BUB1

Species: Mouse
Alias: Bub1, BUB1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: BUB

Sequence

Name Sequence Type Origin Length Description Download
BUB1.NA RNA Sugen 3382 None Fasta, JSON
BUB1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
BUB1.AA Protein Sugen 1059 None Fasta, JSON

Protein domain

Protein domains of BUB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Mad3_BUB1_I BUB1.AA Mad3_BUB1_I 4-126 38 2.9e-61 214.65 Pfam 1-134 (134) Show / Hide
Range on Protein: 4-126
Range on HMM: 1-134/134
Sequence Identity: 38% (51 aa)

LENVFRMFEAHMQSYT---GNDPLGEWESFIKWVEENFPD----NKEYLMTLLEHLMKEFLHKKNYHNDSRFINYCLKFAEYNS----DRHQFFEFLYNQ
|... ..||...|.|.   |.|||. |  .|||.||..|     ....|.||||...|.|.| . |.||.|.....|....| .    . ...|...|||
LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQGGGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNNFDEPRDIFQYMYNQ

GIGTKSSYIYMSWAGHLEAQGELQHASAIFQTGI
|||||... |..|| .||..|..|.|...|| ||
GIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI

Mad3_BUB1_I BUB1.AA Mad3_BUB1_I 4-126 33 4.6e-50 173.56 SMART 1-133 (133) Show / Hide
Range on Protein: 4-126
Range on HMM: 1-133/133
Sequence Identity: 33% (44 aa)

LENVFRMFEAHM--QSYTGNDPLGEWESFIKWVEENFPD----NKEYLMTLLEHLMKEFLHKKNYHNDSRFINYCLKFAEYN----SDRHQFFEFLYNQG
||.. ..||...  .|| |.|||  |  .|||.|.|.|      .. | ||||.....|.. . |.|| |...........     .. ...|...|..|
LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCYNYFDEPREIFQYMYRHG

IGTKSSYIYMSWAGHLEAQGELQHASAIFQTGI
|||...  | .|| ..|..|..|.|..|.| ||
IGTQCALFYEEWAQWYENMGNYQKADEIYQLGI

Kinase BUB1.AA BUB 762-1028 43 4.6e-168 564.64 In-house 1-311 (311) Show / Hide
Range on Protein: 762-1028
Range on HMM: 1-311/311
Sequence Identity: 43% (134 aa)

VYVNHLLGEGAFAQVFEAIHGDVRNA--------KSEQKCILKVQRPANSWEFYIGMQLMERLKP----EVHHMFIKFYSAHLFKNGSILVGELY-SYGT
.......|||..|.|..|.|.|....        ||......|||.|.|.|||||..|..||||.    ..|..|....|.|.....|....|.. .|||
FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGT

LLNVINLYK---NTSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLE-QADED-LATG-------LALIDLGQSIDMKLFPKGTVF
||.|||..|   ....|||.. .|..|...||.|||..|.|||||||||||||.|..|... . ... ...|       |.|||.|.||||.|||.|..|
LLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQRF

TGKCETSG--FQCPEML----SNKPWNYQIDYFGVAATIYCMLFGSYMKVK--NEGGVWKPEGLFRRLPHLD-------MWEEFFHIMLN----IPDCHN
...|||..  |.|.||.    .|.||.||.||||.|||..|||||.||.||  ..|..||.|..|||....|       ||..|||.|||    ||||..
KFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQT

LPSLDFLRQNM
||....|||..
LPMWHELRQQF

Kinase BUB1.AA Ciliate-E2 762-977 18 1.8e-16 53.07 In-house 1-294 (365) Show / Hide
Range on Protein: 762-977
Range on HMM: 1-294/365
Sequence Identity: 18% (57 aa)

VYVNHLLGEGAFAQVFEAIHGDVRN--AKSEQKCILKVQRP-----ANSWEFYIGMQ---LMERLKPEVHHM-----------------------FIKFY
  .. ..|.|.|..|... .  |..  |.  ..  .. ||.     ... .... ..     | .| | | |                        ||.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

SAHL--FKNGSILVGELYSYGTLLNVI-NLYKNTSEK-----VMPQALVLTFAIRMLY---------------MVEQVHSCE-IIHGDIKPDNFILGHRF
 .     .|   || |....|.|.  | | .|.  ..      .    ....    |.                .|  ||   ||| ||||.| ..    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

LEQADEDLATGLALIDLGQSID-------------MKLFPKGT-----------------VFTGKCETSGFQCPEMLSNKP---------WNYQIDYFGV
           . .||.| | .             .|...                    .|   | | |...||.|..|.         ..|..|.. .
-----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

AATIYCMLFGSY
  ..|.|||| .
GVILYEMLFGKP

Kinase BUB1.AA S_TKc 762-1048 15 2.9e-12 2.83 SMART 1-231 (231) Show / Hide
Range on Protein: 762-1048
Range on HMM: 1-231/231
Sequence Identity: 15% (46 aa)

VYVNHLLGEGAFAQVFEAIHGDVRNAKSEQKCILKVQRPANSWEFYIGMQLMERLKPEVHHMFIKFYSAHLFKNGSILVGELYSY--GTLLNVINLYKN-
  .  ..|.|||..|. ..| .     . ... .|. .      ..  .|....     |   .|.| .    .   .| |. .   |.|. .|  ..  
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

TSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQADEDLATGLALIDLGQSIDMKLFPKGTVFTGKCETSGFQCPEMLSNKPWNY
   ...|   .  ..  ..  .|  ||  ||| |.||.|  | .             . ..| | .  .         |  | |  .  ||.|   ....
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGK

-QIDYFGVAATIYCMLFGSYMKVKNEGGVWKPEGLFRRLPHLDMWEEFFHIMLNIPDCHNLPSLDFLRQNMKKLLEQQYS---NKIKTLR-------NRL
  .|   .  ..| || |             .. .|...                       | ...   ..|.|.   .      . |.          
CKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG----------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

I
.
F

Kinase BUB1.AA CK1 873-901 58 1.7e-09 29.4 In-house 138-166 (339) Show / Hide
Range on Protein: 873-901
Range on HMM: 138-166/339
Sequence Identity: 58% (17 aa)

AIRMLYMVEQVHSCEIIHGDIKPDNFILG
||.||. .|..|.| .|| ||||||| .|
AIQMLEALEYMHDCGFIHRDIKPDNFCMG

Kinase BUB1.AA CK1-Unclassified 876-901 50 2.8e-08 20.55 In-house 113-138 (244) Show / Hide
Range on Protein: 876-901
Range on HMM: 113-138/244
Sequence Identity: 50% (13 aa)

MLYMVEQVHSCEIIHGDIKPDNFILG
|.  .|..|.. .|| |||||||  |
MIQRIEYLHNKNFIHRDIKPDNFLMG

Kinase BUB1.AA CK1 876-922 36 3.4e-08 24.51 In-house 114-154 (271) Show / Hide
Range on Protein: 876-922
Range on HMM: 114-154/271
Sequence Identity: 36% (17 aa)

MLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQADEDLATGLALIDLG
|.  .| ||.. .|| |||||||  |        .  .. . .|| |
MIQRIEYVHNKNFIHRDIKPDNFLMGR------YGKHCHQVYIIDFG

Kinase BUB1.AA CK1-G 869-901 48 6.1e-08 22.91 In-house 98-130 (266) Show / Hide
Range on Protein: 869-901
Range on HMM: 98-130/266
Sequence Identity: 48% (16 aa)

VLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILG
|.  || |.  .|.||| . | .|.|||||  |
VCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIG

Kinase BUB1.AA CK1-D 869-901 48 1.6e-07 22.48 In-house 97-129 (261) Show / Hide
Range on Protein: 869-901
Range on HMM: 97-129/261
Sequence Identity: 48% (16 aa)

VLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILG
||  |  |.  .| .|. . || |||||||..|
VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMG

Kinase BUB1.AA Ciliate-E1 768-897 18 2e-06 17.81 In-house 1-139 (202) Show / Hide
Range on Protein: 768-897
Range on HMM: 1-139/202
Sequence Identity: 18% (27 aa)

LGEGAFAQVFEAIHGDVRNAKSEQKCILKVQRPANSW------EFYIGMQLMERLKPEVHHMFIKFYSAHLFKNGSILVGELYSYGTLLNVIN-------
.|.| |..||.|.    .| . .|.... ...  |.       | .   ..|. .| |     |  |  . . ...|.. |.... .|.. ..       
IGNGSFSIVFKAKQ---QNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCC-SLKDYLQNHNRLEY

-LYKNTSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDN
   ... .. . .  ..  .....  ....|.. |||.||||.|
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQN

Kinase BUB1.AA TTBKL 873-901 44 8e-06 15.76 In-house 108-136 (288) Show / Hide
Range on Protein: 873-901
Range on HMM: 108-136/288
Sequence Identity: 44% (13 aa)

AIRMLYMVEQVHSCEIIHGDIKPDNFILG
.|. || . |.|.| .|| |.|| |. .|
GIQCLYALKQMHDCGFIHRDVKPCNCCWG

Kinase BUB1.AA CAMK 767-781 46 3.6e-05 11.81 In-house 1-15 (425) Show / Hide
Range on Protein: 767-781
Range on HMM: 1-15/425
Sequence Identity: 46% (7 aa)

LLGEGAFAQVFEAIH
 ||.|.|..|...||
TLGRGSFGKVKLCIH

Kinase BUB1.AA CAMK 884-977 17 0.001343 6.67 In-house 196-332 (425) Show / Hide
Range on Protein: 884-977
Range on HMM: 196-332/425
Sequence Identity: 17% (24 aa)

HSCEIIHGDIKPDNFILGHRFLEQA--------DEDLATG-LALIDLGQSIDMKL---------------------FPKGTVFTGKCETSGFQC-PEMLS
||. |.| |.||.|  | ... ..         |  . .. . .|| | .. ..                      . .|  ..  | | .. . ||.|.
HSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD--WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

N--------------KPWNYQIDYFGVAATIYCMLFGSY
               .. ....|   .    | || | .
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP

Kinase BUB1.AA TTBKL 764-780 35 0.006277 5.81 In-house 3-19 (288) Show / Hide
Range on Protein: 764-780
Range on HMM: 3-19/288
Sequence Identity: 35% (6 aa)

VNHLLGEGAFAQVFEAI
. ...|||.|.||....
IVKMIGEGGFGQVYHVW

Kinase BUB1.AA CK1 762-797 23 0.01566 4.75 In-house 1-42 (339) Show / Hide
Range on Protein: 762-797
Range on HMM: 1-42/339
Sequence Identity: 23% (10 aa)

VYVNHLLGEGAFA-QVFEAIHGDVRNAKSE-----QKCILKV
  | ...|||.|  |.....  |... |.      ... .||
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKV

Kinase BUB1.AA Ciliate-E1 939-963 24 0.047059 3.05 In-house 170-202 (202) Show / Hide
Range on Protein: 939-963
Range on HMM: 170-202/202
Sequence Identity: 24% (8 aa)

KCETSGFQCPEMLS--------NKPWNYQIDYF
|..|. ...|| .         |...||. | .
KGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY