Gene FRK (Mouse)

FRK

Species: Mouse
Alias: FRK, Frk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: Frk

Sequence

Name Sequence Type Origin Length Description Download
FRK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
FRK.AA Protein Sugen 512 None Fasta, JSON
FRK.NA RNA Sugen 4803 None Fasta, JSON

Protein domain

Protein domains of FRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 FRK.AA SH3 52-116 38 1.1e-21 79.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 52-116
Range on HMM: 1-58/58
Sequence Identity: 38% (25 aa)

QYFVALFDYQARTAEDLSFRAGDKLQVLDTSHEGWWLARHLEKKGTGLGQQLQGYIPSNYVAEDR
.|..||.||||.....|||..||...||. . .||| .|.            .|..|||||.| .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNR-------TGQEGWFPSNYVEEID
SH3_1 FRK.AA SH3_1 55-90 45 5.9e-16 56.79 Pfam 1-37 (49) Show / Hide 
Range on Protein: 55-90
Range on HMM: 1-37/49
Sequence Identity: 45% (17 aa)

VALFDYQARTAEDLSFRAGDKLQVLDTSHE-GWWLAR
|||.||||.....|||. ||...|.. |.. .|| .|
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGR
SH3_2 FRK.AA SH3_2 53-115 21 4.6e-12 45.12 Pfam 1-68 (68) Show / Hide 
Range on Protein: 53-115
Range on HMM: 1-68/68
Sequence Identity: 21% (16 aa)

YFVALFDYQA-RTAED-----LSFRAGDKLQVL---DTSHEGWWLA-RHLEKKGTGLGQQLQGYIPSNYVAED
|.....||.. . ...     |.|..||.. |.   |.. ..||.. . . .. .       |..||..|.|.
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRR-M----RGWFPSQWVEEC
SH3_1 FRK.AA SH3_1 104-109 50 41.156466 0.28 Pfam 44-49 (49) Show / Hide 
Range on Protein: 104-109
Range on HMM: 44-49/49
Sequence Identity: 50% (3 aa)

QGYIPS
.|..||
EGWFPS
SH2 FRK.AA SH2 123-200 49 2.5e-47 140.79 Pfam 1-81 (81) Show / Hide 
Range on Protein: 123-200
Range on HMM: 1-81/81
Sequence Identity: 49% (40 aa)

WFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDEG---VVKHYRIRRLDEGGFFLTRRKVFSTLNEFVNYY
|..| | |..||..|. ..|. |.||.|||||..||..|||.|.|   .||||||.|.|.||...| |. |..|.| |..|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FRK.AA SH2 121-206 44 2.1e-39 138.17 SMART 1-87 (87) Show / Hide 
Range on Protein: 121-206
Range on HMM: 1-87/87
Sequence Identity: 44% (39 aa)

EPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDEGVVKHYRIRRLDEGGFFLTR--RKVFSTLNEFVNYYTTTSDG
.||..| | |..||. |.  ... |.||.|.|||..||..||| ..| ||||||||.|.|.....   |. |..| | ||.|.....|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase FRK.AA Frk 241-498 80 2.1e-193 648.81 In-house 1-260 (260) Show / Hide 
Range on Protein: 241-498
Range on HMM: 1-260/260
Sequence Identity: 80% (208 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ--NDGGSKIHLIQQ
|||..|||||||||||||||||||||||||||||.||||||||||||||.||||||||||||||.|.|||||||||||||||||||  || |..... |.
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGK
||||||||.|||||||||||||||||||||||||||.|.||||||||...||||||||.|....|.|||||||...|||.||||||||||||.||||||.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

MPYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKLEDYF
|||.|||.|.|.||....||.|||.|||||.|.||||||...|..|||||||.|||||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase FRK.AA Src 241-494 64 1.5e-191 642.66 In-house 1-255 (255) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-255/255
Sequence Identity: 64% (166 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ-NDGGSKIHLIQQV
|.|...||.|||||||.|.||..|.|||||||||.|.|..||.||||||.|||.||.||||||. |.||||.||.|.||||..||. .. |...|| |..
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKM
|||||||.|||||||.||||||||||||||||.|..|||||||||..|.| .|.|...|. |.|.||||||||. ..|.||||||||||||.||.|||..
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYS-IMLECWNVEPKQRPTFETLHWKL
|| ||| ..|.|.....||.|.|.|||...|  |||.||. .|.||||||.|.|.|
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FRK.AA SFK-Src 241-498 61 3e-188 563.61 In-house 1-259 (259) Show / Hide 
Range on Protein: 241-498
Range on HMM: 1-259/259
Sequence Identity: 61% (161 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVD
|.| |.|||||||.|| | ||||| |||||||||.|  . ||.|||.|| ||||.|||||||||   |||||||||. |||  ||..  |    . | ||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDI-YESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKM
||||||.|||||| ||..||||||||||||. |. ||.|||..||  . ..|. |. .   | |.|||||||  .|.|||||||||||||..||.||| .
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRV--LAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYSGMTGAQVIQMLSQ--NYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKLEDYF
|| ||| . |.| . .   ||.| | ||| ..| ||..||  ||  |||||.| |..||.|
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase FRK.AA Pkinase_Tyr 241-494 47 4.6e-148 502.07 Pfam 1-270 (270) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-270/270
Sequence Identity: 47% (128 aa)

IQLLKRLGSGQFGEVWEGLWN-----NTTPVAVKTLKPGSMDPN----DFLREAQIMKSL-RHPKLIQLYAVCT-LEDP--IYIITELMRHGSLQEYLQN
|...| ||.|.||||..| |.     ...|||||.||.|.|...    ||.|||.|||.| .||....||.|||  ..|  |||..|.| ||.| .||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D--GGSKIHLIQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIY-ESKHEIKLPVKWTAPEAIRTNKFSIKSDVW
   .. .. . . ..|..|.|.||.||||.|.|||||||||.||.| |. |..||||||     |.| |  .... |||.||.|||.|...||..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGILLYEIITYGKMP-YSGMTGAQVIQML-SQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKL
|||.|..||.|||..| | ||. ..|....  ..||.|.| |||.  |..|..||. .|..||||. .|..|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FRK.AA Src-Unclassified 241-498 48 1.9e-141 476.18 In-house 1-284 (284) Show / Hide 
Range on Protein: 241-498
Range on HMM: 1-284/284
Sequence Identity: 48% (139 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPG---SMDPNDFL--------REAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDG
..||. || ||||||| | | .   |||||..||    | |  ||        .|||||| .||..|..|||||. | |.|||||.|  |||  .|. .|
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GSKIHLIQQ------------VDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHN-----IYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAI
|.  |.               ||.|||||||| ||||  |.||||||||||.|. |     . ||.||||||  |.  .|.|. .   ..|.||.|||..
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARK-KLMQDDNYCMRTGAMFPWKWMAPECF

RTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLSQNYRLPQP--SNCPQQFYS-IMLECWNVEPKQRPTFETLHWKLEDYF
   .|||||||||.||||.|| |.|. || ||    |.  ..  ||.| |    || . |  ||. ||.  | .||||.||      ||
IYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLY----HYF
Kinase FRK.AA TyrKc 241-494 42 2.6e-139 470.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-280/280
Sequence Identity: 42% (121 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSL--RHPKLIQLYAVCTLE-------DPIYIITELMRHGSLQEYLQNDGGS
|.|.| ||.|.||||..| |.  ..||||.||...    ||.|||.||..|  .|| ...||.||| .       .|..|..|.| ||.|..||.. .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KIHLIQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVD-----NEDIYESK---HEIK-LPVKWTAPEAIRTNKFSIKSD
 . . . .... |.|.||.||.|.|.|||||||||.|||| .. |..||||.|  . |     ..| | .|   ..   ||..|.|||.|...||..|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLYEIITYGKMPYSG-----MTGAQVIQMLSQNYRLPQPSN--------CPQQFYSIMLECWNVEPKQRPTFETLHWKL
|||||....|| |||..||.|     |. ..||. . | ||.||| |        ||.  |.||..||. .|..||||...| ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FRK.AA SRM 242-495 52 3.5e-129 434.35 In-house 2-253 (253) Show / Hide 
Range on Protein: 242-495
Range on HMM: 2-253/253
Sequence Identity: 52% (134 aa)

QLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGS-MDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVD
 | ..||.| |||||||||    .||.|  |    |   ..  | | ||.||| ..| |.|||.. ||.|||||||| |.||.||    .    . . .|
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLLD

MAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMP
.| ||| ||.|||.||||||||||||||||. |. ||.||||||  |   .|||   |. . |.|||||||.    .|.|||||||||||.|. ||| .|
FACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIK---DDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCP

YSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKLE
| |||    .|  .  ||.| |  || . .  |||||  .|.|||.| .|  || 
YPGMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase FRK.AA SrcA 241-494 56 1.3e-127 405.53 In-house 1-250 (250) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-250/250
Sequence Identity: 56% (144 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVD
|.| .||| |.||||| | || || ||.|||||| | |. || |||||| ||| ||.|||||   |.||||.|| | .||| ..|... | ...| | ||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

MAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMP
||||||.||||.|  ||||||| | |.||||. | |.|||||||. . |||  |...   | |.|||||||    .| |||||||||||| |..| |..|
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIE-DNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP

YSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKL
| ||    |..   . |..| | .||.  . .| .||  .|  ||||| |   |
YPGMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase FRK.AA TK 241-494 25 5.9e-127 427.92 In-house 1-486 (486) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

IQLLKRLGSGQFG---EVWEGLWNNT--------------------------TPVAVKTLKPG-SMDPND--------------FLREAQIMKSLR----
|.|.| ||.||||   ||..|.|..                           ||||||.||.| .|....              ||.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKLIQLYAVCTLE------------DPIYIITELMRHGS----LQEYLQNDGG---------------------------------------------
 || ...||.||| .             |..|..|.| ||.    |..||..  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------SKIHLIQQVDMAAQVASGMAYLESQ------NYIHRDLAARNVLVGEHNI-----------YKVADFGLA-
                             ..... |.. |..|.|.||.||.|.      |..||||||||.||||.|.            |.|||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RVFKVDNEDIYESKH------------------------EIKLPVKWTAPEAIR---------TNKFSIKSDVWSFGILLYEIITYG-KMPYSGM
     .  .....| | .|.                          |||..|.|||...         ..||..||||||||.|..|| ||| ...| ||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TG---------AQVIQMLSQN--------------YRLPQPSNCP--------------QQFYSIMLECWNVEPKQRPTFETLHWKL
.          ..|...| .               .|.||| .||              . .| .|..||. .|..||||..|| .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FRK.AA SrcB 241-495 56 7e-124 417.85 In-house 1-251 (251) Show / Hide 
Range on Protein: 241-495
Range on HMM: 1-251/251
Sequence Identity: 56% (143 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVD
..| |.||.||||||| | .|| . |||||.|.|.| |. || || .||.| | .|..|||| | | ||||||| | .|.| ..|. | |||..| . .|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMP
|.||.| ||||.| .||||||| | |.|| |  . |.|||||||.   |||  |  .   | |.||||||||    | ||||||||||||.||.|||..|
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIE-DNE--YTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIP

YSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKLE
| ||| ..||. |.. ||.|.| |||.  | || .||   | .||||. |.  |.
YPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase FRK.AA Src-Echino1 241-494 51 4.90000000001e-121 408.4 In-house 1-252 (252) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-252/252
Sequence Identity: 51% (131 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVD
 .. |..|.|..||||.|.||  |||||||||...| | ||| || .|| .||  ..|.||||  ..||||.||||..|.||.||... . .. . . .|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMP
| |..|||| ||.|.|..||||||||||||. |. |.|||||||. .   .|.| .|.  |||.|||||||.   .| |||||||||||. |..|.|..|
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQ---KDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYP

YSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSI-MLECWNVEPKQRPTFETLHWKL
| ||.  .|.. . . ||.|.. .||   | . |. ||  .|.|||||| ||  .
YPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase FRK.AA Abl 241-494 49 1.6e-111 373.42 In-house 1-252 (252) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-252/252
Sequence Identity: 49% (127 aa)

IQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQV
| . ..|| ||.|||.||.|      |||||||  .|. ..||.|| ||| ..|| |.||  ||| | | ||||| | .| | .|| . . .... .  .
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKM
 ||.|.|||| |||....||||||||| |||||.| |||||||||. |   .|.|  .   | |.||||||..  ||||.||||| ||.||.|| |||  
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMK---DDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMS

PYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKL
|| |.   .| . | ..||. .|  ||.. | .|..||. ..  ||.|. .| ..
PYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase FRK.AA S_TKc 241-498 23 4.1e-60 206.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 241-498
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

IQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRH--GSLQEYLQNDGG----SKI
 ..|. .|.| ||.|. . ...    ||.| .|      ....|| ||.|. .|| ...|| |.   | .|...|.. .  |.| .|... |.    ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

HLIQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSI-KSDVWSFGILLYE
.  .   ...|......|. |.. |||||   |.|. |    |..||||||..           . .     . ||| .   ...  |.|.||.|..|||
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IITYGKMPYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHW-----KLEDYF
 .. |. |..  . .......            .... ...  |....|..|||   .       |.  .|
MLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FRK.AA Pkinase 241-488 25 1e-48 172.95 Pfam 1-285 (293) Show / Hide 
Range on Protein: 241-488
Range on HMM: 1-285/293
Sequence Identity: 25% (76 aa)

IQLLKRLGSGQFGEVWEGLWNNT-TPVAVKTLKPGSMDPND---FLR--EAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHG----SLQEYLQ--ND
.......||| ||.|... . .|   ||||..|  . ...     .|  |.||||.|.||  ..|| ... .| ||...|....|    .| .|..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGS--KIHLIQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIY----KVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIR-TNKFSIKS
|.     . ..  ... |...|..|. |.. |||||   |.|. ...      |..|||||..|.   .  ..  . .     . ||| ||  .. . |.
GCFYFSEWECK--FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSFGILLYEIITYGKMPYSGM----TGAQVIQMLSQNYRLPQPSNCP-----------------------QQFYSIMLECWNVEPKQRPTFE
|.||.|..||| .. |. |..|     . .  .||. .. . | ....|                       . . ...  |... ||.|||.|
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE