Gene DDR1 (Mouse)

DDR1

Species: Mouse
Alias: Ddr1, DDR1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: DDR

Sequence

Name Sequence Type Origin Length Description Download
DDR1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 296 Kinase domain by global Sugen HMM Fasta, JSON
DDR1.AA Protein Sugen 911 None Fasta, JSON
DDR1.NA RNA Sugen 3805 None Fasta, JSON

Protein domain

Protein domains of DDR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FA58C DDR1.AA FA58C 31-186 27 1.4e-36 128.78 SMART 1-199 (199) Show / Hide 
Range on Protein: 31-186
Range on HMM: 1-199/199
Sequence Identity: 27% (55 aa)

KCRYALGMQDRTIPDSDISVSSSWSD-------STAARHSRLESSDG-----DGAWCPAGPVF------PKEEEYLQVDLRR-LHLVALVGTQGRHAG--
.|...||| . .|||..|  |||...        ..... ||.   .     |.||||....       ..  . ..|||.| .|.|..| |...  .  
ECNEPLGMEGGHIPDWQITASSSHYWNRDMPWWYWWPHIARLNGNGSNHDYWDNAWCPWKNDYEDWIFDYHCPHWWLVDLGRKTHRVTGV-TITGRRRRG

-GLGKEFSRSYRLR-YSRDGR---------RWMDWKDRW------GQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRA------DRVMSVCLRVELYGC
 | |..    |..  |. |.|         .|. .||.|      . .|. || |..........|||||| .|..| .      .  . .|.|.|||||
HGWGHDDWWTYYWMMYKDDRRDNNERQNGHTWTTYKDFWIEHGTGNSMVFYGNWDNNHPWHNMFHPPMVARYIRIWPTWWNTNATGWHHNYCMRWELYGC
F5_F8_type_C DDR1.AA F5_F8_type_C 47-183 27 7.3e-30 104.77 Pfam 1-140 (140) Show / Hide 
Range on Protein: 47-183
Range on HMM: 1-140/140
Sequence Identity: 27% (40 aa)

DISVSSSWSDSTAARHSRLESSDGD----GAWCP-AGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDG--R-RWMDWKDRWG
 |..||.||..... ..     ||.    ..|.. . . ...  ...|||| . . .  | .|.| .||   .. ..|.. || ||  .  | . ||  |
QITASSQWSGYWGNGWPPDNAIDGNGYPNTFWHSQKWS-NNDDPQWIQVDLGKPYKITGVVYQWRQDGGN--GWVKKYKIQYSNDGGDESNWTTYKDHDG

QEVISGNEDPGGVVLKDLGPPMVARLVRFYPR-ADRVMSVCLRVEL
  |  || | . .|  .. ||..|| ||..|   .   . ..|.|.
-KVFYGN-DND-PVKNMFFPPIKARYVRIHPTSWNNHNWWAMRWEF
Kinase DDR1.AA DDR 608-903 64 1.7e-229 768.72 In-house 1-306 (306) Show / Hide 
Range on Protein: 608-903
Range on HMM: 1-306/306
Sequence Identity: 64% (196 aa)

LRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLK-DPNIIRLLGVCVQDDPLCMITDYMEN-G
|.|.||.||||||||||||||..||....||...||||||.|||||.|||||.|.|||||.||.|.||..| .|||.||.|||.||.|.|||..|||| |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG--MSRNLYAGDYYRVQG----
|||||......||........||...|.|||||........||||||.||...|||||||||||||||....|||.|||  ||||||..|||||.|    
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR

-RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLY-ELMLRCWSREPEQRPPFA
 |...||||||||.||.|||||.|||||||||.||..|.||.||..|||||||||||.||||.||.||||..||.||...| .||.|||.|...|||.|.
QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE

QLHRFL
..|.||
EIHKFL
Kinase DDR1.AA TyrKc 608-903 36 2.5e-131 443.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 608-903
Range on HMM: 1-280/280
Sequence Identity: 36% (119 aa)

LRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL--KDPNIIRLLGVCVQD-------DPLCMI
.....|||||.||||....                     . |||| |..||    | ||..| .||..|  . |||.||.|||.|.       .||...
ITLGKKLGEGAFGEVYKGTWK-------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV

TDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG------
. ||..|||...| ... .                  .. . ||.   |||.||.||.  |..|||||.||||||||.|.||.|||.||..| .      
MEYMPHGDLKDYLRKHRPK------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGES

-DYYRV----QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQ----LTDEQVIENAGEFFRDQGRQVYLSRPPA----CPQTLY
 ||||.    .|...|||||||.|||  |||||.||||.|||..||.. .. . . |.    .....|||.  . .|    . ..  |      ||. .|
KDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMY

ELMLRCWSREPEQRPPFAQLHRFL
..|..|| ..||.|| |...|...
QIMKQCWHEDPEDRPTFSEIHECF
Kinase DDR1.AA Pkinase_Tyr 608-903 38 3.1e-124 421.38 Pfam 1-270 (270) Show / Hide 
Range on Protein: 608-903
Range on HMM: 1-270/270
Sequence Identity: 38% (118 aa)

LRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNA--RNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDP--LCMITDY
..| .|||||.||||....  .             .... . ||||.|...|.. .  | ||..|.|||. | . |||.||.|||. |..|  ..... |
ITFGKKLGEGAFGEVYKGTWKG------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEY

MENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYY-RVQGR
|..|||  .| ..                .... .. ..||.  .|||.|| ||.  |..|||||.|||||.||...||.|||..| .|  ||| |..| 
MPHGDLLDYLRKHR---------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGG

AVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQP-FGQLTDEQVIENA-GEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQ
. |||.||| |||  |||||.||||.|||..||.. ... || .  ...|.|.|    .  |       . .|. ||. .|.||..||  .||.|| |..
GKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGE-QPTYPGMSNEEVYEYIYEDGYR-------MPCPENCPDEIYDLMKQCWHYDPEDRPTFSE

LHRFL
.|..|
IHEQL
Kinase DDR1.AA TK 608-903 25 1.6e-117 395.78 In-house 1-486 (486) Show / Hide 
Range on Protein: 608-903
Range on HMM: 1-486/486
Sequence Identity: 25% (125 aa)

LRFKEKLGEGQFG---EVHLCEVEDPQDLVSSDFPISV---------HKGHPLLVAVKILRPDATKNARN-------------DFLKEVKIMSRLK----
... .||||||||   ||...|.... .. ...|| .          ..| .  ||||.|..... ...              |||.|. .|. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-DPNIIRLLGVCVQD------------DPLCMITDYMENGD----LNQFLSARQLENKATQGLSGD----------------------------------
  |||.||.|||.|.             |..... ||..||    | ..| ..  . .  |  ...                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---TESDQGPTISYPMLLH-------------------VGAQIASGMRYLATL------NFVHRDLATRNCLVGENFT-----------IKIADFGMS--
     .|..|...   ||.                     .|||.||.||. .      ||||||||.|||||||| .           .||||||.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------RNLYAGDYYRVQG------------------------RAVLPIRWMAWECIL---------MGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLT
      | .| .|.|....                        .. |||||||.||..          |||||.||||.|||..||...... .. |...
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

D---------EQVIENAGEFFR-------DQGRQVYLSRPPACP--------------QTLYELMLRCWSREPEQRPPFAQLHRFL
.         ..|.|.  .  |       ..|.   . .|| ||              . .|.||..||...||.|| |.|||..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDR1.AA Trk 608-903 42 4.3e-100 338.84 In-house 1-275 (275) Show / Hide 
Range on Protein: 608-903
Range on HMM: 1-275/275
Sequence Identity: 42% (126 aa)

LRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDL
...|  |||| || | | | .   .|.  .         ...|||| |. ||..||| || .| ...  |. ..|... |||. .||| |.  ||..|||
IVLKWELGEGAFGKVFLAECY---NLCPEQ--------DKMMVAVKTLK-DASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDL

NQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA-GDYYRVQGRAVLPIR
|..| ..    .    . ..    .||      .|..  |||||| |.| . |||||.||||||||.|  .||.|||||| .|   ||||| ..  ||||
NKYLRQHGPDAMCY--AQYQPRQAPGP-LTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIR

WMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFL
||  | |.  |||. |||| |||..||..   . ||. ||    |||     .  ||| . | || .||| .|..|| || |||.||    ..|  .
WMPPESIMYRKFTYESDVWSFGVVMWECFTYGK-QPWYQLSNHEVIE-----CIHQGR-HRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase DDR1.AA Ror 646-900 43 3.1e-90 306.08 In-house 28-272 (308) Show / Hide 
Range on Protein: 646-900
Range on HMM: 28-272/308
Sequence Identity: 43% (110 aa)

HPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVG
|. .||.| .. ||.   . || .|...|..|. |||. ||||| .| |.||.  || .|||  ||  |     .  | | |   . . . . |  ||. 
HCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPH--SDHGCSSDDDRMVKSSLDHPDFLHIA

AQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQ
.|||.|| ||.   |||||||.|||||||  ..||.||| .|  |..||||.|.....|||||. | |. |||...||.| |||.|||.    . ||.  
IQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSEDSDIWSFGVVLWEIWSYGM-QPYYG

LTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLH
    .||    |  |   |.. |. |  ||.  | ||  ||.  |. ||.|   |
YSNQEVI----EMIRN--RHL-LPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIH
Kinase DDR1.AA Musk 648-903 42 9.6e-88 290.02 In-house 30-282 (282) Show / Hide 
Range on Protein: 648-903
Range on HMM: 30-282/282
Sequence Identity: 42% (110 aa)

LLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAR---QLENKATQGLS--GDTESDQGPTISYPMLL
..|||| |. || |    ||  |  .| .   |||..|||||    |.|.   ||  |||| || ..       . .| ..      |   |  .   .|
TMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHRTCSRTHQDRGMRAQVSSPGPPQLKCYHQL

HVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQP
 . .||| || ||    ||||||||||||..|.  .||||||.||. |  |||. ..    |||||. | |.  .||..|||||.|| |||.      ||
CMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYAL-QP

FGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFL
.  .| | ||     . |.  .   || |  ||| .|.|| |||...|  || |.|.|. .
YYGMTHEEVI----YYIRQGNI---LSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase DDR1.AA UTK 608-903 30 6.5e-86 291.72 In-house 1-296 (296) Show / Hide 
Range on Protein: 608-903
Range on HMM: 1-296/296
Sequence Identity: 30% (102 aa)

LRFKEKLGEGQFGEVHLCEVED-----PQDLVSSDFPISVHKGHPLLVAVKILRPDATKNAR--NDFLKEVK---IMSRLK-DPNIIRLLGVCVQDDPLC
... ..||.|.|||||......     ....|. .                  . ||... .   ||..| .   .|....  ||..||.|||.|. |..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--------------HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWM

MITDYMENGDLNQFLS--ARQLENKATQGLSGDTESDQGPTISYPM-LLHVGAQIASGMRYLATLNFVHRDLATRNCLVGEN-------FTIKIADFG--
..| ||||||| ..|   .....              . |..     .|.  ..||.|| ||.. .||||||| |||||...        ..||||||  
IVTEYMENGDLRSYLRRHRPTPP--------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRG

-MSRNLY---------AGDYYRVQGRAVLPIRWMAWECILMG-KFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPA
 |||...           .||. |..  .|||||| |..  . .|||.||||.|||..||...   ..|.. ....||... ..  |       . .|..
GMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGR-----YRMPCPWD

CPQTLYELMLRCWSREPEQRPPFAQLHRFL
|| ..|.||.|||  .|. || | .|  ..
CPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase DDR1.AA TK-Unique 608-903 33 6.2e-84 285.16 In-house 1-294 (294) Show / Hide 
Range on Protein: 608-903
Range on HMM: 1-294/294
Sequence Identity: 33% (105 aa)

LRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLK-DPNIIRLLGVCVQDD-PLCMITDYMENG
|......|||.||.|. .||. .           .| ...  |||| |. .||.  . ||||| ..|. |.  |||...||.|. .| | ..|  |...|
LEVGDVIGEGAFGQVWRGEVWGIW----------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCG

DLNQFLSARQLENKAT-------QGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLAT--LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYR
.|  .|  .. . . .        ..  ......  .||.  |.| . |||.|| |||    ..|||||..||.|..|....||.||||.| .|..  | 
NLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYS

VQ-GRAVLPIRWMAWECIL--MGKF-TTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPAC-PQTLYELMLRCWSREPE
 . ..  .|||||| | ..   | . || ||||.|||..||.. |   .|.... .....|.  . .|       . .|. | ....|.|| .||..|||
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKDIMECIRDGYR-------MPQPEHCCSHEMYNLMKSCWQWEPE

QRPPFAQLHRFL
.|| |.|.   |
ERPSFRQIKHRL
Kinase DDR1.AA InsR 650-905 38 1.1e-78 263.93 In-house 34-278 (278) Show / Hide 
Range on Protein: 650-905
Range on HMM: 34-278/278
Sequence Identity: 38% (100 aa)

VAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPT-----ISYPMLLHV
.|.|..  .|.   | .||.|  .| . .  ...|||||| .  |   .   |. |||  .| .|  |..           . | .     ...  ..  
CAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRPEEEF---------NNPGCNRNQHVPCLDQMHQM

GAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFG
 |.|..|| ||| ..||||||| |||.| . ||.||.|||| | .|  ||||  |.  ||.|||| | .  |.|||.|||| ||| |||.  |  .||  
AAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLG-EQPYQ

QLTDEQVIENAGEFF-RDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFLAD
 |  |||    ...  .| .   .| .|  ||. ..||| .||   |  || | ..   | |
GLSNEQV----LKYIGMDGN---VLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase DDR1.AA Src 650-903 37 2.7e-75 255.24 In-house 26-255 (255) Show / Hide 
Range on Protein: 650-903
Range on HMM: 26-255/255
Sequence Identity: 37% (97 aa)

VAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIA
|||| |.|.    . ..||.| .||  |. .....|. || |..|   .| ||..| | ..| .                ...| ... | |.  .||.|
VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----------------DGEGRHLHLPQLIDMAAQVA

SGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA--GDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLT
.|| ||   |..||||| || |||||   |.||||  | |     | |  .  | .||.|.| |.|. |.||. |||| ||. |.|.    |  |    |
EGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR-VPYPGMT

DEQVIENAGEFFRDQGRQVYLSRPPACPQTLYE-LMLRCWSREPEQRPPFAQLHRFL
 ..|...    .|       . .|. ||. ||| .||.|| ..||||| |. |. ||
NHEVLQQVERGYR-------MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase DDR1.AA CTKA 746-903 46 1.2e-61 205.91 In-house 138-290 (290) Show / Hide 
Range on Protein: 746-903
Range on HMM: 138-290/290
Sequence Identity: 46% (78 aa)

AQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG-DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFG
.||| || ||| . ||||||| ||||.|   .||||||| .| |  .  || |. . |.|.|||| | .  |||..||||||||| |||..      |. 
MQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGE-KPWR

QLTDEQVIENAGEFFRDQGRQVYLSR-------PPACPQTLYELMLRCWSREPEQRPPFAQLHRFL
 ..|  |             | |.|        |. |||.|| .|  ||  || ||| |..| | |
HMSDQEVC------------QAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase DDR1.AA S_TKc 608-908 20 8.9e-46 159.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 608-908
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

LRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMEN--G
 .. .|.|.| ||.|..|   .                   .||.||..        .....|..|... . |||..|..|..  | |.|...|...  |
YEILRKIGKGAFGKVYKCRHKK----------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG

DLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPI
|| ...  |. . .  .             ..  .  .. .||.... |.  ....||||   | |. |  .|||.|||..| |            .   
DLFDYIKKRGRHGLRFP-------------FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTP

RWMAWECILMGKFTT-ASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHR---
 .|| | .   .... ..|.|..|..|.|  |||.  ||   ........ |                  .. . ... .|. ..||.||   .. .   
WYMAPEVL---GYGKCKCDWWSCGCILYE--MLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

-FLADDAL
   ..  .
DIKCHPWF
Kinase DDR1.AA Pkinase 608-903 21 2.7e-39 140.03 Pfam 1-293 (293) Show / Hide 
Range on Protein: 608-903
Range on HMM: 1-293/293
Sequence Identity: 21% (73 aa)

LRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKN--ARNDFL-KEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMEN
.....|.|.| ||.| .|   . ..                .|||||.. . .|    .....  |..|| ||. |||.||....  .| ..|...|.|.
YHIGRKIGSGSFGCVYKCHHKGTGK----------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEG

G----DLNQFLSARQLENKATQGLSGDTESDQGPTI--SYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTI----KIADFGMSRNLYAGDY
|    ||  ..|.                 ... ..  |.  . ..  ||..|. |.   ...||||   |.|. .| .|    ||.||| .. ..    
GLYVMDLFDYIST-----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-N

YRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRSQPFGQL-TDEQVIENAGEFFRDQGRQVYLSRPPACP-----------------
..     .  ...|| | |.   . ....|.|..|..|.|  |||.  || .  ...  ..    ..|. |...  ..|  |.                 
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYE--MLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHN

--QTLYELMLRCWSREPEQRPPFAQL--HRFL
  ... ... .|. . |..|| ..|.  | ..
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDR1.AA CTKA 608-713 38 5.4e-23 73.99 In-house 1-102 (290) Show / Hide 
Range on Protein: 608-713
Range on HMM: 1-102/290
Sequence Identity: 38% (42 aa)

LRFKEKLGEGQFGEVHLCEVE-DPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMS--RLKDPNIIRLLGVCVQDDPLCMITDYMEN
.    |.|||..|.|       ||      ||     ||   .|||| |. .||  .|  || |. . |   .  ||..|||||| |. |. ||. .|  
HCIMFKIGEGHYGQVFRAWLMPDPD-----DFKAQRKKGK--DVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQY

GDLNQFLSA
|||  .| |
GDLHCYLRA
Kinase DDR1.AA Src 608-622 60 1.6e-05 14.71 In-house 1-15 (255) Show / Hide 
Range on Protein: 608-622
Range on HMM: 1-15/255
Sequence Identity: 60% (9 aa)

LRFKEKLGEGQFGEV
.....|||.||||||
IKLCRKLGQGQFGEV
Kinase DDR1.AA Ror 608-623 62 1.9e-05 18.01 In-house 1-16 (308) Show / Hide 
Range on Protein: 608-623
Range on HMM: 1-16/308
Sequence Identity: 62% (10 aa)

LRFKEKLGEGQFGEVH
.|| |.|||.||| |.
VRFMEELGECQFGKVY