. . |.. 
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE--PIYIVTEYMSHGSLLDYLKKDGEG-RHLH

TIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFP--SDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELC
  | . || | .   . | |  ..| | | ||  ..... .|  |  | | |.    |  |     . |.||.  ||... .|.  || | ||.|..|. 
LPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

TSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFT-IMAYCWALLPAERPTFAQLQSCL
|  . ||   .  |    .. |||. .| ||||||.  ||  ||   | .||||. ||. |
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase dnt.AA S_TKc 298-558 16 6.4e-16 56.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 298-558
Range on HMM: 1-231/231
Sequence Identity: 16% (46 aa)

VRLSSLLQEGTFGRVYRGTYND-TQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNN-TRNLKQFLLDPACART-
 ..  .. .|.||.||... ..  . | .| .           ...|  .|    || |   ..|  .  .  ..    ... . .|.... .  . .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSE-ASDSWAFGVLMW
   .  ..  .. |.  ||...||||..| |.   |  .|.  ..|..|  |.| |    . . |        .|. | |   ...  ..| |..|....
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCG-----TPWYMAPEVL---GYGKCKCDWWSCGCILY

ELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQS-CL----SEFY
|...  . |.   ....| . ..           ..|.  ..  |.   |..|||  ..   ..     .. 
EMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase dnt.AA Pkinase 298-441 15 4.2e-10 36.82 Pfam 1-155 (293) Show / Hide 
Range on Protein: 298-441
Range on HMM: 1-155/293
Sequence Identity: 15% (25 aa)

VRLSSLLQEGTFGRVYRGTYNDTQD-VLVKTVAQHASQMQVL--LLL-QEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNT----RNL----KQF
 .. . . .|.||.||...  .|.. | ||..  .   ....  ... .|  ..   .|| |.  ...  . .. . .  . ....              
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST--

LLDPACARTV--TTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRV----KLSD
       ...  .  .. ... |.  .|...||.|..| |.   |. ||..  .    |..|
----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD
Kinase dnt.AA Pkinase 470-554 14 0.00015 17.17 Pfam 181-293 (293) Show / Hide 
Range on Protein: 470-554
Range on HMM: 181-293/293
Sequence Identity: 14% (17 aa)

EALQ-HKQFSEASDSWAFGVLMWELCTSAKQPYAEV------DPFEMEHYLKD-GYRLAQPFNCP-------------------DELFTIMAYCWALLPA
| .. ..  . ..| |..|....|...  . |. .       |. .|    ..  ..   |  |.                   .|.  .. .|... |.
EVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

ERPTFAQLQSC--L
.|||..|.     .
KRPTAEQILQHPWF