Gene Pk92B (Fruit Fly)

Pk92B

Species: Fruit Fly
Alias: Pk92B, CG4720, MEKK5/ASK1, SFO159
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 92B4,

Classification

Group: STE
Family: STE11
Subfamily: ASK

Sequence

Name Sequence Type Origin Length Description Download
Pk92B.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
Pk92B.AA Protein Various 1310 None Fasta, JSON

Protein domain

Protein domains of Pk92B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ASK_nterm_v5 Pk92B.AA ASK_nterm_v5 34-88 58 1.5e-33 117.76 In-house 1-55 (55) Show / Hide 
Range on Protein: 34-88
Range on HMM: 1-55/55
Sequence Identity: 58% (32 aa)

QFERLDFGETNVLETFYNADVAIIDLSILTQQRPLSYHYGVRESFGMKENILTYN
.|.|||||||.....||||||.|.|.|| .||..|.||.|||.||.|..||. |.
EFMRLDFGETDMFDEFYNADVVIVDMSIDHQQPNLFYHLGVRHSFKMRNNIILYC
TPR_ASK_1 Pk92B.AA TPR_ASK_1 203-237 57 9.6e-21 68.49 In-house 1-38 (38) Show / Hide 
Range on Protein: 203-237
Range on HMM: 1-38/38
Sequence Identity: 57% (22 aa)

GEVVHSFMCSLRDVQDYDAMVRLVNDLK---NIPNTRK
|..||.||.|.||.||||.|..||.|||   .|||..|
GDIVHNFMHSYRDIQDYDSMIELVEDLKEGEHIPNCCK
TPR_ASK_2 Pk92B.AA TPR_ASK_2 280-322 60 2.7e-33 105.49 In-house 1-46 (46) Show / Hide 
Range on Protein: 280-322
Range on HMM: 1-46/46
Sequence Identity: 60% (28 aa)

PDMLCLCGRIYKDIFVESDYTD---ATSLAHAIKWYRQSFEVQPNE
|||.|.|||||||.|.||.|||   ..|...||.|||..||.|||.
PDMWCMCGRIYKDMFLESQYTDEAARESRDQAIHWYRKGFEIQPNH
TPR_ASK_3 Pk92B.AA TPR_ASK_3 368-401 82 3.5e-22 80.03 In-house 1-34 (34) Show / Hide 
Range on Protein: 368-401
Range on HMM: 1-34/34
Sequence Identity: 82% (28 aa)

YWDVATFFEISVLANDYAKAIQAAECMFKLKPPN
|||||||||||.||.|| |..||.||||||||||
YWDVATFFEISILACDYHKCMQACECMFKLKPPN
Kinase Pk92B.AA ASK 584-837 81 2.8e-192 645.08 In-house 1-254 (254) Show / Hide 
Range on Protein: 584-837
Range on HMM: 1-254/254
Sequence Identity: 81% (206 aa)

VLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYS
||||||||.|||.||..|||||||||.||..|..||||||||.||.||||||||.|||.|||||.||||||||||||||.||..||||.||||.||.||.
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYT

KQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIEL
||||||||||||..|||||||||||||||||||||||||||.||||.|||.|||||||||||||||||||.||||..|||||||||.||||||||||.||
KQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHEL

GSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFL
|...|||||||.|||||.|||||||..||||||||......|.||..||.||||
GEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase Pk92B.AA STE11 579-837 42 1.9e-160 539.29 In-house 1-303 (303) Show / Hide 
Range on Protein: 579-837
Range on HMM: 1-303/303
Sequence Identity: 42% (128 aa)

QNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQ--------DVQP------LHEEIKLHSQLRHRNIVRYLGSCS---ENGFFKIFMEQVPGGSL
 ... ..|||..||||..... |....|.|.....|.          .|.      ..|||||...|.| |||||.|.|    .|....||||..|||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTET----------FTGTLQ--------
|..|..||||.|..|... .| |||||||.|||.. |.||||||.|.|......|.|..|||..|||| |...|..          .|||..        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEVIDQGVRG-YGPAADIWSFGCTNVEMATGKPPFIELGS-AHAAMFKVGFY-KKHPNIPEELS------ANAKNFILRCFAISVMDRPSASQLLED
.||||||.|. |. || .|||||.||| .||||||||. .... . |||||.| . | ||.|||..|      .....|...|| .   .||.|.|||..
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase Pk92B.AA STE 579-837 28 2.1e-107 363.15 In-house 1-359 (359) Show / Hide 
Range on Protein: 579-837
Range on HMM: 1-359/359
Sequence Identity: 28% (105 aa)

QNRKMVLGKGTYGTVYAARDKQ---------------TQVRIAIKEVPEKNS-----------------QDVQPLHEEIKLHSQLR--HRNIVRYLGSCS
. .  ..|||..|||| |...                |....|||... .|.                 ...| . .|||......  | |||.|.|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ENG-------FFKIFMEQVPGGSLSDLLETKWGPLKDN-----------ESTMAFYSKQILEG-LKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTS
 .|          |.|| ..||||.|....|.|..|..           ||  |.. .|||.| |.|||.. |.|||||..|.|.      ||..|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KRLARINP----------------MTETFTGTLQYMAPEVIDQG----VRGYGPAADIWSFGCTNVEMATGKPPF---IELGSAHAAMFKVGFY------
..|. ...                .. ||.||  .||||||.|.    . ||.  .||||.||| .||||||||.     .    ...|. . .      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KKHPNIPE-------------------ELSANAKNFILRCFAISVMDRPSASQLLE--DPFL
    ...| .|.                   ..| . |.|| .|. .   .||.|||||.   ||.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Pk92B.AA STE11-Unclassified 584-837 34 6.3e-88 298.42 In-house 6-308 (308) Show / Hide 
Range on Protein: 584-837
Range on HMM: 6-308/308
Sequence Identity: 34% (105 aa)

VLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQ----DVQPL-----HEEIKLHSQLRHRNIVRYLGSC--SENGFFKIFMEQVPGGSLSDLLETKWGPL
..|||..|.|| . .. |   .|.|.. ....     |.|        .|.|.  ||.| |||.|.|     ....  ||||..||||.. .|. | |..
FIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLN-KYGCF

KDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSK---------------------RLA-RIN---PMTETFTGTLQ---Y
  .|.. . | |||||||.|||.. |.||||||.|.|. .  |..|..|||..|                      .   ||    .  .  ||..   .
--DEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDF-DGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPFW

MAPEVID-QGVRGYGPAADIWSFGCTNVEMATGKPPFIELGS--AHAAMFKVGFYKKHPNIPEELS-----------ANAKNFILRCFAISVMDRPSASQ
||||||.     |.. ..||||.||| .||||||.|.  .      .|..|..  .  |.||| ||           . .|.|. .|| |   .||.|.|
MAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTANQ

LLEDPFL
|| .||.
LLQHPFI
Kinase Pk92B.AA S_TKc 579-837 30 1.1e-87 298.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 579-837
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

QNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPG--GSLSDLLETKWGPLK---
     ..|||..|.|| .|.| |. . |||...       . .  ||..... .| |||...... . ... ..|| ..|  |.| |... . .. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

DNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGP-AADIWSFGCTNVE
 .| . .|| .||...|.|.|.. |.|||.| .|.|...   ..||.||| ...|        || ||. ||||||.     |||. ..|.||.||.  |
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYE

MATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLE-------DPFL
|..|.|||      ...|||.             |  ||.|| .|.     .||.| ..|.       .|..
MLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Pk92B.AA Pkinase 579-837 29 3.4e-72 250.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 579-837
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

QNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHE----EIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGG----SLSDLLE-TKW
  .. ..|.|..|.|| ...| |. . |.|... ..  . .. .     ||...  |.| ||||..... ...   . || ..||    .|.|...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVV----KISDFGTSKRL-ARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIW
|..   | .  || .|||.||.|.|.. |.|||.| .|.|..   |..    ||.||| .| .    |. . ||.||. |||||||  | ..|||..|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMW

SFGCTNVEMATGKPPFIEL-----GSAHAAMFKVGFYKKHPNIPEELS-------------------ANAKNFILRCFAISVMDRPSASQLLEDPFL
|.||.  ||..|.||| .       .  . .....  . | ..|.. |                    ..| || .|..    .||.| |.|..|..
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Pk92B.AA MEKK15 580-837 43 6.6e-71 241.89 In-house 2-264 (264) Show / Hide 
Range on Protein: 580-837
Range on HMM: 2-264/264
Sequence Identity: 43% (117 aa)

NRKMVLGKGTYGTVYAARDKQTQVRIAIKEVP------EKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLK
 .  .|||| |||||     . |. ||.| |       ||  |. . | ||..|   |.|.||| ||| | |.    |||. |||||.| ..  ..||| 
KKGNILGKGAYGTVYCGLTNTGQL-IAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIIN-RFGPL-

DNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARI------NPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFG
 .|     | ||||.| .||||  .||||||| ||..    |..|. |||  |||.          |     ||  .||||||     |||  .|||| |
-DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIME--TGYGRKSDIWSIG

CTNVEMATGKPPFIELGSAHAAMFKVGFY-KKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFL
||  ||||.|||. ..    |||| .|      | .|.  | .|..|.  |      .||.|||||  ||.
CTVFEMATRKPPWADM-DRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase Pk92B.AA MEKK2 580-837 42 8.5e-69 234.87 In-house 2-262 (262) Show / Hide 
Range on Protein: 580-837
Range on HMM: 2-262/262
Sequence Identity: 42% (115 aa)

NRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKN-----SQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENG--FFKIFMEQVPGGSLSDLLETKWGPL
 |  .||.| .| ||   |  |   .|.| |.  .     ...|| |. ||.|   |.|  || | |   .|.     |||| .||||. | |   .|.|
RRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKA-YGAL

KDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMT---ETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCT
 ..      | .|||||..|||.. |||||||| |.| .  || ||..||| ||||  |        . |||  .|.||||.    |||  ||.|| |||
TET--VTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDS-SGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVIN--GEGYGRKADVWSIGCT

NVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFL
 ||| | |||. |   | ||.||.   .  | .|...| .|..|. |||    .|||||  ||   | 
VVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase Pk92B.AA STE20 584-837 34 6.4e-64 218.68 In-house 6-288 (288) Show / Hide 
Range on Protein: 584-837
Range on HMM: 6-288/288
Sequence Identity: 34% (99 aa)

VLGKGTYGTVYAARDKQTQVR----IAIKEVPEKNS----QDVQPLHEEIKLHSQLRHRNIVRYLGSCSEN----GFFKIFMEQVPGGSLSDLLET--KW
..|.|.||.|| |..|.|.      .||| .. ..     .... .  ||   .|..| |||.|.||   .        | ||   ||||.|....  |.
KIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKC

G------PLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAR-----INPMTETFTGTLQYMAPEVIDQGV---R
|      |.  ||.  |.  ...|.||.|||.. |.|||||.||.|... .| ||..||| .  | .     ...   || ||  .|||||| .      
GKNHKGHPM--NEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTE-DGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDK

GYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHP---NI--PEELSANAKNFILRCFAISVMDRPSASQLLEDPFL
||.  .||||.| |  |||.|.||. .. ..  |||..   .. |       |.  | . ..|. .|  . . .||.|||||. ||.
GYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Pk92B.AA CAMK 584-837 18 2.2e-62 199.56 In-house 1-425 (425) Show / Hide 
Range on Protein: 584-837
Range on HMM: 1-425/425
Sequence Identity: 18% (79 aa)

VLGKGTYGTVYAARDKQTQ------------VRIAIKEVPEK----------------------------NSQDVQPLHEEIKLHSQ-------LRHRNI
.||.|..|.|. ...|.|.            .. ||| .. |                            . .| . .  ||.....       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYLGSCSENGF-------------------FKIFM---EQVPGG----SLSDLLETK--------------WGPLKDNESTMAFYSKQILEGLKYLHEQ
.. .     . .                   . ..|   | ..||     | | .  .              .| ..  |   ..| .||.....|.|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREA--RRYFRQICSAVHYCHSH

DIVHRDIKGDNVLVNTYS----------------GVVKISDFGTSKRLARI-----------------------NPMTETFTGTLQYMA-PEVIDQ-G--
.|||||.| .|.|... .                . .||.||| .... .                        ... .|| ||. ||| |||. . |  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------VRGYGPAADIWSFGCTNVEMATGKPPFIE-----------LGSAHAAMFK---VGFYK-KHPNIPE-------------------ELSANA
          ..|||..|.|| |.    | .|.||| .           .|     .|.    | |   .| ...                   ..|. .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KNFILRCFAISVMDRPSASQLLEDPFL
|..| ..      .|....| |..|..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Pk92B.AA Ciliate-E2 579-837 19 7.4e-57 193.7 In-house 1-365 (365) Show / Hide 
Range on Protein: 579-837
Range on HMM: 1-365/365
Sequence Identity: 19% (75 aa)

QNRKMVLGKGTYGTVYAARDKQTQVRIAIK-----------------EVPEKNSQDVQPLHEEIKLHSQLR-------------------HRNIVRYLGS
 .   ..|.|..|.|| ......| ..|||                    .....  . . .  .  ...|                   | ||...  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CS--ENGFFKIFMEQVPGGSLSDLLETKWGPLKDN--------ESTMAFYSKQILE---------------GLKYLHEQD-IVHRDIKGDNVLVNTYSGV
     .  . . || . ||.| |... ..   . .        |  .....||||.               .|.|||..  |.||||| .|.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

VKISDFGTSKRLARINP-------------------------------MTETFTGTLQYMAPEVID-------QGVRGYGPAADIWSFGCTNVEMATGKP
.||.|||.||..   |                                |. |. ||. |||||..        |.  ||. ..||||.|..  || .|||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFIELGSAHAAMFKVGFYKKHPN----------------------IPEELSANAKNFILR----CFAISVMDRPS-ASQLLEDPFL
||               .... .                      .....| ..|..| .    ..      |.. ..|.|. |..
PF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Pk92B.AA STE-Unique 651-837 27 2.6e-38 133.45 In-house 371-616 (616) Show / Hide 
Range on Protein: 651-837
Range on HMM: 371-616/616
Sequence Identity: 27% (68 aa)

IFMEQVPGGSLSDLLETKWGP--------LKDNESTMAFYSKQILEGLKYLHEQD--IVHRDIKGDNVLVNTYS----GVVKISDFGTSKRLARI-----
||||  ..|.|.....   .|        .   |.  . | .|||||| ||| |   |.|||.| .|.. .         |||.|||...... .     
IFMEYCEHGTLQQIIKRCGCPGNPNNLQLFP--ETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKD

---------------------------------NPMTETFTGTLQYMAPEVI---DQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHA-AMFKVG
                                 |    .  ||  ||.||||   .|.  .|.  .||||.||.  .|..| ||. ....  | .     
NNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIH

FYKKHP-----NIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFL
 ..  |     |||. ..     ||  |.     .||||.|||....|
IHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase Pk92B.AA Pkinase_Tyr 584-780 29 5.5e-27 92.02 Pfam 6-216 (270) Show / Hide 
Range on Protein: 584-780
Range on HMM: 6-216/270
Sequence Identity: 29% (63 aa)

VLGKGTYGTVYAARDK----QTQVRIAIKEVPEKNSQD---VQPLHEEIKLHSQL-RHRNIVRYLGSCS-ENGF--FKIFMEQVPGGSLSDLLETK--WG
.||.| .|.|| .. |    .|..  |.| ..|. ...    . . .|.|. .|| .| ||||..| |. . .     | || .|.|.| | | ..  ..
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

PLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRL-----ARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWS
.  . .  .  .. || .|. ||... ..|||.   |.||.  ..||||.||| .. .       .   ...       ||||.|  |.  .  . |.||
QPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPECINYGK--FTTKSDVWS

FGCTNVEMAT-GKPP-F
|| .  |. | |. | .
FGVLMWEIFTYGEQPTY
Kinase Pk92B.AA TyrKc 579-835 24 1.2e-17 62.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 579-835
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

QNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQL--RHRNIVRYLGSCSEN-------GFFKIFMEQVPGGSLSDLLETKW
   . .|| | .|.|| .. |   .  |.| . |     .. ...|... ..|  .| |||| .| |..        .   | || .|.|.| | |  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

GPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARI---------NPM----TETFTGTLQYMAPEVIDQGVRG
.    . ...  .. || .|  |||.. ..|||.   |.||.    .||||||| |. .              .     . .   .  ||||.|. |.  
PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK--

YGPAADIWSFGCTNVEMAT-GKPPFIE-----LGSAHA-AMFKVGFYKKHPNIPEE-----LSANAKNFILRCFAISVMDRPSASQLLEDP
. .. |.|||| .  |. | |..|  .     .  ... .  | |.. . |  ...      ..   . ...| .    |||. |.. |. 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Pk92B.AA STE-Unique 580-647 31 4.2e-16 53.21 In-house 1-74 (616) Show / Hide 
Range on Protein: 580-647
Range on HMM: 1-74/616
Sequence Identity: 31% (23 aa)

NRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQD------VQPLHEEIKLHSQLRHRNIVRYLGSCSENG
| .  .|.|  |.|. ...|..  | ||| ...|.  |      |... .|| ... |.| |||.|.|.  ..|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGG
Sam7 Pk92B.AA sam7 1185-1247 22 6.1e-08 26.15 In-house 1-70 (70) Show / Hide 
Range on Protein: 1185-1247
Range on HMM: 1-70/70
Sequence Identity: 22% (16 aa)

EVDEQLEQWLTQQEI--DEFSKTLILNEGF-----TFDDFIYNMEKLDLMRLGL-RVGIEVRLWKLIIQER
  .|.. .||   .   ..  .  ....|.     ..|..  .|.. |||..|  |.|   ..|. | | |
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLC-HMTEEDLMEMGITRPGHRKKIWNHIQQMR