Gene EphA8 (Mouse)

EphA8

Species: Mouse
Alias: Epha8, EphA8
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA8.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
EphA8.NA RNA Sugen 4732 None Fasta, JSON
EphA8.AA Protein Sugen 1004 None Fasta, JSON

Protein domain

Protein domains of EphA8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA8.AA Ephrin_lbd 30-203 62 6.8e-134 417.44 Pfam 1-190 (190) Show / Hide 
Range on Protein: 30-203
Range on HMM: 1-190/190
Sequence Identity: 62% (119 aa)

EVNLLDTSTIHGDWGWLTYPAHG---------WDSINEVDESFRPIHTYQVC-NVMSPNQNNWLRTNWVPRDGARRVYAEIKFTLRDCNSIPGVLGTCKE
||.|.||.| ..|.||.|||..|         |. ....||  |||.||||| |||.|||||||||||..|.||.|.| |.|||.|||||.|||.|||||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLHYLESDR--DLG---ASTQESQFLKIDTIAADES-FTGADLGVRRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAILSLRIYYKKC
||||.|.|||.  |.|   .. .|.|. |||||||||| ||  |.| | .||||||| .||||||||||||||.|||.|..|.|.|||||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA8.AA EPH_lbd 30-203 60 1.1e-118 401.48 SMART 1-184 (184) Show / Hide 
Range on Protein: 30-203
Range on HMM: 1-184/184
Sequence Identity: 60% (112 aa)

EVNLLDTSTIHGDWGWLTYPAHG--WDSINEVDESFRPIHTYQVCNVMS---PNQNNWLRTNWVPRDGARRVYAEIKFTLRDCNSIPGVLG-TCKETFNL
||.|.||.|..|..||.||| ||  |. . ..||  .||.||||||||.   |||||||||.|..|.||.|.| |.|||.|||||.|||.| .|||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

HYLESDRDLG---ASTQ-ESQFLKIDTIAADESFTGADLGVRRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAILSLRIYYKKC
 | ||| | .      . |....|||||||||||| .|.| |..|.||||| .|||||.||||||||.|||.|..|.|..||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
FN3 EphA8.AA FN3 328-418 19 2e-08 35.21 SMART 1-69 (69) Show / Hide 
Range on Protein: 328-418
Range on HMM: 1-69/69
Sequence Identity: 19% (21 aa)

PSAPVN---LISS-VNGT------SVTLEWAPPLDPGGRSDITYNAVCRRCPWALSHCEACGSGTRFVPQQTSLAQASLLVANLLAH----MNYSFWIEA
|..| |   |  . |. |      ||||.| ||        ..|                                    | .| ..     .|.|.. |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------------------YTVTGLKPGQYPWTEYEFRVRA

V----NGVS
|    .| .
VNGNDAGEG
FN3 EphA8.AA FN3 439-520 26 8.7e-15 56.37 SMART 1-69 (69) Show / Hide 
Range on Protein: 439-520
Range on HMM: 1-69/69
Sequence Identity: 26% (26 aa)

PSQVVV---IRQERAGQT------SVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPG----TRYVFQVRARTS--AGCG
|. .     .| .  . |      ||.| |..|      |..|.                      .||.|||||    |.|.|.|||...  || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA8.AA Eph 634-891 75 1.7e-210 705.55 In-house 1-264 (264) Show / Hide 
Range on Protein: 634-891
Range on HMM: 1-264/264
Sequence Identity: 75% (199 aa)

IHIEKIIGSGESGEVCYGRLQVP-GQRDV---PVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDG
|.|||.||.|| ||||.|||..| |.|.|   |||||.|||||||.|| ||||||.||||||||||||||||||..| .|||||||||||||.|||.|||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDP--EAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVM
|||..||||||||...||.||||..|.||||||||.||. .|||||||||||| |||||  ||.|||.|||||||||||||||.|.|.|||||||.|.||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVL
|||..|||||||.|.|||||...|.|||||.||.||.||||||||||.|||..||.|...||.|
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA8.AA Pkinase_Tyr 634-891 44 8.4e-139 470.71 Pfam 1-270 (270) Show / Hide 
Range on Protein: 634-891
Range on HMM: 1-270/270
Sequence Identity: 44% (120 aa)

IHIEKIIGSGESGEVCYGRLQ-VPGQRDVPVAIKALKAGYTERQ--RQDFLSEAAIMGQF-DHPNIIRLEGVVT-RGRL--AMIVTEYMENGSLDAFLRT
|.. | .|.|. |||. |..   |.. ..|||.| || |....|  |.||..||.|| |. .||||.|| ||.| .|.    .||.|||..|.|. .||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---DGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRAL-EDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWS
|   ....|. .|..| . . .|| ||.. ..|||||||||.||.  .|.|..||||.|.. .||    ... |||.||.|.|||.|... |...|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVVMWEVLAYGERP-YWNMTNQDVISSV-EEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVL
|||.|||.. ||| | |..|.|..|.  . |.|||.|.|..||  ...||..|||.| ..||.|. ... |
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA8.AA TyrKc 634-891 40 3.1e-128 433.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 634-891
Range on HMM: 1-280/280
Sequence Identity: 40% (116 aa)

IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQF--DHPNIIRLEGVVTRG-------RLAMIVTEYMENGSLDAFL
|. .|..|.|. |||. |..       ..||.| ||..     |.||..|| || ..  .||||.|| ||.| .          |||.|||..|.|. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RTHDGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDD----PEAAYTTA----GGK--IPIRWTAPEAIAFRTF
| | ....  .|. .   . .||.||.. ..|||||||||.||. ....|.|||||||...||     .  | ..    |||  .||||.|||.| ...|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SSASDVWSFGVVMWEVLAYGERPYWN-----MTNQDVISSVEEGYRLPAPMG--------CPRALHQLMLDCWHKDRAQRPRFAHVVSVL
...||||||||.|||.. ||. ||..     |.||.||  |..|||.| |          || ...|.|..||| | ..||.|. ... .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA8.AA TK 634-891 24 4.1e-118 397.77 In-house 1-486 (486) Show / Hide 
Range on Protein: 634-891
Range on HMM: 1-486/486
Sequence Identity: 24% (117 aa)

IHIEKIIGSGESG---EVCYGRLQVPG----------------------QRDVPVAIKALKAGYTERQRQ-------------DFLSEAAIMGQFD----
|...| .|.|. |   ||. |... ..                      .  .|||.| ||.| .. |..             |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIRLEGVVTRG------------RLAMIVTEYMENGS----LDAFLRTHDG---------------------------------------------
 ||||.|| ||.|.|            .  |||.|||..|.    |. .||....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTIVQLVGMLRGVGAGMRYLSDL------GYIHRDLAARNVLVDGRLV-----------CKVSDFGLS-
                              |.|  ||. | . . .||.||...      ...||||||||.||. ..|           ||..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RALEDDPEAAYTTAG-------------------------GKIPIRWTAPEAIA---------FRTFSSASDVWSFGVVMWEVLAYG-ERPYWNM
     .| .....  |....                         ||.||||.|||...         ...|...||||||||.|||.. || | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TNQDVIS-----------------------SVEEGYRLPAPMGCP--------------RALHQLMLDCWHKDRAQRPRFAHVVSVL
.||||..                       .|....|.|.|..||               ....||..|||.| ..||.|. ... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA8.AA UTK 634-891 36 2.5e-105 356.25 In-house 1-296 (296) Show / Hide 
Range on Protein: 634-891
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

IHIEKIIGSGESGEVCYGRLQVPG--QRDVPVAIKALKAGYTERQRQD----FLSEAA---IMGQFD-HPNIIRLEGVVTRGRLAMIVTEYMENGSLDAF
... . .|.|. |||. .|.. .     .. ||.|..... . .| ..    |. ||.   .|.||. |||..|| ||.|..   ||||||||||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRTHDG-------QFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGR-------LVCKVSDFG---LSRALE-------DDPEAAYTTAG-GK
||.|         ..|  |...| . . .|| ||.  |..||||||||.||.         .|||..|||   .||..        ..    |. .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAFR-TFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEG--YRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVL
.||||.||||.. . .|...|||||||||.||....| .|| .|.|..|. .|..|  ||.|.| .||... .||..|||.| . ||.|  .|...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA8.AA Src 634-891 43 5.2e-102 345.21 In-house 1-255 (255) Show / Hide 
Range on Protein: 634-891
Range on HMM: 1-255/255
Sequence Identity: 43% (115 aa)

IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLR-THDGQ-F
|. .. .|.|  ||| .|  .      ..||.| ||.|    . ..|| || || ...|.....|  |....    ||||||..||| ..|. . .|.  
IKLCRKLGQGQFGEVWMGYWNG----NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAY-TTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEV
 . ||. |   | .|| ||.   |||||||||||||.  .|||| |||| | ...| .  |    | |.||.||||||| ...|.  |||||||. ..|.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

LAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQ-LMLDCWHKDRAQRPRFAHVVSVL
  ||  ||  |||..|.  || |||.| |..||  |.. .|| |||||  ||| |.   ..|
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA8.AA SFK-Src 634-895 43 4.1e-97 288.33 In-house 1-259 (259) Show / Hide 
Range on Protein: 634-895
Range on HMM: 1-259/259
Sequence Identity: 43% (114 aa)

IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRT-HDGQFT
|  ||  |||  |.|  ||          ||.| || | .    . ||.||..| .  ||| |.|  | | |    |.|| | .|||  .|.  |    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAM--SAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

IVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLA
. ||| |   | .|| || .  ..|||||||||||    |||| |||.|| |..| |      | | ||.||||||    .||  |||||||. | |.  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGERPYWNMTNQDVISSVEE--GYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALV
||  ||  |||. |.  |.   |||.|.| .|| .....|.||| .    || |      ..   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA8.AA Fer 634-892 32 1.1e-87 297.66 In-house 1-283 (283) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-283/283
Sequence Identity: 32% (92 aa)

IHIEKIIGSGESGEVCYGR------LQVPGQ-RDVPVAIKAL-KAGYTERQRQDFLSEAAIMGQ-FDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFL
....|..|.|  |||. ||      ...  . ..|.|. | .  .. |. |...|. || || . .||||.... || .     ||| |.. .|||| .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RTHDGQ-FTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVD-GRLVCK--VSDFGLSRALEDDPEAAYTT-AGGKIPIRWTAPEAIAFRTFSSASD
.. ...  .. ... |. .. .||.||   . ||||.||||.|.. . ...|  .||||.||...|. .. .   .  |.||||.|||.. ....|...|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGVVMWEVLAYGERPYWN----MTNQDV----ISS-VEEGYRLPAPMGCPRALHQLML-DCWHKDRAQRPRFAHVVSVLD
||||||..||. . |. || .    |..  |    .   ...||..| | ..| .. |.|. .||.||  .|| .....  | 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA8.AA TK-Unique 634-891 31 1.8e-87 296.93 In-house 1-294 (294) Show / Hide 
Range on Protein: 634-891
Range on HMM: 1-294/294
Sequence Identity: 31% (94 aa)

IHIEKIIGSGESGEVCYGRLQVPG---QRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFD-HPNIIRLEGVVTRGR-LAMIVTEYMENGSLDAFLRTHD
. ....||.|. |.|. | .  .     ... ||.|.||.. |. ..||||.|...| . . ||||....|. |.     ||. ||...|.|. .|||  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GQ-------------------------FTIVQLVGMLRGVGAGMRYLSDLGY--IHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAG--GKI
..                          .  .|.  . ..  || ||. . .  .||||.|||||. ...|||..|||..| ...  . .| . .  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PIRWTAPEAIA--FRTF-SSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGC-PRALHQLMLDCWHKDRAQRPRFAHVVSVL
|||| |||..    ... .. ||||||||.|||.. .|..|| .| . |..  ...|||.| | .| ......||  ||.... .|| |. ....|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA8.AA Frk 634-895 43 2.1e-84 286.73 In-house 1-260 (260) Show / Hide 
Range on Protein: 634-895
Range on HMM: 1-260/260
Sequence Identity: 43% (116 aa)

IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLR---THDGQ
|.. . .|||  |||  |.  .     .|||.| ||.|  .   .||| || || .  || .|.|  | |.    .|.|| |..|||  .|.    .  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMD--PNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAY-TTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWE
  . ||| |   | ||| || .  |||||||||||||.  ..||. |||| | |  | |  | .  | ..||.||||||.    |.  |||||||... |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALV
.. ||  ||  |||..|.  |..|||.| | .||  | ..||.|||.|  .|| |  .   |.   
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA8.AA Csk 634-891 41 3.3e-80 272.76 In-house 1-251 (251) Show / Hide 
Range on Protein: 634-891
Range on HMM: 1-251/251
Sequence Identity: 41% (108 aa)

IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGR-LAMIVTEYMENGSLDAFLRTHDGQ-F
.|. . || || | |  | .|  ..    ||.| .|        | || ||..| |  ||| ..| ||.        ||.||| .|.|  .||.   . .
LHLGECIGHGEFGDVMQGEYQ--NRK---VAVKCIKCD-GNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVI

TIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTA---GGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMW
|  ||      |..|| ||     .||||||||.||.  .| |||||||..      |. ..     .||.|| ||||||     ||. |||||||. .|
TRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK------EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLW

EVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVL
|.  .|  ||  .  .||   || |||  || ||| . ...| .||| . |.|| |..|.. |
EIYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase EphA8.AA Syk 634-885 39 4.8e-79 268.9 In-house 1-257 (257) Show / Hide 
Range on Protein: 634-885
Range on HMM: 1-257/257
Sequence Identity: 39% (102 aa)

IHIEKIIGSGESGEVCYGRLQVP----GQRDVPVAIKALKAGYTERQ-RQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHD
.   . ||.|. | |  | ..        . ..|||| |||  ..    | |. || .| | ||| |.|. | .  .   | | |  | |..  .|  | 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIG-ICHAEMMMMVMEMAELGPMHKYLQQHR

GQFTIVQLVGMLR-GVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVM
   |    . ..   |  || ||     .||||||||||   |   |.||||.|.||  | .    | .|| |..| ||| | ...||..|||||||| |
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFA
|| . || .||  |..|.|.  .| | |.. | |||. . ||| .||  .   || | 
WEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EphA8.AA S_TKc 634-895 21 1.9e-41 144.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 634-895
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMEN--GSLDAFLRTHDGQ-
 .| ..||.|  |.|. .|       .  |||| .|        .....| .|. . .||||..| .|        .|.||...  |.|  ... . .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSS-ASDVWSFGV
    |.  .   ... .  .. |. ..| |||||   |.|.|   . |..||||.| |                  . ||| .    ..  ..|.||.|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVS-----VLDALV
...| |. |. |..   .....  .            .. . ...  |..|| ..||    .        ..  .
ILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA8.AA Pkinase 634-882 23 1.8e-39 140.67 Pfam 1-282 (293) Show / Hide 
Range on Protein: 634-882
Range on HMM: 1-282/293
Sequence Identity: 23% (69 aa)

IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTER--QRQDFL-SEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENG----SLDAFLR-
.||...|||| .|.|. .. .  |.    ||.| .|   ..   ...... ||..||  ..||||.|| .......   .|.||.|.|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

THDGQF--TIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVC----KVSDFGLSRAL-EDDPEAAYTTAGGKIPIRWTAPEAIA-FRTFSSA
  .| |  .  ..  ... .  |. |. . | |||||   |.|.| . ..    |..||||.. . .   . ..| .|    ... ||| |   .  ...
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT---PWYMAPEVIRGGQYYGPK

SDVWSFGVVMWEVLAYGERPYWNM----TNQDVISSVEEGYRLPAPMGCP-----------------------RALHQLMLDCWHKDRAQRP
.|.||.|....|.|  |. |...     .  | .  ...  . | .  .|                       ... ... .|..|| ..||
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
SAM_1 EphA8.AA SAM_1 927-991 39 2.3e-27 99.85 Pfam 1-66 (66) Show / Hide 
Range on Protein: 927-991
Range on HMM: 1-66/66
Sequence Identity: 39% (26 aa)

SGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRA-LGITLMGHQKKILGSIQTMR
... . .|..||.||.|..|.|||.. ||... ..|.| ..| .. .|.||.||.|||. |||...
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphA8.AA SAM 926-993 36 1.7e-21 78.63 SMART 1-67 (67) Show / Hide 
Range on Protein: 926-993
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

GSGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQ
 . .   .|.|||.||.|..|.|.|.. |...  ...... .|   .|||. ||.|||| .||.|..|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphA8.AA sam7 929-991 32 5e-20 69.02 In-house 1-70 (70) Show / Hide 
Range on Protein: 929-991
Range on HMM: 1-70/70
Sequence Identity: 32% (23 aa)

NGDLTVGDWLDSIRM---GRYRDHFAAGGY----SSLGMVLRMNAQDVRALGITLMGHQKKILGSIQTMR
  . .|..||..|.|   ..|.|.| . |.    ... ....|. .| ...|||. ||.|||. .|| ||
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_2 EphA8.AA SAM_2 933-991 35 2.3e-17 62.42 Pfam 8-71 (71) Show / Hide 
Range on Protein: 933-991
Range on HMM: 8-71/71
Sequence Identity: 35% (23 aa)

TVGDWLDSIRM-GRYRDHFAAGGYSSLGMV-LRMNAQDV--R-ALGITLMGHQKKILGSIQTMR
.|..||.||.| ..|.| | . |.... .. ..|...|     ..|||. ||.|||. .|| |.
DVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK