Gene HH498 (Mouse)

HH498

Species: Mouse
Alias: HH498, D830019J24Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
HH498.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
HH498.NA RNA Sugen 3042 None Fasta, JSON
HH498.AA Protein Sugen 834 None Fasta, JSON

Protein domain

Protein domains of HH498.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank HH498.AA Ank 133-165 57 1.6e-11 45.78 Pfam 1-33 (33) Show / Hide 
Range on Protein: 133-165
Range on HMM: 1-33/33
Sequence Identity: 57% (19 aa)

GGLTALHIAAIAGHPEAVEVLLQHGANVNVQDA
 | |.||.|.. ||.| |. ||||||.||.|| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 100-132 39 1.1e-05 24.72 Pfam 1-33 (33) Show / Hide 
Range on Protein: 100-132
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

NGFPALHLAVYKDSLELITSLLHSGADVQQAGY
.|| .||||......| .. ||  ||||     
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 66-99 26 0.514205 7.92 Pfam 1-33 (33) Show / Hide 
Range on Protein: 66-99
Range on HMM: 1-33/33
Sequence Identity: 26% (9 aa)

RGLSLLHLCCACGGNKSHIRALMLKGLRPSRLTR
 | . ||| | || ... .. |. .|  .   ..
DGFTPLHLACRCG-HTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 199-232 50 3e-08 34.01 Pfam 1-33 (33) Show / Hide 
Range on Protein: 199-232
Range on HMM: 1-33/33
Sequence Identity: 50% (17 aa)

VGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDN
 |. |||||. .|  ..||.|.. . |||||||.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank HH498.AA Ank 168-198 51 4.8e-08 33.28 Pfam 3-33 (33) Show / Hide 
Range on Protein: 168-198
Range on HMM: 3-33/33
Sequence Identity: 51% (16 aa)

FTPLHIAAYYGHEQVTSVLLKFGADVNVSGE
|||||.|...||..| . ||. |||||.   
FTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 233-263 36 0.014404 13.52 Pfam 1-33 (33) Show / Hide 
Range on Protein: 233-263
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

EDHVPLHFCSRFGHHNIVSYLLQ--SDLEVQPH
.   |||  .| ||...|..|||   |. .|  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 268-289 54 6.4e-05 22.01 Pfam 1-22 (33) Show / Hide 
Range on Protein: 268-289
Range on HMM: 1-22/33
Sequence Identity: 54% (12 aa)

YGDTPLHLACYNGNFEVAKEIV
.|.|||||||..|. ||.|. .
DGFTPLHLACRCGHTEVVKMLL
Ank HH498.AA Ank 338-370 48 4.2e-08 33.5 Pfam 1-33 (33) Show / Hide 
Range on Protein: 338-370
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

DGHTGLHSACYHGHIRLVQFLLDNGADMNLVAC
|| | || ||..||.. |..||..||| |..  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 303-337 28 0.005599 15.0 Pfam 1-33 (33) Show / Hide 
Range on Protein: 303-337
Range on HMM: 1-33/33
Sequence Identity: 28% (10 aa)

FSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGR
  .|. | || .| ... ||.||. .  ..|.. .
DGFTPLHLACRCG-HTEVVKMLLQ-HGADVNAQDD
Ank HH498.AA Ank 380-400 38 0.024004 12.72 Pfam 1-21 (33) Show / Hide 
Range on Protein: 380-400
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DEQTCLMWAYEKGHDAIVTLL
| .|.|..| ..||  .|..|
DGFTPLHLACRCGHTEVVKML
Kinase HH498.AA HH498 462-718 66 5.8e-222 711.12 In-house 1-284 (284) Show / Hide 
Range on Protein: 462-718
Range on HMM: 1-284/284
Sequence Identity: 66% (189 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLL------
|||||.||||||||||||..||||||.|||||...|.|||     ||||||||||.|.||||||||||.||.||||||||||||...|||||.|      
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIG

--------HEQK---RILDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQC
        |.||   ||.|||||..|.||||.||.|||. |..|||||||||||||..|||||||||||||||......||||||||||||||||||.||
GAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQC

TRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYS----IPKPISSLLMRGWNACPEGRPEFSEVVRKL
..|.||.||||||.|.||..|.|.||.|.|||||||.||||||||||...    ||...|.|....|..|||.||.|...|..|
QKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase HH498.AA MLK 462-718 42 5.5e-142 478.01 In-house 1-291 (291) Show / Hide 
Range on Protein: 462-718
Range on HMM: 1-291/291
Sequence Identity: 42% (124 aa)

IEFHEIIGSGSFGKVYKGRCRNKI-----VAIKRYRANTYCSKSD-------VDMFCREVSILCQLN-HPCVVQFVGACLDDPSQFAIVTQYISGGSLFS
|.|||.|||||||||.|||.|||.     ||.||.||... .|||       ..|.||...||...| |||..||.|.||..|..|.||..|..||||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHEQK-------------RILDLQSKLIIAVDVAKGMEYLHSLTQ-PIIHRDLNSHNILLYE------DGHAVVADFGESRFLQSLDEDNMTKQPGNLR
.||...             |. |..... .|...|.||.||||. . |||||||.|||||..|      .|.....|||.||.... . .||....|...
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

WMAPEVF--TQCTRYTIKADVFSYALCLWELLTGEIPFA-HLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKL
||||||.   .|..|..|.||.|....|||.||.|.|.. |..|.|.|. .||...||||....|.....|... ||..|. || |...| .|
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase HH498.AA TKL 468-718 26 4.5e-97 328.79 In-house 1-364 (364) Show / Hide 
Range on Protein: 468-718
Range on HMM: 1-364/364
Sequence Identity: 26% (100 aa)

IGSGSFGKVYKGRCRN----------KIVAIKRYRA--NTYCSKSDVD--------------------MFCREVSILCQLN--HPCVVQFVGACLDDPS-
||||.||.||||..|.          | ||.|...   .  ..|.. .                    .|..|. |.. ..  || .|||.|.|.. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------QFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSLT------QPIIHRDLNSHNILLYEDGH--------------A
           |..||..|..||||...||       .. .. .| |.|.||.|||| .       |||||||.|.|||. |...              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VVADFGESRFLQSLDEDNMTK------------------QPGNLRWMAPEVFTQCT---------------RYTIKADVFSYALCLWELLTGEIPFAHLK
 ..||| |||..   ..|.|.                  | |..|||||||. . .                |. |.||.|....|||.||...|.....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PA---------AAAADMAYHHIRPPIG------------YSIPKPISSLLMRGWNACPEGRPEFSEVVRKL
.          . ..  ...  ||||              ..|.....|... |.. || || |.|.. .|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase HH498.AA TKL-Unique 464-718 32 3.1e-76 259.59 In-house 1-290 (290) Show / Hide 
Range on Protein: 464-718
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

FHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN-HPCVVQFVGACLD---DPSQFAIVTQYISGGSLFSLLH--------
| . ||.|..|.||||  | ..||||.   |   |.. .. | .||...  |. || .|...|.| |   .|... ||. |..|||| ..||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-EQKRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYED-----GHAVVADFGESRFLQSLDEDNMT--------KQPGNLRWMAPEVFTQ
 ...  |..| .. .| |.|.||.|||..  ||||||| | |.|. ..       . ..||| |.|. . .. . .           |..|||||||...
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

C-TRYTIKADVFSYALCLWELLTGEI------PFAHLKPAAAAADMAY--HHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKL
  . |..|.||.|.. .|||..|..|      |. .. . . ..  .|     ||||. ..|| .. |. ..|.  |. || |.|.. .|
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase HH498.AA Dicty4 462-720 36 2.5e-75 250.71 In-house 1-277 (277) Show / Hide 
Range on Protein: 462-720
Range on HMM: 1-277/277
Sequence Identity: 36% (101 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRY-RANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACL---DDPSQFAIVTQYISGGSLFSLLHE-----
| . ..||.||||.||||..| |.||.|     |.  . .    | .||.|.|.. || ...| |||.     |. . ||| | . |.|.||||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QKRILD--LQSK-LIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLD--EDNMTKQPGNLRWMAPEVFTQCTRYTIKAD
 |.  ||  |  . . .| |.|.|| .||. .  |||||| |||.|  ..  . |.||| |.  .      ||.. . |   ||||||  .  .|. |||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM-MHQPYNEKAD

VFSYALCLWELLTGEIPFA--HLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRK--LEE
|.|... |||.||...|..  |  .  ...  . .. ||||  . |.....|. . |.  |. || |.|.. .  ||.
VYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase HH498.AA Pkinase_Tyr 462-718 31 2.2e-66 225.44 Pfam 1-270 (270) Show / Hide 
Range on Protein: 462-718
Range on HMM: 1-270/270
Sequence Identity: 31% (87 aa)

IEFHEIIGSGSFGKVYKGRCR------NKIVAIKRYRANTYCSKSD--VDMFCREVSILCQL-NHPCVVQFVGACL--DDPSQFAIVTQYISGGSLFSLL
|.| . .|.|.||.||||...      .  ||.|  .   ......   ..| ||..|..|| .|| .|...|.|.  ..|.|  ||. |  .|.| . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HEQ---KRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNM-TKQP---GNLRWMAPEVFTQCTRYTI
...   |. |... .| .....|||||||.|    .|||||   |.|. |.... ..||| .| .   ..|.  .|.       .|||||..  .  .|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTT

KADVFSYALCLWELLT-GEIP-FAHLKPAAAAADMA-YHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKL
| || |.  ..||..| ||.| .. . . .   ..   .  | |.    |..| .|... |.. || || |||....|
KSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HH498.AA TK 462-718 16 4.5e-65 216.8 In-house 1-486 (486) Show / Hide 
Range on Protein: 462-718
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

IEFHEIIGSGSFG---KVYKGRCRNK---------------------------IVAIKRYRANTYCSKSDVDM-----------FCREVSILCQLN----
|.. . .|.| ||   .||||. |..                            ||.|  .. .  |. .  .           |..|........    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPCVVQFVGACLDDP-----------SQFAIVTQYISGGS----LFSLLHEQKR---------------------------------------------
 || .|...|.|...              . ||. | ..|.    | . |.. ..                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------ILDLQSKLIIAVDVAKGMEYLHSLT----QPIIHRDLNSHNILLYEDGH-----------AVVADFG---
                              .|... .| .....|.|||||||.     | ..||||  .|.|. |...           . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----ESRFLQSLDEDNMTKQPGN-------------------------LRWMAPEVFTQCT--------RYTIKADVFSYALCLWELLT-GEIPFAHLK
      .| ..| |.   ....|                          .||||||...  .        ..|.| ||.|.  ..||..| |. |..   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PA------------AAAADM------------AYHHIRPPIGYSIP-------------KPISSLLMRGWNACPEGRPEFSEVVRKL
.                  .             | . .|.  .  .             . .  |... |.. || || ||.....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HH498.AA CZAK 462-718 35 9.3e-65 221.46 In-house 1-279 (279) Show / Hide 
Range on Protein: 462-718
Range on HMM: 1-279/279
Sequence Identity: 35% (101 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD---VDMFCREVSILCQLNHPCVVQFVGAC-LDDPSQFAIVTQYISGGSLFSLLHEQKRIL
 .|   || | ||.|||.. | | ||||    | .  |.      || .||||.  | || .|||.||| .| |    ||. .  ||||  || .    .
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

DL--QSKLIIAVDVAKGMEYLHS-LTQ-PIIHRDLNSHNILLYEDGH-------------AVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR
      .. .|.|.|.|| |||   .  ||.|||| | |||| .                . ..||| || .       ||   | | |||||.|     
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSR-EMMEQPFEMTQTMGCLCWMAPECF-KGEN

YTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPIS---SLLMRGWNACPEGRPEFSEVVRKL
|| |.||.|... ||...|.. |   ..|   |   ||   |||.   ..        |. . ||  |. || |....  |
YTEKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase HH498.AA TyrKc 462-718 27 3.1e-60 207.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 462-718
Range on HMM: 1-280/280
Sequence Identity: 27% (81 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQL--NHPCVVQFVGACLDDP------SQFAIVTQYISGGSLFSLLHEQ
|.. ...|.| ||.||||. .   ||.|  ....      . .|.|| .|.|.|  .||..|...|.|...        .  ||. | ..|.| . |.. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL-------DEDNM-----TKQPGNLRWMAPEVFTQCTRY
.. | .. .| .....|.|||||||   ..|||||   |.|. |.... ..||| ||.. .        |   .     .| .  .||||||.. .  ..
RPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF

TIKADVFSYALCLWELLT-GEIPFAH-----LKPAAAAADMAYHHIRPPIGY-------SIPKPISSLLMRGWNACPEGRPEFSEVVRKL
|.| ||.|.  |.||..| |. |        .... . ..    . .|.  .         |. . ..  . |.. || || |||.....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HH498.AA DRK 462-720 35 6.2e-56 187.92 In-house 1-258 (258) Show / Hide 
Range on Protein: 462-720
Range on HMM: 1-258/258
Sequence Identity: 35% (93 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS
|     || |..| |. |  |  .||.|.  .        .  | ||. ..||| || ..|| |.|.  |.   |.. |.. ||| . ||...  .|   
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCN-NPPDICICMEYMPRGSLYNILHDESIEMDWPL

KLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGES-RFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWELLTG
 . .. |.|||| |||. .  |||||| ||| |  |     ||||| | || . ..        |   | ||||     ||| ||||.|.|  |||..| 
MKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRN-QRYTEKADVYSFAIVLWECVTR

EIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKLEE
..|..   .         |  |||.    | .   |. . ||  |  || . |..  || 
QDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase HH498.AA Dicty4-Unclassified 462-718 32 1.2e-54 185.61 In-house 1-263 (263) Show / Hide 
Range on Protein: 462-718
Range on HMM: 1-263/263
Sequence Identity: 32% (87 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSK-SDVDMFCREVSILCQLNHPCVVQFVGACLDDP----SQFAIVTQYISGGSLFSLLH----E
|     || | | ||.||  . | ||.|    | .      .. | .|| ||  . ||  |.  |.|.  |    | . ||.  .  | || . |    |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCI-NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

QKRILDLQS--KLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSY
|.. . | .   . .| |.|.|| .||.    .||||. | |||.  .  . .|||| ||        |||   |  .| .||.      |. |.||.||
QQQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVID--FNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSY

ALCLWELLTGEIPFAHLK-PAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKL
|. |.||.||. |.     .  ||   .    || |  ...  ...|    |   |  || . ... .|
AMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase HH498.AA LRRK 507-720 34 3.4e-51 176.4 In-house 106-351 (351) Show / Hide 
Range on Protein: 507-720
Range on HMM: 106-351/351
Sequence Identity: 34% (87 aa)

REVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKR--I------LDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILL---
.||.|.. ||||..|. .| |. .|  ...|. |.. |.| ..||. |.  .      .. . || ||...||||||||| . ||||||| |.||||   
HEVWIMSHLNHPNIVSLKGFCI-HP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSS

---Y------EDGHAVVADFGESR-FLQSLDEDNMTKQPGNLRWMAPEVFTQC--TRYTIKADVFSYALCLWELLTGE-IPFAHLK-P-----AAAAADM
   .      .. .| .|||| || | |.. .    .  || .|||||.        || |.|..|... ||||||.. .|| ... .          | 
PQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDK

AYHHIRPPIG--YSIPK-----PISSLLMRGWNACPEGRPEFSEVVRKLEE
    .||.|   |  |        ..|..  |.. |. || ||..| .|..
IIEGLRPTIPQHY-CPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase HH498.AA S_TKc 462-722 27 4.6e-50 173.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 462-722
Range on HMM: 1-231/231
Sequence Identity: 27% (77 aa)

IEFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISG--GSLFSLLHEQKRI-
 |....||.|.||||||.| ..  .|||||. .          ....||..|| . .|| .|.. ... |  . . .|. |..|  |.||.......|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTI-KADVFSYA
    ..      ..  .....||.||.   ||||||   |||| |  |  ..||| .|.|        | . | . .|||||.     |.  |.|. |  
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

LCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVR-----KLEECL
 .|.|.|.|. ||          .| ...|.       ...  ..... ..  || ||   |. .     |. . .
CILYEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HH498.AA Pkinase 462-666 29 2.6e-40 143.63 Pfam 1-214 (293) Show / Hide 
Range on Protein: 462-666
Range on HMM: 1-214/293
Sequence Identity: 29% (66 aa)

IEFHEIIGSGSFGKVYKGRCRNK--IVAIKRYRANTYCSKSDVDMFCR-------EVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGG----SLFS
......|||||||.|||.. ..   |||.|. .      |.. .. ..       |..|.  ||||..|.. ... | ..   .|. |  ||    .||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK------KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFD

LLH-EQKRIL--DLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHA----VVADFGESRFL-QSLDEDNMTKQPGNLRWMAPEVFTQCTR
... .... .  . .    ..  ...|.||.||    |||||| . |||. ..||      ..||| ....    ..  ||   | ...|||||   .. 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQY

YTIKADVFSYALCLWELLTGEIPFAH
|. |.|..|. . |.|.|.|. || .
YGPKVDMWSCGCILYEMLCGRPPFPG
Kinase HH498.AA LRRK 462-503 23 4.6e-09 28.2 In-house 1-55 (351) Show / Hide 
Range on Protein: 462-503
Range on HMM: 1-55/351
Sequence Identity: 23% (13 aa)

IEFHEIIGSGSFG-KVYKGRCRN-----KIVAIKRYRA-------NTYCSKSDVD
... | ||.|.|| .||....|.     . ...|.          |.| . ..|.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVA