JAK2

Species: Mouse
Alias: Jak2, JAK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: TK, Secondary Family: JakB,

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
JAK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 278 Kinase domain by global Sugen HMM Fasta, JSON
JAK2.AA Protein Sugen 1132 None Fasta, JSON
JAK2.NA RNA Sugen 5030 None Fasta, JSON
JAK2.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of JAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase JAK2.AA Jak 545-807 40 3.4e-146 491.97 In-house 1-299 (299) Show / Hide
Range on Protein: 545-807
Range on HMM: 1-299/299
Sequence Identity: 40% (120 aa)

LIFNESLGQGTFTKIFKGVRREVGDY----GQLHK--TEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVC--VCGEENILVQEFVKFGSLDT
|...|.||.|.|............|.    .| |.  ..|..||....|...|..|....|.|||.||||.|...|||  .|. |...|.|....|.||.
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLK----KNKNSINI--LWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDIL--QERIPWVPPECIEN-P
||.    ..|. .|.   ||. .|||..|.||.||.|..|||.|||.|||. ||........||.||.||..|.........  .|||||..|||..| .
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

KNLNLATDKWSFG-TTLWEIC----------------SGGDKPLSALDSQRKLQFYEDKHQLPAPK--WTELANLINNCMDYEPDFRPAFRAVIRDLNS
..|.||.|||||| .||||||                ..|..|....|..|||.|||..|.||.|.  |.|..||...|..|.|..||.||..|||||.
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ

Kinase JAK2.AA Jak 266-544 15 5.1e-96 325.31 In-house 1-287 (299) Show / Hide
Range on Protein: 266-544
Range on HMM: 1-287/299
Sequence Identity: 15% (44 aa)

YTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR-GKHKESETLTEQDVQLYCDFPDIIDVSIKQANQECSNESRIVTVHKQDGKVLEIELSSLKEALS
........|...|.........|........||.. ..............|..|||...|......................||......|.........
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

FVS----LIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAG--NQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNE
...    ........|.|......|...............||.......... ....  .......|.........|........|....|.....|...
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

NGEYNLSGTKRNFS--NLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVNQMVFHKIRNED
.... |...|..|.  .|....|||..|......|......|||....|....|.|..||..............|..|...|...|..
FYLT-LAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQR

Kinase JAK2.AA Pkinase_Tyr 545-805 27 7e-83 281.33 Pfam 1-270 (270) Show / Hide
Range on Protein: 545-805
Range on HMM: 1-270/270
Sequence Identity: 27% (78 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVL--DKAHRN-YSESFFEAASMMSQL-SHKHLVLNYGVCVCGEEN---ILVQEFVKFGSLDTY
..|.. ||.| | ...||. .     .. .|..|  |.|  .  |.. ..|.|.. |..|.|| .|...|  ||||.. .|    ..| |... |.|..|
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LKKN---KNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITV-------LPKDILQERIPWVPPECIENP
|.|.   |..... ..|. . | |..| .||.| .||  ..|.|.|. .        . ..| .| | . ..         ..     |.| .|||| . 
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG

KNLNLATDKWSFGTTLWEICSGGDKP-LSALDSQRKLQFY-EDKHQLPAPK--WTELANLINNCMDYEPDFRPAFRAVIRDL
|  . ..| |||| ..|||.. |..|    .. .. ...  || ...|.|.  . |. .|.  |..|.|. || |......|
K-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase JAK2.AA TK 545-805 16 2.4e-58 193.86 In-house 1-486 (486) Show / Hide
Range on Protein: 545-805
Range on HMM: 1-486/486
Sequence Identity: 16% (78 aa)

LIFNESLGQGTFT---KIFKGVRREVGDY------------------GQLHKTEVLLKVLDKAHRNYSESFFE--------------AASMMSQLS----
... . ||.| |    ...||  |. ...                  .   ||.|  |.| . . . .| ||.               |..|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKHLVLNYGVCVCG------------EENILVQEFVKFGS----LDTYLKKNKNS--------------------------------------------
 |...|  ||||. |            |  ..| |... |.    |..||.|...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------INILWKLGVAKQLAWAMHFLEEK------SLIHGNVCAKNILLIREEDRR---TGNPPFIKLSDPGIS-
                               ..  ..|  . |.| .| .|..|       ..|....| |.|. ..  ..   .|..|..|..| | | 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------ITVLPKDIL------------------------------QERIPWVPPECIEN--------PKNLNLATDKWSFGTTLWEICSGGDKPLSALD
         . ..|                                .  | | .|||..          .    ..| |||| ..|||.. |..|     
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SQ---------RKLQFYEDK---------------HQLP----APKW------------TELANLINNCMDYEPDFRPAFRAVIRDL
|          . .  |  .               ...|    .| |            .|.. |.  | .|.|. || |... . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

B41 JAK2.AA B41 33-270 22 2.8e-58 200.87 SMART 1-232 (232) Show / Hide
Range on Protein: 33-270
Range on HMM: 1-232/232
Sequence Identity: 22% (59 aa)

KQIEPVLQVYLYHSLGQAEGEYLKFPSG-EYVAEEICVAASKACGITPVYHNMFALMSETE---RIWY-PPNHVFHIDES----TRHDILYRIRFYFPHW
.  . .. ||....       .|.| .. .. ....|... . |||.|..|..|.|. | .   | |. ........|..         ..|..||.|.|
SPKPRFCRVYFMDGT------TLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDW

YCSGSSRTYRYGVSRGAEAPLLDDFVMSYLFVQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKEKDQT-------PLAVYNSVSYKTFLPKCVRA
..               ... .|. ...|...|.|||...|....|    ..||||..|.|.... ....|..       .  | . .|||.|||| .. 
HG-------------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWID

-------KIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEQF
       ..| .|  .||||. .....      |. |   .||||| ..... .....| |
SIKQSFMHYQMHHKEWRKRIMEWHKNH------CGMTPEEAKLKYLQICQRWPPMYGVEHF

Kinase JAK2.AA TyrKc 545-805 23 6e-29 103.41 SMART 1-280 (280) Show / Hide
Range on Protein: 545-805
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQL--SHKHLVLNYGVCVCG-------EENILVQEFVKFGSLD
. ... || | | ...||. .          ..|  |.| . .    | | . |..|..|  .|...|  ||||. .       |   .| |... |.|.
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

TYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPK-------DIL------QER--IP--W
 ||.|... ..   .|  . | |  | .|..| .||    | |.|. ..          .| || | |  .  .       |        ...  .|  |
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

VPPECIENPKNL--NLATDKWSFGTTLWEICSGGDKPLSA-----LDSQRKLQFYEDKHQLPAPKW----------TELANLINNCMDYEPDFRPAFRAV
 .||||   .    . ..| |||| ..|||.. |..| .      .. |. ... .. . .| |.           .|. ...  | ...|. || |...
MAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

IRDL
....
HECF

Kinase JAK2.AA TKL 551-805 15 4e-26 91.06 In-house 1-364 (364) Show / Hide
Range on Protein: 551-805
Range on HMM: 1-364/364
Sequence Identity: 15% (59 aa)

LGQGTFTKIFKGVRRE---VGDYGQLHK----TEVLLKVLDKAHRNYS---------------------------ESFFEAASMMSQLSHKHLVLNYGVC
.|.|.| ...||. |    ..      .    ..|  |.. . . . .                           . . | . |||.|.| ..|. .|.|
IGSGGFGEVYKGKWRGWGGKC------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYC

VCGEE-------------NILVQEFVKFGS-LDTYLKKNKNSINILWKLGVAKQLAWAMHFLEE--------KSLIHGNVCAKNILLIREEDRRTGNPPF
 |..                .| |... || |....        .  ..  |.. | .|..|          . .|| .   ||||. .     . | ..
CCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMY

-------IKLSDPGISITVLPKD--------------------ILQERI---PWVPPECIENP---------------KNLNLATDKWSFGTTLWEICSG
       .|..| |.| .. ..                      .  ..    | .||....                .  . ..| .|||  ||||...
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

GDKPLSALDSQRK---------LQFYEDKHQLPAP--------------KWTELANLINNCMDYEPDFRPAFRAVIRDL
         ....          . .......| |               ......|.  |.|..|. || |  ..  |
CRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase JAK2.AA TK-Unique 545-805 23 4.2e-24 80.07 In-house 1-294 (294) Show / Hide
Range on Protein: 545-805
Range on HMM: 1-294/294
Sequence Identity: 23% (71 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKT-EVLLKVLD-KAHRNYSESFFEAASMMSQLS-HKHLVLNYGVCVCG-EENILVQEFVKFGSLDTYLKK
| .....|.| |  ...|  ...   .   |.  |..| |  .|.      |.  ..||..|  |...|  .|.|.   |   .. |..  |.|..||..
LEVGDVIGEGAFGQVWRGEVWGIW--KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

NK-------------------NSINILWKLG------VAKQLAWAMHFLEE--KSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISI-----TVLP
..                   .... .  .        |.|.| .| .|..  |  .|...||.|.|| .           .|..| |..      .|. 
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--------DKVCKICDFGMARDVYTNGVYS

KDILQERIP--WVPPECIE-NPKNL-NLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWT---ELANLINNCMDYEPDFRPAFRAV
.   |.|||  | .|| .    ..  .  .| |||| ..|||.. |  | . ... . ..  .| . .| |.     |. ||. .|  .||. || ||..
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQI

IRDL
.  |
KHRL

Kinase JAK2.AA Frk 545-809 24 1.9e-21 70.83 In-house 1-260 (260) Show / Hide
Range on Protein: 545-809
Range on HMM: 1-260/260
Sequence Identity: 24% (69 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLK---KN
. .   || | | ... |            .| | .| | |.     . |   | .| .| |  |.  | ||   |  ... | .. ||| .||.   ..
IQLIRRLGSGQFGEVWEGLWNN--------TTPVAVKTL-KPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDK

KNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDI------LQERIP--WVPPECIENPKNLNLA
 .....   . .| |.|  | .||..  ||  . |.|.|.        |.   .|. | |.   ..  ..       . |.|  |  || . | .   . 
GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV--------GEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAA-NYNKFTIK

TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPK--WTELANLINNCMDYEPDFRPAFRAVIRDLNSLF
 | ||||  | ||   |  | . .  .  ||  .    .| |     .| ... .|   .|. || |  .   |.  |
SDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF

Kinase JAK2.AA SH2 397-487 28 1.2e-20 75.83 SMART 1-87 (87) Show / Hide
Range on Protein: 397-487
Range on HMM: 1-87/87
Sequence Identity: 28% (26 aa)

HSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSG-TKRNFSNLKDLLNCYQMETVR
.  .||.|| . | ..||. |.. | ...| | .. ..| |.. ..     ..||..| .|..| | . . ..| |..| .|.| ||    .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG

Kinase JAK2.AA EGFR 545-806 25 2.1e-19 60.95 In-house 1-258 (258) Show / Hide
Range on Protein: 545-806
Range on HMM: 1-258/258
Sequence Identity: 25% (70 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVL-DKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKN
|     || | | ...||.   . . |.  |  |  ||| ..  .. .| . . | .|  . |.|||   |||.  .   ||  .  .|.|  |....|.
LKKVKVLGSGAFGTVYKGIW--IPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKD

SINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGIS--ITVLPKDILQER----IPWVPPECIENPKNLNLATDKW
 |     |  . | |  | .|||....| .  | |.|.          |  .|  | |..    .  |..  .     | |.  |||.. .    . | |
NIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKS--------PNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHH-RCYTHQSDVW

SFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKW--TELANLINNCMDYEPDFRPAFRAVIRDLN
|.| |.||.   | ||   .  .   .. |.  .|| |.     .  ..  |    .| || |.  .  ..
SYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK

Kinase JAK2.AA UTK 545-681 24 4.2e-19 62.01 In-house 1-151 (296) Show / Hide
Range on Protein: 545-681
Range on HMM: 1-151/296
Sequence Identity: 24% (37 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLD--KAHRNYSE---SFFEAAS---MMSQLS-HKHLVLNYGVCVCGEENILVQEFVKFGSLD
... . |||| |  ..|. .... .  .  .  | .||..  .. .  .|    | | |    ||.|.. | ...  .|||. .|  ..| |. . |.|.
VQLGRQLGQGAFGEVHKARFTQCSE--HMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

TYLKKNKNSIN----ILW---KLGVAKQLAWAMHFLEEKSLIHGNVCAKNILL
.|| ... . .    .|    .|. | . | .|..|... ..|....|.|.|.
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLV

Kinase JAK2.AA S_TKc 545-809 17 6.9e-15 41.44 SMART 1-231 (231) Show / Hide
Range on Protein: 545-809
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKF--GSLDTYLKKNK
  . . .|.|.| | .|.. ..        . .| .|...       |..    .....  |...|  |.|..  ..  .| |..    |.| .|.||..
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NS-----INILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDILQERI---PWVPPECIENPKNLNL-A
       ..  .   ...|.. |. .. ..  ||  .   |||| .           ||..| |..  .         .    ...|| .      .  .
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCK

TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINNCMDYEPDFRPAFRAVIR-----DLNSLF
 | ||.| .|.| .. |  | .    | .. |   .         |. ..|..|....|. ||    . .      .   |
CDWWSCGCILYEMLC-GYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase JAK2.AA Fer 718-806 22 4.6e-13 40.93 In-house 184-283 (283) Show / Hide
Range on Protein: 718-806
Range on HMM: 184-283/283
Sequence Identity: 22% (23 aa)

WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSA---------LDSQRKLQFYEDKHQLPAP--KWTELANLIN-NCMDYEPDFRPAFRAVIRDL
| .||....    . .|| |||| ..|||.. |..|  .         .. |.. .  .. . .| |    .|.....  .|....|. || .  ... |
WLAPETWQTGI-YSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKL

N
.
K

Kinase JAK2.AA Src 545-680 29 2.8e-12 37.96 In-house 1-129 (255) Show / Hide
Range on Protein: 545-680
Range on HMM: 1-129/255
Sequence Identity: 29% (41 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLK--KNK
. . . |||| |   ..|. .         .|.|  |.| ...    | | . |  | .|.|..||  | ||  .|    |.|. . ||| .|||  .  
IKLCRKLGQGQFGEVWMGYWNG--------NTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEG

NSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNIL
 ....   .  | | |  | .||.. .||    |.|.|
RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVL

Kinase JAK2.AA Ack 589-699 31 1.4e-11 35.39 In-house 44-149 (266) Show / Hide
Range on Protein: 589-699
Range on HMM: 44-149/266
Sequence Identity: 31% (36 aa)

NYSESFFEAASMMSQLSHKHLVLNYGVCVCGEEN-ILVQEFVKFGSLDTYLKKNKN----SINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIR
| ...|.  .. | .| | |||  ||| | .     .| |.   ||| . |.| .     .| .|.    . |.| .| .|| | .||  . | |||| .
NCMDDFLREVAIMHSLDHPHLVRLYGV-VLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDF--CMQIAMGMRYLEMKRCIHRDLAARNILLFS

EEDRRTGNPPFIKLSD
 .         .| .|
DD-------RKVKICD

Kinase JAK2.AA Fer 600-671 40 5.3e-11 33.83 In-house 61-134 (283) Show / Hide
Range on Protein: 600-671
Range on HMM: 61-134/283
Sequence Identity: 40% (30 aa)

MMSQ-LSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKN-SINILWKLGVAKQLAWAMHFLEEKSLIH
.| . ..|.. |  |||||  .   .| ||.. ||||.||||||| .. .  |.  . | |. | .|..|  ||
IMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIH

Kinase JAK2.AA UTK 737-805 24 4.3e-09 27.25 In-house 224-296 (296) Show / Hide
Range on Protein: 737-805
Range on HMM: 224-296/296
Sequence Identity: 24% (18 aa)

WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDK--HQLPAPKW--TELANLINNCMDYEPDFRPAFRAVIRDL
|||| ..|||...| .|   .  .. ... ...  ...|.|.    .. .| . |. |.|..|| |. .   .
WSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase JAK2.AA Ack 716-805 30 1.2e-08 25.25 In-house 175-266 (266) Show / Hide
Range on Protein: 716-805
Range on HMM: 175-266/266
Sequence Identity: 30% (28 aa)

IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYE-DKHQLPAPKW--TELANLINNCMDYEPDFRPAFRAVIRDL
..| .|||. . .    | | |.|| ||||  |.| .|  ..     ||  . ..  || |.    .. ..  .| . .|  || | |.  .|
FAWCAPECL-RHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL

Kinase JAK2.AA Pkinase 545-643 18 6e-06 22.18 Pfam 1-102 (293) Show / Hide
Range on Protein: 545-643
Range on HMM: 1-102/293
Sequence Identity: 18% (20 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSE---SFF--EAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFG----SLD
. . . .|.|.| . .|....  |.       .| .|...| |.. ..    .   |.. .|  |.|.. |  |...  . .  .|.|..  |    .| 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQ-IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

TYLK--KNKN
.|..  ....
DYISTWRHGC

Kinase JAK2.AA Src 734-805 30 0.161365 0.87 In-house 181-255 (255) Show / Hide
Range on Protein: 734-805
Range on HMM: 181-255/255
Sequence Identity: 30% (23 aa)

TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKW--TELAN-LINNCMDYEPDFRPAFRAVIRDL
.| ||||  |.|| . |  |    . .  ||  |    .| |.    || . ..  | . .|. || |      |
SDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase JAK2.AA Pkinase 737-805 16 2.726302 2.11 Pfam 196-293 (293) Show / Hide
Range on Protein: 737-805
Range on HMM: 196-293/293
Sequence Identity: 16% (16 aa)

WSFGTTLWEICSGGDKPLSAL----DSQRKLQFYEDKHQ----LPAPKW---------------------TELANLINNCMDYEPDFRPAFRAVIRD--L
||.| .|.| .. |  | .      .  ...| .. . .     . |.|                      |.  .|..| .. |  || .. .  .  .
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF





Kinase JAK2.AA Jak 849-1125 42 1.8e-153 516.14 In-house 1-299 (299) Show / Hide
Range on Protein: 849-1125
Range on HMM: 1-299/299
Sequence Identity: 42% (127 aa)

LKFLQQLGKGNFGSVEMCRYDPLQ------DNTGE--VVAVKKLQHS-TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRD
||....||.|.||.|..||||..|      |...|  .|.|||.||. ...| .||.|||.|.....|..||||.|||.. ........|||..||.|.|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLQ----KHKERIDH--KKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENR---VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK
||.    .||....|  ....|...|||.||.||. |||||.|...|||||..|..   |||..|.|......|||||.........|.|||||.||..|
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

FSV--ASDVWSFG-VVLYELF-TYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQ
|.   |.|.|||| |.|.|.. .|...|.||. .|..|||...|.|| ............|||.|  |.|||| .|..||... .||||||..  ...|
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ

Kinase JAK2.AA Pkinase_Tyr 849-1123 40 3.5e-127 431.37 Pfam 1-270 (270) Show / Hide
Range on Protein: 849-1123
Range on HMM: 1-270/270
Sequence Identity: 40% (116 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-QHSTEEH--LRDFEREIEILKSL-QHDNIVKYKGVCYSAGRR-NLRLIMEYLPYGSLRDYLQK
..|...||.|.||.| ........|||.  ||||.| .....|.  ..|| ||..|.|.| .|.|||.. |||.. |.  .. ..||| |.|.|.|||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---KERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYY-KVKEPGESPIFWYAPESLTESKFSVASDVWS
|   |.....| |||.  ||.||||||  |..||||||.||.||...| |||.||||.. . ....|| .... |  ||.|.|||.. ..||...|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELL-KSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRV
|||...|.||| |.                   |  . ..|.. ....|.|.||.|||||| .|..||. . ..||.|...  . 
FGVLMWEIFTYGEQP--------------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase JAK2.AA TyrKc 849-1123 37 2.7e-121 410.18 SMART 1-280 (280) Show / Hide
Range on Protein: 849-1123
Range on HMM: 1-280/280
Sequence Identity: 37% (113 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSL--QHDNIVKYKGVCYSAGR-----RNLRLIMEYLPYGSLRDYL
......|| |.|| |  ....       . ||||.|....   ..|| ||..|...|  .|.|||.  ||| . ||       | ..||| |.|.|.|||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD------KEYYKVKE--PGE--SPIFWYAPESLTESKF
.||.... .|.||..  ||..|||||  |..||||||.||.|| ....|||.||||.. .  |      |.||..||   |    || |.|||.. ..||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEG--------CPDEIYVIMTECWNNNVSQRPSFRDLSLRV
. .||||||||...|.||| ..  . ...         |  |  ...||..|. .|.|.|.         ||||.| ||..||. . ..||.|...  . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQ---------Q-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF





Kinase JAK2.AA TK 849-1123 19 3.3e-97 326.43 In-house 1-486 (486) Show / Hide
Range on Protein: 849-1123
Range on HMM: 1-486/486
Sequence Identity: 19% (96 aa)

LKFLQQLGKGNFG---SVEMCRYDPLQ---------------------DNTGEVVAVKKLQHSTEEHLRD-----------------FEREIEILKS--L
......||.|.||    | .... ..                      ... . |||| |   .... ..                 . .|......  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHDNIVKYKGVCYSAGR----------RNLRLIMEYLPYGS----LRDYLQKHKER--------------------------------------------
.|.|||.  |||   .           . . ..||| |.|.    |||||.|....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IDHKKLLQYTSQICKGMEYLGTK------RYIHRDLATRNILVENENR-----------VKIGDFG---
                               .. . || .  ||..|||||  |      ...|||||.||.|| ..|.           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTKVLPQDKEYYKVKEPG-----------------------ESPIFWYAPESLT---------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPV
     |.. ...|..||.....|                         || |.|||.|.         . ||. .||||||||...|.||| ..   . .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EF---------MRMIGNDKQGQMIVFH--LIELLKSNGRLPRP--EGCP--------------DEIYVIMTECWNNNVSQRPSFRDLSLRV
             .. . ..|..  ..  | .  .  .|...|  ..||              .|.| .|..||. . ..||.|..|  . 
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGL-N--EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase JAK2.AA UTK 849-1050 30 4.3e-63 214.67 In-house 1-236 (296) Show / Hide
Range on Protein: 849-1050
Range on HMM: 1-236/296
Sequence Identity: 30% (73 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGE-VVAVKKLQ--HSTEEHLR---DFEREIE---ILKSLQ-HDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLR
.....|||.|.|| | ..|...  .  .| .||||..|  ....   .   || .|     ..| .. | |...  ||| . .   . ...|| . |.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

DYLQKHKERID-------HKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE-------NRVKIGDFG---LTKVLP--------QDKEYYKVKEP
.||..|..  .         ..|.. ..|  ||.|| .....||||| ||.||          . .||.|||   ... ..        .. .||.  . 
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GESPIFWYAPESLTES-KFSVASDVWSFGVVLYELFTY
.. || |.|||.||.  .|. .|||||||||..|..|.
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW

Kinase JAK2.AA Frk 849-1127 34 1.9e-61 210.43 In-house 1-260 (260) Show / Hide
Range on Protein: 849-1127
Range on HMM: 1-260/260
Sequence Identity: 34% (97 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ---KHK
......|| | || |   ..     |    ||||.|.  | .  .|| ||  |.|.|.|  ...   ||  .    . .| | .  ||| .|||   .. 
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLKPGTMDP-NDFLREAQIMKKLRHPKLIQLYAVC--TVEEPIYIITELMRHGSLQEYLQAINDKG

ERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE-YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVL
...  ..|.. . |.  || ||  . ||||||| ||.||...| .|| |||| .|| .|.|  |  .     || | |||    .||.. |||||||..|
RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILL

YELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQIR
.|. ||           |   |      |   . .. .. . |.|.| .|| ..| || |||. .  .|| |  |  ....  
TEIITYGR---------MPYPG------MTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF

Kinase JAK2.AA EGFR 849-1050 39 8.5e-61 200.53 In-house 1-199 (258) Show / Hide
Range on Protein: 849-1050
Range on HMM: 1-199/258
Sequence Identity: 39% (80 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST-EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKER
|| .. || | || |    . |  .|    ||.| |. .| ..   .. .|  .. |..|...|.  ||| .    ...|.  |.|||.| ||...||..
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHS---QMQLVTQYMPYGCLLDYVRQHKDN

IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL
|  ..|| .  || |||.||  .| .|||||.||.||   |.||| |||| |.|..|.. |.... |  || | | |.. . ..  .|||||.|| . ||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

FTY
 |.
MTF

Kinase JAK2.AA TK-Unique 849-1050 33 9.5e-61 208.14 In-house 1-235 (294) Show / Hide
Range on Protein: 849-1050
Range on HMM: 1-235/294
Sequence Identity: 33% (79 aa)

LKFLQQLGKGNFGSVEMCRYDPLQ--DNTGEVVAVKKLQ-HSTEEHLRDFEREIEILKSLQ-HDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ--
|......|.|.|| |  . . ..   ..   .||||.|. ..|..  .|| .||...|.|  | |||.  |.| . .  .  .||||.|.|.|..||.  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

--------------------KHKER---IDHKKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESP
                    ..| |   |. | |...  ||..|||||    |. .||||..||.|. . ...||.|||... .  ...| . .. |. |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

IFWYAPESLT--ESKF-SVASDVWSFGVVLYELFTY
| | |||||   .  . .  ||||||||...|.||.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL

Kinase JAK2.AA TKL 855-1123 22 6.4e-59 202.07 In-house 1-364 (364) Show / Hide
Range on Protein: 855-1123
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)

LGKGNFGSVEMCRYD------PLQDNTGEVVAVKKLQH---------------------------STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAG
.|.| || |   ..       |   .||..|||||.                              ..     .|.|| ....|.|.|||...|.| . .
IGSGGFGEVYKGKWRGWGGKCP-S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

-----------RRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKR--------YIHRDLATRNILVENENR-------------
             .| ..||| | |||..||.       . ....   .|..||.|| ...         ||||| ..|||| . ..             
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKIGDFGLTKVLPQDKE---------------YYKVKEPGES-PIFWYAPESLTES----------------KFSVASDVWSFGVVLYELFTYIEKSKS
 .||.|||| ... |...                .. .   .   . | ||| | ..                ..| ..||.|||.||.|..|  .    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

PP--VEFMRMIGNDKQGQMIVFHLIELLKSNGRLP----------RPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRV
|     .| ||..| .   . | .. . .    .|           .. ||...  .|..||. . ..|||| ..  | 
PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase JAK2.AA Src 849-1050 38 1.5e-57 194.03 In-house 1-196 (255) Show / Hide
Range on Protein: 849-1050
Range on HMM: 1-196/255
Sequence Identity: 38% (78 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ-KHKER
.|....||.|.|| | |  .   ..||   |||| |   |  .  .| .|..|.|.|.|...|.   || | .      . ||   ||| |||. . ..|
IKLCRKLGQGQFGEVWMGYW---NGNT--KVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVC-SQEE-PIYIVTEYMSHGSLLDYLKKDGEGR

-IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYE
 .  ..|.  . |. .||.||. ..||||||| ||.|| ..| .|..|||| ... .|.. |  ..    || | ||| ... .|.. |||||||. |.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

LFTY
..||
IVTY

Kinase JAK2.AA Ack 849-1050 39 1.7e-56 189.09 In-house 1-207 (266) Show / Hide
Range on Protein: 849-1050
Range on HMM: 1-207/266
Sequence Identity: 39% (82 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS---TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHK
.. . .|| | ||.|     .    ..   |||| |        . . || ||  |. ||.| ..|.  ||  .     |....|  | ||| | | ||.
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM--LMMVTELAPCGSLLDCLRKHC

E--RIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE-NRVKIGDFGLTKVLPQDKEYYKVKEPG--ESPIFWYAPESLTESKFSVASDVWSF
         |...  ||..|| ||. || ||||||.||||.    . |||.||||   |.| . ||. ...     |. | |||.|.  .|| |||||.|
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF

GVVLYELFTY
|| | | |.|
GVTLWEMFSY

Kinase JAK2.AA S_TKc 849-1130 24 3e-54 187.48 SMART 1-231 (231) Show / Hide
Range on Protein: 849-1130
Range on HMM: 1-231/231
Sequence Identity: 24% (73 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPY--GSLRDYLQKHKE
 ..|...||| ||.|  ||       ||..||.|..        ....|||.|||. .|.||||...|...    .| ..|||..   |.|.||..|.. 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

R-----IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSV-ASDVWSF
.     ..      |. |||...||.  .. |||||   |||. .  ..||.|||| ..|                 .. ||| |   ...  ..|.||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVLYELFT----YIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSL--RVDQIRDSI
|..|||...    .       . . ...||                            ..|   ..  |.. . ..||.  ..    ..  .   .
GCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase JAK2.AA Fer 849-1049 32 4.9e-54 182.43 In-house 1-213 (283) Show / Hide
Range on Protein: 849-1049
Range on HMM: 1-213/283
Sequence Identity: 32% (70 aa)

LKFLQQLGKGNFGSVEMCR-----YDPLQDN-TGEVVAVKKL--QHSTEEHLRDFEREIEILKS-LQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRD
 ..  .||.|.|| |   |     ... . . .   |.|||.   ..|.| ...| .|  |... ..|.|.||. |  ... .  . ..||. . |||..
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYG--VCVDEQPIMIVMEFCNGGSLDS

YLQKHKER-IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN-ENRVK--IGDFGLTKVLPQDKEYYKVK-EPGESPIFWYAPESLTESKFSVA
||.| |.. .  ....... |...|||||  |  ||||.| ||.|. . .. .|  | |||. . .  ... || | .    || | |||...   .| .
YLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPK

SDVWSFGVVLYELFT
.|||||||...| ||
TDVWSFGVMCWEIFT

Kinase JAK2.AA Pkinase 849-1123 21 1.6e-42 151.41 Pfam 1-293 (293) Show / Hide
Range on Protein: 849-1123
Range on HMM: 1-293/293
Sequence Identity: 21% (70 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD--FER--EIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYG----SLRDY
.......|.|.||.|  |.      .||..||||..  ..|..  |    |  ||.|.|.|.|.|||........  .... ..|||.. |    .| ||
YHIGRKIGSGSFGCVYKCH----HKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

LQ-KHKERI--DHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV----KIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLT-ESKFS
.. . . ..  . . .  |  ||..|.||.  .. |||||   |||. |.. .    ||.|||| |..      .         ... ||| .   .. .
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

VASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHL--------IELLKSNGR----LPRPEGCP-------------------DEIYVI
 ..|.||.|..|||...                     |. .  .         ..... ...     ..|. |.                   .|   .
PKVDMWSCGCILYEMLC---------------------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF

MTECWNNNVSQRPSFRDLSLR--V
.. |.. . ..||.....     .
IKWCLCKDPKKRPTAEQILQHPWF

Kinase JAK2.AA UTK 1084-1123 37 3.3e-16 51.94 In-house 254-296 (296) Show / Hide
Range on Protein: 1084-1123
Range on HMM: 254-296/296
Sequence Identity: 37% (16 aa)

SNG---RLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRV
.||   |.|.|..||...| .|..||. ... ||.|.||  ..
CNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase JAK2.AA Src 1087-1123 44 4.3e-14 44.24 In-house 218-255 (255) Show / Hide
Range on Protein: 1087-1123
Range on HMM: 218-255/255
Sequence Identity: 44% (17 aa)

RLPRPEGCPDEIYV-IMTECWNNNVSQRPSFRDLSLRV
|.|.|..||||.|  ||..||..   ||| |  |    
RMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase JAK2.AA TK-Unique 1078-1123 36 6.7e-14 44.43 In-house 248-294 (294) Show / Hide
Range on Protein: 1078-1123
Range on HMM: 248-294/294
Sequence Identity: 36% (17 aa)

LIELLKSNGRLPRPEGC-PDEIYVIMTECWNNNVSQRPSFRDLSLRV
..|...   |.|.||.| ..|.| .| .||. . ..|||||..  | 
IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase JAK2.AA Ack 1087-1123 40 2.4e-12 37.96 In-house 230-266 (266) Show / Hide
Range on Protein: 1087-1123
Range on HMM: 230-266/266
Sequence Identity: 40% (15 aa)

RLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRV
|||||. || .|| .| .||  ..  ||.| ..    
RLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL

Kinase JAK2.AA Fer 1083-1124 27 1.8e-10 31.99 In-house 241-283 (283) Show / Hide
Range on Protein: 1083-1124
Range on HMM: 241-283/283
Sequence Identity: 27% (12 aa)

KSNGRLPRPEGCPDEIYVIMT-ECWNNNVSQRPSFRDLSLRVD
|.. ..| |...|.||. ||.  ||. . ..||.. ..  .. 
KKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase JAK2.AA EGFR 1080-1124 33 3.8e-09 26.34 In-house 214-258 (258) Show / Hide
Range on Protein: 1080-1124
Range on HMM: 214-258/258
Sequence Identity: 33% (15 aa)

ELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVD
.||.   ||| |. |   .|..|  ||      || |. |  . .
DLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK