HSER

Species: Mouse
Alias: HSER, Gucy2c
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
HSER.AA Protein Sugen 1072 None Fasta, JSON
HSER.NA RNA Sugen 3951 None Fasta, JSON
HSER.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 272 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of HSER.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor HSER.AA ANF_receptor 53-387 16 9.1e-26 91.94 Pfam 1-364 (364) Show / Hide
Range on Protein: 53-387
Range on HMM: 1-364/364
Sequence Identity: 16% (65 aa)

NLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCALMGPSCTY-STFQMYLDTELNYPMISAGSYGLSC
.. .|..  .. . ..    . ..|... . ....         .|.| .   .       |. .|. ||||.| ..    . ...| ||||.|.   ..
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY---------CSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCL

DY--KE---TLTRILPPARKL-MYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYF--SE-----VLNFKDVLRR-------S--
..  |.   ...|..|..... ....||. .                        .. |   |. .  ...  ..     .  |.|.||.       .  
TDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQH-----------------------HFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAY

--------EQFQEILTGHN----RKSNVIVMCGTPESF----YDVKGDLQVA-------EDTVVILVDLFSNHYF--------EENTTAPEYMDNVLVLT
        . |...|.  .     |. |||||. |. .      .   .| |       .. | |..|.....|.        ..|... |.|..||..|
VSMVIPWDDDFMDYLKKIKDIIKMKARVIVMCCYPDDMGLLQRQI---MQQAHELGMMSGGYVWIYTDWWMHSYDMQWWYDDDMDNDKFREAMKGVLGFT

LPSEQSTSNTSVAERF---SSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPK----------FARAFRN-LTFQGFAGPVTLDDSGDIDNIMSLLYV
.. . |...    .|.   ... . ...    ...|..|.|. .| ...|.. ..          ......|  .|.|..|.|..||.|.     .. ..
MH-P-SPEFQEFMQRWKKTDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIM

SLD
  |
NWD

Kinase HSER.AA RGC 509-746 34 4.7e-103 348.66 In-house 1-300 (300) Show / Hide
Range on Protein: 509-746
Range on HMM: 1-300/300
Sequence Identity: 34% (106 aa)

DKKKVILKDLKHS----DGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDT------RIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIA
.. .|..|.....    . .|.....  |... | .. ||.||.| .  ..      ... | |||.|||| ..| .     |   ||| || | ..||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN-----DDIKMDWMFKYSFIRDIV

KGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCN----------------------SILPP------KKDLWTAPEHLR----QATIS--------
||| |||.| | .||.|||.|||||||.||||||||.|                      .. ..      || |||||||||    .....        
KGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRG

-QKGDVYSFAIIAQEIILRKE-----TFYTL------SCRDHNEKIFRVENSYG-KPFRPDLFLETA---DEKELEVYLLVKSCWEEDPEKRPD-FKKIE
 ||||||||.||..|||.||.     .|. .      |... .|.. ......| |||||..  ...   .|   ... |.. ||.||||.||| |..| 
TQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIR

STLAK
..|..
KQLKT

Kinase HSER.AA RGC 509-746 34 4.7e-103 348.66 In-house 1-300 (300) Show / Hide
Range on Protein: 509-746
Range on HMM: 1-300/300
Sequence Identity: 34% (106 aa)

DKKKVILKDLKHS----DGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDT------RIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIA
.. .|..|.....    . .|.....  |... | .. ||.||.| .  ..      ... | |||.|||| ..| .     |   ||| || | ..||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN-----DDIKMDWMFKYSFIRDIV

KGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCN----------------------SILPP------KKDLWTAPEHLR----QATIS--------
||| |||.| | .||.|||.|||||||.||||||||.|                      .. ..      || |||||||||    .....        
KGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRG

-QKGDVYSFAIIAQEIILRKE-----TFYTL------SCRDHNEKIFRVENSYG-KPFRPDLFLETA---DEKELEVYLLVKSCWEEDPEKRPD-FKKIE
 ||||||||.||..|||.||.     .|. .      |... .|.. ......| |||||..  ...   .|   ... |.. ||.||||.||| |..| 
TQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIR

STLAK
..|..
KQLKT

Kinase HSER.AA TKL 525-744 22 4e-40 139.62 In-house 68-364 (364) Show / Hide
Range on Protein: 525-744
Range on HMM: 68-364/364
Sequence Identity: 22% (68 aa)

FSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTR-------------IFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKI--
| .. .  .. ... .  |. .|.| ..  .              .. | |||..|||...|.            |. ...   |||.||.||||..   
FRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKW

-----EVHGRLKSTNCVVDSRMV--------------VKITDFGCNSILPPKKD----------------------------LWTAPEHLRQA-------
      .|  ||| |. ||. .               .||.|||    . ....                             | ||| ||..       
CTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKV

---------TISQKGDVYSFAIIAQEIILRKETFYTLSCRDHN------EKIFRVENSYGKPFRPDLFLE-----TADEKELEVYLLVKSCWEEDPEKRP
         . |.| |||||.|.  ||. |.. .| . ....       | .  | .   .| .|.  ..       .    ..  | . ||..||||||
GIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP

DFKKIESTL
 |..| ..|
SFQEILKRL

Kinase HSER.AA TKL-Unique 543-669 27 7.6e-24 81.08 In-house 57-217 (290) Show / Hide
Range on Protein: 543-669
Range on HMM: 57-217/290
Sequence Identity: 27% (45 aa)

NLTKFYGTVK----LDTRIFGVVEYCERGSLREVLND----TISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKI-EVHGRLKSTNCVVDSR-----MVV
|.....|. .       . . |.|||..|||..||..        .. . .... ...  .|||.|| |||...    |. |||.|  ||..     . .
NIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNI

KITDFGCNSILP-----PKKDL-------------WTAPEHLRQ--ATISQKGDVYSFAII
|| |||   ..      ... .             | ||| ||.  ...|.| |||||.|.
KICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIV

Kinase HSER.AA Dicty5 536-678 32 1.6e-20 67.31 In-house 52-201 (260) Show / Hide
Range on Protein: 536-678
Range on HMM: 52-201/260
Sequence Identity: 32% (50 aa)

LLQSDYYNLTKFYGTVKLDTRI-FGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG
. |||  |....||  . ...  | | ||| .|||.. ||| .    |  . .  ...   |||..| .|||  | .|  ||| |  .  .  .|| |||
IFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLND-QRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNI-IHRDLKSMNFLITENWKIKIIDFG

CNSILPPKKDLWT--------APEHLRQATISQKGDVYSFAIIAQEIILRKE
       ..   .        |.|     .  || |||||.|.  |.. |||
TSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKE

Kinase HSER.AA TK 543-668 15 6.9e-17 52.43 In-house 104-382 (486) Show / Hide
Range on Protein: 543-668
Range on HMM: 104-382/486
Sequence Identity: 15% (43 aa)

NLTKFYG-TVKLDTR-----------IFGVVEYCERGS----LREVLNDTI------------------------------------SYPDGTF------
|. ..||  .. ...           .  |.||.. |.    ||. | .                                      ..|. ..      
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQDYDD

-----------------------------MDWEFKISVLNDIAKGMSYLHSSKIE-----VHGRLKSTNCVVDSRMV-----------VKITDFG-----
                             .. . ..    .||.||.|||| ..|     ||. |   || |....|           .||.|||     
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQG

---CNSILPPKKDL-----------------------------------WTAPEHLRQAT---------ISQKGDVYSFAI
       .....|                                    |.||| |.  .          . | ||.|| .
SGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

Kinase HSER.AA Dicty4 560-669 31 1.5e-16 51.92 In-house 80-206 (277) Show / Hide
Range on Protein: 560-669
Range on HMM: 80-206/277
Sequence Identity: 31% (40 aa)

VVEYCERGSLREVLND-TISYPDGTFMDWEFKIS---VLNDIAKGMSYLHSSK-IEVHGRLKSTNCVVDSRMVVKITDFGCNS-ILPPK--KD-------
| ||. .|.| ..|.|      . . .||.  ..      |.|.|| .||..  . .|  ||| |  ||  ..||..|||    . . .  ||       
VTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACG

--LWTAPEHLRQATISQKGDVYSFAII
  .|.||| ..     .| |||||.|.
TPCWMAPEVMMHQPYNEKADVYSFGIV

TyrKc HSER.AA TyrKc 494-744 20 1.6e-13 -3.96 SMART 1-280 (280) Show / Hide
Range on Protein: 494-744
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

DRRRDTIQR-----VRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKF----------YGTVKLD-------TRIFGVVEYCERGSLRE
 .  ... .     |......  .|  | ||..             . . .    ..|.          || .  .         .. |.||.. |.|..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG-------C-------NSILP----PKKDL----WTAP
 | ..          .. ..|   .||.||.|||| .. .|  |   || |... .|||.|||                 . .     .|..    |.||
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCR--DHNEKIFRVENSYGKPFRPDLFLETADE-----KELEVYLLVKSCWEEDPEKRPDFKKIES
| ..  . . | ||.|| .   ||  . .. |         |. ...   . . . .|.  .    .        |.| . |.||.||||.|| |. | .
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

TL
 .
CF

Kinase HSER.AA MLK 560-634 32 2.6e-13 42.64 In-house 88-178 (291) Show / Hide
Range on Protein: 560-634
Range on HMM: 88-178/291
Sequence Identity: 32% (30 aa)

VVEYCERGSLREVLNDTISYPDGTF--------MDWEFKISVLNDIAKGMSYLHSSKIE--VHGRLKSTNCVVDS------RMVVKITDFG
| |||| ||| .||..  | ...          .| .....   ..|.||.|||| .    .|  ||| | ..|        ...||.|||
VMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG

Kinase HSER.AA DRK 560-634 41 2.4e-12 38.14 In-house 75-145 (258) Show / Hide
Range on Protein: 560-634
Range on HMM: 75-145/258
Sequence Identity: 41% (32 aa)

VVEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSK-IEVHGRLKSTNCVVDSRMVVKITDFG
. ||  ||||  .| .. |.      |||   ..   |.|||| |||..  | .|  ||| |  ||    ||. |||
CMEYMPRGSLYNILHDESIE------MDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFG

S_TKc HSER.AA S_TKc 502-751 20 3.6e-12 1.61 SMART 14-231 (231) Show / Hide
Range on Protein: 502-751
Range on HMM: 14-231/231
Sequence Identity: 20% (54 aa)

RVRQCKYDK--KKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCER--GSLREVLNDTISYPDGTFMDWEFKISVLNDI
.|..|.  |  ..| .| .|       |. .  .. | . .  |. |.|..    .... | |||.   |.|.... .  . . .  ..     ...  |
KVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQI

AKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDL-----WTAPEHLRQATISQ-KGDVYSFAIIAQEIILRKETFYTLSCRDHNEK
.... |.|| .| .|  ||  |  .|.  ..||.|||   .|   . .     . ||| |     .  | |..|. .|  | . ..  |.      . ..
CCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQM

IFRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIES--TLAKIFGLF
.|..                      |.  ... |.. ||||||   ..     ..|.   |
MFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase HSER.AA UTK 542-634 32 6.2e-12 37.12 In-house 70-170 (296) Show / Hide
Range on Protein: 542-634
Range on HMM: 70-170/296
Sequence Identity: 32% (33 aa)

YNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPD--GTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSR-------MVVKITD
.|. ...|..  .  .  |.||.|.|.|| .| .    |.  ... . . ...  .||| ||.|||| .. ||. |   || |..        ||.|| |
PNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF-VHRDLAARNCLVHMHRMMWHCMMVCKIAD

FG
||
FG

Kinase HSER.AA Pkinase 543-744 19 1.5e-11 41.93 Pfam 61-293 (293) Show / Hide
Range on Protein: 543-744
Range on HMM: 61-293/293
Sequence Identity: 19% (48 aa)

NLTKFYGTVKLDTRIFGVVEYCERG----SLREVLNDTISYPDGTFM--DWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVV----KITD
|  ..|...  ...|  | |||| |    .| ...       ... .  ...  ....  |..|. |.|| .| .|  ||. |. .|.....    ||.|
NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGI-IHRDLKPENILIDNNGHIDACVKICD

FGC-----NSILPPKKDL-----WTAPEHLR-QATISQKGDVYSFAIIAQEIILRKETFYTL----SCRDHNEKIFRVENSYGKPFRPDLFLETADEKE-
||.     .   .  ...     . ||| .| .  ...| |..|. .|  | ....  |.      . .|....|.|.     .. ...   .. ...  
FGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI-----MGPPLHFDWPWWCSISY

----------------LEVYLLVKSCWEEDPEKRPDFKKIEST--L
                 |   ..|.|.. ||.||| .. |     .
FFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase HSER.AA TK 714-744 38 1.9e-09 27.05 In-house 456-486 (486) Show / Hide
Range on Protein: 714-744
Range on HMM: 456-486/486
Sequence Identity: 38% (12 aa)

EKELEVYLLVKSCWEEDPEKRPDFKKIESTL
... |.|.| ..||..|||.||.|. . . |
CPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase HSER.AA UTK 717-744 39 4.5e-09 27.2 In-house 269-296 (296) Show / Hide
Range on Protein: 717-744
Range on HMM: 269-296/296
Sequence Identity: 39% (11 aa)

LEVYLLVKSCWEEDPEKRPDFKKIESTL
..|| |...||. ||..||||. .....
HPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase HSER.AA MLK 722-744 52 1.1e-08 26.44 In-house 269-291 (291) Show / Hide
Range on Protein: 722-744
Range on HMM: 269-291/291
Sequence Identity: 52% (12 aa)

LVKSCWEEDPEKRPDFKKIESTL
| | ||..||.|||.|. | . |
LMKQCWNQDPHKRPSFRQIVQHL

Kinase HSER.AA Dicty5 722-748 40 2.4e-08 24.8 In-house 234-260 (260) Show / Hide
Range on Protein: 722-748
Range on HMM: 234-260/260
Sequence Identity: 40% (11 aa)

LVKSCWEEDPEKRPDFKKIESTLAKIF
|.|.|| . | .|| ||.|  .. .| 
LIKKCWQQKPHNRPSFKEICKYFESII

Kinase HSER.AA Pkinase_Tyr 718-744 51 3.4e-08 28.36 Pfam 244-270 (270) Show / Hide
Range on Protein: 718-744
Range on HMM: 244-270/270
Sequence Identity: 51% (14 aa)

EVYLLVKSCWEEDPEKRPDFKKIESTL
|.| | |.||..|||.|| |. | . |
EIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase HSER.AA Pkinase_Tyr 560-634 36 4.3e-08 28.02 Pfam 85-156 (270) Show / Hide
Range on Protein: 560-634
Range on HMM: 85-156/270
Sequence Identity: 36% (27 aa)

VVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG
|.||.. |.|.. | .    .|.   . . ...   .|||||.||.| .. .|  |   || |.. .||||.|||
VMEYMPHGDLLDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNC-IHRDLAARNCLVTENNVVKICDFG

Kinase HSER.AA DRK 646-677 53 3e-06 17.05 In-house 168-199 (258) Show / Hide
Range on Protein: 646-677
Range on HMM: 168-199/258
Sequence Identity: 53% (17 aa)

WTAPEHLRQATISQKGDVYSFAIIAQEIILRK
||||| ||      | |||||||.  |.. |.
WTAPEVLRNQRYTEKADVYSFAIVLWECVTRQ

Kinase HSER.AA Dicty4 722-746 37 7e-06 15.76 In-house 251-277 (277) Show / Hide
Range on Protein: 722-746
Range on HMM: 251-277/277
Sequence Identity: 37% (10 aa)

LVKSCWEEDPEKRPDFKKIEST--LAK
|.. ||..||..|| |. | .   |  
LIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase HSER.AA DRK 722-746 36 5.9e-05 12.77 In-house 234-258 (258) Show / Hide
Range on Protein: 722-746
Range on HMM: 234-258/258
Sequence Identity: 36% (9 aa)

LVKSCWEEDPEKRPDFKKIESTLAK
| . ||.|||  || .  .   |  
LMNDCWNEDPQHRPSMQECLERLEA

Kinase HSER.AA TKL-Unique 722-744 43 0.000136 12.32 In-house 268-290 (290) Show / Hide
Range on Protein: 722-744
Range on HMM: 268-290/290
Sequence Identity: 43% (10 aa)

LVKSCWEEDPEKRPDFKKIESTL
| . ||  ||..|| |  | . |
LIQQCWHHDPSQRPSFDEIIHRL

Kinase HSER.AA UTK 646-668 41 0.001528 7.99 In-house 205-228 (296) Show / Hide
Range on Protein: 646-668
Range on HMM: 205-228/296
Sequence Identity: 41% (10 aa)

WTAPEHLRQA-TISQKGDVYSFAI
|.||| | .. . ..| ||.|| .
WMAPEALTHHTRFTTKSDVWSFGV

Kinase HSER.AA MLK 646-669 37 0.010611 5.35 In-house 199-225 (291) Show / Hide
Range on Protein: 646-669
Range on HMM: 199-225/291
Sequence Identity: 37% (10 aa)

WTAPEHL---RQATISQKGDVYSFAII
| ||| .   |  . | | ||.|....
WMAPEVIQQFRCEKYSEKCDVWSWGVV

Kinase HSER.AA Pkinase_Tyr 646-668 39 2.361158 1.82 Pfam 180-202 (270) Show / Hide
Range on Protein: 646-668
Range on HMM: 180-202/270
Sequence Identity: 39% (9 aa)

WTAPEHLRQATISQKGDVYSFAI
|.||| ..    . | ||.|| .
WMAPECINYGKFTTKSDVWSFGV

CYCc HSER.AA CYCc 787-982 45 1.5e-109 371.19 SMART 1-231 (231) Show / Hide
Range on Protein: 787-982
Range on HMM: 1-231/231
Sequence Identity: 45% (105 aa)

AERDRADHLNFMLLPRLVVKSLKEKG-IVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHD-----VYKVETIGDAYVVASGL
.|....|.|  ..||| | ..||...  |.|..|..|||.|.||||||..|. .|||.||.||||.|. ||.|.|.|.     .||||||||||.|.||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PMRNG-------------------NRHAVDISKMALDILSFIGTFELEHL----PGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL
| ||.                    .||..|. .|||......||...|     |. |...|||.|.||...|||||.|||||.||||||.||||||||.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PLRIHMSSSTITIL------KRTDCQFLYEV
| .||.|..|. .|      .| ..||  |.
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP

Guanylate_cyc HSER.AA Guanylate_cyc 814-1001 42 1e-98 339.08 Pfam 1-214 (214) Show / Hide
Range on Protein: 814-1001
Range on HMM: 1-214/214
Sequence Identity: 42% (92 aa)

VEPELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDQIVDHH--DVYKVETIGDAYVVASGLPMR-----NGNRHAVDISKMALDILSF
|... |..|||.|.|||||| .| ...    ||..|.||||.|..|| ..|.|  ..|||.||||.| ..|||| .     ..  ||...  ||||.. .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

IGTFELEHLPGLP-----VWIRIGVHSGPCAAGVVG--IKMPRYCLFGDTVNTASRMESTGLPL--RIHMSSSTITILKRTDC-QFLY--EVRGETYLKG
....  .|... |     ...|||.|.||. |||.|  ..|||||..|||||.||||||||.|.  .||.| .| ..||. .. || .  . ||| ..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

RGTE---TTYWLTG
 | .   .||.|.|
KGKMGEMETYFLHG