Gene Btk29A (Fruit Fly)

Btk29A

Species: Fruit Fly
Alias: CG8049, src2, CT2415, Dsrc28C, src4, Tec29, c-src/fps, Btk29A, S13, SRC 29A, Dm SRC2, fic, fickle, CG18355, dsrc29A, tec29, src28C, Src oncogene 29A, src-4, Dsrc29A, DSrc28, CT41718, DTec29, SFO097, Tec, Src2, Src29A, Tec29A, C-src4, Src29A: Src oncogene 29A, C-src2
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 29A1--2

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
Btk29A.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
Btk29A.AA Protein Various 786 None Fasta, JSON

Protein domain

Protein domains of Btk29A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH Btk29A.AA PH 42-186 16 8e-17 63.13 SMART 1-82 (82) Show / Hide 
Range on Protein: 42-186
Range on HMM: 1-82/82
Sequence Identity: 16% (24 aa)

VVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNG
|.|.| . |.          ..| ||| |. ....|.. .     . .|.|.|......| .                |.. . .               
VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK-----KPKGSIPLSDCTVRE-P---------------CFEIHH-DR--------------

GGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDS
                   |.|. ..||.|. ||..||.......
-------------------TYYFQCESEEEMQEWMQAIQKAIHNN
PH Btk29A.AA PH 42-184 18 1.4e-12 48.01 Pfam 1-92 (92) Show / Hide 
Range on Protein: 42-184
Range on HMM: 1-92/92
Sequence Identity: 18% (27 aa)

VVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNG
|.|.| . |.          ..| ||| |. .. .|.. ..    | .| | |...  |.... .        .. . ||. . .               
VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK---YRPKGSIPLSDC-QVTKVPDN--------KRPHCFQIRT-DR--------------

GGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCE
                   |.|. |.||.|. .|..||...| 
------------------RTYYFQAESEEEMNDWMQAIQSACR
BTK Btk29A.AA BTK 192-223 37 2e-06 29.87 Pfam 1-32 (32) Show / Hide 
Range on Protein: 192-223
Range on HMM: 1-32/32
Sequence Identity: 37% (12 aa)

YRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHW
  |||..| . .||||. ..... ||    ||
QKYHPCFWMNGHWSCCHQTDKNAPGCQPCHHW
SH3 Btk29A.AA SH3 345-401 32 8.9e-20 72.94 SMART 1-58 (58) Show / Hide 
Range on Protein: 345-401
Range on HMM: 1-58/58
Sequence Identity: 32% (19 aa)

KLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDA-LGNVGYIPSNYVKPKA
. |.|||...| . ..||..|.  ..|.... ..|||..    |..|..|||||... 
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 Btk29A.AA SH3_1 348-394 34 5.9e-19 66.86 Pfam 1-49 (49) Show / Hide 
Range on Protein: 348-394
Range on HMM: 1-49/49
Sequence Identity: 34% (17 aa)

VALYPFKAIEGGDLSLEKNAEYEVIDDSQE-HWWKVKDALGN-VGYIPS
||||...| ....||..|.....||..| . .|||...  .. .|..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH2 Btk29A.AA SH2 410-488 39 1.2e-39 118.25 Pfam 1-81 (81) Show / Hide 
Range on Protein: 410-488
Range on HMM: 1-81/81
Sequence Identity: 39% (32 aa)

WYVGDMSRQRAESLLKQ-GDKEGCFVVRKSS-TKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYH
|| |..||| || ||.. | ..| |.||.|. |.| ||||. .. |...||||.|...... ||....|.......|....
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Btk29A.AA SH2 408-494 37 1.4e-32 115.49 SMART 1-87 (87) Show / Hide 
Range on Protein: 408-494
Range on HMM: 1-87/87
Sequence Identity: 37% (34 aa)

YEWYVGDMSRQRAESLLKQG-DKEGCFVVRKSST-KGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSE--KHCCETIPDLINYHRHNSGG
..|| |..||. ||.|||..  ..|.|.|| |.. .| |.||. .|   ..||||.|..|.   ||. |  ....... .|.|...||..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK---GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase Btk29A.AA Tec 526-779 66 1.7e-208 698.98 In-house 1-254 (254) Show / Hide 
Range on Protein: 526-779
Range on HMM: 1-254/254
Sequence Identity: 66% (169 aa)

LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLL
|..|.||||||||||..||||...|.|.||.|||.|||.|||||||||.||.||.|||||||||..||||||||||.||.||||||.|......||..||
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYG
.||..|..||.|||||..|||||||||||||...||||.|||..|||||||||||.|||||.||.||||..|.|.||||||||.||||||.|.||||||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

RLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLAL
...|.||||.|..|..|..|..|...||..|. ||...|||||.|..|..|.. 
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase Btk29A.AA Pkinase_Tyr 526-777 51 8.10000000001e-147 497.86 Pfam 1-270 (270) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-270/270
Sequence Identity: 51% (139 aa)

LMLMEELGSGQFGVVRRGKWR-----GSIDTAVKMMKEGTMSE----DDFIEEAKVMTKL-QHPNLVQLYGVCS-KHRP--IYIVTEYMKHGSLLNYLRR
. ....||.|.||.|..|.|.     . |. ||||.|||.|.|    .||..|||.|..| .|||.|.|||||. . .|  ||||.|||.||.||.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H--EKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV-LDDQY-TSSGGTKFPIKWAPPEVLNYTRFSSKSDVWA
|  .|  .     ||.||.|..||| |||..|.||||||||||||...||||..||||||..  ||.| ...||.|.|||| .||..|| .|..|||||.
HREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGVLMWEIFTCGKMP-YGRLKNTEVVERV-QRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL
.||||||||| |..| |  ..|.||.|.. ..|  ...|. | .||||.||.|| . ||.|| |. .  ||
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Btk29A.AA TyrKc 526-777 43 1.1e-141 477.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-280/280
Sequence Identity: 43% (123 aa)

LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKL--QHPNLVQLYGVCSKH-------RPIYIVTEYMKHGSLLNYLRRHEKT
. | ..||.|.||.|..|.|.  |. ||||.||..  . ||..||..|.||  .|||.|.|||||...        |..||.|||.||.|..|||.|...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDD--------QYTSSG--GTK--FPIKWAPPEVLNYTRFSSKS
   .|  ||..|.|...|| ||...|.|||||||||||||....||..||||.|.. ||         |....  |.|  .||.| .||..|| .|..||
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWAYGVLMWEIFTCGKMPYGR-----LKNTEVVERVQRGIILEKPKS--------CAKEIYDVMKLCWSHGPEERPAFRVLMDQL
|||..||.|||||| |..||       ..|.||.|.|..|  ...|..        | .|.|..|| || . ||.|| |. . ...
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Btk29A.AA Src 526-777 52 2.3e-131 442.74 In-house 1-255 (255) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-255/255
Sequence Identity: 52% (134 aa)

LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLL
. | ..||.|||| |  |.|.|... ||| .|.|||| ..| .||..|.||.|..||||| |||.  |||||||||.||||| ||.. ...   ..  |.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMP
||  ||..|| |||. ||||||||||| ||| .||.||||||||| .   || |... | ||||||  || .|| ||. ||||| .|.|..||.| |..|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YGRLKNTEVVERVQRGIILEKPKSCAKEIYD-VMKLCWSHGPEERPAFRVLMDQL
|   .| ||...|.||  . .|. | .|.|. .|. ||   ||.|| |  | . |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Btk29A.AA SFK-Src 526-781 50 4.2e-131 391.01 In-house 1-259 (259) Show / Hide 
Range on Protein: 526-781
Range on HMM: 1-259/259
Sequence Identity: 50% (131 aa)

LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRR-HEKTLIGNMGLL
  | . ||||||| | .|.| .. . ||| .| |.||.. | .|| || ||.||||.||| ||    ||||.|| || |||| ||.  | . |  .| .|
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSL--RMPQL

LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKM
 ||  ||  || |||  |..|||||||| |||  ||.||.|||..| . .|.  ||   | ||||||  ||  |. ||| |||||..|.|| || | | .
VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYGRLKNTEVVERVQR--GIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVA
||  . | ||. .| |  |  ...|. |  | | .|  || | |..||.|  |  |.    
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Btk29A.AA TK 526-777 27 4.4e-122 411.3 In-house 1-486 (486) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-486/486
Sequence Identity: 27% (132 aa)

LMLMEELGSGQFG---VVRRGKWRGS--------------------------IDTAVKMMKEG-TMSEDDFIE--------------EAKVMTKLQ----
. | ..||.||||   .|..|.|||                           ...||||.||| .||...|..              || .| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQLYGVCSKH------------RPIYIVTEYMKHGS----LLNYLRRHEKTLIG-----------------------------------------
 |||.|.|||||...            .|..||.|||.||.    |..|||.. .. .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------NMGLLLDMCIQVSKGMTYLERH------NYIHRDLAARNCLVGSENV-----------VKVADFG---
                                .|  || || |...|| ||...      |..||||||||||||..||           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARYV-LDDQYTSSG------------------------GTKFPIKWAPPEVLN---------YTRFSSKSDVWAYGVLMWEIFTCG-KMPYGRL
     |||..  || |....                        |.|.||.| .||.||         | .|..|||||..||||||||| | ...|| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KN---------TEVVERVQRG--------------IILEKPKSCA--------------KEIYDVMKLCWSHGPEERPAFRVLMDQL
 |         .||.|...||                ...|. |               .|.||.|. ||.. ||.|| |. | .||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Btk29A.AA Src-Unclassified 526-777 44 4e-114 385.43 In-house 1-284 (284) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-284/284
Sequence Identity: 44% (127 aa)

LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEG---TMSEDDFI--------EEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHE
. |  .|| |||| |  |||||..| ||| |..|   |||   |         .||..|.|..|.|||.||.|||.  |.||.||||  |||| .||   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

KTLIGNMGLL------------LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN-----VVKVADFGLA--RYVLDDQYTSSGGTKFPIKWAPPEVL
... . . ..             |.  ||  || |||   |.|||||||| |.|  |     ||||.|||||  . . || |    | .||.||  ||  
GQYLH-IQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECF

NYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKP--KSCAKEIYD-VMKLCWSHGPEERPAFRVLMDQL
 |  || ||||| ||.| |||.| |. ||    | ||.| | ||  . ||  . |   ||. .|| ||   |. || |  |   .
IYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase Btk29A.AA Abl 526-777 47 8.8e-108 360.74 In-house 1-252 (252) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-252/252
Sequence Identity: 47% (121 aa)

LMLMEELGSGQFGVVRRGKW-RGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLL
.|. . || ||.| |  | | | .   ||| .|| ||  ..|..|| .| ...||||||| ||| .  | ||.||.| .| ||.|||. .....  .  |
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAV-VL

LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPY
| |  |.. || |||....||||||||||||| ...|||||||||| . || ||   | ||||||  || | | .|||||||||.|||.||| | |  ||
LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY

GRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL
  .  ..| .....|  .|.|. | ...|..|. ||   . .||.|. .  ..
PGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase Btk29A.AA SrcA 526-777 49 1.6e-105 334.5 In-house 1-250 (250) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-250/250
Sequence Identity: 49% (124 aa)

LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLL
. |   || |.|| |  | | |.   |.| .| |||| . |.|||..| ||.|  ||||| | |   ||||||||| .|||| .|. .|   .  .  | 
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIVTEYMCKGSLLDFLKDEEGKYL-KLPQLV

DMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYG
||  || .|| |.|| ||||||| | | ||| . . |.||||||| . |. ||.  |.||||||  ||   | ||  |||||..|.|. |. | |..|| 
DMAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP

RLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL
 . | ||.| | ||  .  |. | . ....|. ||   ||||| |  |   |
GMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase Btk29A.AA UTK 526-777 35 2e-104 353.21 In-house 1-296 (296) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-296/296
Sequence Identity: 35% (104 aa)

LMLMEELGSGQFGVVRRGKWR------GSIDTAVKMMKEGTM---SED---DFIEEAK---VMTKLQ-HPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNY
..|...||.|.||.|......      .  | |||  ... .   ...   ||.|||.   .| ... |||...|.|||..  |..||||||. |.|..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRRHEKTL-----IGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSE-------NVVKVADFG---LARYVL----------DDQYTSSGGTK
|||| .|.     . ..  .|.|. ... || ||......|||||||||||..        .|.|.||||   ..|.|           .. |.... ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWAPPEVLNYT-RFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRG--IILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL
 ||.|  ||.|..  ||..|||||..||..|||.| |..||. . | .|...| .|    ...|..|  ..|..|. ||   |.||| |. | .|.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Btk29A.AA Frk 526-781 48 1.6e-103 350.19 In-house 1-260 (260) Show / Hide 
Range on Protein: 526-781
Range on HMM: 1-260/260
Sequence Identity: 48% (126 aa)

LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR-RHEKTLIGNMGLL
. |. .||||||| |  |.|  ..  ||| .| |||  .||. ||..| ||.|| |.||| ||    ||||.|| |.||||..||.   .|    .|  |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLAR-YVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGK
.||  ||  || ||| .||||||||||| ||| .|..|.|||||||  . |..  | |  | .|||||  ||  || .|. |||||..|.|. || | |.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

MPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVA
|||  . | ||.. |..|  . .|  | ...|..|  || . |..|| |  |  .|    
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Btk29A.AA SrcB 526-778 47 3.7e-99 335.73 In-house 1-251 (251) Show / Hide 
Range on Protein: 526-778
Range on HMM: 1-251/251
Sequence Identity: 47% (121 aa)

LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLL
| | . ||.|||| |  | .....  ||| ||.|||| . |..|| || .|||  ||.|| | .|  ||||.||||..|.|| .|.  | . . ..  |.
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKL-SLPKLI

DMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYG
||  |.. || |.||.||||||| | | ||    . |.||||||| . |. ||   | ||||||  || .|.  |  |||||..|.|. || | |..|| 
DMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

RLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLA
   | ||.. ..||  . .|  | .|.|..|..|| . ||||| |  |   | 
GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase Btk29A.AA S_TKc 526-779 22 9.9e-49 169.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 526-779
Range on HMM: 1-231/231
Sequence Identity: 22% (59 aa)

LMLMEELGSGQFGVVRRGKWRG-SIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKH--GSLLNYLRRHEKT---LIG
  .....|.| ||.|.......     |.|..|      .... | ... | .|||.|.||.|.     .|.|.||. .  |.|. |.... .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSS-KSDVWAYGVLMWEIFT
.      .. |. ... |. .|. |||||   | |. .  ..|..|||||| .                . .||||    ..  |.|.|. |....| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

CGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMD-------QLAL
 |. |.    . ... .. .           .|  | .. |.   ||.||    ..           .
-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Btk29A.AA Pkinase 526-777 22 5.3e-48 170.58 Pfam 1-293 (293) Show / Hide 
Range on Protein: 526-777
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

LMLMEELGSGQFGVVRRGKWRGSID-TAVKMMKEGTMSEDDFIE-----EAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHG----SLLNYLR-RHE
. . . .||| ||.|......|. .  ||| .|  . ...  ..     |...| .|.||| |.||...  .. ||.|.||. .|    .|  |.. . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVV----KVADFGLAR---YVLDDQYTSSGGTKFPIKWAPPEVLN-YTRFSSKSDV
..... .  . ... |. .|. |. ... |||||   |.|. .....    |..|||||.   |  .  .|.  || .   ...|||.. ..  ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WAYGVLMWEIFTCGKMPYGRL-------KNTEVVERVQRGIILEKPKSCA-------------------KEIYDVMKLCWSHGPEERPAFRVLMDQ--L
|..|....| .. |. |.          ..  .... .. .  . |..|                    .|  |..| |.   |..|| .. ..    .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF