Gene FES (Mouse)

FES

Species: Mouse
Alias: FES, Fes
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
FES.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 256 Kinase domain by global Sugen HMM Fasta, JSON
FES.NA RNA Sugen 2686 None Fasta, JSON
FES.AA Protein Sugen 822 None Fasta, JSON

Protein domain

Protein domains of FES.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FCH FES.AA FCH 1-94 31 1.4e-28 102.24 SMART 1-103 (103) Show / Hide 
Range on Protein: 1-94
Range on HMM: 1-103/103
Sequence Identity: 31% (32 aa)

MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMS--LQDSG-----GQSWSSGPDSPVS--QSWAEITSQTENLSRVLRQHA
|.|..||....|| .. |.|...||..| |.|.|..|.|...|||. ||..|  ..  .     ... ...... .|  .||... .||...... .||.
MCFWWELWCDDGHEVLLQRQKWGLRWCEDMMKFMRERAKIEEEYAKMLHKLSKQYFNKKGSCGDWRAHRMTHPEMGSLNKSWEVMLQQTDQMAKHHKQHS

EDL
|||
EDL
FCH FES.AA FCH 1-94 17 2.3e-18 66.7 Pfam 1-97 (97) Show / Hide 
Range on Protein: 1-94
Range on HMM: 1-97/97
Sequence Identity: 17% (18 aa)

MGFSSEL--CSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDS----GGQSW-SSGPDSPVSQSWAEITSQTENLSRVLRQHAED
|.|.|..  . ..|. .... .. .....| .......| ....|||  |.... . .    |...  .. .   ....| .. ..||..... .|.||.
MSFWSDDYWQ-WDGFKVLFKRMKQGIQWCEDFAQFFKERAEIEEEYAKKLQKLCKKWFKKKKGSSEYHGTLS---SKKAWHQMLQETEQMAQQHQQFAEN

L
|
L
SH2 FES.AA SH2 460-530 39 9.4e-35 103.86 Pfam 1-81 (81) Show / Hide 
Range on Protein: 460-530
Range on HMM: 1-81/81
Sequence Identity: 39% (32 aa)

WYHGAIPRAEVAELLTH----SGDFLVRESQGKQ-EYVLSVMWDG---QPRHFIIQSSDN--LYRLEGDGFPSIPLLITHL
|||| |.|.|. .||       |.||||||. .. .|.|||..||   . .|..||. ||  .|. ... |.|.. |. | 
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FES.AA SH2 458-536 37 3.3e-28 100.94 SMART 1-87 (87) Show / Hide 
Range on Protein: 458-536
Range on HMM: 1-87/87
Sequence Identity: 37% (33 aa)

QLWYHGAIPRAEVAELLTHS----GDFLVRESQG-KQEYVLSVMWDGQPRHFIIQSSD-NLYRLEG---DGFPSIPLLITHLLSSQQP
| |||| |.|.|. .|| .     ||||||.|.  ...|||||.|.|. .|..|...| . |....     |||.  |. |     ..
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Pkinase_Tyr FES.AA Pkinase_Tyr 561-814 49 3.7e-149 505.77 Pfam 1-270 (270) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-270/270
Sequence Identity: 49% (134 aa)

LVLGEQIGRGNFGEVFSGRLR----ADNTPVAVKSCRETLPPDL--KAKFLQEARILKQY-NHPNIVRLIGVCT-QKQP--IYIVMELVQGGDFLTFLRT
...|...|.|.||||. |...     ...|||||...|.  ..   ...|..||.|.||. .|||||||.|||| |..|  ||||||....|| |..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREE-ADGIY-AASAGLRQVPVKWTAPEALNYGRYSSESDVWS
    . .| .|.||||  . |.|||||||| |||||||||||||||.|| ||.|||..|    |. |  .. | . .|.||.|||..|||.....|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWS

FGILLWETFSLGASP-YPNLTNQQTREFV-EKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQEL
||.|.|| |..|..| ||...|..  |.. |.|.|.||||.||| . .|| |||.|.| .||.|| | ..|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc FES.AA TyrKc 561-814 41 5e-147 495.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-280/280
Sequence Identity: 41% (120 aa)

LVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQY--NHPNIVRLIGVCTQK-------QPIYIVMELVQGGDFLTFLRTE
..||...|.|.||||. |...   ..||||...|      .. |..||||....  .|||||||.|||||.       .|..||||.. .|| . .||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG--------IYAASA--GLRQ-VPVKWTAPEALNYGRYSSE
. .| .|.||..  ..|.|||||.||.|||||||||||||.|... ||||||.||.  |.         | ..   | .  .|..|.|||..|||.....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDVWSFGILLWETFSLGASPYPN-----LTNQQTREFVEKGHRLPCPEL--------CPDAVFRLMEQCWAYEPGQRPSFSIICQEL
|||||||...|| |..|..|||.     ..||. .|.|..|.|.|.|.         |||.....|.|||...| .||.|| |....
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FES.AA Fer 561-815 39 3.3e-140 472.1 In-house 1-283 (283) Show / Hide 
Range on Protein: 561-815
Range on HMM: 1-283/283
Sequence Identity: 39% (113 aa)

LVLGEQIGRGNFGEVFSGR-----LRA-----DNTPVAVKSCRETLPPDL-KAKFLQEARILKQ-YNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFL
 .||...|.|.||||..||     ...     ....|.|| |..... .  ...|..||||... |.|||.|...|||...|||.||||.. ||.....|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RTEGAR-LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTE-KNVLK--ISDFGMSREEADGIYAASAG--LRQVPVKWTAPEALNYGRYSSESD
...... . ......|. .||.|||||.||.|||||.||||||... |...|  ||||||||...|..|. . .  ...||..|.|||....| ||...|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGILLWETFSLGASPYPN------LTNQ--QTREF-VEKGHRLPCPELCPDAVFRLME-QCWAYEPGQRPSFSIICQELH
|||||...|| |. || |||.      .||.  |.|.  ..||...|.|. .|... ..|. |||...| .||... |||.|.
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase FES.AA TK 561-814 25 7.6e-123 413.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

LVLGEQIGRGNFG---EVFSGRLRADN-------------------------TPVAVKSCRETLPPDLKA-------------KFLQEARILKQYN----
..||...|.|.||   ||. |..| .|                         |||||| ..|. . . ..             .||.||...|. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVRLIGVCTQK------------QPIYIVMELVQGGD----FLTFLRTEGAR--------------------------------------------
 |||||||.|||||.            .|..||||....||     ...||.   .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LRVKTLLQMVGDAAAGMEYLESK------CCIHRDLAARNCLVTEKNV-----------LKISDFGMS-
                               | ...|| |  ..|.|||||.||       ..|||||||||||.|.||            ||.|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------REE-ADGIYAASAG-----------------------LRQVPVKWTAPEALN---------YGRYSSESDVWSFGILLWETFSLG-ASPYPNL
       |.   |. | .. .                        ...|..|.|||.||         ||.....|||||||.|.|| |..| . .|...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------QQTREFVEKG--------------HRLPCPELCP--------------DAVFRLMEQCWAYEPGQRPSFSIICQEL
.|         |.  |....|              .|.|.|..||              .....|| |||.|.| .||.|| . ..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FES.AA UTK 561-814 38 7.2e-112 377.96 In-house 1-296 (296) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-296/296
Sequence Identity: 38% (113 aa)

LVLGEQIGRGNFGEVFSGRLRADN-----TPVAVKSCRETLP-PDLKA---KFLQEAR---ILKQYN-HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTF
. ||.|.|.|.||||. .|.. ..       |||| |... . .. ..   .|. |||   ..|| . |||..||.||||| .|..||.|. ..|| ...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR--TEGAR-----LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEK-------NVLKISDFG---MSREEA---------DGIYAASAGLRQ
||  .. ..     |.  ..|.|. | |.||.||.|. ..|||||||||||..        .| ||.|||   |||. .         .  |  ... ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPVKWTAPEALNYG-RYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKG--HRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQEL
.|..|.|||||... |... |||||||...||... |. |||...|.|. ..|..|  .|.|||. ||..|.||| .||.|.|  ||.|  . |..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FES.AA Src 561-814 46 5.1e-106 358.51 In-house 1-255 (255) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-255/255
Sequence Identity: 46% (120 aa)

LVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR--TEGARLRVK
. | ...|.|.||||. |  . .||.||||. ..       . ||||| |.|.  |...|.|  ||.|. ||||| |. . |  |..|.  .|| .|...
IKLCRKLGQGQFGEVWMGYWN-GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLP

TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEA--DGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSL
.|. |    |.||.||||.  ||||||||| || |.|| |. |||  |     | .| |. | . .|.|||||||.||||..  ||||||||||.| .. 
QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAK-FPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTY

GASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFR-LMEQCWAYEPGQRPSFSIICQEL
|  |||  ||... . ||.| |.|||. ||| ..  .| |||  .| ||| | .... |
GRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FES.AA TK-Unique 561-814 36 2.4e-97 329.69 In-house 1-294 (294) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-294/294
Sequence Identity: 36% (108 aa)

LVLGEQIGRGNFGEVFSGRLRADN------TPVAVKSCRETLPPDLKAKFLQEARILKQYN-HPNIVRLIGVCTQKQ-PIYIVMELVQGGDFLTFLRTEG
|..|..||.|.||.|. | .. ..      . |||| ... . .  |..||.|....|.   |||||...|.|| .. | .|.|| ...|. ...||| .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

AR-------------------------LRVKTLLQMVGDAAAGMEYLES--KCCIHRDLAARNCLVTEKNVLKISDFGMSR-EEADGIYAASAGLRQVPV
                           .  |.|..   . | |||||.|  | ..||||.|||.|.||..|.||.||||.| ....| |. . .   .|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWTAPEALN--YGRY-SSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELC-PDAVFRLMEQCWAYEPGQRPSFSIICQEL
.| |||.|   .| | ...|||||||.|.|| |.||| |||.. . . .| ...|.|.| || | ..... ||..|| .|| .||||. | ..|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FES.AA Tec 561-816 42 4.4e-97 328.82 In-house 1-254 (254) Show / Hide 
Range on Protein: 561-816
Range on HMM: 1-254/254
Sequence Identity: 42% (110 aa)

LVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRE-TLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKT
| . . .|.| || |  |..|. .  ||.|  .| .   .    |..||.. .   ||. |.| |||.|..||||| | .. |  | .||... ... ..
LTFMKELGSGQFGVVHLGKWRH-QYDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNM

--LLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLG
  ||.|  |   ||.|||..| |||||||||||| ...| |.|||||.|   |  |  | |    |||| .|| ..| |||| ||||.||.| || ||.|
AILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTK-FPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCG

ASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHS
  ||.|..| .. | | .||||  |.||.. ... | .||  .| .||.|..  ...  
KMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase FES.AA Abl 561-814 43 2.9e-91 304.69 In-house 1-252 (252) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-252/252
Sequence Identity: 43% (112 aa)

LVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR-TEGARLRVKT
... ...| | .|||. |  .  .  ||||. .|   .     ||.|| |.|.  |||.|.|.||||.  | ||. | .  |  | .|| ..   |   .
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTME--VHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVV

LLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGAS
||.|    | ||.|||..  |||||||||||| |....|. |||..|   | .| | || .  |.||||||.| | ..|| |||| ||.||||    | |
LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAK-FPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMS

PYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQEL
||| .  ..  . .|||.|.  || ||. |..|| ||| ...  ||||  | ...
PYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase FES.AA Eph 561-814 40 2.7e-90 303.54 In-house 1-264 (264) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-264/264
Sequence Identity: 40% (107 aa)

LVLGEQIGRGNFGEVFSGRLRAD----NT---PVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA
. . . || | |||| .|||..      .   |||.|  ... .   .. || || |. |..||||.|| || |. .|. || |    |   .|||..  
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

RLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE---EA--DGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGI
.. |  |. |    |.|| || .   .|||||||| || .. | |.||||.||.   ..  .. |  . |   .|..||||||. |....| |||||.||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGG--KIPIRWTAPEAIAYRKFTSASDVWSYGI

LLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQEL
..||  | |  || ...||   . .|.| ||| |  || | ..|| .||.... .|| |. |   |
VMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase FES.AA Csk 561-814 44 7.1e-90 304.89 In-house 1-251 (251) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-251/251
Sequence Identity: 44% (114 aa)

LVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQ-PIYIVMELVQGGDFLTFLRTEGAR-LRVK
| |||.|| |.|| |  | ..  |  ||||  ..     . | || || .  |  ||| |.||||  ...  .||||| .  |  . .||. |   .  .
LHLGECIGHGEFGDVMQGEYQ--NRKVAVKCIKCDGNGMAQA-FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRR

TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGA
 ||.   | ..||.|||.|  .|||||||| || | .| |.|||| ..||  .   .. |    |.||||||||  ...|. |||||||||||| .| | 
QLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSG--KFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGR

SPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQEL
 ||| .  .   . |||| |   || ||..|. .|.|||. .| .||.|  . . |
VPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase FES.AA ALK 561-816 42 2.6e-88 299.69 In-house 1-273 (273) Show / Hide 
Range on Protein: 561-816
Range on HMM: 1-273/273
Sequence Identity: 42% (118 aa)

LVLGEQIGRGNFGEVFSGRLRA-----DNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR----TE
. |.   |.|.||||. |  .         .||.|. .|   ..    |. || |. ..||.|.||.||.| |||| .|| |.  ||| . |||    ..
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

G----ARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN---VLKISDFGMSREEADGI-YAAS----AGLRQVPVKWTAPEALNYGRYSS
.    . |  | |||   | |.|  |||..  |||| |||||| | |    | || ||||.|.    | | |.     |    ||||. |||.  | . |
ESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARD----ITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTS

ESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHS
 .||||||.|.|| |||| .|||. .||.  ||| .| |.  |  ||  |.|.| |||  .|  ||.| .|   .  
KTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase FES.AA S_TKc 561-818 24 6.4e-55 189.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 561-818
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

LVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQG--GDFLTFLRTEGAR----
  ....||.| ||.|. .| . ..  ||.|  .         ....| .|||. .|||||.|..|.   . .|.|||.. |  || .....  | .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSS-ESDVWSFGILLWE
 .   .   ..   . ..||. |.  |||||   | |..|  ..||.|||..|.              .   . ||| |    |.  ..|.||.|..|.|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

TFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQ-----ELHSIR
 .. |  |.|  . |.. . .            .. .  ....|. ..| .||.   . |      .|   
MLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FES.AA Pkinase 561-814 22 3.9e-45 160.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

LVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPD--LKAKFL-QEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGG----DFLTFLR-TEG
...|..||.|.||.|. .. . ..  ||||  .     .  ...... .|..|.|  ||||||||..... |. ||.|||...||    |  ....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ARL--RVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVL----KISDFGMSREEADGIYAASAGLRQVPV---KWTAPEALN-YGRYSSESD
 ..    ...  ..   . |.||. |. .|||||   |.|. .....    ||.||| ..         . .  ....    . ||| .. .  |....|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSFGILLWETFSLGASPYPNL----TNQQTREFVEKGHR----LPCPELCP-------------------DAVFRLMEQCWAYEPGQRPSFSIICQE--
.||.|..|.| .. |  |.|.     .    .. ...  .     ..|..|.                   ..   ... |... | .||..  |.|   
MWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

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