Gene shark (Fruit Fly)
shark
Sequence
Protein domains of shark.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| SH2 | shark.AA | SH2 | 8-97 | 41 | 1.3e-31 | 112.23 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 8-97 Range on HMM: 1-87/87 Sequence Identity: 41% (38 aa) MKWYHGNLSREAADELLKQG-YEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANG . |||||.||| |..|||.. .||.||||.|.. .||.|||. ..|.|.||..|| . ..||. . . | ||..||. . | QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDD--GKYYIDET-WRRKFPSL-ELVNHYQHNPLG |
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| SH2 | shark.AA | SH2 | 10-91 | 38 | 6.8e-29 | 86.65 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 10-91 Range on HMM: 1-81/81 Sequence Identity: 38% (33 aa) WYHGNLSREAADELLKQ-GYEDGTFLVRESSTAAGDFVLSLLCQG---EVCHYQVRRHGGEDAFFSIDDKVQTKILHGLDTLVDYY ||||..||. | .||.. | .|||||||||.. ||..||....| .| ||...|.... . | .... | ||..| WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNG--GYYITGRHK---FCSLQELVEHY |
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| Ank | shark.AA | Ank | 153-185 | 39 | 1.7e-07 | 31.32 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 153-185 Range on HMM: 1-33/33 Sequence Identity: 39% (13 aa) DGQTALHLAALHSDEDILKHLLNAKVQVNSSDS ||.|.||||... .....| ||.. || | DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | shark.AA | Ank | 186-218 | 27 | 0.001437 | 17.13 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 186-218 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) FGCQPLHYAARSKPASFIRTLISAQANVQGRNI |. |||.|.|. .. .. |... |.| .. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | shark.AA | Ank | 220-252 | 33 | 1.5e-05 | 24.27 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 220-252 Range on HMM: 1-33/33 Sequence Identity: 33% (11 aa) NGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTS .|. ||| |...|..| |..|| . | . .. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| SH2 | shark.AA | SH2 | 286-394 | 29 | 7.6e-22 | 79.82 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 286-394 Range on HMM: 1-87/87 Sequence Identity: 29% (33 aa) DQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDD--GPYWPSVEH .|||| ..||||...||.. |.||||.||| . ..||.. ... ||..|| . | . |||. ... ||. . QPWYHGNISREEAEQLLKNP----------GMPDGDFLVRDSES-NPGDYVLSVRWKGKVKHYRIRRNDD------------GKYYIDETWRRKFPSL-E LIAHFMRFSYG |..|... . | LVNHYQHNPLG |
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| SH2 | shark.AA | SH2 | 288-388 | 26 | 7e-17 | 51.39 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 288-388 Range on HMM: 1-81/81 Sequence Identity: 26% (28 aa) WYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQ---VVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHL |||| ..|.|| .|.. . . | |||| ||| . .|....| .|| .|| . | .|| .... .|. .| WYHGKISRQEAERLLMN----------PGNPDGTFLVRESES-TPGDYTLSVRDDGPGDRVKHYRIQRTDNG------------GYYITGRHKFCSLQEL IAHF . |. VEHY |
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| Kinase | shark.AA | Syk | 662-915 | 57 | 4e-204 | 684.42 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 662-915 Range on HMM: 1-257/257 Sequence Identity: 57% (148 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSN---KQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGH ||.|.|||.|.|||||.||...||||||.....||||||...|.. ||||.|||.||..|.|.||||.|||...||.|||.|.|.||.|..|...|.| LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH EITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIW |||||..|..|..|.|.||.|||..|||||||||||.||..||.|||||||||..|...|..||.|..|.||..|||||......|||.|||||||||.| EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW EMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFV ||||.|..||||.......|....|.|...||.||...|..|..||.....|||||| EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV |
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| Kinase | shark.AA | TyrKc | 662-921 | 38 | 2.1e-136 | 460.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-280/280 Sequence Identity: 38% (113 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRL--EHKCIVRLIGIAKG--------EMLMMVQELAPLGSMLQ ..|....|.|.|| |. | . ..||.||| ... ...|.|||..|..| .|..||||.|.. | ||.| |..|.|. .. ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD YILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPG-----STEYQFTQ---GGR--WPIRWYAPESFNL |. .|... ...| .. |||||| ||.|....||||||||.|....|..||||||.|| . . |..| .. ||. .||||.|||..| YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY GIFSHASDVWSFGVTIWEMFSLGAPPYGE-----ISNVDAIKLVDSGERLPQPNL--------CPAYIYAVMQSCWKERPKDRPTFVYLTEFF |.|...||||||||..||.|..|..|| . .|| ..|..|..|.|.||| ||. .| .|..||.| |.||||| . |.| GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | shark.AA | Pkinase_Tyr | 662-921 | 38 | 9.3e-127 | 429.93 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-270/270 Sequence Identity: 38% (106 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKML--SDEHSN--KQEFLREASVMMRL-EHKCIVRLIGIAK--GEM--LMMVQELAPLGSMLQY .......|.|.||.|. | . ... ...||.||| . |.. ...|.|||..|. | |. ||||.|. || ...| |..|.|..| | ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY ILDH---GHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEY-QFTQGGRWPIRWYAPESFNLGIFSHAS .| .. .| | .. |||.|| ||||....||||||||.|.| ...||.|||..| . .| . ..||..||.|.|||..| |.|...| LRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS DVWSFGVTIWEMFSLGAPP-YGEISNVDAIKLV-DSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF |||||||..||.|..|. | | ..|| . .... ..|.|.|.| .||. || .|..||.. |.||||| .. |.. DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | shark.AA | TK | 662-921 | 22 | 1.3e-109 | 368.78 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 662-921
Range on HMM: 1-486/486
Sequence Identity: 22% (112 aa)
LVLDREIGHGEFG---SVHSGWLLRKSG------------------AGEESRLEVAIKMLSDEHSNKQE---------------FLREASVMMRLE----
..| ...|.|.|| |. |.. .... ..|. . .||.||| ..... || ||.||..|. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HKCIVRLIG-IAKG------------EMLMMVQELAPLGS----MLQYILDHGHE--------------------------------------------
|. ||||.| . .| | .|.| |..|.|. ..| .. ..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
------------------------------ITANAELKVWASQIACGMHYLESQ------HFVHRDLAARNILLTARHQ-----------AKISDFGMS-
. ..| .. |||||| ||.|. .||||||||||.|.. ... .||.|||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-------RSLRP-----------------------GSTEYQFTQGGRWPIRWYAPESFN---------LGIFSHASDVWSFGVTIWEMFSLG-APPYGEI
| . . .. .| ..||..||||.|||..| |.|...||||||||..||.|..| .|.||..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
SN---------VDAIKLVDSG--------------ERLPQPNLCP--------------AYIYAVMQSCWKERPKDRPTFVYLTEFF
|| . .... .| |.||| .|| . .| .||.||.. |.||||| | |..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | shark.AA | Ack | 662-921 | 39 | 1.2e-98 | 333.43 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-266/266 Sequence Identity: 39% (108 aa) LVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDE--HSN--KQEFLREASVMMRLEHKCIVRLIGIAK-GEMLMMVQELAPLGSMLQYILD . | ..| |.||.|. | | . .| . .||.| |... .. ..||||...|..|.| .||| |. ||||| ||||.|| | . ITLCEKLGDGCFGVVWRGEWTN-PGGK----HIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK HGHE--ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTAR-HQAKISDFGMSRSLRPGSTEYQFTQGG--RWPIRWYAPESFNLGIFSHASDV . .. . | .. ||| || |||.....||||||||||| .. .||.||| .|.| . | |. | |||. . . ||||||| -HCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDV WSFGVTIWEMFSLGAPPYGEISNVDAIKLVD-SGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF |.||||.||||| | |. . . ....| |||||.| .|| ||..| ||.. | |||||. . ... WMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | shark.AA | UTK | 662-921 | 32 | 2.3e-91 | 309.84 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-296/296 Sequence Identity: 32% (98 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHS-NKQ-----EFLREAS---VMMRLE-HKCIVRLIGI-AKGEMLMMVQELAPLGSML . | |..|.|.|| || . . . |. ..|.. ||.| .. ... ... .|..|| .|.... | ..||.|. ..| .|.| |... |... VQLGRQLGQGAFGEVHKARFTQCSEHMYEMD--VAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR QYILDHGH------EITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARH-------QAKISDFG---MSRSLR-------PGSTEYQFTQG- .| .|.. .. . .. .|..||.||.||.|..||||||||||.|... . ..||.||| ||| . ....| |. SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ GRWPIRWYAPESFNLG-IFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSG--ERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF .||||||.|||... . |...||||||||. ||... |. ||...||..... | | |.|.| ||. .| .|..||. | .||.|. |.... DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | shark.AA | EGFR | 662-922 | 39 | 3.7e-87 | 289.41 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 662-922 Range on HMM: 1-258/258 Sequence Identity: 39% (104 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKML--SDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHE | ... | | || |. | . ||. . ||||.| . . . ..|.|.|| || ...|...|||.|. .. ...| . |.|..| |. | . LKKVKVLGSGAFGTVYKGIWIPE---GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDN ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWE | . . | |. ||| || ||| .. |||||||||.|. . || |||... | . ..||. |||. ||.| | |.. ... |.|||||.|||.|| IGSQHLL-NWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHA-QGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWE MFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFA . |. || |. . |.. ||||||| | .| || .|| .. |||| |.| | LMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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| Kinase | shark.AA | TK-Unique | 662-921 | 34 | 3.4e-81 | 276.05 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-294/294 Sequence Identity: 34% (103 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQ--EFLREASVMMRLE-HKCIVRLIGIAK--GEMLMMVQELAPLG---SMLQYI |.....|| |.|| |. | . ... .... . ||.||| |... . .||.|...|. | |. ||...|. .| |.. | .| | . |.. LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC LDH--GH-------EITANAELKV------------WASQIACGMHYLES--QHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQG-GRW . .| ....... |. .| |||||| ||.| ...|||||.|||.||| ....||.||||.| .. ..|. ... || RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRI PIRWYAPESFN--LGIF-SHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLC-PAYIYAVMQSCWKERPKDRPTFVYLTEFF |||| ||||. |.. . ||||||||..||.|.|||.||..... | .... | |.|||. | . .| .|.|||.. |..||.| .. . PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | shark.AA | SFK-Src | 662-921 | 38 | 7.9e-80 | 236.14 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-259/259 Sequence Identity: 38% (104 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILD-HGHE .| . | | || | | . |||.| | .|||.|| || .| | ..| . || . . || ||.| | . ||. IRLEKKLGSGQFGDVWKGRWNNTT--------EVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRS ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWE . | |.|.| || ||| | ||||||||||.| |. |||||| | . | .| . ||.| ||| | || |||||||. . | LRM-PQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMME MFSLGAPPYGEISNVDAIKLVDS--GERLPQPNLCPAYIYAVMQSCWKERPKDRPTF----VYLTEFF . .| || .| .. || |.|.| | || |..| ||...| ||||| . . .|| IVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF |
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| Kinase | shark.AA | Src | 662-921 | 35 | 1.6e-79 | 269.8 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-255/255 Sequence Identity: 35% (95 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGE-MLMMVQELAPLGSMLQYIL--DHGH . | |..| | || | | . .||.| |. . . ||.|| .| | |. .|.| . | |.|. || |.| . |. IKLCRKLGQGQFGEVWMGYWNGN--------TKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR EITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIW .. . . | |.| || ||||. ..||||||||.| .|. ||| | . . || .| . ||.| ||| .| | |. |||||||. .. HLHLPQLIDM-AAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT EMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYA-VMQSCWKERPKDRPTFVYLTEFF |... | || .| .... |. | |.|.| ||...| .|. ||...|..|||| || .|. EIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | shark.AA | Eph | 662-921 | 40 | 4.7e-77 | 258.36 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-264/264 Sequence Identity: 40% (107 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLE-VAIKMLSDEHSNKQ--EFLREASVMMRLEHKCIVRLIG-IAKGEMLMMVQELAPLGSMLQYILDHG . ... || |||| | .| | .||. | .. ||||.| . .. || .||.|||.| .| |.|| | ..|.. .| | | .|| .. | IKIEKVIGAGEFGEVCCGRLKLPSGKREVW-VDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHD HEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGS---TEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFG ..|. . | || || || . .|||||||||||. .. |.||||.|| |. . .| |.||. |||| ||| ..|. ||||||.| GQFTV-IQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYT-TRGGKIPIRWTAPEAIAYRKFTSASDVWSYG VTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF . .|| | | ||.. || | || .. | ||| | ||. .. |. ||. ...||.| . .. IVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL |
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| Kinase | shark.AA | Fer | 662-922 | 34 | 6.7e-71 | 240.66 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 662-922 Range on HMM: 1-283/283 Sequence Identity: 34% (98 aa) LVLDREIGHGEFGSVHSG--WLLRKSGAGEE-SRLEVAIKMLSDEHSNKQ---EFLREASVMMR-LEHKCIVRLIGIAKGEM-LMMVQELAPLGSMLQYI .|. .| | || |..| | .| | . . ..|. |.. |...| ||..|| .|. . |. .|...|.. | .| | |... || . |. VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL LDHGHE-ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTA-RHQAK--ISDFGMSRSLRPGSTEYQFT-QGGRWPIRWYAPESFNLGIFSHAS ... .. | .. . |.|||| ||.|.. .|||.||||.|... .. | |||||||| .. . . |. . |||| |||... ||.|... KKNKNKTVSDNEKIRM-CYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKT DVWSFGVTIWEMFSLGAPPYGE------ISNV--DAIKL-VDSGERLPQPNLCPAYIYAVMQ-SCWKERPKDRPTFVYLTEFFA |||||||..|| |. || ||.. || .|.| ...| ..| || .| |. .| .||.. |.||||. . . . DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | shark.AA | S_TKc | 662-921 | 23 | 1.6e-43 | 151.84 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 662-921
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)
LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPL--GSMLQYILDHGH-
. |.||.| ||.|. .. . . .||||... . ..|| ..... |. ||.|... . | || |... |....|| ..|.
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH
---EITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSH-ASDVWSFG
. . .. ||.|.. |. |....|||| ||||. . ||.|||..| | . ||| . ... ..|.||.|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG
VTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTE---------FF
....||.. | ||. .|.. . .. |.. |..||| . . .|
CILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | shark.AA | Pkinase | 662-921 | 23 | 8.9e-36 | 127.58 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 662-921 Range on HMM: 1-293/293 Sequence Identity: 23% (73 aa) LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQE---FLR--EASVMMRLEHKCIVRLIGIA--KGEMLMMVQELAPLG----SML ... | || | ||.| .. .. | |. .||.| .. .| .... .| |...| || |..||||... |... ||.|... | . YHIGRKIGSGSFGCV---YKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLF QYIL--DHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQA----KISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFN-LGI || .|| . |.| .. ||..|. |. |. ..|||| |||. . . ||.||| .. .. .. ... ... ||| . DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQY FSHASDVWSFGVTIWEMFSLGAPPYGEI----SNVDAIKLVDSGER----LPQPNLCP-------------------AYIYAVMQSCWKERPKDRPTFVY ....|.||.|....||.. | ||. . . .| ..... . . |..|. .. .|.. ||.|||. YGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ LTEF--F . . | ILQHPWF |
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