Gene EphB6 (Mouse)

EphB6

Species: Mouse
Alias: Ephb6, EphB6
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphB6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 246 Kinase domain by global Sugen HMM Fasta, JSON
EphB6.NA RNA Sugen 3422 None Fasta, JSON
EphB6.AA Protein Sugen 1014 None Fasta, JSON

Protein domain

Protein domains of EphB6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphB6.AA Ephrin_lbd 34-227 42 1.2e-111 348.14 Pfam 1-190 (190) Show / Hide 
Range on Protein: 34-227
Range on HMM: 1-190/190
Sequence Identity: 42% (88 aa)

EEVLLDTTGETSEIGWLTYPPGG---------WDEVSVLDDQRRLTRTFEAC-HVAGLPPGSGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGG
|.||.||. .||..||.|||..|         |.|||..|.. |  ||...| .|      ..|.|||.|...||||||| ...|.|..| |.|. ...|
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNV----MEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAG

TCRETFTLYYRQADE-PDGPDSIAAWHLKRWTKVDTIAADES-FPASSSSSSWAVGPHRTGQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVK
||.|||.||| ..|.  |  .....|. ...||.|||||||| |. .             |.|. ..||.. ||.|||..||||.||||.|||.|||.|.
TCKETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRD-----------FGSRW-MKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVR

LFSYTC
 ....|
VYYKKC
EPH_lbd EphB6.AA EPH_lbd 34-227 44 9.1e-103 348.64 SMART 1-184 (184) Show / Hide 
Range on Protein: 34-227
Range on HMM: 1-184/184
Sequence Identity: 44% (87 aa)

EEVLLDTTGETSEIGWLTYPPGG--WDEVSVLDDQRRLTRTFEACHVAGLPPGSGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGG-TCRETFT
|.||.||..||.|.||.||||.|  |.|||..|....  ||.. |.|.... ...|.|||.||...|||||| ...|.|..| |.|.. ..| .|.|||.
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEIN-EPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFN

LYYRQADEPDGPDSIAAWHLKRWTKVDTIAADESFPASSSSSSWAVGPHRTGQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYTC
||| ..|. ........|. ....|.|||||||||  .            .|.|| ...|.. ||||||...|||.||||.|||.|||.|..| ..|
LYYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRD-----------FGDRV-MKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphB6.AA GCC2_GCC3 299-331 36 6e-06 22.24 Pfam 1-33 (49) Show / Hide 
Range on Protein: 299-331
Range on HMM: 1-33/49
Sequence Identity: 36% (12 aa)

GHQPARGDKLCQACPEGSYKALAGNVPCSPCPA
|..   | . |..|| |.|.  .|.. | |||.
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPP
FN3 EphB6.AA FN3 365-462 15 2e-05 25.3 SMART 1-69 (69) Show / Hide 
Range on Protein: 365-462
Range on HMM: 1-69/69
Sequence Identity: 15% (18 aa)

PSAPRE---LWFE-VQGS------ALMLHWRLPQELGGRGDLLFNVVCKECGGHGEPSSGGMCRRCRDEVHFDPRQRGLTESRVLVGGLRAH----VPYI
|..|.    | .. |  .       . |.|  |            | ..                                  . | ||...      | 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR----------------------------------YTVTGLKPGQYPWTEYE

LEVQAVNG--VSEL
  |.||||  . | 
FRVRAVNGNDAGEG
FN3 EphB6.AA FN3 481-562 23 2.1e-12 48.48 SMART 1-69 (69) Show / Hide 
Range on Protein: 481-562
Range on HMM: 1-69/69
Sequence Identity: 23% (23 aa)

PSAVPV---MHQVSRAAN------SITVSWPQPEQTNGNILDYQLRYYDQAEDESHSFTMTSETNTATVTRLSPG----HIYGFQVRARTA--AGHG
|...|     . ..  ..      |.|.||  |      |. |.                      .||| |.||    . | |.|||...  || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphB6.AA Eph 663-908 57 2.8e-172 578.64 In-house 1-264 (264) Show / Hide 
Range on Protein: 663-908
Range on HMM: 1-264/264
Sequence Identity: 57% (153 aa)

IKIEEVIGAGSFGEVRRGRLQPR-GRREQ---AVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREG
||||.|||||.||||..|||... |.||.   .|||..|.|| .|. ...||..|...|||.||||.|||||||||||||..|| ||.|.|||||||..|
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHSPQ--------------GSSSLLRWAAPEVITHGKYTTSSDVWSFGILM
||...|||.|.||.|..|.|||....||| |.||..||||.|||||...|.|..              |.....||.|||.|...|.|..|||||.||.|
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
||||||||||||||..|.|..||||..|||||..||..|| ||||.|||||..||||.|.|...
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphB6.AA TK 663-908 21 8.7e-94 314.77 In-house 1-486 (486) Show / Hide 
Range on Protein: 663-908
Range on HMM: 1-486/486
Sequence Identity: 21% (103 aa)

IKIEEVIGAGSFG---EVRRGRLQPRGRRE----------------------QAVAIQALWAGGAESLKMTFL----------------GRAALLGQ--F
|......|.| ||   ||..|....|.. .                      . ||.  | .| |.| .. |.                  .... .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNILRLEGVVTKS------------RPVMVLTELMELGP----LDSFLRQREG---------------------------------------------
.||||.|| ||.|..            .|.|...|.|..|     |...||.. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFSSLQLVAMQRGVAAAMQYLSSF------AFVHRALSARSVLVNSHLV-----------CKVARLGHSP
                              |..  ||. | . .|..|.||.|        |||| | || .||....|           ||.|  | |.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

QGS-------------------------------------------SSLLRWAAPEVIT---------HGKYTTSSDVWSFGILMWEVMSYG-ERPYWDM
|||                                              .|| |||...         .||.|| |||||||.||||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NE---------QEVLNAIEQE--------------FRLPPPPGCP--------------PGLHLLMLDTWQKDRARRPHFDQLVAAF
.          |||.. ....              .|.|.||.||              . ...||.. |..| ..|| |.||. ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphB6.AA UTK 663-908 32 1.5e-79 270.6 In-house 1-296 (296) Show / Hide 
Range on Protein: 663-908
Range on HMM: 1-296/296
Sequence Identity: 32% (95 aa)

IKIEEVIGAGSFGEVRRGRLQPRG--RREQAVAIQALWAGGAESLKMT----FLGRAA---LLGQFQ-HPNILRLEGVVTKSRPVMVLTELMELGPLDSF
... . .|.| ||||...|...    . |..||. .. ....   ...    |.  |.   ...||. |||.||| ||.|.. | |..||.|| | |.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------QREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSH-------LVCKVARLG---HSPQGSS---------------SL---
||       ... .... |.. | . .|..||||.|  |||| | || .||..|       .|||.| .|    | . ..               .    
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

--LRWAAPEVITHG-KYTTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQE--FRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
  .|| |||..||. ..||.|||||||...||....| .|| .|....|. ...     |.|.|..||  .  ||.. |..| ..|| |..||...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphB6.AA TyrKc 663-908 29 1.3e-74 255.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 663-908
Range on HMM: 1-280/280
Sequence Identity: 29% (86 aa)

IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQF--QHPNILRLEGVVTKS-------RPVMVLTELMELGPLDSFL
|. ....| | ||||..|..       . ||.  | ..     .. |.  | .. ..  .||||.|| ||.|..        |.|...|.|..| |...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKV-----ARLGHSP--------QGSSS---LLR------WAAPEVITHGKY
| ......  .|. .   .|. |.||.|  ..|| | || .||.. ...|.     .| ...           ...     .      | |||.| .||.
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTSSDVWSFGILMWEVMSYGERPYWD-----MNEQEVLNAIEQEFRLPPPPG--------CPPGLHLLMLDTWQKDRARRPHFDQLVAAF
|| |||||||..|||...||. ||..     |. |||.. ..| .|.|.||         ||. .. .|.. |. | . || | ...  |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphB6.AA TK-Unique 663-908 30 8.7e-71 241.48 In-house 1-294 (294) Show / Hide 
Range on Protein: 663-908
Range on HMM: 1-294/294
Sequence Identity: 30% (89 aa)

IKIEEVIGAGSFGEVRRGRLQPRG--RREQ-AVAIQALWAGGAESLKMTFLGRAALLGQFQ-HPNILRLEGVVTKSR-PVMVLTELMELGPLDSFLRQRE
.....||| |.||.| || . ..   . .|  ||. .| ..  .  |. || ..... .   ||||....|. |||  |.| . | .. | |...||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GQ-------------------------FSSLQLVAMQRGVAAAMQYLSS--FAFVHRALSARSVLVNSHLVCKVARLGHS----------PQGS--SSLL
..                          |. .|.    ..| .|.||.|    .||| |.|| ||.....|||.. .| .           ..|     .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWAAPEVIT--HGKY-TTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGC-PPGLHLLMLDTWQKDRARRPHFDQLVAAF
|| |||..   || | || |||||||.||||....|..|| .|   .....|.. .|.| |..| .. .. ||  .||...  || |.|..  .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphB6.AA Frk 663-912 34 1.8e-57 197.25 In-house 1-260 (260) Show / Hide 
Range on Protein: 663-912
Range on HMM: 1-260/260
Sequence Identity: 34% (93 aa)

IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLR--QREGQF
|..   .|.| ||||  |.       .  ||.. | .| ..     ||  | .. . .|| ...|  | |   |....||||. | |  .|.  ...|. 
IQLIRRLGSGQFGEVWEGLWN----NTTPVAVKTLKPGTMDP--NDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

SSL-QLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHSP-------------QGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMWE
  . ||| |   ||| | || |  ..|| | || |||. |..||.|  |                .|    ..| ||| .   |.|. |||||||||. |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMI
.. ||  ||  | ..|||. .....|.| ||.||. |  .||. |..|  .|| |. |   ... .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphB6.AA Csk 663-908 33 8e-53 178.58 In-house 1-251 (251) Show / Hide 
Range on Protein: 663-908
Range on HMM: 1-251/251
Sequence Identity: 33% (86 aa)

IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSR-PVMVLTELMELGPLDSFLRQREGQ-F
... | ||.| || |. | .|      . ||.  .   | . .   ||  |.   | .|||  .| ||. ..   . . .| |  | |  .|| |. . .
LHLGECIGHGEFGDVMQGEYQ-----NRKVAVKCIKCDGNGMAQA-FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVI

SSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHSPQGSSSLL---------RWAAPEVITHGKYTTSSDVWSFGILMWEVMSYG
.  ||      |...| || .  |||| | || .||   .| ||   | . . .| .           | |||   |.|..| |||||||||.||. |.|
TRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFG

ERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
  ||  .  ..| ...|  .|  .| ||||  . .| ..|. . |.|| | |..   
RVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase EphB6.AA Src-Echino1 663-908 32 1.8e-52 180.32 In-house 1-252 (252) Show / Hide 
Range on Protein: 663-908
Range on HMM: 1-252/252
Sequence Identity: 32% (85 aa)

IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREGQ-FS
 .... || | .||| .|  .     .  ||...|  .     .  ||  | .. . .| .|...  |   . |. ..||||. | | ..|.. ...   
LRMDKKIGKGHCGEVWKGVWN----GNTPVAVKTLKEKT--MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVK

SLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGH----------SPQGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMWEVMSYG
  .|. |   .|. |.|| |  .||| |.|| |||.   |||.| .|           . ||    ..| ||| . .|..|  |||||||||| |.. .|
MTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFG

ERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLL-MLDTWQKDRARRPHFDQLVAAF
  || .| ..|||. ... .|.| .  ||  |. . |.  | ||  .|| |. |   |
RYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase EphB6.AA Pkinase_Tyr 819-908 45 2.7e-45 154.01 Pfam 179-270 (270) Show / Hide 
Range on Protein: 819-908
Range on HMM: 179-270/270
Sequence Identity: 45% (42 aa)

RWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERP-YWDMNEQEVLNAI-EQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
.| |||.| .||.|| |||||||.||||...||| | |..|  .||...| |.  |.|.|..||. .. ||.. |..| ..|| | ...  .
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphB6.AA Pkinase_Tyr 663-805 30 1.5e-41 141.3 Pfam 1-153 (270) Show / Hide 
Range on Protein: 663-805
Range on HMM: 1-153/270
Sequence Identity: 30% (47 aa)

IKIEEVIGAGSFGEVRRGRLQ-PRGRREQAVAIQALWAGGAESL--KMTFLGRAALLGQF-QHPNILRLEGVVT-KSRP--VMVLTELMELGPLDSFLRQ
|.. ...|.|.||||..|..    .  .. ||.  |  |  ..   .  |.  |... |. .||||.|| ||.| ...|  ... .|.|..| |...||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---EGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVA
.   .....  .|. | . .|..|.||.|  ..|| | || .||.. .|.|..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKIC
Kinase EphB6.AA CTKA 766-908 36 5.7e-39 128.49 In-house 134-290 (290) Show / Hide 
Range on Protein: 766-908
Range on HMM: 134-290/290
Sequence Identity: 36% (58 aa)

VAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHS---PQG-------SSSLL--RWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGER
| | . .|| | ||..  |||| | .| .|. .  . |.| .||.     .       |....  || ||| .  ||... ||||.||.|.||.|| || 
VYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEK

PYWDMNEQEVLNAIEQE--FRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
|.  |  ||| .|.      |||.|. ||  |  .|   |.   . || | .|    
PWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase EphB6.AA Src 819-908 45 1.4e-37 125.19 In-house 165-255 (255) Show / Hide 
Range on Protein: 819-908
Range on HMM: 165-255/255
Sequence Identity: 45% (41 aa)

RWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHL-LMLDTWQKDRARRPHFDQLVAAF
.| ||| |..|..|. |||||||||..|...||  ||  |. .||| ..|. .|.| |..||. |.  .||  |.||  .|| |. |   .
KWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphB6.AA SFK-Src 819-912 38 1.3e-35 102.61 In-house 164-259 (259) Show / Hide 
Range on Protein: 819-912
Range on HMM: 164-259/259
Sequence Identity: 38% (37 aa)

RWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQ--EFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMI
.| |||  .  .. . |||||||||| |.  ||  ||  |  .|||  ...    |.| ||.||. .. .|.| ||.    || |. |    .   
KWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphB6.AA Src 663-805 34 9.8e-28 91.27 In-house 1-139 (255) Show / Hide 
Range on Protein: 663-805
Range on HMM: 1-139/255
Sequence Identity: 34% (50 aa)

IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLR-QREGQ-F
|| .. .|.| ||||  |      . .  ||.  | .|        ||  | .. ...|.....|  |...  |.   ||.|. | |  .|. ..||.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

SSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVA
.  ||. |   ||. |.||.|  ..|| | || |||. ..|||||
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVA
Kinase EphB6.AA SFK-Src 663-810 38 1.7e-26 75.01 In-house 1-143 (259) Show / Hide 
Range on Protein: 663-810
Range on HMM: 1-143/259
Sequence Identity: 38% (58 aa)

IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREGQFSS
|. |.  |.| ||.| .||         .||.  |   || | .  ||  |... . .|||  .|  | |   |. . ||||  | |  .|.. .|.   
IRLEKKLGSGQFGDVWKGRWN----NTTEVAVKTLKP-GAMSAEE-FLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

L-QLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHS
. ||| |   ||. | ||    |||| | || |||    ||||.  | |
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMS
Kinase EphB6.AA S_TKc 663-912 19 8.7e-19 69.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 663-912
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)

IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMEL--GPLDSFLRQREGQ-
 .| ..|| |.||.|...|        . |||  .        ...   .. |    .|||| .| .|      . . .|...   | | .....| .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVA------RLGHSPQGSSSLLRWAAPEVITHGKYTT-SSDVWSFGILMWEVM
    |.  .   . . .. |..|. |  ..|| |    .|...  . |..      .| ..  |.   . . ||||.   .|.. ..|.||.|....| .
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGT---PWYMAPEVL---GYGKCKCDWWSCGCILYEML

SYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF-----DKMI
. |. |..  ..|.... |            .| .  ..   .||| ..||   .. ..      .  .
C-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphB6.AA CTKA 663-754 33 1.6e-18 58.69 In-house 1-101 (290) Show / Hide 
Range on Protein: 663-754
Range on HMM: 1-101/290
Sequence Identity: 33% (34 aa)

IKIEEVIGAGSFGEVRRGRLQPRGR-------REQAVAIQALWAGGAESLKMTFLGRAALLG--QFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFL
  |   || | .|.| |  | |.         . . ||.  | . . |     ||. | .|   .| |||.||| ||.|.. |    .| | .| | ..|
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL

R
|
R
Kinase EphB6.AA Pkinase 818-908 18 2.7e-13 48.1 Pfam 175-293 (293) Show / Hide 
Range on Protein: 818-908
Range on HMM: 175-293/293
Sequence Identity: 18% (22 aa)

LRWAAPEVIT-HGKYTTSSDVWSFGILMWEVMSYGERPYWDM------NEQEVLNAIEQ-EFRLPPPPGCP-------------------PGLHLLMLDT
....|||||  . .|....|.||.|....|... |. |...       ....... | . ... . |  |.                   . .  .. . 
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WQKDRARRPHFDQLVAA--F
..|| ..|| ..|..    |
LCKDPKKRPTAEQILQHPWF
Kinase EphB6.AA Pkinase 663-787 22 3.2e-13 47.85 Pfam 1-132 (293) Show / Hide 
Range on Protein: 663-787
Range on HMM: 1-132/293
Sequence Identity: 22% (30 aa)

IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAES--LKMTFL-GRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELG----PLDSFLR-
..|...||.||||.|.... .  |.    ||.  ..  ...|  ..  ..   ....  ..||||.|| .... .. . . .|..| |     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

QREGQF--SSLQLVAMQRGVAAAMQYLSSFAFVHR
.|.| |  |  ..  . . .. ...|. |  ..||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR
SAM_2 EphB6.AA SAM_2 938-1003 30 9.4e-23 80.93 Pfam 1-71 (71) Show / Hide 
Range on Protein: 938-1003
Range on HMM: 1-71/71
Sequence Identity: 30% (22 aa)

LDFPCLDSPQAWLSAIGL-ECYQDNFSKFGLSTFSDV-AQLSLEDL--P-GLGITLAGHQKKLLHNIQLLQ
 ....... ..||..||. ..| |||...|...|... |.....||     .|||..||.||... || ..
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM EphB6.AA SAM 938-1005 36 3.8e-20 74.17 SMART 1-67 (67) Show / Hide 
Range on Protein: 938-1005
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

LDFPCLDSPQAWLSAIGLECYQDNFSKFGLSTFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLLQQH
 | .. .. ..|| .||.. | |||.| |....  ....|.|||  .|||..||.||.|. || ....
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphB6.AA sam7 941-1003 30 5.3e-19 65.4 In-house 1-70 (70) Show / Hide 
Range on Protein: 941-1003
Range on HMM: 1-70/70
Sequence Identity: 30% (21 aa)

PCLDSPQAWLSAIGL---ECYQDNFSKFGL----STFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLLQ
.  .. . || .||.   . | |||...|     ...........|||  .|||. ||.||... || ..
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_1 EphB6.AA SAM_1 947-1003 37 2e-14 54.09 Pfam 9-66 (66) Show / Hide 
Range on Protein: 947-1003
Range on HMM: 9-66/66
Sequence Identity: 37% (22 aa)

QAWLSAIGLECYQDNFSKFGLSTFSDVAQLSLEDLPG-LGITLAGHQKKLLHNIQLLQ
. || .||.. | |.| . |........|.. |||   .|.||.||.||... || | 
CEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK