Gene EGFR (Mouse)

EGFR

Species: Mouse
Alias: Egfr, EGFR
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
EGFR.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
EGFR.NA RNA Sugen 5983 None Fasta, JSON
EGFR.AA Protein Sugen 1210 None Fasta, JSON

Protein domain

Protein domains of EGFR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain EGFR.AA Recep_L_domain 57-168 40 8.5e-44 148.98 Pfam 1-121 (121) Show / Hide 
Range on Protein: 57-168
Range on HMM: 1-121/121
Sequence Identity: 40% (50 aa)

NCEVVLGNLEITYVQRN----YDLSFLKTIQEVAGYVLIALN--TVERIPLENLQIIRGNALYEN-TYALAILSNYGTNRTGLRELPMRNLQEILI--GA
||.|. ||||||..  .    .||||...|.|. ||.||. .   .  ....||.||||. |...  |||.|..|.     ||.|| |.|| .|..  | 
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNM---GLQELWMWNLKNITRKNGG

VRFSNNP--ILCNMDT-IQWRDIV
|...|||   ||...| |.|..|.
VYIHNNPHPKLCYTHTEIMWWMIY
Furin-like EGFR.AA Furin-like 184-338 43 3.7e-82 270.0 Pfam 1-182 (182) Show / Hide 
Range on Protein: 184-338
Range on HMM: 1-182/182
Sequence Identity: 43% (80 aa)

PSSCP--------KCDPSC------PNGS-CWGGGEENCQKLTKIICAQQCSH-RCRGRSPSDCCHNQCAAGCTGPR-ESDCLVCQKFQDEATCKDTCPP
. .||        .|.|.|       .|. ||| ....||.||| .|..||.| ||.|..|..||| ||..|||||. ..||..| .|... ||.|.|||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

LMLYNPTTYQMDVNPEGKYSF-GATCV--KKCP-------RNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCN
.|.|||||.||..||.|.|.| |..||  |.||        ||.|...|.|.| | ..|.|.||.. ..|..|.||| |||.
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU EGFR.AA FU 228-270 33 2e-06 28.34 SMART 1-48 (48) Show / Hide 
Range on Protein: 228-270
Range on HMM: 1-48/48
Sequence Identity: 33% (16 aa)

PSDC--CHNQCAAGCTGPRESDCLVC--QKFQDE-ATCKDTCPPLMLY
 . |  || .|| ||.||.. .|. |   .....  || ..|||   .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain EGFR.AA Recep_L_domain 361-481 30 1.7e-39 134.52 Pfam 1-121 (121) Show / Hide 
Range on Protein: 361-481
Range on HMM: 1-121/121
Sequence Identity: 30% (40 aa)

YCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHG-QFSLAVVGLN---ITSLGLRSLKEI
 || | |.|.|... ....        ....|. .....||||.|||. . .| ..|. |.||.|||||...|. ...|...      ...|....||.|
NCTVIYGNLEITWRDEHNE--------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNI

SD--GDVIISGNR--NLCYANT-INWKKLF
..  |.|.|. |   .||| .| |.|....
TRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU EGFR.AA FU 496-547 30 3.3e-08 34.51 SMART 1-48 (48) Show / Hide 
Range on Protein: 496-547
Range on HMM: 1-48/48
Sequence Identity: 30% (17 aa)

EKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRG---RECVEKCNILEGEPR
.. |    . |.| |.. ||||| | .|.|| .   .   ..||..|.  .|. .
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
Furin-like EGFR.AA Furin-like 514-539 40 8.5e-05 16.35 Pfam 72-98 (182) Show / Hide 
Range on Protein: 514-539
Range on HMM: 72-98/182
Sequence Identity: 40% (11 aa)

GCWGPE-PRDCVSCQNVSRGRECVEKC
|| ||  ..|||.| ...    ||..|
GCTGPNNDTDCVACRHFYHNGTCVDQC
FU EGFR.AA FU 552-601 37 1.7e-12 48.73 SMART 1-48 (48) Show / Hide 
Range on Protein: 552-601
Range on HMM: 1-48/48
Sequence Identity: 37% (20 aa)

NSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPH---CVKTCPAGIMG
...|  |||||.      .|.| |||.|. |.|. ...|   ||..||.|  .
DGVCKPCHPECAT-----GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU EGFR.AA FU 614-654 25 0.164144 0.28 SMART 1-48 (48) Show / Hide 
Range on Protein: 614-654
Range on HMM: 1-48/48
Sequence Identity: 25% (12 aa)

NNVCHLCHANCTYGCAGPGLQGCEV---WPSGPK----IPSIATGIVG
..||. ||..|  || |||   |     . ....    ...   |  .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Kinase EGFR.AA EGFR 714-971 80 8.49999999999e-203 679.43 In-house 1-258 (258) Show / Hide 
Range on Protein: 714-971
Range on HMM: 1-258/258
Sequence Identity: 80% (208 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGS
.||.||||||||||||||.||||||.||||||||.|||.|.||||.|.|||||||||||.||..||||.|..|..||.||.|||||||||||.|||||||
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

QYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFG
|.||||||||||||.|||..|.|||||||||||||.|.||||||||||||| ..||||||.|||.||||||||.|.||.|||||||||||||.|||||||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

SKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFS
.||||||||..|...|||||||||||||||||||.||||||||.|.||.|.||. ||.
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase EGFR.AA TyrKc 714-970 36 9.1e-132 444.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-280/280
Sequence Identity: 36% (105 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV--DNPHVCRLLGICLT--------STVQLITQLMPYGCLLDY
 ...|.||.||||.|||| |.       |.||.| |.| .     .....|| .| ..  ..|.. ||.|.|..          . ... .||.|.|.||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAE------EKEYHAE---GGK--VPIKWMALESILHRI
 |.|....  . ||..|.|||.||.||......||||||||.||. ...|||.||||.. .. .      .. |..    |||  .||.|||.|.| ...
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTHQSDVWSYGVTVWELMTFGSKPYDG-----IPASDISSILEKGERLPQPPI--------CTIDVYMIMVKCWMIDADSRPKFRELILEF
.|..|||||.||. ||..|.| .|| |     ......   ...|.|.||||         |. ..|.|| .||. |...|| |.|.. .|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EGFR.AA Pkinase_Tyr 714-970 40 5.4e-130 440.89 Pfam 1-270 (270) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-270/270
Sequence Identity: 40% (109 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA--NKEILDEAYVMASV-DNPHVCRLLGICL--TST--VQLITQLMPYGCLLDYVRE
 ...|.||.||||.|||| | ..... |||||.| |.| .....   .. . || .| .  ..|.. ||.|.|.       . ... .||.|.|||| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKE-YHAEGGKVPIKWMALESILHRIYTHQSDVWSY
|   |...  . ||..|.||||||.|||.....||||||||.||. . .|||.|||||...  ..   . ..|||.||||||.|.| ....|..|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTVWELMTFGSKP-YDGIPASDISSIL-EKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEF
||. ||..|.| .| | |.. ...   . |.|.|.|.|. |. ..|..| .||. |.. || |.|.. ..
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EGFR.AA TK 714-970 21 5.4e-105 353.0 In-house 1-486 (486) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-486/486
Sequence Identity: 21% (105 aa)

FKKIKVLGSGAFG---TVYKGLWIPE---------------------GEKVKIPVAIKELRE--ATSPKANKE--------------ILDEAYVMAS--V
 . .|.||.|.||   .||||.|...                     .|..|.|||.| |.|  |.|... ..               . |. .| .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DNPHVCRLLGICLTST-------------VQLITQLMPYGC----LLDYVREHKDN--------------------------------------------
. |.. ||.|.|. .              . ... .||.|.    |.|| |.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IGSQYLLNWCVQIAKGMNYLEDR------RLVHRDLAARNVLVKTPQH-----------VKITDFG---
                               .  . || .|.|||.|| ||...      ..|||||||||.||    .           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLGAEEKEYHAE------------------------GGKVPIKWMALESILHRI---------YTHQSDVWSYGVTVWELMTFG-SKPYDGI
     ||. .. ..  | ..                        |||.||.||| |....|.         .|..|||||.||..||..|.|   .| |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PA---------SDISSILEKG--------------ERLPQPPICT--------------IDVYMIMVKCWMIDADSRPKFRELILEF
.           ..   |..|               |.|||| |.               ..| .| .||  |.. || |..|  ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EGFR.AA Syk 720-964 39 1.9e-87 296.81 In-house 7-257 (257) Show / Hide 
Range on Protein: 720-964
Range on HMM: 7-257/257
Sequence Identity: 39% (98 aa)

LGSGAFGTVYKGLWIPE---GEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQY
.|.| ||.| ||        |||. |.|||| |. ... |   .|.. || ||.  |.|.. |..|||.     ..  . . | ...|  .|.. |  . 
IGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRHEITANN

LLNWCV-QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFG
 |     |.| || ||| .  |||||||||||  .    || |||. | ||| ...| |. .|| |.|| | |.|  ..  |.|||||.||| ||    |
VLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYG

SKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR
 ||| ..  ...   .|.|.|...|. |  ..| .| |||  ..  || | 
QKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EGFR.AA Ack 714-970 38 2e-85 288.13 In-house 1-266 (266) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-266/266
Sequence Identity: 38% (103 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA--TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTV-QLITQLMPYGCLLDYVREHKD-
 .  . ||.| || | .|.|        |.||.| ||    ..|..  . | |. .| | | ||. || |. |..   ...| | | | |||  |.|.  
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRT

-NIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKITDFGLAKLLGAEEKEYHAEGGK---VPIKWMALESILHRIYTHQSDVWSYGV
       |...|.|||.|| ||| .|..||||||||.|. .. . ||| ||||   || .|  |  |. .   ||. |.| |.. ||  .| ||||..||
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

TVWELMTFGSKPYDGIPASDISSILE-KGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEF
| ||  ..| .|. | ....|   .. .|||||.|. |  |.| .|..||  ..  ||.| ..   .
TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase EGFR.AA UTK 714-970 31 3e-82 279.58 In-house 1-296 (296) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-296/296
Sequence Identity: 31% (92 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKI-PVAIKELR-EATSPKANK---EILDEAY---VMASVD-NPHVCRLLGICLTST-VQLITQLMPYGCLLDY
 .  . ||.||||.|.|. . .. | ..   ||.|... .|.....     ... ||    .|. ..  |.| ||.|.|. .    ..| .|. | |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

VREHKDNIG-------SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-------QHVKITDFG---LAKLLGA--------EEKEYHAEG-GK
.| |... .       .  .| ....|| ||.||. ...|||||||||.||          . .|| |||   .......        |  .| | . ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPIKWMALESILHR-IYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKG--ERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEF
.||.||| |.. |.  .|..|||||.||..||..|.|..|| |. . ..   ...|   |.|.|. |  .||..|..||. | . || |..|  ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EGFR.AA TK-Unique 714-970 31 1.3e-81 277.46 In-house 1-294 (294) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-294/294
Sequence Identity: 31% (94 aa)

FKKIKVLGSGAFGTVYKGLWIP--EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD-NPHVCRLLGICLTST--VQLITQLMPYGCLLDYVREHK
..  .|.|.||||.|..|   .  ...  .. ||.| |..  ..   .. |.|. .| ...  |.. ..||.| .|.  ...|   .|.|.|..| |. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DN-------------------------IGSQYLLNWCVQIAKGMNYLED--RRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG--GKVP
..                         | .. |.....|||.||.||.   .. |||||.|||||.     .||.|||.|. . . ...|  ..  |..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IKWMALESIL--HRIY-THQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPIC-TIDVYMIMVKCWMIDADSRPKFRELILEF
|.|||.||..  |..| | .|||||.||. ||..|.|. || |.|..||   ...| |.|||. | . ..| .|  ||  ....|| ||... ..
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EGFR.AA Src 714-970 35 1.3e-79 270.13 In-house 1-255 (255) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-255/255
Sequence Identity: 35% (93 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTS-TVQLITQLMPYGCLLDYVR--EHKDN
.| .. ||.| || |..|.|     . ...||.| |...|   ...  | || .| ... ... .|. .| .   .  .| .|  |.|||| .  .   .
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY-HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWEL
.  . |.    |.|.||.||| ....||||||||||| .   .|. |||||.|.  .. ||   .| |.||||.| | |... .|  |||||.|.  .|.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYM-IMVKCWMIDADSRPKFRELILEF
.|.|  || |    .    .|.| |.|.|. |   .|. || .||  |.. || |  |   .
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EGFR.AA FAK 715-975 35 9.3e-78 260.1 In-house 2-285 (285) Show / Hide 
Range on Protein: 715-975
Range on HMM: 2-285/285
Sequence Identity: 35% (101 aa)

KKIKVLGSGAFGTVYKGLWI-PEG----------------------EKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLI
.  ...| | || ||.| .. ...                         || ||||  .. ...    . . |||.|   | ||. .|.|||    . .|
TLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWII

TQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMALESILH
  |..|| |  | . .|.      |. .| |... | ||| .. |||| |||||||  |. ||  ||||  ..   .  |.|   || |||||. |||  
MELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKWMSPESINF

RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMAR
| .|  |||| .|| .|| . .| ||. ..  .|.   .|.||||| || |    | .| .||  |   ||.|.||  . ...  
RRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase EGFR.AA Abl 714-970 40 3.1e-70 233.39 In-house 1-252 (252) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-252/252
Sequence Identity: 40% (105 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGIC-LTSTVQLITQLMPYGCLLDYVRE-HKDNI
    . || | .| ||.|.|     . .  ||.| |.| |   . .| | || .|  .  | . .|||.|   .   .||  |.|| ||||.||  ....
IMMKHKLGGGQYGEVYEGVW----KRHDCTVAVKTLKEDT--MEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL

GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMT
 .  ||    ||| ||.||| |  .|||||||| ||   . ||. |||||...  .    || | | |||| | ||. .  .  .|||| .|| .||. |
PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHA-GAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIAT

FGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEF
.|  || ||  |..   |||| |. .|. |  .|| .| .||  ..  ||.|.|.  ..
YGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase EGFR.AA Met 715-964 33 3.1e-70 229.39 In-house 1-271 (271) Show / Hide 
Range on Protein: 715-964
Range on HMM: 1-271/271
Sequence Identity: 33% (93 aa)

KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR--EATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTV---QLITQLMPYGCLLDYVREHK
 . .|.| | || ||.|  ..  |.  ....|.| |    .|      . | |. .|   | |.|  |.|||| .       ..  |  | |. ..|  .
HFDDVIGQGHFGCVYHGMYHDNDGN--EHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQ

DNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY---HAEGG--KVPIKWMALESIL--------HRI-YT
 |.    |.  | |.||||.|.  .. ||||||.|| .      ||. ||||.  .   .|||   . . .  . |.||||.|.           .. .|
NNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDM-DYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFT

HQSDVWSYGVTVWELMTFGSKPYDGIPA-SDISSILEKG--ERLPQPPICTIDVY-MIMVKCWMIDADSRPKFR
 .||||| ||  ||||| |. ||  .    ||.  |. |   |||||. |   .|  .| .||  ..  || | 
TKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase EGFR.AA S_TKc 714-971 20 1.2e-46 162.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 714-971
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPY--GCLLDYVREHKDN-
.......|.||||.|||. ..      .  ||||...        . |. |  .. . . |....|.... .. . ... ...   | |.|| .... . 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTH-QSDVWSYGVT
    .       .. ||.....|. ... .||||   |.|. .  |.||.|||||..|             .   .|| | .    |..  .|.|| |..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIL--------EFS
..|... |  |..     ..  ...|          . ..  .. ||.  | . ||   |.          .. 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EGFR.AA Pkinase 714-970 20 6.4e-37 131.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 714-970
Range on HMM: 1-293/293
Sequence Identity: 20% (63 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILD----EAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPYG----CLLDYV
.......|||.||.|||. .. .|.     ||.|...   . | .|.. .    |...|.... |...||....   . . ... ... |     | ||.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-EHKDNI--GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV----KITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL-HRIYTHQ
. . . ..    . . ... ||..|..|. ... .||||   |.|..   |.    ||.||||||..  . .   . .  . . .|| | |. .. |.. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGVTVWELMTFGSKPYDGI----PASDISSILEKGER----LPQPPICT-------------------IDVYMIMVKCWMIDADSRPKFRELILE
.|.||.|....|... |  |..|     .  |   ....  .     . |  |.                    .   .. .|.  |  .|| ....   
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--F
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PWF