Gene FGFR2 (Mouse)

FGFR2

Species: Mouse
Alias: Fgfr2, FGFR2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
FGFR2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 277 Kinase domain by global Sugen HMM Fasta, JSON
FGFR2.AA Protein Sugen 840 None Fasta, JSON
FGFR2.NA RNA Sugen 5223 None Fasta, JSON

Protein domain

Protein domains of FGFR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 FGFR2.AA IGc2 72-133 31 3.3e-15 57.77 SMART 1-56 (56) Show / Hide 
Range on Protein: 72-133
Range on HMM: 1-56/56
Sequence Identity: 31% (20 aa)

APGESLELQCM--LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTAARTVD
 .|.|..|.|    .... |.|.| | .|         . .|.|| .|| |||.|.|.|   . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR2.AA IG 66-144 21 9e-13 49.68 SMART 1-58 (58) Show / Hide 
Range on Protein: 66-144
Range on HMM: 1-58/58
Sequence Identity: 21% (18 aa)

PEAYVVAPGESLELQCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDS---GLYACTAARTVDSETW--YFMVNVT
|. ..| .||...|.|  .    |.|.                  |.| ...| ||   | | |.|     . .    . . |.
PP-VTVKEGETVTLTC-VS---QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FGFR2.AA V-set 60-126 17 0.001127 14.5 Pfam 1-110 (128) Show / Hide 
Range on Protein: 60-126
Range on HMM: 1-110/128
Sequence Identity: 17% (19 aa)

KYQISQ--PE----AYVVAPGESLELQCMLK-------DAAVISWTKDGVHLGPNNRTVL---------------IGEY----------------LQIKG
  |..|  |.      .|..|.|..|.| ..       .   |.| ..   .|. ....                 ...                |.|. 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

ATPRDSGLYAC
..| ||| | |
LQPSDSGTYYC
I-set FGFR2.AA I-set 88-128 34 0.005671 12.6 Pfam 31-77 (92) Show / Hide 
Range on Protein: 88-128
Range on HMM: 31-77/92
Sequence Identity: 34% (16 aa)

VISWTKDGVHLGP-NNRTVLIGEY-----LQIKGATPRDSGLYACTA
..||.|||  | | ..| .   .      | |....|.|.| | |.|
QVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
I-set FGFR2.AA I-set 193-267 29 1.8e-15 55.03 Pfam 17-92 (92) Show / Hide 
Range on Protein: 193-267
Range on HMM: 17-92/92
Sequence Identity: 29% (23 aa)

TVKFRCPAGGNPTPTMRWLKNGKEFKQ-EHRIGGYKVRNQH---WSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDV
|..| | . |.|.|.  |.|.|.. .. ..|   ..... .    .|... | |.| | ||| ..|..|.   | .| |
TARFECQVTGDPPPQVSWFKDGQPLRPDSDR---HQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FGFR2.AA IGc2 189-257 31 2.4e-15 58.24 SMART 1-56 (56) Show / Hide 
Range on Protein: 189-257
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

PAANTVKFRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYG
   ..| ..||| |||.|. .|.| |..                |.|  ..| |.| |.|||...|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR2.AA IG 183-268 16 1.4e-10 42.44 SMART 1-58 (58) Show / Hide 
Range on Protein: 183-268
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

KRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK---GNYTCLVENEYGSINH--TYHLDVV
 . . | .  ||...| .      ...|.                       |.. .| |.|    |.|.| ..  .|..    . .| | 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGv FGFR2.AA IGv 193-252 21 0.001849 5.6 SMART 1-76 (76) Show / Hide 
Range on Protein: 193-252
Range on HMM: 1-76/76
Sequence Identity: 21% (17 aa)

TVKFRCPAGGNPTPTMRWLKN-------GKEFKQEHRIGGYKVR----NQH--------WSLIMESVVPSDKGNYTCLV
.|.  | . |. . .| |..        ||. .  ..  .|| |     .         ..| | .. |.| |.|.| .
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY--SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
V-set FGFR2.AA V-set 193-267 16 0.01055 11.15 Pfam 23-128 (128) Show / Hide 
Range on Protein: 193-267
Range on HMM: 23-128/128
Sequence Identity: 16% (18 aa)

TVKFRCPAGGNP----TP-TMRWLK-NGK------------EFKQE----HRIGGYKVRNQ--------HWSLIMESVVPSDKGNYTCLVENE-YGSINH
.|...|    ..    .. .. | .                 ....    .  . .| | .        ..|| . .. ||| | |.| | |. ...  |
SVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGH

TYHLDV
 ..| |
GTRLTV
IG FGFR2.AA IG 282-379 20 4.2e-16 60.73 SMART 1-58 (58) Show / Hide 
Range on Protein: 282-379
Range on HMM: 1-58/58
Sequence Identity: 20% (21 aa)

PANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA---GEYTCLAGNSIGISFH--SAWL
|   . ..|..|.. | |      .|.|                                    | | ||..||.   |.|.| |    |  .   ...|
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTL

TVL
||.
TVQ
IGc2 FGFR2.AA IGc2 288-368 25 3.9e-09 37.61 SMART 1-56 (56) Show / Hide 
Range on Protein: 288-368
Range on HMM: 1-56/56
Sequence Identity: 25% (21 aa)

VVGGDVEFVCKVYSDAQPHIQWIK--HVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIG
  |..|.. |..  .  | |.|.|  ...                               | |.|||.||.|.|||.| |..|
HEGQSVTLTCPATGNPDPNIHWYKGQPLP---------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FGFR2.AA I-set 348-378 51 2.2e-07 27.6 Pfam 62-92 (92) Show / Hide 
Range on Protein: 348-378
Range on HMM: 62-92/92
Sequence Identity: 51% (16 aa)

IRNVTFEDAGEYTCLAGNSIGISFHSAWLTV
|.||. .|.|.||| | || | .  .| |||
ISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set FGFR2.AA V-set 348-378 34 0.000128 17.76 Pfam 97-128 (128) Show / Hide 
Range on Protein: 348-378
Range on HMM: 97-128/128
Sequence Identity: 34% (11 aa)

IRNVTFEDAGEYTCLAGNS-IGISFHSAWLTV
|.|.. .| | |.| . |. ...  |. .|||
ISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGv FGFR2.AA IGv 292-363 17 0.000296 13.58 SMART 1-76 (76) Show / Hide 
Range on Protein: 292-363
Range on HMM: 1-76/76
Sequence Identity: 17% (14 aa)

DVEFVCKVYSDAQPHIQWIKHV------EKNGSKYGPDGLPYLKVLKAAGVNTT----DKEIEVLYIRNVTFEDAGEYTCLA
.|.  ||.  .   .. |...        |  . .|          .  ..  .    .|    | ..|.. || | |.|  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY-----SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
I-set FGFR2.AA I-set 282-311 30 4.719734 2.69 Pfam 7-36 (92) Show / Hide 
Range on Protein: 282-311
Range on HMM: 7-36/92
Sequence Identity: 30% (9 aa)

PANASTVVGGDVEFVCKVYSDAQPHIQWIK
| ..   .| ...| |.|  | .| ..| |
PKDVEVQEGETARFECQVTGDPPPQVSWFK
V-set FGFR2.AA V-set 275-312 14 17.321985 0.06 Pfam 1-49 (128) Show / Hide 
Range on Protein: 275-312
Range on HMM: 1-49/128
Sequence Identity: 14% (7 aa)

PI-LQAGLPA----NASTVVGGDVEFVCKVYSDA----QP-HIQWIK-H
.. ...  |.      . ..|..|.. |.. .|     .. .|.|.. .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQ
Kinase FGFR2.AA FGFR 500-776 74 2.2e-239 801.52 In-house 1-293 (293) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-293/293
Sequence Identity: 74% (217 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR
|||||.|||||||||.||||.|||.|.|....||||||||...|.|||||||||||||||||||||||||||.|||.|||||||||...||||..|||||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PPGMEYSYDIN-------RVPEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL
||||.|..|..       | ||.|        .|.||||||.||.|||||||||.|||||||||||||||...||||.||||||||..||||.|||||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|.|||||||||||||||||||||.|||.|||.|.||.|||.|| ||||.|.|||||||.||.||..|.|.||..|||..|.||||||||||.|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FGFR2.AA Pkinase_Tyr 500-776 48 1.1e-158 537.99 Pfam 1-270 (270) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-270/270
Sequence Identity: 48% (138 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD--LSDLVSEMEMMKMIGKHKNIINLLGACT-QDGP--LYVIVEYASKGNLREY
.|.|| ||||.||.|..... |   |. .. ..|||||||..|....  . |. .|...|| .|.|.||..|.|.|| |..|  .|...||. .|.|..|
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY-KKTTNGRLPVKWMAPEA
||..|             .... | |||..  .| |.|||||.|..||||||||||.|||||||.||.|||||||| | ||| .|...|.||.||||||.
LRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LFDRVYTHQSDVWSFGVLMWEIFTLGGSP-YPGIPVEELFKLL-KEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
......|..|||||||||||||||.|..| |||.. ||..... ..|.||..| ||. |.|..|..|||. |..||||....|.|
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGFR2.AA TyrKc 500-776 42 1.3e-154 520.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-280/280
Sequence Identity: 42% (130 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG-KHKNIINLLGACTQD-------GPLYVIVEYASKGNL
.|||| ||||.||.|. ...           ..|||||||.||    . |. .|...|...| .|.||..|.|.|||.       .||....||...|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI-------DYYKKTT--NG
..|||..||                 . |||.|  .| |.|||||.|..||||||||||.||.||...||.||||.||| .        |||.|..  .|
KDYLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R--LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG-----IPVEELFKLLKEGHRMDKPTN--------CTNELYMMMRDCWHAVPSQRP
.  ||..|||||.......|..||||||||.||||||.|..||||     .. .|.....|.|.||..| |        |. |.|..|..|||. |..||
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TFKQLVEDL
||....|..
TFSEIHECF
Kinase FGFR2.AA TK 500-776 29 1.6e-136 459.85 In-house 1-486 (486) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-486/486
Sequence Identity: 29% (143 aa)

LTLGKPLGEGCFG---QVVMAEAVGIDKDKPKEA------------------VTVAVKMLK--DDATEKDLSD--------------LVSEMEMMKM-IG
.|||| |||| ||   .| ..|. |......|..                  ..|||||||  |......  |              ...||.||.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHKNIINLLGACTQD------------GPLYVIVEYASKGN----LREYLRARRPPGME-----------------------------YSYDINRVPEE-
.|.||..|.|.|||.            .|.....||...|.    ||.|||..||....                             .| . . ..|. 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

-----------QMTFKDLVS-------------------CTYQLARGMEYLASQKC------IHRDLAARNVLVTENNV-----------MKIADFG---
           . |.|||..                   . .|.|.|||||.|..|      .||||||||.||.||||            ||||||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDINN------------------------IDYYKKTTNGRLPVKWMAPEALFDRV---------YTHQSDVWSFGVLMWEIFTLG-GSPYPGI
     |||||..                         |||.....|.||..|||||.|.|||         .|..|||||||||||||||.| . .|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PV---------EELFKLLKEG--------------HRMDKPTNCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL
.          .|....|..|              .|| .| .|.               |.| .|..|||. |..||||.||.| |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGFR2.AA Ret 500-778 48 7.79999999999e-125 421.02 In-house 1-293 (293) Show / Hide 
Range on Protein: 500-778
Range on HMM: 1-293/293
Sequence Identity: 48% (144 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD-ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG--PLYVIVEYASKGNLREYLR
| |.. |||| ||||| | |  | . .|    |||||||| . |.   . || ||... | .  | ..| |.|||.||.  |. .||||.  | |||.||
LQLDDTLGEGHFGQVVKAQAFHI-RGHP-GYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

ARRPPGMEYSYDI-NR------VPE--EQMT-----FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNG
  |  |  | | | ||       |   .  .     .|...|   |  .|| ||.. | .||||||||||| |  ..|| |||| ||.   | | |   .
LSRKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKD

RLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
|.||||||.|.|.| ||| .|||||||||.||| |.|..|||||| | |. ||| |.||| | ||  |.| .|| ||   |  || || .  |. .
RIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FGFR2.AA TK-Unique 500-776 44 7.1e-121 407.88 In-house 1-294 (294) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-294/294
Sequence Identity: 44% (133 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV-TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLRA
|..|. .||| ||||  .|..||.  |. ..   ||||||||.||. | .|. .| .||| .|.|.||...||.|| .. | . | ||...|||. ||| 
LEVGDVIGEGAFGQVWRGEVWGIW--KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

RRP---PG-------MEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS--QKCIHRDLAARNVLVTENNVMKIADFGLARDINN-IDYYKKTTNGRL
.||   ..       .   ..  ....|  . |||..  .|.|.|||||||  .|..||||.|||||.||..| ||.|||.|||...  .| .... ||.
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

PVKWMAPEALF--DRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNC-TNELYMMMRDCWHAVPSQRPTFKQLVEDL
|..|||||.|   ...| | .|||||||||||||||||. ||||.| ... .....|.||..| .| ..|.|  |. ||. .|..||.| |..  |
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FGFR2.AA Tie 508-776 46 2.9e-104 318.31 In-house 1-267 (267) Show / Hide 
Range on Protein: 508-776
Range on HMM: 1-267/267
Sequence Identity: 46% (129 aa)

EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSY
|| ||||. |    | ||  |  . ||.||.|. | |.|  | . |.|.|  .|.| |||||.||| . | ||| .|||  ||| ..||  |    . ..
EGNFGQVMKAM---IKKDGLK--MEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAF

DINRVP------EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH
 ...           .. . ..      ||||.||. ..||||||||||.|| || | |||||||.|     . | |.| |||||.||| |.|   ||| 
AREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTT

QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
.|||||.|||.||| .||| || |.   ||.. | .|.||..| || .|.| .|| ||   | .||.| |.. .|
KSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FGFR2.AA UTK 500-776 35 8e-104 351.22 In-house 1-296 (296) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-296/296
Sequence Identity: 35% (108 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDATEKDLS---DLVSEME---MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
. ||..||.| ||.| .|... ..   . . . |||| .. .......     |.  |     |||.   | |...|.| |||..|.....||...|.||
VQLGRQLGQGAFGEVHKARFTQCS--EHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN-------NVMKIADFG---LARDIN---------NI
 |||  ||  .         .... |  ..... .. ||||.||.|....||||||||.||...       .| ||||||   ..|..|         . 
SYLRRHRPTPP--------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWES

DYYKKTTNGRLPVKWMAPEALFDR-VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG--HRMDKPTNCTNELYMMMRDCWHAVPSQRPTFK
.||... ..|.|..||||||| ..  .|..||||||||..|||.| |  ||||.  ..... . .|  .|| .|  |  ..|..|..|||. |. ||.|.
YYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFE

QLVEDL
.||. .
DLVQQM
Kinase FGFR2.AA VEGFR 618-776 59 2e-99 336.64 In-house 171-332 (332) Show / Hide 
Range on Protein: 618-776
Range on HMM: 171-332/332
Sequence Identity: 59% (97 aa)

TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARD-INNIDYYKKTTN-GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI
| .||..  .| |||||.|||.|||||||||||.|..|||| || ||||||. |   . |.. .. |||| ||||||..||.||| .|||||.||..|||
TMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEI

FTLGGSPYPGIP-VEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|.||||||||.   ||... ||.| || .|  || |.|  | ||||  | .||.|  ||| |
FSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FGFR2.AA Src 500-776 39 7.4e-98 331.41 In-house 1-255 (255) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-255/255
Sequence Identity: 39% (111 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR
..| . ||.|.|| | |.        . .  . |||| || .    .  ..  | . ||   .|.....|.  |.|. | | . || |.|.| .||..  
IKLCRKLGQGQFGEVWMG--------YWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRV
           .  . .. ...|.. . | |.||.|| |.. |||||||||||| |||| |.||||||| | .  | |   .  ..|.||.||||.  ..
-----------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGR

YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYM-MMRDCWHAVPSQRPTFKQLVEDL
.|  |||||||.|..||.| |  ||||   .| .. .. | || .|.||  |||.  |. |||. | |||||. | . |
FTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGFR2.AA RTKB 500-776 40 4.1e-94 317.64 In-house 1-264 (264) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-264/264
Sequence Identity: 40% (113 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR
. ||. ||.| ||.|  |    .      ..  .|.| || .| . .  |  ||| .|| .| | |.| ..| | || |. . ||..  ||||.|||.. 
VWLGEKLGNGAFGEVFQAW---VRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMC-

PPGMEYSYDINRVPEEQMT---FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD
           | .....    .. ||.   | |.|| .| ... |||||.||||||. .   ||.|||.|| | . .|  .||  |||.|||||| . .
-----------RASQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECY--ETTCTRLPIKWMAPESWAH

RVYTHQS-DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
| || .| ||||||| |||||.||| ||.  .. ..|..|  |||. ||     . . .|..|| . ...||.|. ||. .
RIYTTKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FGFR2.AA PDGFR 614-776 57 7.1e-93 298.5 In-house 195-358 (358) Show / Hide 
Range on Protein: 614-776
Range on HMM: 195-358/358
Sequence Identity: 57% (94 aa)

EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMW
..  |..||.. .|| |.|||.|||  |.||||||||||...  | || |||||||| |   |    | |||||||||| .|| ||| ||||||.|.| |
SNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLW

EIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|||.|||.||||.||.. | |. ||| ||..|   . | |  |. || . | .||||.||.. |
EIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FGFR2.AA S_TKc 500-780 23 8.2e-55 189.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 500-780
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK--GNLREYLRA
 ......|.| ||.|  .  ..           ||.|..|         .. .|....|.  .|.||..|....   . ||.. ||..   |.|..|.. 
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

RRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR
|...|             ...  .  . .||.....||. |.. |||||   |.|..|  . ||.|||||| .         |       .|||| |   
RGRHGLR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

VYTH-QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVE-----DLDRIL
 |..  .|.||.|....| .. |  |.|   ....||...           . |.  ..| |..  |..|||  .. .      ..  .
GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGFR2.AA Pkinase 500-776 22 4.6e-48 170.78 Pfam 1-293 (293) Show / Hide 
Range on Protein: 500-776
Range on HMM: 1-293/293
Sequence Identity: 22% (71 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV---SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG----NLR
...|...|.| ||.|  .  .|  |       .|||| .| . ....        || ..||.. .|.||. |..... .. .|.. ||. .|     | 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

EYLRARRPPGMEYSYDINRVPEEQM--TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM----KIADFGLARDINNIDYYKKTTNGRLPV
.|...                .  .  . ... .. ||..||.||. |...|||||   |.|. .|..     ||.|||||. .. .  .  .|      
DYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP

KWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI----PVEELFKLLKEGHRMDKPTNCT-----------------------NELYMMMRDC
 .|||| .  .. |.. .|.||.|....| .. |  |.||     .  .  .....  . . . ..                         |.   ...|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WHAVPSQRPTFKQLVED--L
..  |..|||..|....  .
LCKDPKKRPTAEQILQHPWF
Kinase FGFR2.AA VEGFR 500-599 53 1.4e-43 151.07 In-house 1-101 (332) Show / Hide 
Range on Protein: 500-599
Range on HMM: 1-101/332
Sequence Identity: 53% (55 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT---QDGPLYVIVEYASKGNLREYLR
| |||.||.| ||||. |.|.||.| ..    ||||||||  ||      |.||..|.. ||.| |  |.||.||   | ||| |||||  .|||  |||
LKLGKMLGRGAFGQVHEASAFGIRKMET--CTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

ARR
. |
TKR
Kinase FGFR2.AA PDGFR 500-599 48 2.2e-35 110.82 In-house 1-98 (358) Show / Hide 
Range on Protein: 500-599
Range on HMM: 1-98/358
Sequence Identity: 48% (48 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR
| .|| || | ||.|| | | |. |  .  . .|||||||  |       | ||  .|   |.| ||.|||||||  || |.| ||   | | .||. .|
LQFGKTLGSGAFGKVVEATAYGLSKSQA--VMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR