Gene IGF1R (Mouse)

IGF1R

Species: Mouse
Alias: IGF1R, Igf1r
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
IGF1R.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 271 Kinase domain by global Sugen HMM Fasta, JSON
IGF1R.AA Protein Sugen 1369 None Fasta, JSON
IGF1R.NA RNA Sugen 11978 None Fasta, JSON

Protein domain

Protein domains of IGF1R.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain IGF1R.AA Recep_L_domain 51-161 39 9.2e-47 158.94 Pfam 1-121 (121) Show / Hide 
Range on Protein: 51-161
Range on HMM: 1-121/121
Sequence Identity: 39% (48 aa)

NCTVIEGFLHILLISKAEDYRSY---RFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFY--NYALVIFEMTN--LKDIGLYNLRNITR--GAI
|||||.| |.|..... .. ...    ||....||.|||..|. ..... ..||||..||| .||.  ||||.|... |  |......||.||||  | .
NCTVIYGNLEITWRDEHNE-LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGGV

RIEKNA--DLCYLST-IDWSLIL
.|..|   .|||. | |.|..|.
YIHNNPHPKLCYTHTEIMWWMIY
Furin-like IGF1R.AA Furin-like 175-333 47 2.4e-80 264.08 Pfam 1-182 (182) Show / Hide 
Range on Protein: 175-333
Range on HMM: 1-182/182
Sequence Identity: 47% (88 aa)

PKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTN--RCQ----KMCPSVCGKRACT--ENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPP
..||.|.||||.| .. |.|||||..|.||||..|   ||    |.||. |..|.||   ..||||..|||.|  |...| ||||||.|. |.||..|||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

----------------GTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHDDECMQECPSGFIRNS-TQSMYCIPCEGPCPKVCG
                |||.|||||||....|...   ...|   .|||..||| |||||...|  ...| | |||||||||| 
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKL--SHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU IGF1R.AA FU 227-270 42 1.2e-14 55.93 SMART 1-48 (48) Show / Hide 
Range on Protein: 227-270
Range on HMM: 1-48/48
Sequence Identity: 42% (21 aa)

NNEC--CHPECLGSCHTPDDNTTCVACRHYYYK---GVCVPACPPGTYR
...|  |||||.. |  |. ...|..|.|.||.   |.||. ||||.|.
DGVCKPCHPECATGCWGPG-PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain IGF1R.AA Recep_L_domain 353-468 38 4.1e-45 153.39 Pfam 1-121 (121) Show / Hide 
Range on Protein: 353-468
Range on HMM: 1-121/121
Sequence Identity: 38% (46 aa)

GCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEG-NYSFYVLDNQN--LQQLWDWNHRNLTVRSGKMYF
.||...||| |..|...|. .|...| ..|...|||..|.....|..|||..||| | |..  .. ||..|..||.|  ||.||.||..|.| . |..|.
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGGVYI

AFNP--KLCVSEIYRMEEVTG
 .||  ||| .... |.....
HNNPHPKLCYTHTEIMWWMIY
FN3 IGF1R.AA FN3 490-593 12 0.000251 21.62 SMART 1-69 (69) Show / Hide 
Range on Protein: 490-593
Range on HMM: 1-69/69
Sequence Identity: 12% (15 aa)

ESDVLR---FTSTTTWKN------RIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPW----T
 . . .   .. | . ..       . ..|    ||        .|.|.                                       ..||||.    |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK---PP--------IVGYR-------------------------------------YTVTGLKPGQYPWT

QYAVYVKAVTLTMVEND
.| . |.||. ...   
EYEFRVRAVNGNDAGEG
FN3 IGF1R.AA FN3 612-815 6 1e-06 29.43 SMART 1-69 (69) Show / Hide 
Range on Protein: 612-815
Range on HMM: 1-69/69
Sequence Identity: 6% (14 aa)

PSIPLD---VLSASNSSS------QLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCA
|. | .   .   . .|.      .. ..|.||          ||...                                                    
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR----------------------------------------------------

CPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVMQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPF----T
                                                                                       ....|.|     |
--------------------------------------------------------------------------------------YTVTGLKPGQYPWT

LYRIDIHSCNHEAEKLG
 |.. .   |. .   |
EYEFRVRAVNGNDAGEG
FN3 IGF1R.AA FN3 833-915 15 4e-07 30.93 SMART 1-69 (69) Show / Hide 
Range on Protein: 833-915
Range on HMM: 1-69/69
Sequence Identity: 15% (15 aa)

DDIPGP---VTWEPRPEN------SIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPG-----NYTARIQATSL--SGNG
 . |.    .....  ..      |. |.| .|      |. |.                        ...  | ||     .|. |..| .    | |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase IGF1R.AA InsR 1000-1270 74 3.1e-233 781.13 In-house 1-278 (278) Show / Hide 
Range on Protein: 1000-1270
Range on HMM: 1-278/278
Sequence Identity: 74% (206 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPET--RVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP
|...||.|||||||||||.|||.|.||...  |.|||||||.||||||||||||||||||||||||||||||.|.|||..|.||.||.|||||||||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

EVEQNNLVLI----PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTT
|.|.||....    .|.|..|.|||.||.||||||.|.||||||||.|||||..|||||||||||||||||.|||||||||.||||||.|||||||||||
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

HSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKD
|||||||||||||..||.|||||||||||||... |.|..|..|.|||....|||.|||||.|||||.||.|| ...|
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase IGF1R.AA Pkinase_Tyr 1000-1268 45 2.8e-153 519.72 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-270/270
Sequence Identity: 45% (127 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRE--RIEFLNEASVMKEF-NCHHVVRLLGVVS-QGQP--TLVIMELMTRGDLKSYLR
||....||.|.||.||.|..||  .|.... ||.|...| |. ..  | .|..||..||.. .....|||.||.. ||.|   ...||.|  |||..|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYY-RKGGKGLLPVRWMSPESLKDGVFT
. |           |.... ..||. .||.||.|| .....|||||||||.|.|...|||.|||..||||..||| ||.|.| ||..||.||....|.||
KHR-------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

THSDVWSFGVVLWEIATLAEQP-YQGLSNEQVLRFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSI
| ||||||||..||| |. ||| |.|.|||.|....  .|. ...|.|||| . .||..||.|.|..||.| ||.  .
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IGF1R.AA TyrKc 1000-1268 40 2.6e-143 483.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-280/280
Sequence Identity: 40% (122 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEF--NCHHVVRLLGVVSQG-------QPTLVIMELMTRGDLKS
||....|| | || ||.|..|        . ||.|...| |    | .|..||..|...  .  ..|||.||..|.       .| ...||.|  ||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYET-------DYYRK----GGKGLLPVR
|||. ||.           .........  ||.||.||  ....|||||||||.|.|..||||.|||..||||.        |||||    |||..||.|
YLRKHRPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

WMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQG-----LSNEQVLRFVMEGGLLDKPDN--------CPDMLFELMRMCWQYNPKMRPSFLEIIG
||.||....|.||| ||||||||..||| |. .||| |     .||..|...|..|. ...|.|        ||| ....|..||...|..||.| ||. 
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

SI
 .
CF
Kinase IGF1R.AA TK 1000-1268 25 9.40000000001e-119 399.94 In-house 1-486 (486) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

ITMNRELGQGSFG---MVYEGVAKGVV--------------------KDEPETRVAIKTVNE--AASMRERIE-----------FLNEASVMKEFN----
||. ..||.| ||   .||.| ..|                      |.. .|.||.|.. |  |.|..|...           ||.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-CHHVVRLLGVVSQG------------QPTLVIMELMTRGD----LKSYLRSLRPEVEQNNLVLIP----------------------------------
 . ..|||.||..||            .| ...||.|  ||    |..|||. ||.  ..     .                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PSLSKMIQMAGEIADGMAYLNAN------KFVHRDLAARNCMVAEDFT-----------VKIGDFGMT-
                               ...  .. |.  ||.||.|| ..      .|||||||||||.|.|. .           .||.|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RDIYETDYYRKGG------------------------KGLLPVRWMSPESLKDGV---------FTTHSDVWSFGVVLWEIATLAEQPYQG-L
       ||||. |.|.. .                        .| ||.|||.||.|.|.|         ||| ||||||||..||| |....|| | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------EQVLRFVMEGGLL--------------DKPDNCP--------------DMLFELMRMCWQYNPKMRPSFLEIIGSI
||         ..|.... .|| |               .|..||              .....||..||.|.|. ||.| ..   .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IGF1R.AA UTK 1000-1268 38 3.4e-109 369.09 In-house 1-296 (296) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-296/296
Sequence Identity: 38% (115 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERI---EFLNEAS---VMKEFN-CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSY
.   |.|||| ||.|... .. .   ..| .||.|. . .|.. .|.    .|..||    .|| |. . .|.||.||..|..|.....|.| .||| ||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED-------FTVKIGDFG---MTRDIY---------ETDYYRKGG
||. ||..... . |   .| ....||  ||.||.||   .||||||||||| |...        ..||.|||   |.|...         |..||.. .
LRRHRPTPPACPHWL---TLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

KGLLPVRWMSPESLKDG-VFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGG--LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSI
 . .|.|||.||.| ..  |||.|||||||||.||| | . .|| |.||.||. .|..||  .. .|. ||. ...||. ||.|.| .||.| ..   .
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase IGF1R.AA Sev 1000-1268 47 6.6e-104 347.08 In-house 1-277 (277) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-277/277
Sequence Identity: 47% (132 aa)

ITMNRELGQGSFGMVYEGVAKGVV-KDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE
 .. | || | || |||| || .    | | ||||||    .   | .||| || .|  |.   .| ..||   . |  .|||.|  ||| .|||  |  
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

VEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE-------DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVF
  || .     .|. .. |   |. |  ||    |||||||.||| | .         .|||||||  ||||  ||||| | ||||||||.|||| ||.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSI
|| ||||.||.  ||| ||  |||   ||  ||..| .|| |. |..||| |. .|| ||.  |  ||||  .   .
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase IGF1R.AA ALK 1000-1270 43 1.9e-102 346.65 In-house 1-273 (273) Show / Hide 
Range on Protein: 1000-1270
Range on HMM: 1-273/273
Sequence Identity: 43% (120 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEV
||  | ||.| || ||.|  ..   |  .  ||.||  | .|  .   |..|| .|  ||   |||..|.  | || ... |.|  ||.||.||  ||. 
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

EQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFT---VKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPESLKDGVFTTHS
|  .. ..    .  .| .  .| |  ||  |.|.||| |||||          .||.|||| ||| | .|||||||. ..|| || || . ||.||. .
ESLQPSQL--TMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKT

DVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKD
||||||| .|||  |   || | .|..|. || ||| .| | |||   . .|. |||  |  ||.|  |. .|..
DVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase IGF1R.AA Musk 1000-1268 42 6.8e-98 324.1 In-house 1-282 (282) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-282/282
Sequence Identity: 42% (119 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-E
|   |..|.| || |.   | | | .|.|| ||.|   . ||      |  ||  | ||    .|.||||   |.|    .| |  |||  .|.|  |  
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

VEQNNLVLI----------PPSLSKM--IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL
. .                || |. .   .|| .|| |||||.  .||||||| |||.. |   ||| |||. | ||  |||.  .    |.||| |||.
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

KDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSI
 .  ||. ||||..||.||||   |.||| |.. | |. .. .|  |  |.|||  ...||| ||| ||  ||.| .|  .|
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase IGF1R.AA Trk 1000-1268 39 1.5e-97 330.38 In-house 1-275 (275) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-275/275
Sequence Identity: 39% (108 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE-
| . .||| | || |. .  .  . ..  . ||.||  .|.    | .|  || .. .   .|.|.. ||   ..| | . | |  |||. |||.  |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

---VEQNN-LVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE-TDYYRKGGKGLLPVRWMSPESLKDGVFTT
   .. .    . |  ...|   | .|| || |.    |||||.|.|||.|...  |||||||| ||.|. ||||| |... ||.||| |||     ||.
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

HSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGL-LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSI
 |||||||||.||. |   ||. .|||  |  ....| . |..|  ||  ....|. |||  |..| .  .|   |
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase IGF1R.AA TK-Unique 1000-1268 35 5e-95 322.01 In-house 1-294 (294) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-294/294
Sequence Identity: 35% (106 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPET-RVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQ-PTLVIMELMTRGDLKSYLRSLR
.......|.|.|| |. | ..|. |.. .. .||.|.... |.  .. .||.|...|||  .| ..|..||.    . |.. ||| . .|.| .|||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PE-----------------VEQNNLVLIPPSLSKMIQMAGEIADGMAYLNA--NKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY-ETDYYRKGGKGLL
|.                  .....  | | .  ... | .|| ||.||     |.|||||.|||....||...||.||||.||.| ...| .....| .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKD--LYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

PVRWMSPESLK--DGVF-TTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNC-PDMLFELMRMCWQYNPKMRPSFLEIIGSI
|.|||.|||||  .|.. || ||||||||..|||.|| ..|| |........ . .|  ...|..| .. ...||. |||..|..|||| .|.  .
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase IGF1R.AA CTKB 1000-1261 42 4.3e-87 295.66 In-house 1-260 (269) Show / Hide 
Range on Protein: 1000-1261
Range on HMM: 1-260/269
Sequence Identity: 42% (112 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNC-HHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE
| .   || | ||.|| | || .. |   | |||| . ...|     .|. |  .|.       .|||||.     | |...||| .||||  ||  || 
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVTPVAIKMLQDSSSEATN-DFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRPK

VEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVW
  .   .    |  ..  ||  .||||||.   . ||||||||||.| ... | |||||. ||.|   ||   .   ||.|||||||. |||.|| ||||
TSKPSAL----SPRRLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVW

SFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEG-GLLDKPDNCPDMLFELMRMCWQYNPKMRPSF
|.|.|.||| | |  || . ..|  |   .  .   . .|  ||| ...||  ||   |  |.||
SYGIVIWEIMTFAKMPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISF
Kinase IGF1R.AA FGFR 1000-1268 35 8.2e-85 288.07 In-house 1-293 (293) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-293/293
Sequence Identity: 35% (105 aa)

ITMNRELGQGSFGMVYEGVAKGVVKD--EPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHH-VVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR
 |.   || | || |  . |||...|  | |. ||.| . . .. .. .    |  .||    |  ...|||. .|. |  || |.  .| |. .||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PEV-EQNNLVL-------IPPSLS------------KMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL
|   ..             .|.              . ...|  .| || ||   | .||||||||  | .|.  || |||  ||| ..||||| . | |
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLS-NEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSI
|. || ||.| | |.|. |||||.|| |||| |. .||| .    |.   . .||  ..|| ||.  .. .|. ||  .|. ||.| ... ..
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase IGF1R.AA S_TKc 1000-1276 20 7.9e-40 139.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 1000-1276
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTR--GDLKSYLRSLRP
 .. |..|.|.|| || .. |.        .|||| ..        . ...| ...|. .. ..|.|..|    .   ..||..    |||..|... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

EVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTT-HSD
.  .  .     .      .. .|.....|.  ....||||   | .. |  ..||.|||. | .                 .|.|| |    ...  .|
HGLRFPF-----PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCD

VWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEM-EPSF
.||.|..|.| ..  . |..    ..... ..           .. . ...| |.|..|. ||.  |.  .  | .  | |
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IGF1R.AA Pkinase 1000-1268 19 3e-38 136.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1000-1268
Range on HMM: 1-293/293
Sequence Identity: 19% (61 aa)

ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFLN--EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRG----DLKSYL
..  | .|.|||| ||... ||  |     .||.|... . ... .... ..  |...||..|. ..|||....  ..   ..||..  |    ||..|.
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV----KIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPESLK
.       ... ...  |    . .. .|. |..|. .....||||   |... .. ..    ||.|||  . . |  .   ..  | .  ..|.|| ..
ST------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPEVIR

-DGVFTTHSDVWSFGVVLWEIATLAEQPYQGL----SNEQVLRFVMEGGLLDKPDNCP-----------------------DMLFELMRMCWQYNPKMRP
 .   .. .|.||.|..|.| ..  . |..|     .    .  . . .  . . ..|                       . . .... |....|| ||
GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

SFLEIIGS--I
.. .|  .  .
TAEQILQHPWF