Gene Pak3 (Fruit Fly)

Pak3

Species: Fruit Fly
Alias: SFO051, PAK3, dPAK3, CG14895, Pak3
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 89C7

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
Pak3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
Pak3.AA Protein Various 569 None Fasta, JSON

Protein domain

Protein domains of Pak3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD Pak3.AA PBD 19-76 36 2.1e-21 77.21 Pfam 1-60 (60) Show / Hide 
Range on Protein: 19-76
Range on HMM: 1-60/60
Sequence Identity: 36% (22 aa)

EIGAP-TNFQRHFHVSRNQETGDLEGLPAPWVRLMNSQ-ITRDEQDKNPDAAYHAVKYYN
.|..| |||... || ....|| ..|.|  | .|..|  |...|| .||.|. ..|..|.
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD Pak3.AA PBD 20-55 36 0.00038 20.09 SMART 1-38 (38) Show / Hide 
Range on Protein: 20-55
Range on HMM: 1-38/38
Sequence Identity: 36% (14 aa)

IGAPT-NFQRHFHVS-RNQETGDLEGLPAPWVRLMNSQ
|..|| ||.   ||   ...||...|||  | .|  . 
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase Pak3.AA PAKA 293-545 61 3.4e-182 611.56 In-house 1-260 (260) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-260/260
Sequence Identity: 61% (161 aa)

YKTTQEVGKGASGIVFIAADLQNESQ--VAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETV-----
||.....|.|||| |..|........  ||.|...||||..|.||..||.|.|...|||.||..|.||.  .|.||||||||.||.||||.|..      
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLV--DDELWVVMEYMEGGCLTDVITQCCNIQCN

-MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEG-DEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIE
 |.|.|||.||||.|....|.|.|..|||||||||.|||||||||.|||||||...  ..||.|||||||||||||..||.|..||||||.|||||||||
YMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIE

GQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL
|.||||.|.||||.||||.||.||||..||.|....||||.||.|.|||||.|.|||.||||
GEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase Pak3.AA STE20 293-545 40 1.9e-144 486.15 In-house 1-288 (288) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-288/288
Sequence Identity: 40% (117 aa)

YKTTQEVGKGASGIVFIAADLQNESQ----VAVKTIDMKNQ----SSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPE--DQLWVVMEYMDGGPLTDVVT
|. ....|.|..| |. | . ..  .    ||.| ......     ....|..||...|...|.| |.....|| . .  |.||.||||..|| |||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ETV----------MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEG-----DE-KRQTMVGTPYWMAPEVVTR----
...          |.| |||..|||.| . ..||...|||||||.||.||..||.|| .|||.|| ..      .  ||.|.|||||||||||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIA--ANGRPDIKS--WDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL
 |.|. |.|||| ||.||||.||.|||. . |.||...|.   |. |. |.   .| ||...||.|.|||.... |.||..||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Pak3.AA STE 293-545 29 1.5e-118 400.14 In-house 1-359 (359) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-359/359
Sequence Identity: 29% (107 aa)

YKTTQEVGKGASGIVFIAADL------QNESQ---------VAVKTIDMKNQ-----------------SSKDLILTEIRVLKDFN--HKNLVNFLDAYL
..  ...||||.| |. |..       ..  .         .|.| ....|.                 . .. || ||...|..|  |.| |.....|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LEP-----EDQLWVVMEYMDGGPLTDVVTE---------------TVMKERQIACVCRETLYA-ISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCA
 |      .|.||..||||||| |.|.. .               ....| |||..||..| .  ..|| ..|||||||..|.||     || .|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

NIEG-----------------DEKRQTMVGTPYWMAPEVVTR------KKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAAN-----------
...                  ..||.|.|||| ||||||...      |.|. |.||||.|...|||..|.||.  ..|.||...|. |           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GRPDIKSW-----------------DKLSPNLQDFLDRCLQVEVDRRATADELLS--HPFL
    . | ...                  .|.||...||...||| . . |.||..||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Pak3.AA PAKB 294-545 50 1e-113 384.1 In-house 2-252 (252) Show / Hide 
Range on Protein: 294-545
Range on HMM: 2-252/252
Sequence Identity: 50% (129 aa)

KTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIAC
.    .| |  ||| || .     |||||  |.  |    |   |. .. |. |.| |.. . ||   .| ||||||.|.|| |||.||.| |.| ||| 
DNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLV--GDELWVVMEFMEGGALTDIVTHTRMNEEQIAT

VCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYET
|||  | | ..|||.|.|||||||| .||  || || .|||||| .  .  ||. .|||||||||||. |  || .|||||.||| |||..| |||  | 
VCRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEP

PLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL
||.|.  |  .  | .|   | || |..||||.|  .. .|.|| ||| ||||
PLQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase Pak3.AA S_TKc 293-545 31 4.5e-91 309.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDG--GPLTDVVTETV-----
|.  ...|||| | |. . .     .||.| |.       . |. ||..||  .|.|.|...|..     | |..||||.||  | | |.  .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVTRKKYGK-KVDIWSIGIMAIEMI
  . | .......... |. ..| .||||||.| .|.||     .|..|||... .       |..|||..|||||.   .||| |.|.||.|.. .||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

EGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLS-------HPFL
 |.||.   .. . . .|              || . ||...|||.. ..| || |.|        ||..
CGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Pak3.AA Pkinase 293-545 27 2.4e-88 304.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLIL----TEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGG----PLTDVVT--
|.. . .|.|..| |... .  .. .||||.|. ....|. ..     .||...| .||.| | ..|..    .| ...||||..||     | |...  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

-ETVM--KERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSV----KVTDFGFCAN--IEGDEKRQTMVGTPYWMAPEVVT-RKKYGKKVDIW
 ....   |... ......| .. ..|..||||||.|..|.|.  .| .    |..|||...   .  ..  .| .|||..|||||.  ...||.|||.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SIGIMAIEMIEGQPPYLYE----TPLRALYLIAANGR----PDIKSWDKLS-----------------PNLQDFLDRCLQVEVDRRATADELLSHPFL
|.|.. .||. |.||.  .    . .. ...|. ...     |.  |.  |                 ....||...||..   .| ||...| ||..
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Pak3.AA YSK 293-545 36 1.3e-79 239.28 In-house 1-257 (257) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-257/257
Sequence Identity: 36% (95 aa)

YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSK-DLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTE---TVMKE
.. .  .|.|  | |. . | . .  ||.|.||    .   ..|  || .| .    .  ... .||      ||..|||  || . |         . |
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDT--KLWIIMEYCGGGSCLDLMKPKYVGQFDE

RQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIE-GDEKRQTMVGTPYWMAPEVVTR--KKYGKKVDIWSIGIMAIEMIEGQ
 .|| . || | . ..||    ||||||. ||||  .| ||. |||  . |     ||.|.|||||||||||.     .|  |.||||.|| |.||  |.
KYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGE

PPYLYETPLRALYLIAANGRPDIKSWD-KLSPNLQDFLDRCLQVEVDRRATADELLSHPFL
|||    |.|.. ||  |  |  .  . . | .. .| . ||  .   | .|.|||.| | 
PPYCDYHPMRVMFLIPKNNPPKLE--GRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase Pak3.AA MKC 293-545 34 2.3e-73 250.06 In-house 1-260 (260) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-260/260
Sequence Identity: 34% (90 aa)

YKTTQEVGKGASGIVFIAAD-----LQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPED-QLWVVMEYMDGGPLTDVVTE-TV
|| .  ||||. | |. |         . . ||.| .. .    .   | ||..|. .|| | | .. ....   |  .| |||.|.|| |..      .
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMK--HDDEIWMVMEFMQGGTLEEASQNSHK

MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQ
 .|..|| ||.| | ... ||.. |.|||.|| |.    || .|  |||.|.. .   ... |.| |.||.||    | ..  .|||| || . ||  | 
FCESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHEKEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGR

PPYLYETPLRALYLIAANGRPD---IKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL
||.  . .. |  . | ||  .    ..  . |. . |||  |||     |.||..|| |||.
PPH-HKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase Pak3.AA MST 293-545 38 8.1e-73 230.76 In-house 1-254 (254) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-254/254
Sequence Identity: 38% (99 aa)

YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKD--LILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVV--TETVMKE
.      | |. | |. | ..|. . ||.| .   |    |   |. ||. ... . |. | . . |.   . ..| |||| ..| . |..  |  .  |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV-NE---DLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNE

RQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCAN-IEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPP
 ||||... ||     ||   .||||||. | ||  .|  |  |||  .  ..   ||.| .|||||||||| .  || .|.|||| || |||| || ||
QQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPP

YLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL
|    | ||. .|  .  |  |  .. |... ||. .||| . . |.|| .||.||| 
YSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase Pak3.AA CAMK 298-545 18 7.2e-72 230.64 In-house 1-425 (425) Show / Hide 
Range on Protein: 298-545
Range on HMM: 1-425/425
Sequence Identity: 18% (80 aa)

EVGKGASGIVFIAADLQNE------------SQVAVKTIDMK----------------------------NQSSKDLILTEIRVLKD-------FNHKNL
. |.|. |.|. . . ..              .||.| || |                            ...... .. ||...|         .|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNFLDAYL------------LEP------EDQLWVVM---EYMDGG----PLTDVVTET----------------VMKERQIACVCRETLYAISFLHAKG
......|                      ..... ||   ||..||     | | ..|                  ..||. . . |  . |. ..| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKSDNVLL-GMD----------------GSVKVTDFGFCANIEG------------------------DEKRQTMVGTPYWMA-PEVVTRKK---
|.|||.| .|.||   .                . .|..|||| . ...                        ..| .|..|||. || |||. .|.   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YGKKVDIWSIGIMAIEMIEGQPPYLYETP------------LRALYLIAANGRPD-IKS-------------WDKLSPN--------LQ
           ||.|.|.||.|..   |  | ||.  ..             .. |.    .|. | . .             ||. | .         .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFLDRCLQVEVDRRATADELLSHPFL
|.. ..|||. ..|.|... |.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Pak3.AA KHS 293-545 41 7.6e-71 237.49 In-house 1-258 (258) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-258/258
Sequence Identity: 41% (109 aa)

YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTET-VMKERQI
|   | || |  | |. | | | .. .||| | |  .    .|  || ..||  | |.| .  .||   .|.||..|||  || | |.   |  ..|.||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLR--RDKLWICMEYCGGGSLQDIYHVTGPLSELQI

ACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVTRKK---YGKKVDIWSIGIMAIEMIEGQPP
| |||||| .. .||..| .|||||  |.||  .| ||. |||  |.|     ||.  .|||||||||| . ..   |..  |||..|| |||. | |||
AYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPP

YLYETPLRALYLIAANG--RPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL
     |.|||.|..  .   | .|  .| |..  .|.  .|  .  .| ||. ||.|||.
MFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase Pak3.AA STE11 293-545 30 8.6e-67 228.21 In-house 1-303 (303) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-303/303
Sequence Identity: 30% (91 aa)

YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSS----------K----DLILTEIRVLKDFNHKNLVNFLDAYLLEP-EDQLWVVMEYMDGGPL
..  .  |||| | |. . .. .   .||| |  .|...          .    ..|  ||...| .||||.| .... | .. .| . . |||. || |
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TDVVTETV----MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGS-VKVTDFGFCANIEGD-----EKRQ------TMVGTPY--------
 ..         . |  |    .  |.....||..|||||||| .|.||  ||  .| .||| .  ....     ....      .| ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVTRKK---YGKKVDIWSIGIMAIEMIEGQPPYLYET--PLRALYLIAANGRPDIKSWDKLS------PNLQDFLDRCLQVEVDRRATADELLSH
||||||... .   ||.|.||||.|   |||. |.||.   .  .  |.. |...  | .   ...|      ....|||..|.. .   |.||..|| |
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase Pak3.AA Pkinase_Tyr 293-488 26 8.4e-27 91.39 Pfam 1-216 (270) Show / Hide 
Range on Protein: 293-488
Range on HMM: 1-216/270
Sequence Identity: 26% (57 aa)

YKTTQEVGKGASGIVFIAADL----QNESQVAVKTIDMKNQSS---KDLILTEIRVLKDF-NHKNLVNFLDAYL--LEPEDQLWVVMEYMDGGPLTDVVT
 .  .. |.|| | |. .       ... .||||..  .  ..   ..  . |....| . .|.|.|... . .   ||  |...||||| .| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLR

ET-----VMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKR-QTMVGTPY---WMAPEVVTRKKYGKKVDIWS
.        .  .. . |..   . ..|..|..||||.   |.|.. .. ||..||| .  |. |.   ..  |..    |||||.   .|.  | |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

IGIMAIEMIE-GQPP-Y
 |.   |..  |. | |
FGVLMWEIFTYGEQPTY
Kinase Pak3.AA TyrKc 293-545 23 7.3e-25 89.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 293-545
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDF--NHKNLVNFLDAYLLEPE------DQLWVVMEYMDGGPLTDVVTET
 .  .. | || |.|. .       |||||..       .  .. |.|... .  .|.|.|... .. ....      ..|..|||||..| | |   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

V--MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGD-----EKRQTMV----GTP-----YWMAPEVVTRKKYGKK
    . ..    |       ..|| |..||||.   |.|.| .. ||..||| . .|. |     .|   ..    |.       |||||.   .|.  |
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDIWSIGIMAIEMIE-GQPPYLY-----ETPLRALYLIAANGRPDIKSWDK------LSPNLQDFLDRCLQVEVDRRATADELLSHPFL
 |.|| |..  |.   ||.||        .. ... .. . .|...   |        .. . .   .| . . . | |  |.  | ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF