Gene CYGX (Mouse)

CYGX

Species: Mouse
Alias: CYGX, Gucy2d
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
CYGX.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 271 Kinase domain by global Sugen HMM Fasta, JSON
CYGX.AA Protein Sugen 1117 None Fasta, JSON
CYGX.NA RNA Sugen 3444 None Fasta, JSON

Protein domain

Protein domains of CYGX.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor CYGX.AA ANF_receptor 88-422 20 1.6e-64 225.46 Pfam 1-364 (364) Show / Hide 
Range on Protein: 88-422
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

LPSIATQLAVDQVNQDAS-LLPGSQLDFKVLPT----GCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGGD------
 .  | ..|....|.| . ||||  |..... .     | .. |.|..  | . |.|..||.... |...| .|. |.. ..||.| .|.   .      
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

----LVPTLPSA-ADVLLSVMRH-FGWARWAIVSSHQDI--WVTT---AQQLATAFRTHGLPIGLV---TSLGPGEKGATEVCKQLHS--VHGLKIVVLC
    .||.  .  ...... ..| |||.. |.. ...|   |...   .. . ...| ||... ..   ..  |... ...  |...    .. ...|.|
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVMC

MHSALLGGLEQTTLLHCAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSL-ESSPESHAFTATEMSGGATANLEPEQVSPLF
......| |.|  ....|.|.|...|  |....|... .....   | .. |   ..||...||.. . . ||| . |. . .        ....... .
CYPDDMG-LLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-WWYDDDMDNDKFREAMKGVLGFTMHP-SPEFQEFMQRWKK-------TDTEMNYYA

GTIYDAVILLAHALNRSETHGAGLSGAH----------LGDHVRA-LDVAGFSQRIRTDG-KGRR-LAQYVILDTD
...|||| |.||||..  . . . . .           | .. ..     |...... |  .|||  ..|.|...|
AYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase CYGX.AA RGC 576-814 33 4.6e-114 385.23 In-house 1-300 (300) Show / Hide 
Range on Protein: 576-814
Range on HMM: 1-300/300
Sequence Identity: 33% (101 aa)

QGEWVWLKKFEAG---VAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPG------VSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRY
.|.|||.||.. .    . |...| . .|...|...|.|.. |.|... |         ..| |.|.||||.|.| |... .||.||.|.. |...|..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHHRRF-PHGRLKSRNCVVDTRFVLKITDHGY-----AEFLES-------------HCSSRPQPAPEELLWTAPELLRGP------------GKATFKGD
|||. .  ||.|||.||||| |.|.||||.|       .| ..             .. . ..|  ...||||||.||..             . |.|||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VFSLAIILQEVLTRDP-----PYCSW----GLSAEEIIRKVASPPP-----LCRPLVSPD------QGPLECIQLMQLCWEEAPDDRPS-LDQIYTQFKS
|.|..||..|..||       |.| |     || .|||..|. ||.     ..||....|      . . ....||. ||.| |..||. .|||..|.|.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CYGX.AA RGC 576-814 33 4.6e-114 385.23 In-house 1-300 (300) Show / Hide 
Range on Protein: 576-814
Range on HMM: 1-300/300
Sequence Identity: 33% (101 aa)

QGEWVWLKKFEAG---VAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPG------VSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRY
.|.|||.||.. .    . |...| . .|...|...|.|.. |.|... |         ..| |.|.||||.|.| |... .||.||.|.. |...|..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHHRRF-PHGRLKSRNCVVDTRFVLKITDHGY-----AEFLES-------------HCSSRPQPAPEELLWTAPELLRGP------------GKATFKGD
|||. .  ||.|||.||||| |.|.||||.|       .| ..             .. . ..|  ...||||||.||..             . |.|||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VFSLAIILQEVLTRDP-----PYCSW----GLSAEEIIRKVASPPP-----LCRPLVSPD------QGPLECIQLMQLCWEEAPDDRPS-LDQIYTQFKS
|.|..||..|..||       |.| |     || .|||..|. ||.     ..||....|      . . ....||. ||.| |..||. .|||..|.|.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CYGX.AA TKL 601-812 22 3.6e-39 136.46 In-house 76-364 (364) Show / Hide 
Range on Protein: 601-812
Range on HMM: 76-364/364
Sequence Identity: 22% (67 aa)

LRKLREMRHENVTAFLGLFVGPGV-------------SAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRR--------FPHGRLKS
.. ..  ||.|.  |.|    |.               ..| | | .|||...|.       |  . .. ||  ||. ||| ..          |  |||
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKS

RNCVVDTRFV--------------LKITDHGYAEFLESHCSSRPQP------------------APEELLWTAPELLRGP---------------GKATF
.|. ||  .               .||.| | . |.. . ..  .                       . | |||.|||                .... 
KNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSE

KGDVFSLAIILQEVLTRDPPY-CSWGLSAE------EIIRKVA--SPPPLCRPLVSP-------DQGPLECIQLMQLCWEEAPDDRPSLDQIYTQF
| ||.| .|.| |.||| .|| . .  . .      |.. .|.  . .|.. |  .        .. | . ..||| ||.. |..||| ..|  ..
KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CYGX.AA TKL-Unique 608-812 28 1.6e-30 104.97 In-house 53-290 (290) Show / Hide 
Range on Protein: 608-812
Range on HMM: 53-290/290
Sequence Identity: 28% (69 aa)

R-HENVTAFLGLFV----GPGVSAMVLEHCARGSLEDLLQ---------NENLRLDWTFKASLLLDLIRGLRYLHHRR--FPHGRLKSRNCVVDTR----
. |.|.. . |  .     |. . .|.| | .||| |.|.         |.|. |..  . .. .|  .|. ||||.     |. |||.|  || .    
HYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIA

-FVLKITDHGYAEFLESH---CSSRP-----QPAPEELLWTAPELLRGP-GKATFKGDVFSLAIILQEVLTRDP------PYCSWGLSAEEIIRKVAS--
 .  || | | . |. .     ....     |    ...| |||.||..  . . | ||.| .|.| | .||.       ||   |.. |... .|..  
EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQ--GMDQEQWCEMVHYME

---PPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQF
   .||.      |.  | |   |.| ||   |..|||.|.|..  
ENYRPPI------PNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase CYGX.AA TK 598-812 15 2e-30 98.58 In-house 86-486 (486) Show / Hide 
Range on Protein: 598-812
Range on HMM: 86-486/486
Sequence Identity: 15% (62 aa)

LSFLRKLREMR-----HENVTAFLGLFVGP------------GVSAMVLEHCARGS----LEDLLQNE--------------------------------
|.... .  |.     |.|.  ..|  . .            .   .|.|... |.    | | |..                                 
LEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDIT

-------------------------------------------NLRLDWTFKASLLLDLIRGLRYLHHR------RFPHGRLKSRNCVVDTRFV------
                                           . .|.   .    ... .|..||| .      .| |. |  ||| |. . |      
YSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFD

-----LKITDHGYA--------EFL---ESHCSSRPQPAPEELLW-----------------------TAPELLRG--------PGKATFKGDVFSLAII
      ||.| | .          .   .  ...... ..  . |                       .||| |..         || | | ||.|. . 
GCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVL

LQEVLT--RDPPY--CSW------GLSAEEIIRKVAS--------------PPPLCRPLVSPD---------QGPLECIQL-MQLCWEEAPDDRPSLDQI
. |..|  . |.|   |       | . .|..... .                .. .|   ||         ..| | ... || ||.. |.|||. .|.
MWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQL

YTQF
. |.
HEQL
Kinase CYGX.AA Pkinase 604-812 20 3.6e-24 86.53 Pfam 54-293 (293) Show / Hide 
Range on Protein: 604-812
Range on HMM: 54-293/293
Sequence Identity: 20% (52 aa)

LREMRHENVTAFLGLFVGPGVSAMVLEHCARG----SLEDLLQ-NENLRL--DWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVL----KI
.....|.|.  ... |  ..   ||.|.|  |    .| |...  .. ..  ..    . .. ..||| |.| ... |  ||. |. .| . ..    ||
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKI

TDHGYAEFLESHCSSRPQPAPEE----LLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGL------SAEEIIRKVASPPPLCRPLVSPDQ
.| | |....      ... .      . . |||..||  . . | |..|. .|| |.|.. ||..  |       .  ..|... .||.  ..   .. 
CDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP--GHCWHDNHDQMQMICRIMGPPLH-FDWPWWCS

GP-----------------LECIQLMQLCWEEAPDDRPSLDQIYTQ--F
..                  ||....  |..  | .||. .||     |
ISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CYGX.AA RIPK 603-812 24 5.5e-17 54.39 In-house 49-290 (290) Show / Hide 
Range on Protein: 603-812
Range on HMM: 49-290/290
Sequence Identity: 24% (60 aa)

KLREMRHENVTAFLGLFVGP------GVSAMVLEHCARGSLEDLLQNENLR----LDWTFKASLLLDLIRGLRYLHHRR--FPHGRLKSRNCVVDTRFVL
..  .|.|..   .|    .      .  . | |  . |||...|. .       . |  .  ..   ..|  |||       |  ||  |  ||  |  
HMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHV

KITDHGYAEFLE-SHCSS--------RPQPAPEE---LLWTAPELLR-GPGKA----TFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPL
|| | | | ... ||  .        . .   ..   |   .||..| .  |.    | | || | ||.. ||||.  ||   ...   ... ..   | 
KIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPC

CRPLVSPDQGP-----LECIQLMQLCWEEAPDDRPSLDQIYTQF
  |.  |.. |      . |.|||.||. .|.|||.   .  ..
LQPV--PEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase CYGX.AA DRK 718-814 38 4.7e-16 50.9 In-house 168-258 (258) Show / Hide 
Range on Protein: 718-814
Range on HMM: 168-258/258
Sequence Identity: 38% (37 aa)

WTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKS
||||| ||  .  | | ||.| ||.| |..||  ||   |     ... |       || . | ..|   ||||. ||.| |  |||....     .
WTAPEVLRNQR-YTEKADVYSFAIVLWECVTRQDPYF--GMPTFQVVFSVGR--HGMRPPM-PQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
S_TKc CYGX.AA S_TKc 541-813 17 4.7e-14 29.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 541-813
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

SESRSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCAR--GSLE
 |   ..  |.  .| ..  ..              |. | .|.       .   . .. |.|    .|.|.  ... |.  .   ||.|.|    |.| 
YEILRKIGKGAFGKVYKCRHKK-------------TGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLF

DLLQNENLR-----LDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELL----WTAPELLRGPGK
|.... . .     ..    ....  ....| |.| ... |  ||  |  .|.  ..||.| | | .|              .     . |||.|    .
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL----G

ATF-KGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYT--------QFK
 .. | |. |. .|| | |.. ||..      .....|.                . |...... |..  |..||.  .. .        .. 
YGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc CYGX.AA TyrKc 567-812 22 3.1e-13 -8.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 567-812
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

LEHTNV-------ALYQGEWVWL----KKFEAGVAPDLRPSSLSFLR---KLREM--RHENVTAFLGLFVGP-------GVSAMVLEHCARGSLEDLLQN
..   .         |.|.|  .    |.  ..           |.|    ...   .|.|. ...|  . .       .   .|.|... |.| | |..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

ENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESH----------CS----SRPQPAPEELLWTAPELLRGPGK
   .| .  . |  ..  .| .|||.... |  |  ||| |. ... ||.| | . .....           .    ..  . |  . |.||| ..  ||
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP--IRWMAPECINY-GK

ATFKGDVFSLAIILQEVLTR-DPPYCS-WG--LSAEEIIRKVASPPPLCRPLV-----SPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQF
 |.| ||.|  . . |..|. ..||       .|..|.|..| .   . .|       .    | |  |.|. ||.| |.|||.  .|. .|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CYGX.AA MLK 600-753 28 1e-12 40.54 In-house 55-236 (291) Show / Hide 
Range on Protein: 600-753
Range on HMM: 55-236/291
Sequence Identity: 28% (53 aa)

FLRKLREMRHEN----VTAFLGLFVGPGV-SAMVLEHCARGSLEDLLQNEN-------------LRLDWTFKASLLLDLIRGLRYLHHRRF---PHGRLK
. |.|| ..|.|    . .|.|    |.   . |.| |. ||| ..| ...              . |  ....  |.  ||. |||       .|  ||
ECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLK

SRNCVVD------TRFVLKITDHGYAEFLESHCS---S-RPQPAPEELLWTAPELL---RGPGKATFKGDVFSLAIILQEVLTRDPPY
|.| ..|         .|||.| | . .. ..|.   | .  .|     | ||| .   |. .| . | ||.| ...| |.|||  ||
SHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA-----WMAPEVIQQFRC-EKYSEKCDVWSWGVVLWEMLTREVPY
Kinase CYGX.AA Dicty4 717-814 31 5.2e-12 36.51 In-house 182-277 (277) Show / Hide 
Range on Protein: 717-814
Range on HMM: 182-277/277
Sequence Identity: 31% (32 aa)

LWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVAS---PPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQ--
.|.||| ... .  . | ||.| .|.| | |||. ||   . . ....| |..    ||.      ||..|   ..|.| ||.. |  |||  .|  .  
CWMAPEVMMHQP-YNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPI------PDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRI

FKS
  .
LEH
Kinase CYGX.AA TKL-ciliate2 718-813 34 3.2e-11 33.12 In-house 184-273 (273) Show / Hide 
Range on Protein: 718-813
Range on HMM: 184-273/273
Sequence Identity: 34% (33 aa)

WTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFK
| ||| ..     | | |||| .||| |.  |.|||   . . . .  ||       || . | . | .  .||| ||..  . |||...|  ...
WMAPEVIKA-FYYTEKADVFSYSIILWEIASREPPYR--NKKGDVVAEKVMC--NNLRPTI-PKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase CYGX.AA TKL-ciliate2 607-668 41 3.8e-11 32.86 In-house 53-114 (273) Show / Hide 
Range on Protein: 607-668
Range on HMM: 53-114/273
Sequence Identity: 41% (26 aa)

MRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLH
.|| |.  |||        ....| | ||||  ||||.. || |  .  . ||  ||  |||
LRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLH
Kinase CYGX.AA DRK 604-696 32 7.6e-11 33.0 In-house 51-145 (258) Show / Hide 
Range on Protein: 604-696
Range on HMM: 51-145/258
Sequence Identity: 32% (31 aa)

LREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFP---HGRLKSRNCVVDTRFVLKITDHG
.   || |.  |.|    |     . |   ||||   | .| . .||    .. .|  .|. ||| .  |   |  ||| |  ||  .  |. | |
MCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCN-PIIIHRDLKSHNLLVDEHWQVKVADFG
Kinase CYGX.AA Pkinase_Tyr 604-694 24 3.1e-08 28.51 Pfam 57-154 (270) Show / Hide 
Range on Protein: 604-694
Range on HMM: 57-154/270
Sequence Identity: 24% (24 aa)

LREM-RHENVTAFLGLFVGPGVS---AMVLEHCARGSLEDLLQNE---NLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITD
.... .|.|.  ..|  .  | .    .|.|... |.| | |..    . .|.   . .  ..  .|. ||. ... |  |  ||| |.  .| ||.|
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICD
Kinase CYGX.AA MLK 789-812 41 7.5e-08 23.45 In-house 268-291 (291) Show / Hide 
Range on Protein: 789-812
Range on HMM: 268-291/291
Sequence Identity: 41% (10 aa)

QLMQLCWEEAPDDRPSLDQIYTQF
.||. ||.. | .||| .|| ...
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase CYGX.AA Pkinase_Tyr 789-812 41 3.4e-07 25.0 Pfam 247-270 (270) Show / Hide 
Range on Protein: 789-812
Range on HMM: 247-270/270
Sequence Identity: 41% (10 aa)

QLMQLCWEEAPDDRPSLDQIYTQF
.||..||.. |.|||.  .|. |.
DLMKQCWHYDPEDRPTFSEIHEQL
Kinase CYGX.AA Dicty4 630-696 29 1e-06 18.21 In-house 82-159 (277) Show / Hide 
Range on Protein: 630-696
Range on HMM: 82-159/277
Sequence Identity: 29% (23 aa)

EHCARGSLEDLLQN------ENLRLDWTFKAS---LLLDLIRGLRYLHHRR--FPHGRLKSRNCVVDTRFVLKITDHG
| . .|.|. || .      ..  |||.   .   . .|  ||. .|| .   . |  ||| |  ||  .. |..| |
EYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFG
CYCc CYGX.AA CYCc 851-1046 45 4.8e-104 352.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 851-1046
Range on HMM: 1-231/231
Sequence Identity: 45% (104 aa)

LERRKTERLLSQMLPPSVAHALKMG-TTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHD-----VYKVETIGDAYMVASGL
 |..|..||| ||||..||. || | ..|.|. .| |||.|.||||||.... ..|..|| .|||.|| || ..| |.     .||||||||||||.||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PRRNG-------------------NRHAAEIANLALDILSYAGNFRMRHA----PDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL
|.||.                    .|| .||. |||... ...| ..|     |. |.|.| |.|.||.|.||||..|||||.||||||.||||||||.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PYRIHVSQSTVQAL------LSLDEGYKIDV
| .||||..| ..|      .. .... . .
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc CYGX.AA Guanylate_cyc 878-1065 42 6.9e-91 313.05 Pfam 1-214 (214) Show / Hide 
Range on Protein: 878-1065
Range on HMM: 1-214/214
Sequence Identity: 42% (92 aa)

VEPEYFDQVTIYFSDIVGFTTISALSE----PIEVVGFLNDLYTLFDAVLDSH--DVYKVETIGDAYMVASGLPRR-----NGNRHAAEIANLALDILSY
|... .|.|||.|.|||||| ... ..    |...| .|||.|| || ..| |  ..|||.||||.||..|||| .     ..  ||. .|. |||.. |
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

AGNFRMRHAPDVP-----IRVRAGLHSGPCVAGVVG--LTMPRYCLFGDTVNTASRMESTGLPY--RIHVSQSTVQALLSLD-EGYKI--DVRGQTELKG
.. ..  |..  |     |..| |.|.||.||||.|  . |||||..|||||.||||||||.|.  .||||..|.. |  .. . . .    ||. ..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGLE---ETYWLTG
|| .   |||.|.|
KGKMGEMETYFLHG
HNOBA CYGX.AA HNOBA 843-872 46 1.4e-08 32.61 Pfam 205-234 (234) Show / Hide 
Range on Protein: 843-872
Range on HMM: 205-234/234
Sequence Identity: 46% (14 aa)

QERTEELELERRKTERLLSQMLPPSVAHAL
.. ..||| |..||..|| .|.|.|||  |
EQMHRELEEEKKKTDDLLYSMFPKSVANRL