Gene CYGF (Mouse)

CYGF

Species: Mouse
Alias: CYGF
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
CYGF.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 280 Kinase domain by global Sugen HMM Fasta, JSON
CYGF.AA Protein Sugen 1108 None Fasta, JSON
CYGF.NA RNA Sugen 3572 None Fasta, JSON

Protein domain

Protein domains of CYGF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor CYGF.AA ANF_receptor 71-412 20 3.7e-74 257.47 Pfam 1-364 (364) Show / Hide 
Range on Protein: 71-412
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

LPEVAAALAIERISRDKT-FDRSYSFEYVILNE----DCQTSKALASFISHQQMASGFVGPANPGFCEAASLLGTSWDKGIFSWACVNHELDN--KHSFP
 .. |. .|||.| .| . ... ....|.....    || .  |.| .  | ... ...|| ... |.... . . |.. ..||.| . .|..  | ..|
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

TFSRTLPSPIRV-LVTVMKY----FQWAHAGVISSDEDI--WMHT---ANRVSSALRSQGLPVGVV---LTSGRDSQSIQKALQQIRQ--ADRIRIIIMC
.| ||.||.  .   .....    |.|.. .|| .|.|   | ..   .... ..||. |...  .    .  .........| .|..  ... |.|.||
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVMC

MHSALIGGETQTHFLELAHDLKMTDGTYVFVPYDVLLYSLPYKHSPYQVLRNNPKLREAYDAVLTITVESHEKTFYEAYAEAAARGEIPEKPDSNQVSPL
......| . |  ... ||.| |..| ||....| ...|...  ..| .. .|.|.|||...||..|.     .... . . . .       .. .... 
CYPDDMG-LLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-WWYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK-------TDTEMNYY

FGTIYNSIYFIAQAMNNAMKKNGRASAAS----------LVQHSRN-MQFYGFNQLIKTDS-NGNG-ISEYVILDTN
....|...| .|.|..|. .... .....          |... .| ..| |. . .. |. .|.   . |.|....
AAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase CYGF.AA RGC 567-811 37 1.3e-123 416.91 In-house 1-300 (300) Show / Hide 
Range on Protein: 567-811
Range on HMM: 1-300/300
Sequence Identity: 37% (113 aa)

EGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSG------MFAIVSEFCSRRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKY
||||||.||.. ..... . .. |. . . .|..|.|.|.|. .| . |.       ...||.|.||| ||.||| |||.|.|||||.|.. |..||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHHREF-IHGRLKSRNCVVDGRFVLKVTDYGF-----NDILEM-------------LRLSEEEPSEEELLWTAPELLRAP---------GGIRLGSFAGD
|||...  ||.|||.|||||.|.|.|.||.|.     .   ..             .| ..|.|.....||||||.||..         .....|...||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFAIIMQEVMVRGA-----PFCMM----DLPAKEIIDRLKMPPP-----VYRPVVSPE------YAPAECLQLMKQCWAEASEQRPT-FDEIFNQFKT
||||.|||.|...|.      ||||.    .|  .|||...| ||.     ..|| ....       .. ..|.||..||||  |.||. || |..|.||
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CYGF.AA RGC 567-811 37 1.3e-123 416.91 In-house 1-300 (300) Show / Hide 
Range on Protein: 567-811
Range on HMM: 1-300/300
Sequence Identity: 37% (113 aa)

EGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSG------MFAIVSEFCSRRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKY
||||||.||.. ..... . .. |. . . .|..|.|.|.|. .| . |.       ...||.|.||| ||.||| |||.|.|||||.|.. |..||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHHREF-IHGRLKSRNCVVDGRFVLKVTDYGF-----NDILEM-------------LRLSEEEPSEEELLWTAPELLRAP---------GGIRLGSFAGD
|||...  ||.|||.|||||.|.|.|.||.|.     .   ..             .| ..|.|.....||||||.||..         .....|...||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFAIIMQEVMVRGA-----PFCMM----DLPAKEIIDRLKMPPP-----VYRPVVSPE------YAPAECLQLMKQCWAEASEQRPT-FDEIFNQFKT
||||.|||.|...|.      ||||.    .|  .|||...| ||.     ..|| ....       .. ..|.||..||||  |.||. || |..|.||
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CYGF.AA TKL 597-809 21 4.5e-35 122.83 In-house 78-364 (364) Show / Hide 
Range on Protein: 597-809
Range on HMM: 78-364/364
Sequence Identity: 21% (65 aa)

MMKDLRHENVNPLLGFFYDSGM-------------FAIVSEFCSRRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKYLHHRE--------FIHGRLKSRN
||. |||.|. ...|.  ...              ..|| |.|.. ||...|.       |  . .. ||  .|| ||| ..         ||  |||.|
MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

CVVDGRFV--------------LKVTDYGFNDILEMLR----------------LSEEEPSEE--ELLWTAPELLRAPGGIRLGSFAG------------
. ||  .               .|..|.|.   ...                  ....  . .   . | |||.||  | . . . .|            
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLR--GQMNYTEKVGIDEFCKGFEYSE

--DVYSFAIIMQEVMVRGAPF----CMMDLPA-------KEIIDRLKMPPP------VYRPVVSPEYAPAECLQLMKQCWAEASEQRPTFDEIFNQF
  |||||.|.. |.. |  |.    .|. ...       . ..|. . ||.      ... .. ....| .  .||..||..  |.||.|.||  ..
KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK-MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CYGF.AA TKL-Unique 598-809 28 2.6e-28 97.01 In-house 49-290 (290) Show / Hide 
Range on Protein: 598-809
Range on HMM: 49-290/290
Sequence Identity: 28% (72 aa)

MKDLR-HENVNPLLGFFY----DSGMFAIVSEFCSRRSLEDILT---------NDDVKLDWMFKSSLLLDLIKGMKYLHHRE--FIHGRLKSRNCVVDGR
|| |. |.|.  . |.      . . . ||.|.|.. || | |.         |.  ||..  . .. .|  .|| ||||.|   ||. |||.|  || .
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN

-----FVLKVTDYGFNDILE-MLRLSEEEPS-------EEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGA------PFCMMDLP-AKEII
     .  |. | |.  ..  ... .  |..       . ...| |||.|| .    . |   |||||.|.. |   |        |.  ||    .|..
SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMV

DR--LKMPPPVYRPVVSPEYAPAECLQLMKQCWAEASEQRPTFDEIFNQF
.    . .||.      |.  | |   |..|||.  ..|||.|||| .  
HYMEENYRPPI------PNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase CYGF.AA TK 584-809 15 3.5e-26 84.15 In-house 57-486 (486) Show / Hide 
Range on Protein: 584-809
Range on HMM: 57-486/486
Sequence Identity: 15% (66 aa)

IKSIK----SSASDVFE-----------------MMKDLR-----HENVNPLLG-------------FFYDSGMFAIVSEFCSRRS----LEDILTNDDV
.| .|    .|. . |.                 .|| ..     |.|.  |.|             .  ... . || |...  .    | | | . . 
VKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRP

K---------------------------------------------------------------------------LDWMFKSSLLLDLIKGMKYLHHR-
|                                                                           |.   .    ... .|| ||| . 
KFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKN

-----EFIHGRLKSRNCVVDGRFV-----------LKVTDYGFNDILE--MLRLSEEEPSEEELL-------------------------------WTAP
      |.|. |  ||| |. . |            |..|.|  .  .  . |  ...                                      |.||
CEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAP

ELLRAPGG-----IRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLPA---------KEIIDRLKM------------------PPPVYRP-------VVS
| |.          .  . . ||.|| . | |.. .|.     ...          .|....|..                  |.|.. |          
ECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMH-P

PEYAPAECLQLMKQCWAEASEQRPTFDEIFNQF
|. .|.|  .||.|||..  |.||||... .|.
PHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CYGF.AA Abl 597-809 29 1.7e-23 74.84 In-house 48-252 (252) Show / Hide 
Range on Protein: 597-809
Range on HMM: 48-252/252
Sequence Identity: 29% (64 aa)

MMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDIL-TNDDVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNDIL
.||...|.|.  |||       | |. || .   | | |  .|  .|. .    .   .  ||.|| .|.|||  |  |||.|    ..|| |.|   ..
IMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMM

EMLRLSEEEPSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRG-APFCMMDLPAKEIIDRLKMPPPVYRPVVSPEYAPAECLQLMKQCWAE
.      .      . ||||| |         |   ||. | ... |.   | .|.  .||  ... ..|      || .  ||  | .  .||.|||  
KDDTYTAHAGAKFPIKWTAPESL----AYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDL--SHVYHKLEK---GYR-MERPEGCPPKVYELMRQCWQW

ASEQRPTFDEIFNQF
    ||.| || ...
SHTDRPSFKEIHHAM
Kinase CYGF.AA TK-Unique 656-809 25 3.9e-23 76.69 In-house 142-294 (294) Show / Hide 
Range on Protein: 656-809
Range on HMM: 142-294/294
Sequence Identity: 25% (43 aa)

KGMKYLHH--REFIHGRLKSRNCVVDGRFVLKVTDYGFND------ILEMLRLSEEEPSEEELLWTAPELLR-APGGIRLGSF---AGDVYSFAIIMQEV
.||.||.   ....|..| .||. . ...|.|..|.|. .       ..| . ... |    . | ||| |. .      | .    .||.||...| |.
CGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP----IRWMAPESLKCY-----HGMYHTTKSDVWSFGVLMWEI

MVRGAPFCMMDLPAKEIIDRLKMPPPVYRPVVSPEYAPAECLQLMKQCWAEASEQRPTFDEIFNQF
.  || .   ..|.|.   ......  ||. . ..... |. .|||.|| .  |.||.|..| ...
FTLGA-CPYPGMPWKD---IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase CYGF.AA RIPK 596-809 25 6.1e-23 74.99 In-house 48-290 (290) Show / Hide 
Range on Protein: 596-809
Range on HMM: 48-290/290
Sequence Identity: 25% (62 aa)

EMMKDLRHENVNPLLGFFYDS------GMFAIVSEFCSRRSLEDILTNDDVK----LDWMFKSSLLLDLIKGMKYLHHRE--FIHGRLKSRNCVVDGRFV
..|. ||.|.. |..||  .       ....|| |.    ||.. |.    .    . |  .  ..   . || |||      ||  ||  |  ||. | 
KHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFH

LKVTDYGFNDILEMLRLSEEEP---------SEEE---LLWTAPELLR--APGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLPAKEIIDRLKMPPP
 |. | |    ...  .  ..          | ..   |   .||..|   .  |.  . . |||||||.| ||. .  |.    ..   ..   .   |
VKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRP

VYRPVVSPEYAP-----AECLQLMKQCWAEASEQRPTFDEIFNQF
   ||  ||| |     ..  .||..||. ....||.| |.  ..
CLQPV--PEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase CYGF.AA Src-Echino1 596-809 26 1.4e-19 64.15 In-house 46-252 (252) Show / Hide 
Range on Protein: 596-809
Range on HMM: 46-252/252
Sequence Identity: 26% (57 aa)

EMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTNDDVK-LDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNDI
..|| .|||..  .     |.    || |  |. .|.| | ... | .       .  ..  || ||  ....|  |  || .|.   | |. |.|   .
NVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARM

LEMLRLSEEEPSEEELLWTAPELLRAPGGIRLGSFA--GDVYSFAIIMQEVMV-RGAPFCMMDLPAKEIIDRLKMPPPVYRPVVSPEYAPAECLQL-MKQ
..      ..     . |||||       .  |.|    ||.|| |.| |..   . |.  |   ..|..|...     || .  ..  |    .. | .
MQKDVYCGKQGAKLPIKWTAPEA------ALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGMM--NREVLDQVDR---GYR-MPKMHHCPDSLYMMCMMK

CWAEASEQRPTFDEIFNQF
||   . |||||. . . |
CWHKDPQQRPTFEFLHDFF
Kinase CYGF.AA DRK 596-690 35 1.4e-14 45.88 In-house 49-145 (258) Show / Hide 
Range on Protein: 596-690
Range on HMM: 49-145/258
Sequence Identity: 35% (34 aa)

EMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKYLHHRE--FIHGRLKSRNCVVDGRFVLKVTDYG
..|. ||| |.   .|    .    |. |. .| ||  || .. ...||    .. .|  ||| ||| ..   ||  ||| |  ||  .  || |.|
NLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFG
TyrKc CYGF.AA TyrKc 558-809 24 5.3e-14 3.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 558-809
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

YENSNI-------AIYEGDWVWLKKFPPGDFGD--IKSIKSSASDVFE------MMKDL--RHENVNPLLGFFYDS-------GMFAIVSEFCSRRSLED
 .   .        .|.| |            .  .|..|..|  . .      .|. |  .|.|.  |.|   ..       .   || |...  .| |
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILTNDDVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNDIL----------EMLRLSEEEPSE--EELLWTAPELLRAP
 | .   || .  . |  ..  .|| |||.. .||  |  ||| |. ... |..| |    .          .. | .|.. .     . |.||| .   
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

GGIRLG--SFAGDVYSFAIIMQEVMVRGAPFCMMD----LPAKEII------DRLKMPPPVYRPVVSPEY----APAECLQLMKQCWAEASEQRPTFDEI
   . |  ... ||.|| . | |.. .|..    .    ....|.|      .|.. || .|     |      .|.|  |.|||||.|  |.|||| ||
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-----P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

FNQF
  .|
HECF
S_TKc CYGF.AA S_TKc 532-810 15 3.8e-13 15.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 532-810
Range on HMM: 1-231/231
Sequence Identity: 15% (47 aa)

FQII--------SEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVS
..|.        ..|  .|  .                      |  | .|. .            ..    ...|  .|.|.  |...|.| . . .| 
YEILRKIGKGAFGKVYKCRHKK---------------------TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVM

EFCSR--RSLEDILTNDDVK-----LDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEEPSEEELL----W
|.|.    .| |.. .   .     ..     ...  ......|.| . .||  ||  |  .|   ..|..| |.  .|              .     .
EYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWY

TAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLPAKEIIDRLKMPPPVYRPVVSPEYAPAECLQLMKQCWAEASEQRPTFDEIFN-----
 |||.|        | .. |..|. .|. | ...  ||.      ........               . |.......|.    |.|||  |...     
MAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

---QFK
   .. 
KCHPWF
Kinase CYGF.AA DRK 732-811 32 1.5e-10 31.98 In-house 184-258 (258) Show / Hide 
Range on Protein: 732-811
Range on HMM: 184-258/258
Sequence Identity: 32% (27 aa)

DVYSFAIIMQEVMVRGAPFCMMDLPAKEII---DRLKMPPPVYRPVVSPEYAPAECLQLMKQCWAEASEQRPTFDEIFNQFKT
|||||||.  |.. |  |.  |  |   ..   .| .| ||.      |.. |.   |||. || |   .||...|.      
DVYSFAIVLWECVTRQDPYFGM--PTFQVVFSVGRHGMRPPM------PQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase CYGF.AA Pkinase_Tyr 596-690 29 6.4e-10 34.23 Pfam 55-156 (270) Show / Hide 
Range on Protein: 596-690
Range on HMM: 55-156/270
Sequence Identity: 29% (30 aa)

EMMKDL-RHENVNPLLGFFY-DSGM--FAIVSEFCSRRSLEDILTND---DVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTD
..|| | .|.|.  |.|  . ...     || |..   .| | | .    . .|.   . .  ..  ||| ||. . .||  |  ||| |.  .| |..|
KIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICD

YG
 |
FG
Kinase CYGF.AA Pkinase_Tyr 777-809 54 2.3e-09 32.35 Pfam 238-270 (270) Show / Hide 
Range on Protein: 777-809
Range on HMM: 238-270/270
Sequence Identity: 54% (18 aa)

PEYAPAECLQLMKQCWAEASEQRPTFDEIFNQF
||..|.|  .||||||..  |.|||| || .|.
PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CYGF.AA Pkinase 596-691 23 5.6e-09 32.82 Pfam 52-158 (293) Show / Hide 
Range on Protein: 596-691
Range on HMM: 52-158/293
Sequence Identity: 23% (25 aa)

EMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRR----SLEDILT-NDDVKL--DWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVL----
..|| |.|.|.  |...|.|..   .| |.|       .| |...  .. ..  ..    . .. ...|..|.| . .||  ||. |. .| . ..    
QIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV

KVTDYGF
|..| |.
KICDFGL
Kinase CYGF.AA Pkinase 714-809 19 2e-08 30.86 Pfam 179-293 (293) Show / Hide 
Range on Protein: 714-809
Range on HMM: 179-293/293
Sequence Identity: 19% (23 aa)

APELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMM----DLPAKEIIDRLKMPPPVYRPVVSPEYAP-----------------AECLQLMKQCW
|||..|   | .  . . |..|. .|. |.. .  ||.      .   .  . ...|.||. ..   .   .                  ||....| |.
APEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

AEASEQRPTFDEIFNQ--F
.   ..|||...|..   |
CKDPKKRPTAEQILQHPWF
CYCc CYGF.AA CYCc 848-1043 47 7.79999999999e-108 365.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 848-1043
Range on HMM: 1-231/231
Sequence Identity: 47% (109 aa)

IEKQKTEKLLTQMLPLSVAESLKKGC-TVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHD-----VYKVETIGDAYMVASGL
.||||...||.|||| .||..|| |  .|.|. .| ||..|.||||||.......|..||..|||.|| || ||. |.     .||||||||||||.||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PKRNGS-------------------RHAAEIANMSLDILSSVGTFKMRHM----PEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGL
| ||..                   .|| .||...||......||...|     |. |.|.|||.|.||||.||||..|||||.||||||.||||||||.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PYRIHVSLSTVTIL------QTLSEGYEVEL
| .|||| .|  .|      .  ....|.| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc CYGF.AA Guanylate_cyc 875-1062 42 7.7e-92 316.21 Pfam 1-214 (214) Show / Hide 
Range on Protein: 875-1062
Range on HMM: 1-214/214
Sequence Identity: 42% (90 aa)

VEPEGFDLVTLYFSDIVGFTTISAMSE----PIEVVDLLNDLYTLFDAIIGSH--DVYKVETIGDAYMVASGLPKR-----NGSRHAAEIANMSLDILSS
|... .| ||..|.|||||| ... ..    |...|..|||.|| || ... |  ..|||.||||.||..||||..     ..  ||. .|.|.||.. .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VGTFKMRHMPEVP-----VRIRIGLHSGPVVAGVVG--LTMPRYCLFGDTVNTASRMESTGLPY--RIHVSLSTVTILQTLS-EGYEV--ELRGRTELKG
....   | .  |     ...|||.|.|||||||.|  . |||||..|||||.||||||||.|.  .|||| .|...|...  . .|.  . ||  ..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGTE---ETFWLVG
|| .   ||..| |
KGKMGEMETYFLHG
HNOBA CYGF.AA HNOBA 839-869 48 5.7e-08 30.39 Pfam 204-234 (234) Show / Hide 
Range on Protein: 839-869
Range on HMM: 204-234/234
Sequence Identity: 48% (15 aa)

IRERTEELEIEKQKTEKLLTQMLPLSVAESL
... ..||| ||.||..|| .|.| |||. |
LEQMHRELEEEKKKTDDLLYSMFPKSVANRL