trbl

Species: Fruit Fly
Alias: trbl, SFO196, tribbles, CG5408
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 77C1

Classification

Group: CAMK
Family: Trbl

Sequence

Name Sequence Type Origin Length Description Download
trbl.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
trbl.AA Protein Various 484 None Fasta, JSON

Protein domain

Protein domains of trbl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase trbl.AA Trbl 142-397 55 2.4e-200 638.67 In-house 1-256 (256) Show / Hide
Range on Protein: 142-397
Range on HMM: 1-256/256
Sequence Identity: 55% (142 aa)

CVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELR-RSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETE
|...|.||...|.|.....|..|...|..|...|||| .....||..||..|..| |.....||.....|||||||||||||....|.|.||.|||||.|
CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVI-LGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEE

ARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQ
|...|||.||.|..||..||.||||||.||.|.||.|||||.||||.|.|..||||.|.||.|||.|..||.||.|..|.||.||||||||.|||||||.
AARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGR

YPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL
|||.....|||.|.||.|...||..||...|.|...|||....|||||.||.|.||.
YPFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF

Kinase trbl.AA CAMK 223-397 21 1.5e-46 147.63 In-house 148-425 (425) Show / Hide
Range on Protein: 223-397
Range on HMM: 148-425/425
Sequence Identity: 21% (60 aa)

YENLHTYIRHA---------------KRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEAR---------------TKLQYESLEGSMILD
.. |  ||.                 .|..| ||| .|.|||. |. || ..|. ||||.    . |  .                ..       . ..|
FDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD

G-----------------------EDDTLSDKIGCPLYTA-PELLCPQ------------QTYKGKPADMWSLGVILYTMLVGQYPFYEK----------
.                       |.. ...  |.| | | ||.|  .            ..| |...||||.|||||.||.| .|||..          
PGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEW

---ANCNLITVIRHGNVQ-IPLT-----------------------LSKSVRWLLLSLLRKDYTERMTASHIFLTPWL
      .|   |. |. . .|                         .|.... |. ..|..| ..|||.. .   ||.
IGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase trbl.AA SgK495 225-395 34 8.5e-32 95.82 In-house 1-171 (171) Show / Hide
Range on Protein: 225-395
Range on HMM: 1-171/171
Sequence Identity: 34% (60 aa)

NLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPA
||  .. | ||| | |.  ||| . . |   |.  |. |||||         . ..          |  | | | |. | | | .|. |   . |.|||.
NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTH-QITITNFCLGKHLVSEHDLLKDQRGSPAYISPDVLS-GRPYRGKPS

DMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPL--TLSKSVRWLLLSLLRKDYTERMTASHIFLTP
||| |||.|.||| ||.|||. .   |   |.     ||     |     |. .||  |  .|.||. .  . 
DMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVIEAV

Kinase trbl.AA CAMKL 292-397 27 7.2e-30 92.38 In-house 184-297 (297) Show / Hide
Range on Protein: 292-397
Range on HMM: 184-297/297
Sequence Identity: 27% (32 aa)

DGEDDTLSDKIGCPLYTAPELLCP-QQTYKGKPADMWSLGVILYTMLVGQYPFY----------EKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRK
.|....|.   | | | |||..   .. | |...|.||.|||||.|..|..||            . .  ... .  ..  |.. .| ..| |. ..| .
FGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQV

DYTERMTASHIFLTPWL
. ..|.|.  |   ||.
NPEKRPTIHQIMNHPWM

Kinase trbl.AA MARK 303-397 38 5.2e-26 82.15 In-house 167-262 (262) Show / Hide
Range on Protein: 303-397
Range on HMM: 167-262/262
Sequence Identity: 38% (37 aa)

GCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKA--NCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL
| | | |||..  .. | |...|.|||||.||.|..|..|| ..   . .|   |..|. .||  .||. | |. .||  .  ||.|.. |   ||.
GTPPYMAPEIFL-KKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase trbl.AA MELK 225-397 30 4.2e-25 82.47 In-house 83-254 (254) Show / Hide
Range on Protein: 225-397
Range on HMM: 83-254/254
Sequence Identity: 30% (53 aa)

NLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPA
..  || . .|| | |.| .| ||   .   |  |   ||||   . | .. . ||    |        .   |    | | | ||||.  .| |.|  |
EMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQ-YIGSEA

DMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL
|.||.|..||....|  || .     .   |  |  . |  || . . ||  .|  | . |.   ..   ||.
DVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV

Kinase trbl.AA CAMKK 288-397 27 3e-24 73.5 In-house 246-396 (396) Show / Hide
Range on Protein: 288-397
Range on HMM: 246-396/396
Sequence Identity: 27% (41 aa)

SMILDGEDDTLSD-----------KIGCPLYTAPELLCP-QQT-------------YKGKPADMWSLGVILYTMLVGQYPFYEKANCNLIT---VIRHGN
|.|..|.|.|||.             | | ..||||.    |.             |.||.||.|.||| ||... |. ||... .  |      |   .
SHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDP

VQIPL-------------TLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL
.. |               .|     |.. .|.|. |.|.|.. |   ||.
IKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV

Kinase trbl.AA Ciliate-E2 302-397 26 1.6e-20 67.14 In-house 248-365 (365) Show / Hide
Range on Protein: 302-397
Range on HMM: 248-365/365
Sequence Identity: 26% (34 aa)

IGCPLYTAPELLC-PQ------QTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIP------------------LTLSKSVRWLLLS
.| | | ||| |   .      |.. .. .|.|||||||| || |..||        .  |  .....|                  . .|...  |.  
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK

----LLRKDYTERMT-ASHIFLTPWL
    .| ||  .|.| .. |.  ||.
FGKRMLQKDPEKRITGWEQILNHPWF

Kinase trbl.AA Ciliate-E2-Unclassified 295-397 26 3.1e-20 66.9 In-house 216-352 (352) Show / Hide
Range on Protein: 295-397
Range on HMM: 216-352/352
Sequence Identity: 26% (37 aa)

DDTLSDKIGCPLYT----APELLCPQQTYKG--KPADMWSLGVILYTMLVGQYPFY------------EKANC-----NLITVIRHGNVQIPL-------
.. .....| | |     |||.|. |. ..   . .|.|||||||| || |.||||            ..  .     .|.  |  .|.|.|        
QQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIP

-TLSKSVRWLLL----SLLRKDYTERMTASHIFLTPWL
 ..|...  ..     ..| |.  .|.|.. |.  ||.
KHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase trbl.AA ULK 303-397 29 1.7e-19 65.88 In-house 209-324 (324) Show / Hide
Range on Protein: 303-397
Range on HMM: 209-324/324
Sequence Identity: 29% (34 aa)

GCPLYTAPELLCPQ--QTYKG-KPADMWSLGVILYTMLVGQYPFYEKANCNLI--------------TVIRHGNVQIPL-----TLSKSVRWLLLSLLRK
| ||| ||..|  |  |   . . .|.||||.|.| || |.|||..  .....              . |.  ..|.|.      .|. .. |.  .| .
GTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQY

DYTERMTASHIFLTPWL
| ..|..   ||  ||.
DEKDRISWEEIFNHPWF

Kinase trbl.AA Pkinase 305-397 25 1.1e-15 56.52 Pfam 175-293 (293) Show / Hide
Range on Protein: 305-397
Range on HMM: 175-293/293
Sequence Identity: 25% (31 aa)

PLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEK------ANCNLITVIRHGNVQIPLTLS---------------------KSVRWLLLSL
| | |||..   ..| |...||||.|.||| || |. ||...          .|  |... .  .   .                     .. . .. ..
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LRKDYTERMTASHIFLTPWL
|.|| ..| || .|.  ||.
LCKDPKKRPTAEQILQHPWF

S_TKc trbl.AA S_TKc 129-397 19 1.2e-14 38.11 SMART 1-231 (231) Show / Hide
Range on Protein: 129-397
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

YRHLVDL----TASNLRCVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQ---ERDSTGGVTG
|. |  .     ..  .|... ||... . |..             ..   |..     .|| |   .|..    |. |.    ...   .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGD---------

VYENLHTYIRHAKR------LCETEARAIFHQICQTVQVCHRNGIILRDLKL-----------------KRFYFIDEARTKLQYESLEGSMILDGEDDTL
    |..||.. .|      . | .|| ...|||. .. ||..||| ||||                  ...                            
----LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL----------------------------

SDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFL-----
.  .| | | |||.|     | ....|.||.|.||| ||.|. ||.     .. .....         |.... ..  .|.|| ..|.||  ..      
TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--TPWL
   ||.
KCHPWF

Kinase trbl.AA MARK 225-267 44 3.4e-12 36.34 In-house 88-132 (262) Show / Hide
Range on Protein: 225-267
Range on HMM: 88-132/262
Sequence Identity: 44% (20 aa)

NLHTYIRHA--KRLCETEARAIFHQICQTVQVCHRNGIILRDLKL
.|. ||. .   ||.| |||.||.||.  |. ||...|. ||.|.
ELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP

Kinase trbl.AA CAMKL 226-267 41 1.2e-08 23.51 In-house 110-155 (297) Show / Hide
Range on Protein: 226-267
Range on HMM: 110-155/297
Sequence Identity: 41% (19 aa)

LHTYIRHA----KRLCETEARAIFHQICQTVQVCHRNGIILRDLKL
|. ||.      .|. | ||| .| ||.  |. ||..||. ||.|.
LFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKP

Kinase trbl.AA Ciliate-E2-Unclassified 225-267 24 3e-06 17.69 In-house 107-172 (352) Show / Hide
Range on Protein: 225-267
Range on HMM: 107-172/352
Sequence Identity: 24% (16 aa)

NLHTYIRH-----------------AKRLCETEAR-----AIFHQICQTVQVCHRNG-IILRDLKL
.|. ||..                  |.. | .|.      .| ||.|  . .|... || ||.|.
DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP

Kinase trbl.AA Ciliate-E2 225-267 22 1.6e-05 14.92 In-house 120-189 (365) Show / Hide
Range on Protein: 225-267
Range on HMM: 120-189/365
Sequence Identity: 22% (16 aa)

NLHTYIRHAKRLC-----------ETEARAIFHQICQ---------------TVQVCHRNG-IILRDLKL
.|  ||.. |  .           | |.. |. ||.|                .. .| .. || ||.|.
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP

Kinase trbl.AA Pkinase 226-267 34 1.8e-05 20.45 Pfam 91-136 (293) Show / Hide
Range on Protein: 226-267
Range on HMM: 91-136/293
Sequence Identity: 34% (16 aa)

LHTYIR--HAKRL--CETEARAIFHQICQTVQVCHRNGIILRDLKL
|..||.    ...   | |.. .. ||.. .. ||..||| ||||.
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP

Kinase trbl.AA ULK 225-267 36 0.000147 12.17 In-house 103-154 (324) Show / Hide
Range on Protein: 225-267
Range on HMM: 103-154/324
Sequence Identity: 36% (19 aa)

NLHTYIR---------HAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKL
.| .||            ||| | ||. .|.|||.  .  | ..|| ||.|.
DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKP

Kinase trbl.AA CAMKK 234-266 12 0.012193 3.7 In-house 150-223 (396) Show / Hide
Range on Protein: 234-266
Range on HMM: 150-223/396
Sequence Identity: 12% (9 aa)

KRLCETE---------------------ARAIFHQICQTVQVCH-RNG-------------------IILRDLK
. ..|..                     |. .| .... .. .|  ..                   || ||.|
SIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIK