Gene Pak (Fruit Fly)

Pak

Species: Fruit Fly
Alias: SFO134, DPak, Pak, pak, D-Pak, p65[PAK], Dpak1, p21-associated kinase, CG10295, DPAK, dPAK1, PAK, PAK1, PAK2
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 83E4

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
Pak.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
Pak.AA Protein Various 704 None Fasta, JSON

Protein domain

Protein domains of Pak.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD Pak.AA PBD 82-140 60 6.8e-29 103.17 Pfam 1-60 (60) Show / Hide 
Range on Protein: 82-140
Range on HMM: 1-60/60
Sequence Identity: 60% (36 aa)

NISYP-TNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFD
 || | |||.||.|||.|. ||.|||||. |..||  |.|||.|||.|||||.||...  
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD Pak.AA PBD 83-118 57 2.9e-15 57.96 SMART 1-38 (38) Show / Hide 
Range on Protein: 83-118
Range on HMM: 1-38/38
Sequence Identity: 57% (22 aa)

ISYPT-NFEHTVHVG-FDAVTGEFTGMPEAWARLLMNS
|| || ||.|.|||| .|. ||||||.|. |..|| ..
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase Pak.AA PAKA 430-681 72 2.3e-201 675.25 In-house 1-260 (260) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-260/260
Sequence Identity: 72% (189 aa)

YTKMEKIGQGASGTVYTAIESSTGME--VAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETC------M
|..||||||||||.||.|....|..|  |||||||...||||||||||||||.|.||.|.|||.|||||..||||||||. ||.||||.|..|      |
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

DEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGE
||||||.||||.||.|||.|....||||||||||||| |||||.||||||||...||.||.|||||||||||||..||||..||| ||||||||||.|||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
||||||.||.|.|||||||||.||..||.|. |.||||.||.|.||||||| .||.||||
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase Pak.AA STE20 430-681 48 7.29999999999e-166 557.31 In-house 1-288 (288) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-288/288
Sequence Identity: 48% (140 aa)

YTKMEKIGQGASGTVYTAIESSTGME----VAIKQMNLSQQ----PKKELIINEILVMRENKHPNVVNYLDSYLVS----EELWVVMEYLPGGSLTDVVT
|...||||||..|.||.|.. .|| .    ||||.|||...    ...|.|..||..|.. ||||.|.|..|||..    .|||.||||. ||||||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ETC----------MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISP-----EQSKRTTMVGTPYWMAPEVVTR----
...          |.| |||..||||||.|..||.|..||||||.|||||. ||.|||.|||.|||...     .|.|| |.|||||||||||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIA--TNGKPEIKE--KDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
 |.|. |.| |||||.||||.||||||....|..|...|.  .|..|. |.  ..| |. |.||.|.||..... |..| .||||||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Pak.AA PAKB 431-681 56 1.1e-139 470.37 In-house 2-252 (252) Show / Hide 
Range on Protein: 431-681
Range on HMM: 2-252/252
Sequence Identity: 56% (142 aa)

TKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVC
..  ||| |  |.|  | | .||  ||.|.|.|  |   ||  ||. .||. .|||.|.  .|||| .|||||||.. ||.|||.||.| |.| |||.||
DNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATVC

REVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPL
| |||||..|||  ||||||||| |||  || |||.|||||||.| |  ||  .|||||||||||. |  ||..|| |||||| ||||.||||| || ||
RQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPL

KALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
.|.  |  .  | .|.  | |.  ..|||..|  .. .|..| .||.||||
QAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase Pak.AA STE 430-681 32 2.9e-131 442.36 In-house 1-359 (359) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-359/359
Sequence Identity: 32% (117 aa)

YTKMEKIGQGASGTVYTAIES------STGME---------VAIKQMNLSQQ-----------------PKKELIINEILVMRENK--HPNVVNYLDSYL
....||||.||.||||.|.        .|| .         .|||||||...                  ... |..|| .|.. .  |||.|.|...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VS-------EELWVVMEYLPGGSLTDVVTETCMD---------------EGQIAAVCREVLQA-LEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCA
.        .|||..|||..||||.|.. ....                | |||..||..|.. |..|| ...||||||..||||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QISPE----------------QSKRTTMVGTPYWMAPEVVTR------KQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATN-----------
|....                |.||.|.|||| ||||||...      |.|. |.| ||||...|||..|.||. ...|..|...|..|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GKPEIKE-----------------KDKLSSAFQDFLDQCLEVEVDRRASALDLLK--HPFL
    . | ...                 ..|.|. |.||...||. . . |..| .|||  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Pak.AA YSK 430-681 43 8.49999999999e-107 322.63 In-house 1-257 (257) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-257/257
Sequence Identity: 43% (112 aa)

YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKK-ELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTE---TCMDEGQ
.|| |.|| |  | || .|.  |.  ||||  .| .     |.|  || .  . . |.. .|. ||| .  ||..|||. |||. |         .|| .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTR--KQYGPKVDLWSLGIMAIEMVEGEPP
|| . ||.|..|..|| ...||||||. |.||  .| ||| |||  .||   | || |.|||||||||||.     .|  |.| ||||| |.||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
|    |.... ||  |  |.  |. . | .| .| . ||. .   | || .|||| | 
YCDYHPMRVMFLIPKNNPPKL-EGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase Pak.AA S_TKc 430-681 31 2.6e-103 350.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPG--GSLTDVVTETC-------
|....|||.|| |.|| ... .|| .||||...       | |..|| .... .|||.|...|..   ..|..||||..|  |.| |.  .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGP-KVDLWSLGIMAIEMVE
..| ... .......|||..| ...||||.| .||||     .|..|||...|.       ||..|||..|||||.   .||. |.| ||.|.. .||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLK-------HPFL
|.||.   .. . . .|              |. . ||...||... ..| .| ..|.       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Pak.AA Pkinase 430-681 29 9.1e-99 339.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIIN----EILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGG----SLTDVVT---E
|.. .|||.|..|.|| ... .|| .||.|..... . .......    || .|.. .|||.| ..|..  . ....||||..||    .| |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TCM--DEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSV----KLTDFGFCAQI-SPEQSKRTTMVGTPYWMAPEVVT-RKQYGPKVDLWSL
.|.  .| ..  .....|..||..|.. .||||.|..|||.  .| .    |..|||...|.    .|  || .|||..|||||.  .. |||||| ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMAIEMVEGEPPYLNE----NPLKALYLIATNGKPEIKEKDKLS---------------------SAFQDFLDQCLEVEVDRRASALDLLKHPFL
|.. .||. |.||. ..    | .  ...|. ...|....    .                     ....||.. ||..   .| .| ..|.||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Pak.AA MST 430-681 42 3.7e-95 302.92 In-house 1-254 (254) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-254/254
Sequence Identity: 42% (110 aa)

YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYL--VSEELWVVMEYLPGGSLTDVV--TETCMDEGQ
....||.|||. | || ||  .|| .||||...       . ||.||  | . | ...| | .||.    ...| ||||  .||. |..  |     | |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYL
||.... .|| |. || |  ||||||. ||||  .|  || |||  .| .  . || | .|||||||||| .   |  |.| ||||| |||| ||.||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYS

NENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
.  |  |. .| ..  |  |. .. |. | ||. .||  . . |..| .||.||| 
DIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase Pak.AA FRAY 430-681 38 2.1e-83 258.85 In-house 1-277 (277) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-277/277
Sequence Identity: 38% (107 aa)

YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQP--KKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDV----VTETC---
|   | ||.||...|..|.      ..|||  ||        . .| || .|  ..||||| |  |..| ||||.|| || .||. |.    . .     
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEPHK

---MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISP-----EQSKRTTMVGTPYWMAPEVVTRKQ-YGPKVDLWSLG
   .||  || . .|||..|...| |. ||||||..|||.| ||.. . |||  | .        .  |.|.|||| ||||||.   . |  |.|.||.|
QGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCWMAPEVMEQVHGYDFKADIWSFG

IMAIEMVEGEPPYLNENPLKALYLIATNGKP--EIKEKDK-----LSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
| |||.. | .||    | | | |.  |  |  |  | ||      .  |.. ...||  .  .|  |  |||| | 
ITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase Pak.AA KHS 430-681 42 4.7e-81 272.36 In-house 1-258 (258) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-258/258
Sequence Identity: 42% (109 aa)

YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTET-CMDEGQIAA
|  . ..| |  | || | .  ..  .|.| . .  .   ..|  ||..|.. .|||.| |  |||  . ||..|||  |||| |.   |  . | ||| 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEV--VTRK-QYGPKVDLWSLGIMAIEMVEGEPPYL
||||.||.|..||... .|||||  ||||  .| ||| |||  |||.   .||   .||||||||||  | ||  |.   |.|..|| |||. |  ||  
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

NENPLKALYLIATNG--KPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
.  |..||.|..  .   |..|.|.| |..| .|. ..|  .  .| .|  ||.|||.
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase Pak.AA MKC 430-681 37 6.1e-78 265.25 In-house 1-260 (260) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-260/260
Sequence Identity: 37% (99 aa)

YTKMEKIGQGASGTVYTAIE-----SSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSE-ELWVVMEYLPGGSLTDVVTE-TCMD
|.  ...| |. |||| |            .|||| |. .   ..    ||| . .  .||| | |. |....  |.| |||.. || |..         
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFC

EGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEP
| .|| ||.|.||.|. ||... .|||.|| ||    || .|| |||.|.  | | ...  |.| |.||.||    ||..  .| ||.|| . ||. |.|
ESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHE-KEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRP

PYLNENPLKALYLIATNGKPE---IKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
|.  ....||  . ||||       . . . |  | ||| |||.     |..|  ||||||.
PH-HKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase Pak.AA STE11 430-681 33 1.1e-76 261.01 In-house 1-303 (303) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-303/303
Sequence Identity: 33% (100 aa)

YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPK----------K----ELIINEILVMRENKHPNVVNYLDSYLV---SEELWVVMEYLPGGSL
..| |.||.|| ||||...  .|| ..|.||. .  . .          .    ..|  || .|.  .|.| | |... |     ... . ||| |||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TDVVTET--C--MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGS-VKLTDFGFCAQISPEQSKRTT----------MVGTPY--------
 ..      .  .||  |    . .|..| .||....|||||| .||||  ||  .||.||| . ... . .. ..          | ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVTRKQ---YGPKVDLWSLGIMAIEMVEGEPPYLNE--NPLKALYLIATNGKPEIKEKDKLS------SAFQDFLDQCLEVEVDRRASALDLLKH
||||||... .   || |.| ||||   |||. | ||. |   |.  |.. |... || .   ...|       . .|||..|.| .   |..| .||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase Pak.AA TyrKc 430-681 23 2.9e-30 107.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 430-681
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMREN--KHPNVVNYLDSYLVS-------EELWVVMEYLPGGSLTDVVTETC
 |. .|.| || |.|| .. .   ..||.| .. .    .| ...|. .|..   .|||.|. .   . .       | |..|||| |.|.| |   .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPE----QSKRTTMV----GTP-----YWMAPEVVTRKQYGPKV
      .    |  . .  |.|| ...||||.   |.|.| .. || .||| .  |  .     || . ..    |.       |||||.   . . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DLWSLGIMAIEMVE-GEPPYLN-----ENPLKALYLIATNGKPEIKEKDK------LSSAFQDFLDQCLEVEVDRRASALDLLKHPFL
| || |..  |.   |..|| .      ..  .. .. . . ... . |        ...  .   || . . . | .  ..  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Pak.AA Pkinase_Tyr 430-624 27 3e-29 99.66 Pfam 1-216 (270) Show / Hide 
Range on Protein: 430-624
Range on HMM: 1-216/270
Sequence Identity: 27% (60 aa)

YTKMEKIGQGASGTVYTAIES----STGMEVAIKQM-NLSQQPK--KELIINEILVMREN-KHPNVVNYLDSYL-VSEE--LWVVMEYLPGGSLTDVVTE
 |...|.|.|| |.|| ..      .|...||.| . . . ..   .|  ..|. .|..  .|||.|...   .  .|   ...|||| |.|.| |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T-----CMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQI--SPEQ-SKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSL
        .  ..   |... ...|.|.... ||||.   |.|.. .. || .||| .  |    .   ||.       |||||.   . .  | | || 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GIMAIEMVE-GEPP-Y
|.   |..  || | |
GVLMWEIFTYGEQPTY