Gene KDR (Mouse)

KDR

Species: Mouse
Alias: Kdr, KDR
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
KDR.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 327 Kinase domain by global Sugen HMM Fasta, JSON
KDR.AA Protein Sugen 1345 None Fasta, JSON
KDR.NA RNA Sugen 5464 None Fasta, JSON

Protein domain

Protein domains of KDR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG KDR.AA IG 38-121 16 6.4e-05 23.59 SMART 1-58 (58) Show / Hide 
Range on Protein: 38-121
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

KDILTILANTTLQITCRGQRDLDWLWPNAQRDSEERVLVTECGGGDSIFCKTLTIPRVVGNDT---GAYKCSYRDVDIAS--TVYVYVR
   .|  .  |...||  .  . |.                           ||| .|  .|.   | | |  .  .. |  .....|.
PP-VTVKEGETVTLTC-VS-QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set KDR.AA I-set 89-105 52 2.995777 3.36 Pfam 59-75 (92) Show / Hide 
Range on Protein: 89-105
Range on HMM: 59-75/92
Sequence Identity: 52% (9 aa)

TLTIPRVVGNDTGAYKC
|||| .|   |.| |.|
TLTISNVQPDDEGKYTC
IG KDR.AA IG 137-220 13 0.156016 4.27 SMART 1-58 (58) Show / Hide 
Range on Protein: 137-220
Range on HMM: 1-58/58
Sequence Identity: 13% (12 aa)

IVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRISWDSEIGFTLPSYMISYA---GMVFCEAKINDETYQS--IMYIVVV
   .| .   ||...|  |    ....                       .|. .   . .   |  .|.|.    .|.|    .. | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG KDR.AA IG 233-327 17 6.8e-15 56.72 SMART 1-58 (58) Show / Hide 
Range on Protein: 233-327
Range on HMM: 1-58/58
Sequence Identity: 17% (17 aa)

PHEIELSAGEKLVLNCTARTELNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLSTLTIESVTKSDQ---GEYTCVASSGRMIKR-NRTFVRVH
|  .. ..|| ..|.| .         ..|.                              ||| .|...|.   |.|.|.|. . ...  . | ..|.
PP-VTVKEGETVTLTC-VS-------QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set KDR.AA V-set 227-326 16 2.6e-07 27.03 Pfam 1-128 (128) Show / Hide 
Range on Protein: 227-326
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

DVILSP--PH----EIELSAGEKLVLNCTAR--TELNVGL-DFTWHS-PPSKSHHKKIV---NRDVKP---------FPGTV-AKMFLS----TLTIESV
.. ...  |.    ... . |... |.|. .  .. . .  ...|    |. . .. |.   .... .         |.|.|   .  |    .||| ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TKSDQGEYTCVASSG-RMIKRNRTFVRV
. || | |.|.....  ..  . | ..|
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set KDR.AA I-set 292-312 57 2.5e-05 20.62 Pfam 58-78 (92) Show / Hide 
Range on Protein: 292-312
Range on HMM: 58-78/92
Sequence Identity: 57% (12 aa)

STLTIESVTKSDQGEYTCVAS
.||||. |...| |.|||||.
YTLTISNVQPDDEGKYTCVAT
IGc2 KDR.AA IGc2 239-316 21 0.000269 16.07 SMART 1-56 (56) Show / Hide 
Range on Protein: 239-316
Range on HMM: 1-56/56
Sequence Identity: 21% (17 aa)

SAGEKLVLNCTARTELNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLSTLTIESVTKSDQGEYTCVASSGRM
  |. ..|.| |.   .     .  . |                         .||||..||..| |.|||.|..   
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set KDR.AA I-set 359-419 26 1.9e-09 34.58 Pfam 27-92 (92) Show / Hide 
Range on Protein: 359-419
Range on HMM: 27-92/92
Sequence Identity: 26% (18 aa)

YPAPDIKWYRNGRPIES---NYTMIVGD----ELTIMEVTERDAGNYTVILTNPISMEKQSHMVSLVV
.| |.. |...|.|. .    . |   .     ||| .|. .|.| ||.. ||.    ...  ..| |
DPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS--FGEAECTAELTV
IG KDR.AA IG 339-420 19 3.1e-09 37.91 SMART 1-58 (58) Show / Hide 
Range on Protein: 339-420
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

KSLVEATVGSQVRIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVTERDA---GNYTVILTNPISMEKQS-HMVSLVVN
 . |.. .|. |...  .       |.||                 ||| .|.. |.   |.|.   |   .....| . . | | 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
IGc2 KDR.AA IGc2 345-407 31 2.4e-05 25.0 SMART 1-56 (56) Show / Hide 
Range on Protein: 345-407
Range on HMM: 1-56/56
Sequence Identity: 31% (20 aa)

TVGSQVRIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTVILTNPIS
  | .|... .   .|.|.|.||. | |..       . .||| .||. |.|.|| . .||..
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set KDR.AA V-set 335-419 18 0.002272 13.45 Pfam 1-128 (128) Show / Hide 
Range on Protein: 335-419
Range on HMM: 1-128/128
Sequence Identity: 18% (24 aa)

GSGMKS--------LVEATVGSQVRIPVKYL-SY----PAPDIKWYRNGRPIESNYTMI-------------------VGDE------------LTIMEV
 | ..         .|.. .|  |..| .|  .|    .  .| ||| ..| ... ..|                    | .            |||. .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TERDAGNYTVILTNPISMEKQSHMVSLVV
.. | | |.   .|. ..    | . |.|
QPSDSGTYYCAVWNC-NEDYFGHGTRLTV
C2-set_2 KDR.AA C2-set_2 358-403 28 0.115947 8.39 Pfam 32-72 (101) Show / Hide 
Range on Protein: 358-403
Range on HMM: 32-72/101
Sequence Identity: 28% (13 aa)

SYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTVILT
.||.|.| ||.||.| .      .. ...|.. .|.|... .. .|
GYPPPQITWYLNGQPMV-----PNEKTEAITTTSEQDPETGLYTVT
IG KDR.AA IG 432-546 13 0.005541 16.84 SMART 1-58 (58) Show / Hide 
Range on Protein: 432-546
Range on HMM: 1-58/58
Sequence Identity: 13% (17 aa)

SPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPGQTSPYACKEWRHVEDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVS-----ALY
.|  . . |   |||| |       .|.||                                                     |.|  . ..     . |
PP-VTVKEGETVTLTC-VS------QIWWY-----------------------------------------------------LTI-NVQPEDSQQHGTY

KCEAINKAGRGER--VISFHVI
 |.|   .| ..    .  .| 
YCQAT--HGQYWSIQGTTLTVQ
I-set KDR.AA I-set 526-545 35 28.859436 0.02 Pfam 73-92 (92) Show / Hide 
Range on Protein: 526-545
Range on HMM: 73-92/92
Sequence Identity: 35% (7 aa)

YKCEAINKAGRGERVISFHV
|.| | |..|  |  ..  |
YTCVATNSFGEAECTAELTV
IGc2 KDR.AA IGc2 560-647 20 6.3e-05 22.11 SMART 1-56 (56) Show / Hide 
Range on Protein: 560-647
Range on HMM: 1-56/56
Sequence Identity: 20% (18 aa)

TEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKT
 | .||.| | |. |   | .||| |..                                 .   . ..|... | | |.|.|. .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG KDR.AA IG 554-657 12 7.4e-05 23.38 SMART 1-58 (58) Show / Hide 
Range on Protein: 554-657
Range on HMM: 1-58/58
Sequence Identity: 12% (14 aa)

QPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQ---GDYVCSAQDKKTKKR
.|     | |.|.| | .      ...||                                            . |....|.   |.|.| |. ..... 
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWS

--HCLVKQL
     .. .
IQGTTLTVQ
IGc2 KDR.AA IGc2 677-742 40 4.3e-22 80.64 SMART 1-56 (56) Show / Hide 
Range on Protein: 677-742
Range on HMM: 1-56/56
Sequence Identity: 40% (27 aa)

TIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRNLTIRRVRKEDGGLYTCQACNVLG
 .|.... ||||.|||.| |.|.| .. |          .|  |||..|..|| |.|||.|.|  |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set KDR.AA I-set 665-752 29 1.9e-21 75.27 Pfam 1-92 (92) Show / Hide 
Range on Protein: 665-752
Range on HMM: 1-92/92
Sequence Identity: 29% (27 aa)

PMITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVE-DSGIVLRDGN---RNLTIRRVRKEDGGLYTCQACNVLGCARAETLFII
| .|  . ... ..|||.. .| ..|.|.| ..||||.. | . .. .. .  .     |||..| ..| | |||.| | .| | ..   ..
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG KDR.AA IG 671-753 25 8.5e-16 59.73 SMART 1-58 (58) Show / Hide 
Range on Protein: 671-753
Range on HMM: 1-58/58
Sequence Identity: 25% (22 aa)

LENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRNLTIRRVRKEDG---GLYTCQACNVLGCARA--ETLFIIE
 . .|   |||.. || .|     .|.|.                    ||| .|..||    | |.|||    |.. .  .|  ...
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGv KDR.AA IGv 681-737 18 0.000466 11.6 SMART 1-76 (76) Show / Hide 
Range on Protein: 681-737
Range on HMM: 1-76/76
Sequence Identity: 18% (14 aa)

TIEVTCPASGNPTPHITWFKDN------ETLVE------DSGIVLRDGN--------RNLTIRRVRKEDGGLYTCQA
.....| .||. . ...|..           .|       . . .   |          ||....| || | |.|. 
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
C2-set_2 KDR.AA C2-set_2 665-709 16 0.001324 15.32 Pfam 1-59 (101) Show / Hide 
Range on Protein: 665-709
Range on HMM: 1-59/101
Sequence Identity: 16% (10 aa)

PMITGNLENQTTT--IGETIEVTC----PASGNPTPHITWFKDNETL--------VEDS
|.|... . ...    ... ..||     ..|.| |.||| ......        ....
PEIEPPPTQLEWQYQENMEVVATCVFPWSCGGYPPPQITWYLNGQPMVPNEKTEAITTT
V-set KDR.AA V-set 663-737 11 0.003172 12.95 Pfam 1-112 (128) Show / Hide 
Range on Protein: 663-737
Range on HMM: 1-112/128
Sequence Identity: 11% (13 aa)

MAPMITGNLE----NQTTTIGETIEVTCPASGNP----TP-HITWFK-DNE-----------------TLVEDSGIVLRDGNR----------NLTIRRV
. .. . . .      |   |.... .|  | ..    .. .|.|..  .                  .   ... . ..  .          .|||. .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

RKEDGGLYTCQA
. .| | |.|..
QPSDSGTYYCAV
Kinase KDR.AA VEGFR 832-1158 73 9.80000000001e-271 905.69 In-house 1-332 (332) Show / Hide 
Range on Protein: 832-1158
Range on HMM: 1-332/332
Sequence Identity: 73% (245 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLRGK
|||||.|||||||||.||.||||.|..||.||||||||||||.|||||||||||.||||||||||||.||.|||  ..||||||||.|.|||||.||| |
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RNEFVPYKSKGARFRQGKDYVG-ELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLA
|..||||..|....||.|...| ....|.|||.||..|.|||..|.|...||..|||..|..|...||.||.|.|||||||||.||||||||||||||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNILLSEKNVVKICDFGLARD-IYKDPDYVRKGD-ARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAP
||||||.|.||||||||||||. |||||||||||| .|||.||||||.|||.|||..|||||.||.||||||||.||||||.||||||.|||.|.|||||
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

DYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL
||.|||.|..||||||..|..||.||||||||
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase KDR.AA Pkinase_Tyr 832-1158 40 9.80000000001e-155 524.67 Pfam 1-270 (270) Show / Hide 
Range on Protein: 832-1158
Range on HMM: 1-270/270
Sequence Identity: 40% (136 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSE--HRALMSELKILIHIGHHLNVVNLLGACTKPGGP--LMVIVEFCKFGNLSTYLR
...|| ||.||||.| .. ..| |.  |. .||||||||||.|..  ....|.|.||. ..||| |.|.|.|.||. |.|  .....|... |.| .|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

GKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDL
 .|                                                                |. ||...|.....|.|||||.|.|..||||||
KHR--------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

AARNILLSEKNVVKICDFGLARDIYKDPDY-VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP-YPGVKIDEEFCRRL-KEGTRMR
||||.|..|.|||||||||||||||.|  | . .|...|| |||||| |.....|..|||||||||.||||..|..| |||.  .||..... ..| || 
AARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMP

APDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL
.|.....|.|. |..|||.||..||.|||..|.|
CPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase KDR.AA TyrKc 832-1158 35 2.1e-140 473.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 832-1158
Range on HMM: 1-280/280
Sequence Identity: 35% (128 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIG-HHLNVVNLLGACTKPG------GPLMVIVEFCKFGNLST
..||| ||.||||.| .. .          .||||||||.|    ....|.|..|. ..| || |.|.|.|.||..|      .|||...|... |.|  
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIH
||| .|..                                                                 |....|. ...|.|.|||.|.|..|||
YLRKHRPK-----------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIH

RDLAARNILLSEKNVVKICDFGLARDIYKD------PDYVRKG---DAR--LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGV----KI
|||||||.|..|...|||.||||.|||| |       || ||    ...  ||..|||||.|.....|..||||||||..||||..|..||||.    . 
RDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS

DEEFCRRLKEGTRMRAPDY--------TTPEMYQTMLDCWHEDPNQRPSFSELVEHL
..|  ...|.| ||. |..         ..|||| |..||||||..||.|||..| .
NQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase KDR.AA TK 832-1158 26 4.90000000001e-132 444.94 In-house 1-486 (486) Show / Hide 
Range on Protein: 832-1158
Range on HMM: 1-486/486
Sequence Identity: 26% (137 aa)

LKLGKPLGRGAFG---QVIEADAFGID--------------------KTATCKTVAVKMLKEGATHSEHRALM----------------SELKILIH-IG
..||| ||.|.||   .| .. ..|..                    |. .. .|||||||||...|. . ..                .|.|.. | .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHLNVVNLLGACTKPG-----------GPLMVIVEFCKFGN----LSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFV
|| |.|.|.|.||...           .|.|...|... |.    | .||| .|..| .. .......... .   |   ..                . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LH--HC----------------M-

EEK-----SLSDVEEEEASEELYKD----------------------------FLTLEHLICYSFQVAKGMEFLASRKC------IHRDLAARNILLSEK
  |     |....... ..|. |.|                            .||...|. ...|.|.|||.|.|..|      .||||||||.|..|.
--KGDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGEN

NV-----------VKICDFG--------LARDIYKDPDYVRKG------------------------DARLPLKWMAPETIFDRV---------YTIQSD
||           .||.|||        ||||||.| ||.||.                        ...||..|||||...|||         .|..||
NVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSD

VWSFGVLLWEIFSLGASPYPGVKID---------EEFCRRLKEG--------------TRMRAPDYTT--------------PEMYQTMLDCWHEDPNQR
|||||||.||||..|. ||.|   .         .|....|..|               || .|.. .              .|.|. |..|||.||..|
VWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDR

PSFSELVEHL
|.||.|.| |
PTFSQLHEQL
Kinase KDR.AA TK-Unique 832-1158 35 2.2e-112 379.65 In-house 1-294 (294) Show / Hide 
Range on Protein: 832-1158
Range on HMM: 1-294/294
Sequence Identity: 35% (120 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCK-TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKR
|..|. .|.||||||. ....||.|.   .  |||||||..||  .......|.... ..| | |.|..||.|||...| | | |.|  ||| .||| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

NEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYK--DFLTLEHLICYSFQVAKGMEFLAS--RKCIHRD
 . ..   ...  .                                         .  .... ..  ...... |. . .|.|.|||.|||  .|..|||
PAMRQHQ-TYGNLK-----------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRD

LAARNILLSEKNVVKICDFGLARDIYKDPDYVRK-GDARLPLKWMAPETIF--DRVY-TIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR
|.|||.||.|..|.||||||.|||.|.. .|... .  |.|..||||| .   ...| |..|||||||||.||||.||| ||||.. .. . .....| |
LCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYR

MRAPDYT-TPEMYQTMLDCWHEDPNQRPSFSELVEHL
|  |..  ..|||. |  ||...| .||||....  |
MPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase KDR.AA PDGFR 985-1158 59 4.3e-107 344.92 In-house 182-358 (358) Show / Hide 
Range on Protein: 985-1158
Range on HMM: 182-358/358
Sequence Identity: 59% (105 aa)

EEEEASEELYKD---FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYT
.| .  .|| .|    ||.. |.|.|.|||||||||||  |.||||||||.|| .  ||||||||||||| .|  || || ||||.|||||| ||| |||
IEQDVKNELMEDDSNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYT

IQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL
.||||||.|.||||||||| .||||. .|..| .  ||| ||  |.. . |.|. |  || .|| .||.|..|.. |
TQSDVWSYGILLWEIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase KDR.AA FGFR 998-1158 59 2.2e-92 313.23 In-house 133-293 (293) Show / Hide 
Range on Protein: 998-1158
Range on HMM: 133-293/293
Sequence Identity: 59% (97 aa)

LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRK-GDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEI
||  .|.   .|||.|||.|||||||||||||||.| .. .| ||||||||||| .. || || .. ||| ||||||  |||||| ||||||.|||||||
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDI-HCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL
. .| .|||..   ||    |||| ||  |  .. |.|  | .|||. | |||.| .||| |
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase KDR.AA Src 832-1158 33 2.8e-77 262.08 In-house 1-255 (255) Show / Hide 
Range on Protein: 832-1158
Range on HMM: 1-255/255
Sequence Identity: 33% (110 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRN
.|| . ||.| || | .    |. .  |   |||| ||.|    .  |.  | .|.     | ..|.|.  |..   |   . |. . |.| .||.    
IKLCRKLGQGQFGEVWM----GYWNGNT--KVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKK---

EFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARN
                                                            .     | |..||  . |||.||..| |.. |||||||||
------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARN

ILLSEKNVVKICDFGLARDIYK--DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYT
.| .|.||.|..|||||| . |  |  |. . .|..| ||.||| |  ...|| |||||||.||.||.. |  |||| .  .|  .... | ||  |.  
VLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMT-NHEVLQQVERGYRMPCPHNC

TPEMYQ-TMLDCWHEDPNQRPSFSELVEHL
 .|.|.  || |||.|| ||| |  | . |
PDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase KDR.AA Ret 995-1160 45 1.1e-69 237.23 In-house 124-293 (293) Show / Hide 
Range on Protein: 995-1160
Range on HMM: 124-293/293
Sequence Identity: 45% (77 aa)

KDFLT-----LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSF
|| ..     .  .| .  |. ||| .|.. | .||||||||.|. |  . || |||| ||.| |  ||..   |.| ||||.|  .| ||| .||||||
KDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSF

GVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHLGN
|||.|||  .||.||||.   |  .  || | ||  |.    |||  |. || . |. ||.|  .   .  
GVLCWEIVTMGANPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase KDR.AA UTK 996-1158 35 1.7e-69 236.91 In-house 113-296 (296) Show / Hide 
Range on Protein: 996-1158
Range on HMM: 113-296/296
Sequence Identity: 35% (66 aa)

DFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEK-------NVVKICDFG---LARDIY---------KDPDYVRKGDARLPLKWMAPETIF
..|||....|.. ..| ||..|.|....||||||||.|. .        .|.||.|||   ..|...          .. | . .. |.|..||||| . 
HWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALT

DR-VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEG--TRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL
..  .|..||||||||..|||.. |. ||||   ... . .. .|   ||..|.    ..|. |..||| ||  ||.| .||. .
HHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase KDR.AA RTKB 998-1158 42 6.1e-59 197.34 In-house 106-264 (264) Show / Hide 
Range on Protein: 998-1158
Range on HMM: 106-264/264
Sequence Identity: 42% (69 aa)

LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQS-DVWSFGVLLWEI
|  . |. .. |.|.|| || ... |||||.|||.|.. .   ||||||.|| |  | . .... .||| |||||| . .| ||..| |||||||  |||
LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEI

FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL
||||. ||.  .   .    |  | |.  |    ....  | .|| ... .||.|.|||. .
FSLGGTPYQQYRN-GDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase KDR.AA Tie 998-1158 46 5.6e-58 174.74 In-house 111-267 (267) Show / Hide 
Range on Protein: 998-1158
Range on HMM: 111-267/267
Sequence Identity: 46% (75 aa)

LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIF
|. . .. .   ||.||..|. ..||||||||||||  |  | || ||||.|    |  ||.|   ||| .||| | .   ||| .|||||.||||||| 
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIV

SLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL
|||  || |.    |.  .| .| ||  |     |.|. |  || . | .||.|.... .|
SLGGTPYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase KDR.AA PDGFR 832-934 56 2.7e-53 169.28 In-house 1-102 (358) Show / Hide 
Range on Protein: 832-934
Range on HMM: 1-102/358
Sequence Identity: 56% (58 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRN
|..|| || ||||.|.|| |.|. |.    .|||||||. |  ||  ||||||||. | |.|.|.||||||||. |||  .| |.| .| |  ||. || 
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTH-GGPIYIITEYCCYGDLLNYLHRKRH

EFV
 |.
SFH
Kinase KDR.AA Pkinase 832-1158 19 2.7e-45 161.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 832-1158
Range on HMM: 1-293/293
Sequence Identity: 19% (70 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKML-KEGATHSEHRALMS--ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFG----NLST
...|...|.|.||.|     .   .  |.|.|||| . |... .......    |..|. .. .| |.| |.....  .. . .. |.|  |     |..
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFD

YLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFL--TLEHLICYSFQVAKGMEFLASRKC
|...                                                                 ..  .  . .....|  |...|.|.. |...
YIST----------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGI

IHRDLAARNILLSEKNVV----KICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGV----KIDEEF
|||||   |||.......    ||||||||. ..    ..   .    . .|||| |  .. |.  .|.||.|..|.| .. |  |.||     ..|. .
IHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQ

CRRLKEGTRMRAPDYTT---------------------PEMYQTMLDCWHEDPNQRPSFSELVEH--L
. ... |.. . . ...                     .|. . . .|.. ||..||.. ....|  .
MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KDR.AA FGFR 832-930 51 4.3e-39 130.84 In-house 1-100 (293) Show / Hide 
Range on Protein: 832-930
Range on HMM: 1-100/293
Sequence Identity: 51% (52 aa)

LKLGKPLGRGAFGQVIEADAFGIDKT--ATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGK
| |||.|| |.||||. | |.|||.   .   ||||||||...|  .   | ||. ..  || | |..||||.||  .||| ||||.|. |||  .|| .
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQ-EGPLYVIVEYCHHGNLRDFLRAR

R
|
R
Kinase KDR.AA Ret 832-930 44 2.1e-32 107.99 In-house 1-100 (293) Show / Hide 
Range on Protein: 832-930
Range on HMM: 1-100/293
Sequence Identity: 44% (45 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEG-ATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPG-GPLMVIVEFCKFGNLSTYLRGK
| |.. || | ||||. | || |   .   ||||||||.. |. || ..| ||. .|  .  | .|. |.|||.  .  |...|||.||.| |  .||  
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R
Kinase KDR.AA S_TKc 832-1158 21 2.6e-31 111.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 832-1158
Range on HMM: 1-231/231
Sequence Identity: 21% (72 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKF--GNLSTYLRGK
 ......|.||||.|  .   .     | . ||.|..|        . ...|..|| .  || |.|.|....    . | .. |.|    |.| .|.. .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

RNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAA
. .  ...                                                            ..  |  .|  |.....|.. |.. |||||  
GRHGLRFP------------------------------------------------------------FPE-HARFYMYQICCALEYCHSHGIIHRDLKP

RNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTI-QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDY
 ||||.|  ..||||||||| .               . .|||| .    |.   .|.||.|..|.| .. |  |.|    ...  ....          
ENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------

TTPEMYQTMLDCWHEDPNQRPSFSELVE-------H--L
 .||. . .  |.. ||..||.  |. .       |  .
-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KDR.AA Tie 841-930 43 2.7e-26 76.49 In-house 2-87 (267) Show / Hide 
Range on Protein: 841-930
Range on HMM: 2-87/267
Sequence Identity: 43% (39 aa)

GAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKR
| ||||. |    | |      ||.||.||.| . .||  | || ..  .||| |..||.||| .  | | | .|. ..|||  .||  |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEH-RGYLYVAIEYAPYGNLLDFLRKSR
Kinase KDR.AA RTKB 832-930 37 1.9e-18 58.81 In-house 1-97 (264) Show / Hide 
Range on Protein: 832-930
Range on HMM: 1-97/264
Sequence Identity: 37% (37 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKR
..||. || ||||.|  |  .    . | . .|.| || ||   |. .  ||. ..  .| | ||. ..| | .   |... ||.| .|||  |||  |
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQ-DEPYILLVELCELGNLRDYLRMCR
Kinase KDR.AA UTK 832-927 30 2.6e-18 59.25 In-house 1-102 (296) Show / Hide 
Range on Protein: 832-927
Range on HMM: 1-102/296
Sequence Identity: 30% (31 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLK-EGATHSEHR---ALMSELK---ILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLST
..||..||.||||.| .|..  ..  ..   |||| .. ....  |..    .| | .   .. .  .| ||..|.| ||. .. .|...|... |.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLR
|||
YLR