Gene FLT3 (Mouse)

FLT3

Species: Mouse
Alias: FLT3, Flt3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
FLT3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 336 Kinase domain by global Sugen HMM Fasta, JSON
FLT3.NA RNA Sugen 3657 None Fasta, JSON
FLT3.AA Protein Sugen 1000 None Fasta, JSON

Protein domain

Protein domains of FLT3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FLT3.AA IG 79-162 15 0.004891 17.31 SMART 1-58 (58) Show / Hide 
Range on Protein: 79-162
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

AATVEVAESGSITLQVQLATPGDLSCLWVFKHSSLGCQPHFDLQNRGIVSMAILNVTETQA---GEYLLHIQSEAANYTV--LFTVNVR
   |.| | ...||.   .     .  |                      . | ||..  .   |.|    .  . .|.    .|. |.
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 FLT3.AA IGc2 264-338 16 0.000142 18.72 SMART 1-56 (56) Show / Hide 
Range on Protein: 264-338
Range on HMM: 1-56/56
Sequence Identity: 16% (12 aa)

KVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPS
. |......|.    |..   .|   .. |.                 .  | . .   ..| |||||. . . .
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP----------------WNWTLTIKNVT-PEDSGYYTCYARNPWG
IG FLT3.AA IG 258-346 14 0.00669 16.13 SMART 1-58 (58) Show / Hide 
Range on Protein: 258-346
Range on HMM: 1-58/58
Sequence Identity: 14% (14 aa)

LPQLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDT---GYYTCSSS--KHPS-QSALVTIL
 | .  |.||.. ..| .        ..|                               . .| ..|.   | |.|  .  .. | |.. .|..
PP-VTVKEGETVTLTC-VS------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
Kinase FLT3.AA PDGFR 611-946 60 6.8e-272 883.01 In-house 1-358 (358) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-358/358
Sequence Identity: 60% (218 aa)

LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREK
|.|||.|||||||.|..|||||.||......|||||||..|.|.||||||||||.|.|||.|.||||||||||..||.|.|.||||||||||||..||..
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

FHR---------TWTEIFKEHNFSFYPTFQAHSN--------SSMPGSREVQ--LHPPLDQLSGFNGN---LIHSEDEIEYENQKRLAEEEEEDLNVLTF
||.         ||......||||||.....|..        ||...|..|.   |...|.......|    .||..|..|..|....|..|.|.||||.
FHQHHPEKPKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNVLTY

EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLG
.|||||.||||||||||..|.||||||||||||..||||||||||||||||..||.|||.||||||||||||||.|...||..|||||||||||||||||
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG

VNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL
.|||||.|||..|||.|..|..|.|||.|.|.||..||.||.||..|||.|..|..||
GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FLT3.AA Pkinase_Tyr 611-946 39 3e-150 509.48 Pfam 1-270 (270) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-270/270
Sequence Identity: 39% (137 aa)

LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCE--KEALMSELKMMTHLGHHDNIVNLLGACT-LSGP--VYLIFEYCCYGDLLNYLR
..|||.||.||||.|. .|..| .. .  |.||||||||.|.. .  .|..|.|.|.|..||||.|||.|.|.||  ..|  .|...||...||||.|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFL
..|                                                                        || . || .|||....|.|||||.|
KHR------------------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYL

EFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSY-VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP-YPGIPVDANFYK
| | |.||||||||.|||...||||||||||||| .|. | ..||...||.||||||....|..|.||||||.|.|.||||..|  | |||.  .. .|.
ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYE

LI-QSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL
.| ..|  |..| .... || .|..||..|  .||.|  . ..|
YIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FLT3.AA TyrKc 611-946 32 5.2e-143 482.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-280/280
Sequence Identity: 32% (119 aa)

LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLG-HHDNIVNLLGACTLS-------GPVYLIFEYCCYGDLLN
...||.||.||||.|. .|..        |||||||||| |    .|..|.|...|..|| ||.|||.|.|.|| .       .|.....||...|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGM
|||..|.|                                                                           |. .||| |..|.|.||
YLRKHRPK---------------------------------------------------------------------------LCMKDLLSFCWQIACGM

EFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSD-------SSYVVRG--NAR--LPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP
|.|. | |.||||||||.||.....|||.||||.||| .|       . |....  ...  ||..|||||....|..|.||||||.|...||||..|  |
EYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQP

YPGI----PVDANFYKLIQSGFKMEQPFY--------ATEGIYFVMQSCWAFDSRKRPSFPNLTSFL
|||.      ..  ......|. |.|| .        ... .| .|..||..|  .||.| .. ...
YPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FLT3.AA TK 611-946 24 1.9e-127 429.6 In-house 1-486 (486) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-486/486
Sequence Identity: 24% (129 aa)

LEFGKVLGSGAFG---RVMNATAYGIS--------------------KTGVSIQVAVKMLKEKADSCEKEALM----------------SELKMMTH-LG
...||.||.|.||   .|. ....|..                    |.|. ..||||||||.... ..| ..                .|.||| | ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHDNIVNLLGACTLS------------GPVYLIFEYCCYGD----LLNYLRSKREKF--------------------HRTWTEIFKEHNFSFYPTFQAHS
||.|||.|.|.|| .            .|.... ||...||    |..|||..|.||                    |.                     
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC---------------------

NSSMPGSREVQLHPPLDQLSGFNGN-----LIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLC-------------------FAYQVAKGMEFLEFK--
                     .  .      ..|...  .|.|. . .. ..... ||. |||.                   ...|.|.|||.|. |  
---------------------M--KGDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNC

----SCVHRDLAARNVLVTHGKV-----------VKICDFG--------LARDILSDSSYVVRG------------------------NARLPVKWMAPE
     .|||||||||.||....|           .||.|||        ||||| ||. |....                        ...||..|||||
EFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPE

SLFEGI---------YTIKSDVWSYGILLWEIFSLG-VNPYPGIPV--------DANFYKLIQSG--------------FKMEQPFYAT-----------
.|....         .|.||||||.|.|.||||..| . .|.|..         .. .......|              . |.|| ...           
CLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPH

---EGIYFVMQSCWAFDSRKRPSFPNLTSFL
   | .| .||.||..| ..||.|  | ..|
CPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FLT3.AA TK-Unique 611-946 36 1.5e-107 363.61 In-house 1-294 (294) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-294/294
Sequence Identity: 36% (127 aa)

LEFGKVLGSGAFGRVMNATAYGIS-KTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSG-PVYLIFEYCCYGDLLNYLRSKR
||.|.|.|.|||| |  ... ||. . .  ..|||||||..|.  .| ....|..|| .|| | |||..||.|| |. |...|.||| .|.|..|||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-EKFHR-TWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNV-LTFEDLLCFAYQVAKGMEFL
 ...   |   .                                                        .. .......  .. .||. ||.|.|.|||.|
PAMRQHQTYGNLK-----------------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYL

EF--KSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVR-GNARLPVKWMAPESLF--EGIY-TIKSDVWSYGILLWEIFSLGVNPYPGIPVDA
.   | .|||||.|||||.|..||.||||||.|||.  .  |.   .  |.|..|||||||   .|.| |.||||||.|.|.||||.||  ||||.| . 
ASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD

NFYKLIQSGFKMEQPFYA-TEGIYFVMQSCWAFDSRKRPSFPNLTSFL
 . ..|. |. |.|| .  .. .| .|.|||  .  .||||  ... |
-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FLT3.AA VEGFR 777-946 52 2.1e-94 319.97 In-house 159-332 (332) Show / Hide 
Range on Protein: 777-946
Range on HMM: 159-332/332
Sequence Identity: 52% (92 aa)

EEEEEDLN--VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARD-ILSDSSYVVRGN-ARLPVKWMAPESLFEGIYTIKS
.|. ||.    || |||.|...|||.|||||. . |.||||||||.|..  .|||||||||||. | .|  || .|. .||| |||||||.|. .||..|
DEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYS

DVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL
||||||..||||||||  ||||. .|  |.. . .|  |. | |.| .|| .|..||  .   ||.|  |   |
DVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FLT3.AA UTK 611-946 27 8.7e-85 287.99 In-house 1-296 (296) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-296/296
Sequence Identity: 27% (101 aa)

LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEA----LMSELK---MMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNY
...|. ||.|||| | .|..  .|  .   .|||| ....||.  ...    .| | .   || .. .| |...|.| || ..| ... ||.. |||..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGME
||. |...                                                                     ..   || ...||.|...| ||.
LRRHRPTPP--------------------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQ

FLEFKSCVHRDLAARNVLVTHG-------KVVKICDFG---LARDIL-------SDSSYVVRGNA--RLPVKWMAPESLFEG-IYTIKSDVWSYGILLWE
.|. . .|||||||||.||..         |.||.|||   ..|..        ...|| .. .   |.|..|||||.| ..  .|.||||||.|...||
YLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWE

IFSLGVNPYPGIPVDANFYKLIQSG-FKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL
|.. |  ||||.  .. .  .   |   |..|    . .| .|..||. | ..||.|. |....
IWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FLT3.AA Src 611-946 30 1.5e-84 287.15 In-house 1-255 (255) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-255/255
Sequence Identity: 30% (104 aa)

LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREK
. . . ||.| || |  ..  |      ...|||| ||..    . ||.  | . |. |  |...|.|.  |.   |.| . || . | || ||.     
IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

FHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSC
                                                                     ...   | ...|. .| |||.||..|| .  
---------------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNY

VHRDLAARNVLVTHGKVVKICDFGLARDILS--DSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSG
.||||||||||| .. |.|..|||||| ..   |  |. |  |..|.||.||| . .| .||||||||.||||.||.. |  ||||    .   . .. |
IHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGM-TNHEVLQQVERG

FKMEQPFYATEGIYF-VMQSCWAFDSRKRPSFPNLTSFL
..| .|    . .|  .|. ||  | ..|| |  | .||
YRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FLT3.AA FGFR 763-946 50 2.6e-84 286.41 In-house 107-293 (293) Show / Hide 
Range on Protein: 763-946
Range on HMM: 107-293/293
Sequence Identity: 50% (94 aa)

SEDEIEYENQKRLAEEEE---EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMA
..|  || ..| .  |..   | .  ||. ||  .|||||.|||.|. . |.|||||||||||| . | ||||||||||| .   |  ..| |||.||||
KKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMA

PESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL
||.||. .|| .|||||||.|||||. .|  |||.||     ||. ..|  || |   .. || .| .|| | .  ||.|  |   |
PEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FLT3.AA Ret 785-948 47 1.4e-66 226.4 In-house 126-293 (293) Show / Hide 
Range on Protein: 785-948
Range on HMM: 126-293/293
Sequence Identity: 47% (80 aa)

VLT-----FEDLLCFAYQVAKGMEFL-EFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYG
|..     . ... || |. ||| .| | |  ||||||||||||  |.. || |||| ||.  | ||| |   |.||||||.|||.  .|| ||||||.|
VINRFDIGMKMIISFAWQICKGMHYLSEMK-LVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFG

ILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGC
.|.|||  .| ||||||| . . . |   |. |. |    | .| .|  ||.    |||.|  . . .  
VLCWEIVTMGANPYPGIPPE-RLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FLT3.AA KIN6 785-946 43 2e-66 218.48 In-house 140-305 (305) Show / Hide 
Range on Protein: 785-946
Range on HMM: 140-305/305
Sequence Identity: 43% (72 aa)

VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK---VVKICDFGLARDILSDSSYVVRGNAR-LPVKWMAPESLFEGIYTIKSDVWSYGIL
.... ||. ||.|.. |||.|  | |.|||||||||||| |      || ||||.| .. |..  . .  | ||.||||||.|    . .||||||.|.|
CIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVL

LWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL
..|.||||  |||...        . ||  ...| ...| || .|||||. ..  || |  .   .
MFEMFSLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase FLT3.AA Tie 786-946 48 7.5e-60 180.55 In-house 111-267 (267) Show / Hide 
Range on Protein: 786-946
Range on HMM: 111-267/267
Sequence Identity: 48% (78 aa)

LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF
|. . .| ||  ||.||..|  | |.||||||||.||    | || ||||.|   .|  || .   ||||.||| |||   .|| ||||||||.||||| 
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIV

SLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL
|||  || |.   |..|. .  |..||||    . .| .|. ||     .||.|  .   |
SLGGTPYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FLT3.AA VEGFR 611-711 57 5.2e-52 179.12 In-house 1-104 (332) Show / Hide 
Range on Protein: 611-711
Range on HMM: 1-104/332
Sequence Identity: 57% (60 aa)

LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTL---SGPVYLIFEYCCYGDLLNYLRSK
|  ||.|| |||| |. |.| || |.   . |||||||| |.. |. ||||||||..|.||| | ||.||.||     ||.  | ||||.| |.||||.|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

REKF
|. |
RMYF
Kinase FLT3.AA Pkinase 611-946 19 2.7e-41 147.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-293/293
Sequence Identity: 19% (74 aa)

LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKE--ALM-SELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYG----DLLNY
...|...|||.||.|     |   . | ...|||| .| . ....|.  ..  ||...| .| .|.||| |..... .. .|...|||  |    ||  |
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVL--TFEDLLCFAYQVAKG
..                                                                           .. ...  . ... ...||...|
IST--------------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRG

MEFLEFKSCVHRDLAARNVLVTHGKVV----KICDFGLAR---DILSDSSYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYP
.|..  ....||||   |.|. .  ..    ||||||||.      .   ... |  .    .|||| .     |. |.|.||.|..|.| .. |  |.|
LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW----YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFP

GI------PVDANFYKLIQSGFKMEQPFYAT-------------------EGIYFVMQSCWAFDSRKRPSFPNLTSF--L
|         .. ...  .  .. . |   .                   |    .. .|...|  |||... .     .
GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FLT3.AA FGFR 611-708 48 2.9e-34 114.17 In-house 1-100 (293) Show / Hide 
Range on Protein: 611-708
Range on HMM: 1-100/293
Sequence Identity: 48% (48 aa)

LEFGKVLGSGAFGRVMNATAYGISKT--GVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKR
|  ||.|| |.||.|  |.| || .      | |||||||. .   .   | ||. ||   | | ||.||||.||  || | | |||  | |  .||..|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
Kinase FLT3.AA Tie 620-708 46 8.6e-32 93.52 In-house 2-87 (267) Show / Hide 
Range on Protein: 620-708
Range on HMM: 2-87/267
Sequence Identity: 46% (41 aa)

GAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKR
| || || |.   | | |  ..||.||.|| |   ..   | || .|  .||| ||.||.|||   | .|.  ||  || ||..||. |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSR
Kinase FLT3.AA Ret 611-708 40 9.6e-27 88.34 In-house 1-100 (293) Show / Hide 
Range on Protein: 611-708
Range on HMM: 1-100/293
Sequence Identity: 40% (41 aa)

LEFGKVLGSGAFGRVMNATAYGIS-KTGVSIQVAVKMLKEK-ADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSG--PVYLIFEYCCYGDLLNYLRS
| ....|| | ||.|. |.|  |  ..|    |||||||.  | | |  .| ||. .   .  | ... |.|||. ..  |  || ||| || |  .|| 
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTT-VAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRL

KR
 |
SR
Kinase FLT3.AA S_TKc 611-946 19 1.5e-25 92.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 611-946
Range on HMM: 1-231/231
Sequence Identity: 19% (69 aa)

LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCY--GDLLNYLRSKR
 |.....|.||||.|. ..  .        .||.|..|        | ...|.... .  ||.|||.|....   . .|...|||    |||. |.....
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

EKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK
 .  |                                                                       ...  .  ...||.....|..  .
RHGLR----------------------------------------------------------------------FPFPE-HARFYMYQICCALEYCHSH

SCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTI-KSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQS
  .||||   |.|...  ..||||||||| .                 .|||| |    |.  |.|.|| |..|.| .. |  |.|    ..  .|.|  
GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-

GFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTS---------FL
          ..     .. |. .| .|||.   .           ..
----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FLT3.AA KIN6 641-709 46 1.1e-19 61.56 In-house 46-114 (305) Show / Hide 
Range on Protein: 641-709
Range on HMM: 46-114/305
Sequence Identity: 46% (32 aa)

QVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKRE
|.||||| . ||  ..  .| |   |  ||||. .||.||  | | ...|. |||| .||| ||| ...
QCAVKMLPSHADEMAHHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQ