Gene ATM (Mouse)

ATM

Species: Mouse
Alias: ATM, Atm
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: ATM

Sequence

Name Sequence Type Origin Length Description Download
ATM.NA RNA Sugen 11964 None Fasta, JSON
ATM.AA Protein Sugen 3066 None Fasta, JSON
ATM.kin_dom Protein Kinase Domain None 304 None Fasta, JSON

Protein domain

Protein domains of ATM.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TAN ATM.AA TAN 5-166 20 6.4e-48 167.92 Pfam 1-168 (168) Show / Hide 
Range on Protein: 5-166
Range on HMM: 1-168/168
Sequence Identity: 20% (35 aa)

LNDLLI--CCRQLEHDRATERRKEVDKFKRLIQDPETVQHLDRHSDSKQGKYLNWDAVFRFLQKYIQKEMESL-RTAKSNVSATTQSSRQKKMQEISSLV
.....|  ||..|..|....| ...|...............  |..... . ..|...|..|...|.|| ..  | .... |. |..|............
MSTHDINKCCNLLQSDKIKDRNDALDNLEHILKSNPRNSQF--HHNRNRLNDKQWHKIFEALFRCIEKEKRKYCRNRNKKKSQSTANSSENRLSSCAYAL

RYFIKCANK--RAPRLKCQDLLNYVMDTVKDSS---NGLTYGADCSNILLKDILSVRKYWCEVSQQQWLE
|.|. |...  . .|...........||..|..       .. |.| .||...||....||. ...||. 
RLFVECGCHDIKFKRKHYMAIVDHITDTFPDPDSGSLCEPCSVDYSKCLLSTLLSYPPHWCHLMRHQWEH
FAT ATM.AA FAT 2102-2499 14 4.5e-70 234.87 Pfam 1-408 (408) Show / Hide 
Range on Protein: 2102-2499
Range on HMM: 1-408/408
Sequence Identity: 14% (63 aa)

QELRYQAAWRNMQWGL-C---------------------ASAGQEVEGTSYHESLYNALQCL--RNREFSTFYESLRYASLFRVKEVEELSK-GSLESVY
..| ..||||..|| . .                     ..  .|   .... |...|..||  . ..|.|. |  || .  |   ..|...  . || .
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDE---PTWDRSFFQAILCLYKHHNQFDTY-EAHRYIDKARQLLDTEWTACLPGESYN

SLYPTLSRLQAIGELENSGELFSRSVT---------DRERSEAYWKWQKHSQLLKDSDFSFQEPLMALRTVILETLVQKEMERSQGACSKDILTKHLVEF
. ||.. |.|.. ||| . . .|. ..           .. .  . |.|. .  | ............|........|..| .|. .. .  ....  .|
RHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM-NSFCYRGPHEDMWMWIKF

SVLARTFKNTQLPERAIFKIKQYNSAICG-----ISEWHLEEAQVFWAKKEQSLALSILKQMIKKLDSSFKDKENDAGLKVIYAECLRVCGSWLAETCLE
. |.|   ..|| |...... .|... ..     ...|. .... .||...|  |...|......  ..  . .|.. ..  ...               
ANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTY---------------

NPAVIMQTYLEKAVKVAGSYDGNSRELRNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQTLLKRAKEEVGLLREHKI-QTNRYTVKVQRELELDECA
           .. ... ......    .. |.... .... . .|  .|.||. ...|.|.  |.  .. ... ...   . ... ..  .......|.
-----------NLEVINNTNLEYFYTKLLA-MRCYHKQGMWQWKLY--EEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQ

LRALRE----DRKRFLCKAVENYINCLLSGEE--HDLWVFRLCS
 .....    ........||.... .. ....  .. . .||..
PQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Kinase ATM.AA ATM 2723-3026 92 8.8e-283 914.41 In-house 1-304 (304) Show / Hide 
Range on Protein: 2723-3026
Range on HMM: 1-304/304
Sequence Identity: 92% (281 aa)

RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSEDGAHRRYRPNDFSANQCQKKMMEVQKKS
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||...|.| |||||.||||||||| |||||||||||||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNEDGAHKRYRPNDFSAFQCQKKMMEVQKKS

FEEKYDTFMTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSR
|||||. || .|||| |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| |
FEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTR

DIVDGMGITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESDLHSTPNADDQECKQSLSDTDQSFNKVAERVLMR
||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| .|| | ||||||||  ||| ||||||||||||||
DIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMR

LQEK
||||
LQEK
Kinase ATM.AA PIKK 2692-2962 41 8.49999999999e-137 460.76 In-house 1-290 (290) Show / Hide 
Range on Protein: 2692-2962
Range on HMM: 1-290/290
Sequence Identity: 41% (121 aa)

TIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLV
 |...         .  || |   |.|||| ..|.||..|||||....|.||..||.||...|..||.|.|.||.|.|.|||.|..||....|...| ..
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

NSEDGAHRRYRPNDFS-----------------ANQCQKKMMEVQKKSFEEKYDTFMTICQN-FEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVG
. ....| |.......                 ..|.|...|..|.....||.  |. ..|| . ..|......||.||. |.|.| .||||.|....||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHVQNILINEQSAELVHIDLGVAFE-QGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVL
|||||||||..||.|..|..|.||||.|..|| ....||.||.||||| |..|..||..|||||||||||..|..||...|||.|..||.
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase ATM.AA PI3Kc 2723-3026 27 7.2e-120 405.44 SMART 1-336 (336) Show / Hide 
Range on Protein: 2723-3026
Range on HMM: 1-336/336
Sequence Identity: 27% (91 aa)

RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSEDGAH--------------------RRYR
. ..|..||||||. |.|.|...|...|...|.|.|.|....||..|.....|..||.. .... . ...... ..                    ..| 
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY-

PNDFSANQCQKKMMEVQKKSFEEKYDTFMTICQNFEPVFRYFCMEKFLDP-AVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG
........|...||. .....|.........|....||.. ...|.| ||  .|.| |  .|||.|  ..|.||||.|||| .||.. ... ...|||.|
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

VAFEQGKILPTP-----ETVPFRLSRDIVDGMG----ITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPL-FDWTMNPLKALYLQQRPEDE--SD
 .|..|. .|..     |.||||| .|.|..||    ..|..| ||.||......||..........|...|||. ..|.|.. .  ||.|| . .  ||
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSD

LHSTPNADDQECKQSLSDTDQSFNKVAERVLMRLQEK
 .... .....|.. ......|... .  ....... 
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase ATM.AA PI3_PI4_kinase 2721-2972 18 2.8e-62 218.03 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2721-2972
Range on HMM: 1-300/300
Sequence Identity: 18% (64 aa)

ERRQLVKGRDDLR--QDAVMQQVF-----------------------QMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSED
. ....|| ||||  ||. | | .                       ...|.... . ..|.|.... .|...|.. ..|..|                 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIE-----------------

GAHRRYRPNDFSANQCQKKMMEVQKKSFEEKYDTFMTICQNF--------------------------------------------EPVFRYFCMEKFLD
                           . . ..||..|  ..                                            .  ...| .... |
---------------------------WVPNCTTFHEIPRTYMVKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWF-WKHNPD

P-AVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILI--NEQSAELVHIDLGVAFE--QGKILPTPETVPFRLSR------DIVDGM------GITGVE
.   |.| |  ..||.|  ..|.||||.||||  ||..  .. . .|.||| | .|.  ..| .. ||.||||. .      ..|..|      . .| .
AYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDY

GVFRRCCEKTMEVMRSSQETLLTIV-------EVLLYDPLFDWTM
| ||..|.......|. .. ...         | ...|.|..|..
GWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase ATM.AA ATR 2691-2962 31 3.2e-59 200.29 In-house 1-267 (267) Show / Hide 
Range on Protein: 2691-2962
Range on HMM: 1-267/267
Sequence Identity: 31% (86 aa)

VTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYL
  |  |     .   |  || |   |||||    . | .||||.|   ... .. | ....  | |.| . . || |.|| ......||   |. .   |
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

VNSEDGAHRRYRPNDFSANQCQ-KKMMEVQKKSFEEKYDTF-MTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILI
        . ..     .   | .. |. . .   ||   |   .     |.|. .   .|.||  |.  | .| || |  ..||||.|||||| .||||
-------DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILI

NEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVL
..   |.||.|  . | .|. .  ||.||||| . .| |||  . .|.||| || .| .||  .. .. ...  
DKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase ATM.AA FRAP 2854-2972 46 1.4e-40 141.1 In-house 132-251 (251) Show / Hide 
Range on Protein: 2854-2972
Range on HMM: 132-251/251
Sequence Identity: 46% (56 aa)

VWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQ
.|||.|  |||| || |..||||||||||  ||... ..  .|||| |  ||   .    || .|||| | .|  | ..|.|| .|  ||  |.|.|   
IWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHK

ETLLTIVEVLLYDPLFDWTM
| .. . |   ||||| | .
ESVMAVLEAFVYDPLFYWRL
Kinase ATM.AA DNAPK 2871-2972 33 1.4e-21 75.17 In-house 199-301 (301) Show / Hide 
Range on Protein: 2871-2972
Range on HMM: 199-301/301
Sequence Identity: 33% (34 aa)

IVGYILGLGDRHVQNILINEQSAELVHIDLGVAFE-QGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFD
| ..||| ||||  | ..|    . . || | .|   .  || ||  |||| |  .  |   .. |...      |  .|.    |.  ..|   ||.||
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD

WTM
|  
WKN
Kinase ATM.AA SMG1 2852-2914 50 3.5e-20 63.44 In-house 180-242 (242) Show / Hide 
Range on Protein: 2852-2914
Range on HMM: 180-242/242
Sequence Identity: 50% (32 aa)

PAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPE
|  |.    .| || |  |.||||.||||||. |.||     | ||||  . ||.|| |  ||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase ATM.AA FRAP 2721-2779 42 1e-16 58.06 In-house 1-59 (251) Show / Hide 
Range on Protein: 2721-2779
Range on HMM: 1-59/251
Sequence Identity: 42% (25 aa)

ERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
|   | ||..|.|||    | | . |.||. |.||.|. | |  | ..||| ..| . |
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGW
Kinase ATM.AA DNAPK 2691-2792 33 4.1e-14 47.61 In-house 2-103 (301) Show / Hide 
Range on Protein: 2691-2792
Range on HMM: 2-103/301
Sequence Identity: 33% (34 aa)

VTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYL
| |  |         |  || |   | | .|   ..||  |||||    | ||  |  .        | |   || ..|.  | | .||   ||   . |
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL

VN
 |
NN
Kinase ATM.AA SMG1 2709-2786 33 2e-06 17.25 In-house 10-87 (242) Show / Hide 
Range on Protein: 2709-2786
Range on HMM: 10-87/242
Sequence Identity: 33% (26 aa)

PKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPI
|| .  .|||||    | || .||  |  . |   . ||.          .     | | ||  |||.. |  |  |.
PKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL
FATC ATM.AA FATC 3034-3066 48 1.6e-16 56.0 Pfam 1-33 (33) Show / Hide 
Range on Protein: 3034-3066
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

TVLSVGGQVNLLIQQAMDPKNLSRLFPGWKAWV
. ||| .||. |||.|.||.||.....|| .|.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW