Gene ALK (Mouse)

ALK

Species: Mouse
Alias: ALK, Alk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: ALK

Sequence

Name Sequence Type Origin Length Description Download
ALK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
ALK.NA RNA Sugen 5918 None Fasta, JSON
ALK.AA Protein Sugen 1621 None Fasta, JSON

Protein domain

Protein domains of ALK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LDLa ALK.AA LDLa 441-477 25 2.1e-05 22.57 SMART 1-47 (47) Show / Hide 
Range on Protein: 441-477
Range on HMM: 1-47/47
Sequence Identity: 25% (12 aa)

LQSS-----FTCWNGTVLQLGQACDFHQDCAQGEDEG-----QLCSK
  ..     |.| ||. . . . || . ||. |.||.     . |..
TCPPDHPNQFQCGNGRCIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ
MAM ALK.AA MAM 484-640 20 4.4e-24 89.41 Pfam 1-175 (175) Show / Hide 
Range on Protein: 484-640
Range on HMM: 1-175/175
Sequence Identity: 20% (38 aa)

CNF--ENG-FCGWTQSPLSPHMPRWQV------RTLRDAHSQGH------QGRALLLSTTDI-LASEGATVTSATF-PAPMKNSPCELRMSWLIRGVLR-
|.|  | | .|||||.. . .   |..      .|.    .. |      .|  ....|.    . . |  .| .| |...  . |.|.. . ..|    
CDFEDEDGNLCGWTQDWTDDF--DWTRQSGPTPHTHYTGPWMDHTHGGQCSGHYMYVETS-HQQEGQTARLLSPWFYPPRG--PHCCLQFWYHMYGSHVH

-GNVSLVLVENKTGKEQSRTVWHVATDEGLSLWQHTVLSLLDV-TDRFWLQIVTWWGPGSRATVGFDNISIS----LDCYL
 |  .... ||...... ...| .. . | . ||.. . |    ...|..... ..|.|.|  ...|.||.|     .| .
PGTLNVYVRENDNQGGWQTPLWSRSGNQG-NSWQQAHVTLNQFWPQPFQVVFEGVRGRGWRGDIAIDDISLSEGIMEPCPE
MAM ALK.AA MAM 479-640 13 0.000107 -29.59 SMART 1-192 (192) Show / Hide 
Range on Protein: 479-640
Range on HMM: 1-192/192
Sequence Identity: 13% (27 aa)

PAGFYCNFENG----FCGWTQSPLSP-HMPRWQVRTLRD---------AHSQGHQGRA-----LLLSTTDILA-SEGATVTSATFPAPMKNSPCELRMSW
. .. |.|| |    .||| |.  .     .|.. .  .          . ..| .       . . |..  .  . |.  | .....  .. . |. . 
TSCGNCDFEWGNDHTMCGWHQDWWDDTG-FHWEWVSSHTFNHYAMSHDGPHRDHTMGNGSGHYMYFETSMGKPGGQTARLISPPLYPN--RDQHCLQFWY

LIR---GVLRGN-VSLVLV-ENKTGKEQS--RTVWHVATDEGLSLWQHTVLSLLD--VTDRFWLQIVTWWG-PGSRATVGFDNISISLD----CYL
      |   |.  .. .  ||.... .    ..|..  . |   |..  ...     .  | .   .| |  ...  .. |.|... .    | .
HMYHRKGSHTGTKLCVYVRYENNHPQDMWNNCLIWNRHGHQGRQ-WHQAEVTIHTGFWQQPFQVVFEGWRGSQWHCGYIALDDINFWNHPHENCWK
Kinase ALK.AA ALK 1120-1389 75 3e-234 784.49 In-house 1-273 (273) Show / Hide 
Range on Protein: 1120-1389
Range on HMM: 1-273/273
Sequence Identity: 75% (206 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRP
|||.|.||||||||||.||.|.||.|..|.|||.|||||.||.|||.||.|||||..||||||.|||||...|..|..|.||.|.|||.||||||.||.|
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

N--QPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDI-YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDT
.  ||..|.| |||....|.|.||.|||||||||||||||||||||.|.||.|||.|||||||| |||.||||||.||.|||||||||||.||||||||.
ESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDV

WSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
||||||.||||||||||||...||||.||||.|||||||.|||.||||||||||||||||||.|..|||.|.|
WSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase ALK.AA Pkinase_Tyr 1120-1387 47 3.5e-143 485.56 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-270/270
Sequence Identity: 47% (131 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQD--ELDFLMEALIISKF-NHQNIVRCIGVSL-QALP--RFILLELMAGGDLKSFLR
||... ||.|||||||.|   |   |   ..||||.|.| .....    ||. || | ... .|.||||..|| . |  |   .| .|.|..|||...||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYY-RKGGCAMLPVKWMPPEAFMEGIFTS
. |   ... .| | |||. ...||.|..|||....||||.||||||.|.   ....||.|||.|||||  .|| ||.| ..||.|||.||....|.||.
KHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

KTDTWSFGVLLWEIFSLGYMP-YPSKSNQEVLEFV-TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
|.| ||||||.||||..| .| ||  ||.||.|..  .|.||..|.||| ..|..|.|||...||||| |. |.|..
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ALK.AA TyrKc 1120-1387 43 8.8e-143 481.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-280/280
Sequence Identity: 43% (132 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKF--NHQNIVRCIGVSLQA-------LPRFILLELMAGGDLKS
|||.. ||.|||||||.|. .        .|||||.| | .    . ||. || | .|.  .|.||||..|| .|         | .|..|.|..||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRA-------SYYRKGG--CAM--LPVKW
.||..||.      | | |||. . .||||..||.....||||.||||||.. ..   ..||.|||..||||         .|||| .  ..   ||..|
YLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-----KSNQEVLEFVTSGGRMDPPKN--------CPGPVYRIMTQCWQHQPEDRPNFAIILER
|.||....|.||.|.| |||||..||||..| .|||      .|||||.|.| .|.||..|.|        ||  .|.||.|||...|||||.|. | |.
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase ALK.AA TK 1120-1387 25 2.1e-119 402.13 In-house 1-486 (486) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

ITLIRGLGHGAFG---EVYEGQVSGMP--------------------NDPSPLQVAVKTLPEVCSEQDEL-------------DFLMEALIISKFN----
|||.. ||.|.||   |||.|.. |..                     .  . .||||.| | .....|              |||.||.......    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HQNIVRCIGVSLQA------------LPRFILLELMAGGD----LKSFLRETRPRPNQ-----------------------------------------
 |.||||..||..|              |  |..|.|..||    |...||. ||. ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------PTSLAMLDLLH-------------------VARDIACGCQYLEEN------HFIHRDIAARNCLLTCPGA--------GRIAKIGDFG----
        |..| . |||.                    ...||||..||...      .|.|||.||||||..  .         |...||.|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----MARDIYRASYYRKGG------------------------CAMLPVKWMPPEAFMEGI---------FTSKTDTWSFGVLLWEIFSLGYMPYPS-KS
    .|||||. ..|.. .                         ..||..||.||......         ||.|.| ||||||.||||..| .||.   |
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------QEVLEFVTSG--------------GRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPNFAIILERI
|         |||.|....|               || .|..||                .|..|.|||...|||||.|. ..|..
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ALK.AA Sev 1120-1387 45 8.70000000001e-115 383.9 In-house 1-277 (277) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-277/277
Sequence Identity: 45% (127 aa)

ITLIRGLGHGAFGEVYEGQVSGMP-NDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETR-P
 .| | || ||||||||||.         . .||.|||      |.   || || . |||.| |||  .|| |   | .| .|.| |||| ..||  | .
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

RPNQPT---SLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG--A--GRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIF
 .  |     |  .||.    ||. || |||. ||.||| |.|||| .     .   |. |||||| |||||   |||| |   ||| || ||  | |.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
|.  | |.||.| ||| .||  ||| .|| ||| .|  ||| ..| .||  .. .|.|||.  |..|| |  . . .
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase ALK.AA InsR 1120-1389 40 4.1e-103 347.2 In-house 1-278 (278) Show / Hide 
Range on Protein: 1120-1389
Range on HMM: 1-278/278
Sequence Identity: 40% (115 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPL--QVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRP
|.||| .| |.|| ||||   |.. |      ..|.||. |  |  . ..||.|| .  .||. ..||  ||  .  |  .  |.|. |||||.||  ||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

RPN-QPTSLA-------MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGI
    . . .          ...  | .|. |  ||. . |.||| |.|||.     .    |||||||.||||   ||||||  |||| ||.||   .|.
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVN---HDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV-TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
||.. | |||||.|||. .||  ||   || .||...   |. ..|| |||  .. .| .|||.|| .|| |  |.. .  
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase ALK.AA UTK 1120-1387 38 1.1e-101 344.09 In-house 1-296 (296) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-296/296
Sequence Identity: 38% (113 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELD----FLMEAL---IISKFN-HQNIVRCIGVSLQALPRFILLELMAGGDLKSF
. | | ||.||||||... .   ..    ..||||.. .  . |.| .    |..||    . ..|. |.|..| .|| .|  |  |..|.|..||| |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRETRPRPN-QPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG----AGRIAKIGDFG---MARDIY---------RASYYRKGGCAM
||  || |. .|..| . ..|. |.|||.| |||.. .|.|||.||||||..  .     ....||.|||   |.|...          . ||.. .  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LPVKWMPPEAFMEG-IFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGG--RMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
.|..|| |||. ..  ||.|.| |||||..|||.. | .|||  ||..|...|. ||  || .|. || ||||.|..||.  |..||.|  .....
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ALK.AA TK-Unique 1120-1387 35 5.2e-92 311.98 In-house 1-294 (294) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-294/294
Sequence Identity: 35% (106 aa)

ITLIRGLGHGAFGEVYEGQVSGMP-NDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN-HQNIVRCIGVSLQAL-PRFILLELMAGGDLKSFLRETR
... . .| ||||.|. |.|.| . ..  . .||||.| .  ...|. ||| |. . ..   |.|||.|.|..     | .|..| ...|.| ..||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-------------------PRPNQPTSLAMLDLLHVARDIACGCQYLEE--NHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIY-RASYYRKGGCAM
                   |. ...... . ||.| | .|||| .||..   ...|||..|||.|||    . ..||.|||||||.| .  | ....  .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQGR

LPVKWMPPEAFM--EGIF-TSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNC-PGPVYRIMTQCWQHQPEDRPNFAIILERI
.|..||.||..   .|.. |.|.| ||||||.||||.|| .|||. .. ...| .. | ||. |..| .  .| .| .|||. ||.||.|. |. |.
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ALK.AA Trk 1120-1387 40 1.6e-89 303.66 In-house 1-275 (275) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-275/275
Sequence Identity: 40% (112 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPR-
| |.. || |||| |. ..   ....  .. |||||| .    .   ||  || .  .  ||.||.  ||     | ..  | |  |||. .||   |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

----PNQP----TSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYR-ASYYRKGGCAMLPVKWMPPEAFMEGI
     .||    . | . ..|..|..|| |  |. . ||.|||.|.||||    |.. | ||||||| ||.|    ||| |.  |||. |||||. |   
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLV---GQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRK

FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGR-MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
||   | ||||| .||.|. |  |.   ||.|| |... |   .. |. ||  || ||  ||| .|. | |   | ..|
FTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase ALK.AA Fer 1120-1388 34 1.9e-86 293.54 In-house 1-283 (283) Show / Hide 
Range on Protein: 1120-1388
Range on HMM: 1-283/283
Sequence Identity: 34% (99 aa)

ITLIRGLGHGAFGEVYEGQ-----VSGMPNDPSPLQVAVKTL-PEVCSEQDELDFLMEALIISK-FNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFL
.||.  || ||||||| |.       |.  .. .. |.||..  |. ..    .|. || |. . ..| |.|...||. .  |  |..|.. ||.|.|.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAK---IGDFGMARD--IYRASYYRKGGCAMLPVKWMPPEAFME
...  .     .. . ...  . ..||| .||.... |||||||||||..   .. . |   | ||||.|.   |  .|. |    ..|..|..||..  
KKNKNK-----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYH---KDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQT

GIFTSKTDTWSFGVLLWEIFSLGYMPYPS----KSNQEV----LEF-VTSGGRMDPPKNCPGPVYRIMT-QCWQHQPEDRPNFAIILERIE
||...||| |||||..||||. |. |||       . .|     .  ...| .| .|...| ....||. ||||. |||||... | ....
GIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase ALK.AA Musk 1120-1387 38 2e-80 265.44 In-house 1-282 (282) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-282/282
Sequence Identity: 38% (109 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRP--
|  .| .| |||| |.     |.  .   . |||| | .  |.|   ||  || .. .| |.|||.  ||     |   |.| || |||  ||.   |  
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

---RPNQPTS------------LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPP
   |. |  .            |  ...| .|..||||  || |  |.|||.| ||||    .     || |||..| || . ||.  .    |. ||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLI---NEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPP

EAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
|. .   ||   | |..||.|||||| .  ||   .  ||. ..  | ..  | |||  || .| .||| .| ||| |. | . |
ESIWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase ALK.AA Src 1120-1387 40 3.9e-79 268.5 In-house 1-255 (255) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-255/255
Sequence Identity: 40% (109 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRP
|.|.| || | ||||..|   |        .|||||| .     .  .|| || |  |. |...|.   |  |  | .|  |.|. | |  .|..     
IKLCRKLGQGQFGEVWMGYWNGN------TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----D

NQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIY--RASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTW
 .  .| . .|.  |  .| | .|||.. .|||| |||| |    | . ..|..||| || |      |  . | |..|.||. |||. .| || |.| |
GEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLV---GENNVCKVADFGLARLIKEDDDEYCARHG-AKFPIKWTAPEAINYGRFTIKSDVW

SFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYR-IMTQCWQHQPEDRPNFAIILERI
|||.||.||.. | .|||  .|.|||. |  | ||  |.|||  .|  ||.|||. .||.|| |... .  
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ALK.AA S_TKc 1120-1390 22 1.8e-34 121.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 1120-1390
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAG--GDLKSFLRETRP
 ...| .|.||||.|| ..  .     .  .||.| ..         ... |  | .| .| |||....|       .. .|.. |  |||...... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

RPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS-KTDT
....   .   .  .... |.|. .|. ....||||.   | ||.        ||.|||.|| .                 .|.|| .    ..  | | 
HGLR-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE------RIEYC
||.|..|.| .. || |.|    |.... .            . ..  .. .|.|  ||.||    .|.        .. 
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ALK.AA Pkinase 1120-1387 21 3.7e-28 100.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1120-1387
Range on HMM: 1-293/293
Sequence Identity: 21% (66 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL---DFL-MEALIISKFNHQNIVRCIGVSLQALPRFIL--LELMAGG----DLK
....| .| |.||.||...  | .      .||||... . .| ..    ... .|. |  ..|| ||||....     .. |   .|.. ||    ||.
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF

SFLRETRPRPNQPTSL--AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIA---KIGDFGMARDI-YRASYYRKGGCAMLPVKWMPPE
....       . ...   . .. .... |..| .|. .. .||||.   |.|.     | |.   ||.||| |. . |  .   .. |  ..  .|.||
DYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW--YMAPE

AFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK----SNQEVLEFVTSGGRMDPPKNCP-----------------------GPVYRIMTQCWQHQPE
  .     ..| | ||.|..|.| .. |. |.|..    .  . .. .   .. ... ..|                        .   ... |..  |.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

DRPNFAIILER--I
.||... ||.   .
KRPTAEQILQHPWF