Gene HRI (Mouse)

HRI

Species: Mouse
Alias: Eif2ak1, HRI
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: HRI

Sequence

Name Sequence Type Origin Length Description Download
HRI.AA Protein Sugen 619 None Fasta, JSON
HRI.NA RNA Sugen 2805 None Fasta, JSON
HRI.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 414 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of HRI.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HRI.AA HRI 273-580 65 3.4e-244 817.55 In-house 272-613 (613) Show / Hide 
Range on Protein: 273-580
Range on HMM: 272-613/613
Sequence Identity: 65% (224 aa)

SSSSIVFAELTPEKEKPFGESEVKN-----------ENNNLVSYTANLVVRNSSESESSIELQEDGLTDLS---VRPVVRHQLPLGHSSELEGNFTSTDE
.||.|.|...|..|||.||||..||           .||..|.||.|.|.|||.|.||.|||||.|||...   ......||.|..|.......|..|.|
NSSEIIFVRQTQRKEKHFGESDKKNSYEKIKITATTKNNKIVKYTTNPVIRNSAELESTIELQENGLTRIHNRIRTAIFHHQQPIRHNKHRRSIFWDTQE

SS---EGNLNLLGQTEVRYHLMLHIQMQLCELSLWDWITERNKRSREYVDEAACPYVMAS--VATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQ
||   |.|....||||..||.|||||||||||||||||.||||||||||||..||||||.  |..||||..|||.||||||.|||||.||||||||.|||
SSPEVESNYWPRGQTEFKYHYMLHIQMQLCELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQ

---QVKIGDFGLACADIIQN------------ADWTNRNGKGTRTHTSRVGTCLYASPEQLEGSQYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVR
   |||||||||||.||.|.            .||||||...|.|||||||||.|||||||.|||||.||||||.||||.|||||||||||||.||||||
GHPQVKIGDFGLACEDILQEPKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVR

TGRIPESLSKRCPVQAKYIQLLTGRNVSQRPSALQLLQSELF
||.|||||.|||||||||||.||.|| ||||||.||||||||
TGQIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase HRI.AA PEK 167-580 27 2.4e-180 605.43 In-house 1-655 (655) Show / Hide 
Range on Protein: 167-580
Range on HMM: 1-655/655
Sequence Identity: 27% (178 aa)

FEELAILGKGGY-GRVYKVRNKLDGQHYAIKKILIKSAT---------------KTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVV-QPQDRVPIQ
|||...|||||. |.||||.|||||..||||.| .....               |. |.|||||||.|| |.|||||.||.||||....  |.|.. ..|
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

LPS------------------------------LEVLSEQEGDRDQGGVKDNES-----SSSIVFAELTPEKEKPFGESE--------------VKNENN
|.|                              ..|.|| ..||.|.|.|...|     ||.... | ...... ...|.              ..|||.
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENE

NLVSYTANLVVRNSSE----------------------------------------SESSIELQEDGLTDLSVRPVVRHQLPLGHSSELEG---------
. .||. ..|...||.                                        |..|.....|| .| ...    .| .. ...  .          
SHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQS

-------------------------NFTSTDESSEGNLNLLGQTEVRYH-------LMLHIQMQLCELSLWDWITERN----------------------
                         ......|..| | | . ...  .|       ..|.|||..|| .........|                      
HKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYI

------------KRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQ----QVKIGDFGLACADI--------------
            .. |.. ||..|..... .. .||....||..|||..|..||||||.||||.  .|    ||||||||||. ..              
MNQCCFQSTWSMNM-RQW-DENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQ

-------IQNADWTNRNGKGTRT-------------------------HTSRVGTCLYASPEQLEGS-----QYDAKSDMYSLGVILLELFQPFGTEM-E
       . |..|.|.|.. . |                         ||..||||||.|||||.|.     .|. |.||||||.|..|...|| |.| |
SYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMME

RATVLTGVRT------GRIP-ESLSKRCPVQAKYIQLLTGRNVSQRPSALQLLQSELF
|...|| .|.      | .| ... ...|.||..||... .. .||||| |.||.|.|
RVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase HRI.AA HRI 167-272 57 5.9e-77 261.97 In-house 1-127 (613) Show / Hide 
Range on Protein: 167-272
Range on HMM: 1-127/613
Sequence Identity: 57% (73 aa)

FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVVQP---------------------QDR
||...|.||||||||||||.|||.||||||||.||..||..|||..|||||||.|||.|||.||.|||||||..||                     .||
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHVHQIQPQQRLMLGLGSFTDMGNGFEGEEDR

VPIQLPSLEVLSEQEGDRDQGGVKDNE
..|..|..||..|||.||.|.|||..|
EEIEEPEEEVEEEQEEDREQCGVKKDE
Kinase HRI.AA GCN2 419-580 33 8.1e-47 161.85 In-house 312-511 (511) Show / Hide 
Range on Protein: 419-580
Range on HMM: 312-511/511
Sequence Identity: 33% (68 aa)

KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLAC-----------------------------ADIIQNADWTNRN-GKGTR----TH
..| ...||. |||..|..|||||| ||||   ...|||||||||                              . . |. . ...  . ..     .|
RYFRQILEGLNYIHSQGMIHRDLKPSNIFLDC-CGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHH

TSRVGTCLYASPEQLEGSQYDAKSDMYSL-GVILLELFQP-FGTEMERATVLTGVRTGRIPESLSK----RCPVQAKYIQLLTGRNVSQRPSALQLLQSE
|..||| .| .|||.  | |. | ||||| |.|..|...| | |.|||. .|.  |   .|. . |    . . |.. |. .. .. ..|||| ||||.|
TGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHE

LF
. 
FL
Kinase HRI.AA S_TKc 167-580 17 1.5e-41 145.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 167-580
Range on HMM: 1-231/231
Sequence Identity: 17% (74 aa)

FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSEQEGDRDQG
.| | ..|||..|.|||.|.| .|...|||.|                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

GVKDNESSSSIVFAELTPEKEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIELQEDGLTDLSVRPVVRHQLPLGHSSELEGNFTSTDESSEGNLNL
                                                                               . . | .  .     .   .|
------------------------------------------------------------------------------EHIRREIQILKK--HHPNIVKL

LGQTEVRYHLMLHIQMQLCEL---SLWDWITERNKRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA
..  .      |.. | .|.    .| | | .|... . .       .    .| .......... |.|..||.|||||| ||.|     ..||.|||||
YDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF-------PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLA

CADIIQNADWTNRNGKGTRTHTSRVGTCLYASPEQLEGSQYDA-KSDMYSLGVILLELFQ---PFGTEMERATVLTGVRTGRIPESLSKRCPVQAK-YIQ
.                    |. .||  | .|| |   .|.  |.|..|.|.|| |..    ||  .|..   . |              . .||  |.
RQL------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIR

LLTGRNVSQRPSALQLLQ-------SELF
 .  .. ..||.| ..||        . |
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HRI.AA PEK 483-580 33 4.9e-35 113.61 In-house 644-758 (758) Show / Hide 
Range on Protein: 483-580
Range on HMM: 644-758/758
Sequence Identity: 33% (39 aa)

THTSRVGTCLYASPEQLEGS----------------QYDAKSDMYSLGVILLELFQP-FGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNV
.|| .||| ||.||||. .                 .|. | | |||| |. ||. | | |.|||..... .| | .| .. .  | ... ||...  | 
RHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNP

SQRPSALQLLQSELF
..||.| |.. . .|
DERPTADQISMHDFF
Kinase HRI.AA Pkinase 378-580 22 4.4e-33 118.06 Pfam 75-293 (293) Show / Hide 
Range on Protein: 378-580
Range on HMM: 75-293/293
Sequence Identity: 22% (54 aa)

LHIQMQLCEL-----SLWDWITERNKRSREYVDEAACPY-VMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQV----KIGDFGLAC-AD
... | .||      .|.|.|.           .. ...     .. ... ....|. |.|.|||.|||||| ||...  . ..    ||.|||||. .|
IYMVMEYCEGGLYVMDLFDYIST----------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD

IIQNADWTNRNGKGTRTHTSRVGTCLYASPEQLE-GSQYDAKSDMYSLGVILLELFQ---PFGTE-----MERATVLTGVRTGRIPESLSKRCPVQ----
               .  |...||  |..|| .  |. |. |.||.|.|.|| |..    ||  .     ..   ..  .. ...... .. |..     
-----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFF

-------------AKYIQLLTG---RNVSQRPSALQLLQSELF
                ......   .. ..||.| |.||.. |
RHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HRI.AA PEK 167-235 42 2.4e-29 94.21 In-house 1-76 (758) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-76/758
Sequence Identity: 42% (32 aa)

FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKS-------ATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIE
||.   ||.||.| |... ||.|.  ||||.|  ..        ...   ||.|||. || | |.||| |. || |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase HRI.AA GCN2 167-235 50 4.8e-28 95.05 In-house 1-72 (511) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-72/511
Sequence Identity: 50% (36 aa)

FEELAILGKGGYGRVYK-VRNKLDGQHYAIKKILIKSATKTDCMK--VLREVKVLAGLQHPNIVGYHTAWIE
|||...||||| |.|.| |||..||. |||||. |... . .  |   .|||| |. |.|...| |..||||
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIE
Kinase HRI.AA Ciliate-E2 388-580 19 8e-28 92.57 In-house 120-365 (365) Show / Hide 
Range on Protein: 388-580
Range on HMM: 120-365/365
Sequence Identity: 19% (53 aa)

SLWDWITERNKRSREY------VDEAACPYVMASVAT-------KIFQELVEGVFYIHNMG-IVHRDLKPRNIFLHGPDQQVKIGDFGLA---------C
.|.|.| ...| . .        .|  . |.|. ..         .. ...... |.|. . |.|||.|| ||..      .|| ||||.         .
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNR

ADIIQNADWTNRNGKGTRTHTS-------------RVGTCLYASPEQLEGSQ---------YDAKSDMYSLGVILLELF---QPFGTEMERATVLTGVRT
 .  | . |    .  | ....              .||  | .|| |.| .         || |.|..|||||| |.     ||               
TH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------------

GRIPESLSKRCPVQAKYI------------------------QLLTG-------RNVSQRPS-ALQLLQSELF
    .   | |...                            .|.         .. ..|.. . |.|. . |
----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase HRI.AA CAMK 386-517 24 8.4e-27 82.79 In-house 146-324 (425) Show / Hide 
Range on Protein: 386-517
Range on HMM: 146-324/425
Sequence Identity: 24% (46 aa)

EL--SLWDWITERNKRSREYVDEAA------CPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD----------------QQVKIGDFG
||   | |.|.|. ... |     .      . ..  . | ..|. ....| |.|...|||||||| || |   .                 ..|| |||
ELFDDLFDYIVEHGCYGEEF----DQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG

LACADII-----QNADWTNRNGKGTR---------THTSRVGTCLYAS-PEQLEGSQ--------------YDAKSDMYSLGVIL
.|.  .      ...|  ...    .           . ..||  |.. || |.|..              |. |.|| |.||||
FANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase HRI.AA PKR 378-542 37 1.4e-24 84.84 In-house 96-238 (272) Show / Hide 
Range on Protein: 378-542
Range on HMM: 96-238/272
Sequence Identity: 37% (62 aa)

LHIQMQLCEL-SLWDWITERNKRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACADIIQNADWTNR
| |||  |.   |  |. .|..   | || .        ..  ..  .|.|| |||  ...|||||| ||||   ....|||||||. |  ..|      
LFIQMEFCDKGTLEQWMRNRRQ---EKVDKV--------LILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVD-ERHIKIGDFGLVTA--LKN------

NGK-GTRTHTSRVGTCLYASPEQLEGSQYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVRTGRI
 ||  ||    | ||  | ||||.   .|    |.| ||.|| ||     ||.|.    . .| | .
DGKSRTR----RKGTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDF
Kinase HRI.AA NEK 167-235 38 2.9e-23 79.04 In-house 1-75 (286) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-75/286
Sequence Identity: 38% (29 aa)

FEELAILGKGGYGRVYKVRNKLDGQH-----YAIKKILIKSATKTDCMKVL-REVKVLAGLQHPNIVGYHTAWIE
.|..  .|.| .|.||||| | ||.|     |..||| ... .  .  . .  ||..|. |.|||||.|. ..||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE
Kinase HRI.AA STE 415-520 27 5.7e-22 74.45 In-house 151-261 (359) Show / Hide 
Range on Protein: 415-520
Range on HMM: 151-261/359
Sequence Identity: 27% (33 aa)

SVATKIFQELVEG-VFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACADIIQNADWTNRNG--------KGTRTHTSRVGTCLYASPEQLEG----
|.  .| .....|   |.|...|.|||.|| ||.|      ||. |||. |. .... .   . .         .    .. |||  . .|| ...    
SQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGV-CGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG

--SQYDAKSDMYSLGVILLEL
  ..||.|.|..|||  ..|.
RDKGYDTKCDIWSLGCTIIEM
Kinase HRI.AA PEK 378-463 33 8.7e-20 61.66 In-house 414-513 (758) Show / Hide 
Range on Protein: 378-463
Range on HMM: 414-513/758
Sequence Identity: 33% (37 aa)

LHIQMQLCEL-SLWDWITER-NKRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQ----------------------
. ||||||.  .| ||.  | . .||.           ...   .|  ..||| |||..|. ||||||.|||.   .|                      
MYIQMQLCRKETLKDWMRNRCTMESRP-----------WMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGH

-QVKIGDFGLA
  .|||||||.
QIIKIGDFGLV
Kinase HRI.AA Pkinase 167-239 26 3.6e-19 68.86 Pfam 1-75 (293) Show / Hide 
Range on Protein: 167-239
Range on HMM: 1-75/293
Sequence Identity: 26% (20 aa)

FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLR--EVKVLAGLQHPNIVGYHTAWIEHVHV
.. . ..|.|..|.||| ..| .|. .|.|.|  ... .  ..  .|  |..... |.||||| .. .. .. |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHI
Kinase HRI.AA PEK-Unclassified 167-235 35 4.3e-19 62.75 In-house 1-74 (835) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-74/835
Sequence Identity: 35% (26 aa)

FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIK-SATKTDC----MKVLREVKVLAGLQHPNIVGYHTAWIE
| ..  .|.||.. ||.. .|.|   ||.|.| ..    | |      | ..||  .| . ||||. |   |||
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIE
Kinase HRI.AA PEK-Unclassified 485-583 27 7e-18 58.39 In-house 731-835 (835) Show / Hide 
Range on Protein: 485-583
Range on HMM: 731-835/835
Sequence Identity: 27% (30 aa)

TSRVGTCLYASPEQL-----------EGSQYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNVSQRPSALQ
|| .|| .|.|.||.            .  |. . |.||.|.|....| .. | ||| . .  .. | .|     . |  |  |.        .||    
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRP----

LLQSELFQTT
 | | . || 
-LLSKIEQTL
Kinase HRI.AA STE 167-240 19 6.2e-17 56.42 In-house 1-115 (359) Show / Hide 
Range on Protein: 167-240
Range on HMM: 1-115/359
Sequence Identity: 19% (22 aa)

FEELAILGKGGYGRVYKVRNKL---------------DGQHYAIKKILIKSATK---------------TDCMKVLREVKVLAGLQ--HPNIVGYHTAWI
.| . ..|||..| ||| .|.                 |. .|||.. ... ..               ..  ..|.|.|..  ..  ||||| |. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------EHVHVV
         ......
KEGHNHKNDDELWIC
Kinase HRI.AA CAMK 172-227 21 7.2e-17 50.2 In-house 1-101 (425) Show / Hide 
Range on Protein: 172-227
Range on HMM: 1-101/425
Sequence Identity: 21% (22 aa)

ILGKGGYGRVYKVRNKLDG------------QHYAIKKILIKSATKT--------------------------DCMKVLREVKVLAGLQ-------HPNI
.||.|..| |.....|...            |..||| |  | ...                           |. .|.||....  ||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

V
.
I
Kinase HRI.AA NEK 419-463 37 8.4e-16 52.48 In-house 118-170 (286) Show / Hide 
Range on Protein: 419-463
Range on HMM: 118-170/286
Sequence Identity: 37% (20 aa)

KIFQELVEGVFYIHNM-----GIVHRDLKPRNIFLHGPDQQ---VKIGDFGLA
..|. .. .. |.|..      |.|||.|| ||||   . .   |||||||..
DWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase HRI.AA PKR 167-233 38 2.2e-15 51.41 In-house 1-61 (272) Show / Hide 
Range on Protein: 167-233
Range on HMM: 1-61/272
Sequence Identity: 38% (26 aa)

FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPNIVGYHTAW
|...  .| ||.| |.| . ..||. |.||..      |    |  .||. || |.| ||| ||  |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRV------KYNNEKAEHEVQALAKLDHVNIVHYHSCW
Kinase HRI.AA PEK-Unclassified 417-463 41 7.9e-15 47.42 In-house 615-662 (835) Show / Hide 
Range on Protein: 417-463
Range on HMM: 615-662/835
Sequence Identity: 41% (20 aa)

ATKIFQELVEGVFYIHNMG-IVHRDLKPRNIFLHGPDQQVKIGDFGLA
.  | .. . .  .||  . .||||.|| |||.     |.|||||||.
CREITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLV
Kinase HRI.AA TyrKc 167-580 13 5.2e-11 -44.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 167-580
Range on HMM: 1-280/280
Sequence Identity: 13% (63 aa)

FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGL--QHPNIVGYHTAWI---------EHVHVVQP-------QDRVPI
 . . .|| | .|.||| . |         .  .|.  .   .  .|| ...  |  .|||||  . . .         | . .|         .|.   
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QLPSLEVLSEQEGDRDQGGVKDNESSSSIVFAELTPEKEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIELQEDGLTDLSVRPVVRHQLPLGHSSE
  |                                                                                                 
HRPK------------------------------------------------------------------------------------------------

LEGNFTSTDESSEGNLNLLGQTEVRYHLMLHIQMQLCELSLWDWITERNKRSREYVDEAACPYVMASVATKIFQELV----EGVFYIHNMGIVHRDLKPR
                                                                   . .| . .      .|  |.| ....||||  |
-------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAAR

NIFLHGPDQQVKIGDFGLACADIIQNADWTNRNGKGTRTHT---SR-VGTCLYASPEQLEGSQYDAKSDMYSLGVILLELF----QPFGTE----MERAT
|. .. .  .|||.||||. .  | . |..  ...  |. .   .. .      .|| .  . .  ||| .| || . |.|    ||   .    |. . 
NCLVGENH-TVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE

VLTGVRTGRIPESLSKRCP-----VQAKYIQLLTG---RNVSQRPSALQLLQSELF
|.  |..|. ..     .|       ..  |. .    .. ..||.  ..   |.|
VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase HRI.AA Ciliate-E2 167-227 21 9.1e-11 33.17 In-house 1-95 (365) Show / Hide 
Range on Protein: 167-227
Range on HMM: 1-95/365
Sequence Identity: 21% (20 aa)

FEELAILGKGGYGRVYKVRNKLDGQHYAIK----------------------KILIKSATKTDCM--KVLREVK----------VLAGLQHPNIV
.. . ..|.|..| |||........ .|||                      ||..|.  .   .  ...||..          .|  |.||||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNII
Kinase HRI.AA NEK 485-520 43 2.6e-09 29.37 In-house 181-217 (286) Show / Hide 
Range on Protein: 485-520
Range on HMM: 181-217/286
Sequence Identity: 43% (16 aa)

TS-RVGTCLYASPEQLEGSQYDAKSDMYSLGVILLEL
..  |||  |.|||....  |. |||. |||..| |.
YTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEM
Kinase HRI.AA Pkinase_Tyr 430-463 44 8.3e-07 23.68 Pfam 126-158 (270) Show / Hide 
Range on Protein: 430-463
Range on HMM: 126-158/270
Sequence Identity: 44% (15 aa)

YIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA
| ......||||  ||. .. .  .|||.|||||
YLESKNCIHRDLAARNCLVTENN-VVKICDFGLA
Kinase HRI.AA Pkinase_Tyr 167-227 29 0.002104 12.15 Pfam 1-67 (270) Show / Hide 
Range on Protein: 167-227
Range on HMM: 1-67/270
Sequence Identity: 29% (20 aa)

FEELAILGKGGYGRVYKVRNK----LDGQHYAIKKILIKSATKTD--CMKVLREVKVLAGL-QHPNIV
 . .  ||.| .|.||| . |     .... |.|..   .|.. .    . .||.|..  | .|||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIV
Kinase HRI.AA STE 563-580 30 0.004365 6.89 In-house 340-359 (359) Show / Hide 
Range on Protein: 563-580
Range on HMM: 340-359/359
Sequence Identity: 30% (6 aa)

RNVSQRPSALQLLQ--SELF
.. ..||.| |||.   . .
KDPNKRPTASQLLKSEHPFI
Kinase HRI.AA PEK-Unclassified 376-399 37 0.050065 1.41 In-house 500-523 (835) Show / Hide 
Range on Protein: 376-399
Range on HMM: 500-523/835
Sequence Identity: 37% (9 aa)

LMLHIQMQLCELSLWDWITERNKR
. . ||| ||  ..   |. |||.
FIFYIQMELCHYTTARYIINRNKK
Kinase HRI.AA NEK 566-580 40 0.063631 3.03 In-house 272-286 (286) Show / Hide 
Range on Protein: 566-580
Range on HMM: 272-286/286
Sequence Identity: 40% (6 aa)

SQRPSALQLLQSELF
.||||. |.|.  . 
EQRPSCNQILEMPFI