Gene KIT (Mouse)

KIT

Species: Mouse
Alias: Kit, KIT
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
KIT.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 335 Kinase domain by global Sugen HMM Fasta, JSON
KIT.AA Protein Sugen 979 None Fasta, JSON
KIT.NA RNA Sugen 5211 None Fasta, JSON

Protein domain

Protein domains of KIT.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 KIT.AA IGc2 49-105 19 0.0012 9.86 SMART 1-56 (56) Show / Hide 
Range on Protein: 49-105
Range on HMM: 1-56/56
Sequence Identity: 19% (12 aa)

EAGDTLSLTCI---DPDF-VRWTFKTYFNEMVENKKNEWIQEKAEATRTGTYTCSNSNGLT
. |....|||.   .||  ..|..    ..... .....  . ..    |.|||. .|   
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP-WNWTLTIKNVTPEDSGYYTCYARNPWG
IG KIT.AA IG 43-113 16 0.007804 15.55 SMART 1-58 (58) Show / Hide 
Range on Protein: 43-113
Range on HMM: 1-58/58
Sequence Identity: 16% (13 aa)

QSELIVEAGDTLSLTCIDPDFVRWTFKTYFNEMVENKKNEWIQEKAEATRT---GTYTC--SNSNGLTS--SIYVFVR
.. . | .|.|..|||  .  ..|.                .  ....  .   |||.|  . .   .|  .... |.
PP-VTVKEGETVTLTC-VS-QIWWY---------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IG KIT.AA IG 122-206 17 0.28279 2.03 SMART 1-58 (58) Show / Hide 
Range on Protein: 122-206
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

GLPLFGKEDSDALVRCPLTDPQVSNYSLIECDGKSLPTDLTFVPNPKAGITIKNVKRAYH--RLCVRCAAQRDGTWLHS-DKFTLKVR
   . .|| ...  .|  .  |.. |                       .|| ||...    .   .|.|.  .   .| . .||.|.
PP-VTVKEGETVTLTC-VS--QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG KIT.AA IG 219-311 19 3.8e-10 40.94 SMART 1-58 (58) Show / Hide 
Range on Protein: 219-311
Range on HMM: 1-58/58
Sequence Identity: 19% (19 aa)

ETSHLLKKGDTFTVVCTIKDVSTSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSARVDDS---GVFMCYANNTFGSANV--TTTLKVV
   .. | |.| |  | ..       ..|..                            ||| .....||   |.. | |.   |..    .|||.| 
PP-VTVKEGETVTLTC-VS-------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set KIT.AA I-set 277-310 50 4.5e-08 29.91 Pfam 59-92 (92) Show / Hide 
Range on Protein: 277-310
Range on HMM: 59-92/92
Sequence Identity: 50% (17 aa)

TLTISSARVDDSGVFMCYANNTFGSANVTTTLKV
||||| .  ||.|.  |.| | ||.| .| .|.|
TLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 KIT.AA IGc2 225-300 23 2e-06 28.61 SMART 1-56 (56) Show / Hide 
Range on Protein: 225-300
Range on HMM: 1-56/56
Sequence Identity: 23% (18 aa)

KKGDTFTVVCTIKDVSTSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSARVDDSGVFMCYANNTFG
. |...|  |   . .   | .|.| . . .                     ||||......|||.  ||| |  |
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG KIT.AA IG 323-413 12 3.2e-05 24.59 SMART 1-58 (58) Show / Hide 
Range on Protein: 323-413
Range on HMM: 1-58/58
Sequence Identity: 12% (12 aa)

NTTVFVTDGENVDLVVEYEAYPKPEHQQWIYMNRTSANKGKDYVKSDNKSNIRYVNQLRLTRLKGTEG---GTYTFLVSNSDASASV--TFNVYVN
   | |  ||.| |   ..      . .|                            |.. ...       |||.  ..    ...   .....| 
PP-VTVKEGETVTLTC-VS------QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set KIT.AA I-set 366-410 17 2.177821 3.83 Pfam 41-92 (92) Show / Hide 
Range on Protein: 366-410
Range on HMM: 41-92/92
Sequence Identity: 17% (9 aa)

VKS-DNKSNIRYVN----QLRLTRLKGTEGGTYTFLVSNS--DASASVTFNV
... ... ...|..     |. .. .    |.||  ..||   |..... .|
LRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 KIT.AA IGc2 429-501 21 0.006057 3.13 SMART 8-56 (56) Show / Hide 
Range on Protein: 429-501
Range on HMM: 8-56/56
Sequence Identity: 21% (16 aa)

LQCVAEGFPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLVVQSSIDSSVFRHNGTVECKASNDVG
|.| |.|.|.|.| ||.  | .                      ..  ..  | .  . . |. .|.|.| .|
LTCPATGNPDPNIHWYK--GQPLP--------------------WNWTLT--IKNVTPEDSGYYTCYARNPWG
I-set KIT.AA I-set 429-444 31 0.098695 8.39 Pfam 20-35 (92) Show / Hide 
Range on Protein: 429-444
Range on HMM: 20-35/92
Sequence Identity: 31% (5 aa)

LQCVAEGFPEPTIDWY
..| ..| |.|.. |.
FECQVTGDPPPQVSWF
I-set KIT.AA I-set 493-511 21 7.385187 2.03 Pfam 74-92 (92) Show / Hide 
Range on Protein: 493-511
Range on HMM: 74-92/92
Sequence Identity: 21% (4 aa)

ECKASNDVGKSSAFFNFAF
.|.|.| .|.... ..   
TCVATNSFGEAECTAELTV
Kinase KIT.AA PDGFR 592-926 65 3.8e-276 896.91 In-house 1-358 (358) Show / Hide 
Range on Protein: 592-926
Range on HMM: 1-358/358
Sequence Identity: 65% (233 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDS
|.||||||.||||||||||||||.||.|.|.||||||||.||..|.||||||||..|.||.||||||||||||.|||...||||||||||||.|.|||.|
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

FI-----------FSKQEEQAEAALYKNLLHSTE--------PSC-DSSNEYMDMKPGVSYVVPTKTD---KRRSARIDSYIERDVTPAIMEDDELALDL
|.           .|.|........|||..|..|        .|| ||....|.|..||...|.....   ...|...|||||.||....||||...|..
FHQHHPEKPKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNVLTY

DDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLG
.|||.|||||||||.|||||||.||||||||.||.||...|||||||||||.||||||||||||||||||||||||.||||..||||||||.|||.||||
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG

SSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLI
..||||||||||||||||||.||..|.|||.|.|..|..|||.||.|||||.|..|..
GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase KIT.AA Pkinase_Tyr 592-926 38 6.4e-152 515.14 Pfam 1-270 (270) Show / Hide 
Range on Protein: 592-926
Range on HMM: 1-270/270
Sequence Identity: 38% (133 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTE--REALMSELKVLSYLGNHMNIVNLLGACT-VGGP--TLVITEYCCYGDLLNFLR
..|||.||.||||.|...|..|  ...  ..|||||||..|.  .  ||..|.|.|... ||.| |||.|.|.||  |.|   ....||...||||..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLA
..|                                                                       .|. .|.. |||....|.||||..|.
KHR-----------------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLE

SKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNY-VVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSP-YPGMPVDSKFYKM
|||||||||||||.|.|.... ||||||||||| ||..| ...|...||.||||||.|. ...| .|||||.|. .||.|..| .| ||||  .. .|..
SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEY

I-KEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLI
| ..| ||  ||..|.|.||.|| ||..|| .||||..... .
IYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase KIT.AA TyrKc 592-926 33 7.50000000001e-141 475.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 592-926
Range on HMM: 1-280/280
Sequence Identity: 33% (121 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG-NHMNIVNLLGACTVG-------GPTLVITEYCCYGDLLN
...||.|| ||||.|...|..        ..|||||||..|    ||..|.|..... || .| |||.|.|.|| .       .| ....||...|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMA
.||..|.                                                                           | ..|||||..|.|.||.
YLRKHRPK--------------------------------------------------------------------------LCMKDLLSFCWQIACGME

FLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRND-------SNYVVKG--NAR--LPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPY
.|.|||||||||||||.|...... ||.||||.||| .|       . |..|.  ...  ||..|||||.|. ...|..|||||.|. .||.|..| .||
YLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPY

PGM----PVDSKFYKMIKEGFRMVSPEH--------APAEMYDVMKTCWDADPLKRPTFKQVVQLI
|||      ..  .. .|.|.||  |..        .|.|||..||.||..|| .||||.......
PGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase KIT.AA TK 592-926 24 5.6e-127 427.99 In-house 1-486 (486) Show / Hide 
Range on Protein: 592-926
Range on HMM: 1-486/486
Sequence Identity: 24% (125 aa)

LSFGKTLGAGAFG---KVVEATAYGLI--------------------KSDAAMTVAVKMLKP--SAHLTEREA--------------LMSELKVLSY-LG
. .||.||.|.||   .| .....|..                    |... ..|||||||.  ... .|...              ...|.|.... ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHMNIVNLLGACTVG------------GPTLVITEYCCYGD----LLNFLRRKRDSFIF---SKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSY
.| |||.|.|.|| |            .| ....||...||    |...||..|. |.    .......    .| |.|.             |  |.. 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHC-------------M-KGDI-

VVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLS-------------------FSYQVAKGMAFLASK------NCIHRDLAARNILLTHGRI
    .  ...|.  . . |.|. . ...|....|.. |||.                   ...|.|.||..|.||      |..||||||||.|.... .
----TY-SHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNV

-----------TKICDFG--------LARDIRNDSNYVVKG------------------------NARLPVKWMAPESIFSCV---------YTFESDVW
            ||.|||        ||||| .|..|..|.                        ...||..|||||.... |         .| .||||
CKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVW

SYGIFLWELFSLG-SSPYPGMPV--------DSKFYKMIKEG--------------FRMVSPEHAP--------------AEMYDVMKTCWDADPLKRPT
|.|...||.|..|   .|.||.         .  .......|              .||  |.|.|              .|.||.|. ||..|| .|||
SFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPT

FKQVVQLI
|.|... .
FSQLHEQL
Kinase KIT.AA TK-Unique 592-926 33 2e-108 366.52 In-house 1-294 (294) Show / Hide 
Range on Protein: 592-926
Range on HMM: 1-294/294
Sequence Identity: 33% (119 aa)

LSFGKTLGAGAFGKVVEATAYGLI-KSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGG-PTLVITEYCCYGDLLNFLRRKR
| .|...| |||| |  ... |.. ..|.   ||||||| .|..|.. ....|......|| | |||..||.||  . |.. | ||| .|.|...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

------------DSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDEL--ALDLDDLLSFS
            .                                                                ... |.|. .  .... ||..| 
PAMRQHQTYGNLK---------------------------------------------------------------FDFHHMPDKPRTEPISPKDLYHFA

YQVAKGMAFLAS--KNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVK-GNARLPVKWMAPESIF--SCVY-TFESDVWSYGIFLWELFSLGS
.|.|.||..|||  |...||||.|||.|||.. . ||||||.|||....  |. . .  |.|..||||||.     .| | .|||||.|...||.|.||.
WQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA

SPYPGMPVDSKFYKMIKEGFRMVSPEHA-PAEMYDVMKTCWDADPLKRPTFKQVVQLI
 |||||| .. . ..|..|.||  |||  . ||| .||.||  .| .||.| |... .
CPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase KIT.AA VEGFR 766-926 57 6.7e-96 324.9 In-house 170-332 (332) Show / Hide 
Range on Protein: 766-926
Range on HMM: 170-332/332
Sequence Identity: 57% (93 aa)

LDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARD-IRNDSNYVVKGN-ARLPVKWMAPESIFSCVYTFESDVWSYGIFLWE
|.. ||...|.|||.|| ||||..|||||||||||||.   . |||||||||. |  | .|| ||. .||| |||||||||  |||  |||||||.||||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

LFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLI
 |||| |||||  .| .|.. .|.| ||  |. .. |.|..|  ||  .|  ||.|   |   
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase KIT.AA UTK 592-926 27 6.3e-88 298.43 In-house 1-296 (296) Show / Hide 
Range on Protein: 592-926
Range on HMM: 1-296/296
Sequence Identity: 27% (100 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAH-LTERE---ALMSELK---VLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNF
. .|..||.|||| | .|..         | |||| ....|   .|.|    .| | .   .....  |.|...|.| || ..|....|||.. |||...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAF
||| |...                                                                    .....|.|...|......| ||..
LRRHRPTPP-------------------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQY

LASKNCIHRDLAARNILLTHGR-------ITKICDFG---LARDIRN--------DSNYVVK-GNARLPVKWMAPESIFSC-VYTFESDVWSYGIFLWEL
|.|....||||||||.|... |       . ||.|||   ..|.. .        .|.|. . .. |.|..|||||.. .   .|. |||||.|...||.
LHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEI

FSLGSSPYPGMPVDSKFYKMIKEG--FRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLI
.. |. |||||  . .  . . .|   || .|.. |...|..|. || .|| .||.|...|| .
WTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase KIT.AA Src 592-926 30 2.9e-85 289.58 In-house 1-255 (255) Show / Hide 
Range on Protein: 592-926
Range on HMM: 1-255/255
Sequence Identity: 30% (103 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDS
. . . ||.| || | ...  | .|      |||| |||     . ||.  | ...  |  | ..|.|.  |. . | . .||| . | || .|..    
IKLCRKLGQGQFGEVWMGYWNGNTK------VAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

FIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASKNCI
                                                                    .... .| | .|.... |||.|||.| |.| |
--------------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYI

HRDLAARNILLTHGRITKICDFGLARDIR-NDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR
||||||||.|  .. . |..|||||| |  .| .|. .  |..|.||.||| |   ..|  |||||.|| |.|... |  |||||       .... |.|
HRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGM-TNHEVLQQVERGYR

MVSPEHAPAEMYD-VMKTCWDADPLKRPTFKQVVQLI
|  |.. |.|.|. .|. ||..|| .||||.   .  
MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase KIT.AA FGFR 770-926 55 1.9e-81 276.9 In-house 137-293 (293) Show / Hide 
Range on Protein: 770-926
Range on HMM: 137-293/293
Sequence Identity: 55% (87 aa)

DLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGS
|| |. ||||.|| .|||. ||||||||||.| | . . ||||||||||| .   |  ..| |||.||||||. |. ||| .|||||||. ||| . .| 
DLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGG

SPYPGMP-VDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLI
.|||. | |    ||  ||| ||  |.. . |.| .|  || . |  ||||||.|  .
QPYPHIPSVE-ELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase KIT.AA Ret 770-928 47 4.1e-66 224.8 In-house 136-293 (293) Show / Hide 
Range on Protein: 770-928
Range on HMM: 136-293/293
Sequence Identity: 47% (76 aa)

DLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGS
...||  |. |||..|..   .||||||||.|.  ||| || |||| ||.  |  || .   |.||||||.|| .  |||  |||||.|. .||.  .| 
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

SPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEK
.|||| | . . .   | |.||  ||    ||| .|..||   | ||| || . . .||
NPYPGIPPE-RLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase KIT.AA RTKB 760-926 40 1.2e-61 206.63 In-house 100-264 (264) Show / Hide 
Range on Protein: 760-926
Range on HMM: 100-264/264
Sequence Identity: 40% (68 aa)

EDDELALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFES-DVWSYG
. . . |  . |..|. |.|.||||| ..| |||||.|||.|.. ..  ||||||.|| | ..   . .. .|||.|||||||. .  ||  | ||||.|
QHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHEC--YETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFG

IFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLI
.  || ||||. ||.  ..   ||     |.|. .|. .|......|. || ... .||.|. .|.. 
VTMWEIFSLGGTPYQQYRNGDIFY-WLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase KIT.AA Tie 771-926 48 1.4e-60 182.8 In-house 116-267 (267) Show / Hide 
Range on Protein: 771-926
Range on HMM: 116-267/267
Sequence Identity: 48% (76 aa)

LLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSS
.| |   ||.|| .|. |.||||||||||||     ..|| ||||.   | |  || |   ||||.||| ||.   ||| .|||||||..|||. |||  
ILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLS---RGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIVSLGGT

PYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLI
|| ||   ...|. . .|.||  |     |.||.|. ||   | .||.| |..  .
PYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase KIT.AA VEGFR 592-721 45 2.6e-52 180.09 In-house 1-137 (332) Show / Hide 
Range on Protein: 592-721
Range on HMM: 1-137/332
Sequence Identity: 45% (62 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTV---GGPTLVITEYCCYGDLLNFLRRK
|  || ||.||||.|.||.| |. |.    ||||||||. |   |  |||||||.|  .|.| | ||.||.||    .|| .|| ||||.| |.|.|| |
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RDSFIFSKQE----EQAEAALYKNLLHSTEPSCDSSN
|. |   .      .|. ...   .  .  .. ||.|
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGN
Kinase KIT.AA Pkinase 592-926 20 5.8e-44 156.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 592-926
Range on HMM: 1-293/293
Sequence Identity: 20% (77 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLT--EREALM-SELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYG----DLLNF
. .|...|.|.||.|     |  .. .   .|||| .| .      .....  ||....  | || ||| |..... ..   ...|||  |    ||  .
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELAL--DLDDLLSFSYQVAKGM
...                                                                         ... ..  . ... .. ||...|.
IST-------------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGL

AFLASKNCIHRDLAARNILLTHGRIT----KICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIF-SCVYTFESDVWSYGIFLWELFSLGSSPYPGM--
... |...|||||   |||. .   .    ||||||||. ..   |..          .|||| |  .  |. ..|.||.|. |.|... |  |.||   
EYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCW

----PVDSKFYKMIKEGFRMVSPEHAP-------------------AEMYDVMKTCWDADPLKRPTFKQVVQL--I
      . ....  .  ..  .|.  .                    |. |..| |.. || ||||..|..|   .
HDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KIT.AA FGFR 592-689 46 3.7e-37 124.17 In-house 1-100 (293) Show / Hide 
Range on Protein: 592-689
Range on HMM: 1-100/293
Sequence Identity: 46% (46 aa)

LSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKR
|. ||.|| |.||.|. |.| |. ..  ....|||||||| ... ..   | ||. ..   | | ||.||||.|| .||  || |||  | |  ||| .|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
Kinase KIT.AA Ret 592-689 43 8.4e-29 95.47 In-house 1-100 (293) Show / Hide 
Range on Protein: 592-689
Range on HMM: 1-100/293
Sequence Identity: 43% (44 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPS-AHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGG--PTLVITEYCCYGDLLNFLRRK
| ...||| | ||.|| |.|  .       ||||||||   |   |  .| ||. .|  . || ... |.|||.  .  ||..| ||| || |  |||  
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R
Kinase KIT.AA Tie 601-689 42 5.7e-26 75.48 In-house 2-87 (267) Show / Hide 
Range on Protein: 601-689
Range on HMM: 2-87/267
Sequence Identity: 42% (38 aa)

GAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKR
| ||.|. |.   . |    | ||.||.|  |   ..   | || |.  .| | ||.||.|||   |   | .||  || ||.|||. |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSR
Kinase KIT.AA S_TKc 592-930 20 9.4e-25 89.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 592-930
Range on HMM: 1-231/231
Sequence Identity: 20% (72 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCY--GDLLNFLRRKR
  .....| ||||||  ..  .         ||.|..|        | ...|...|.   .| |||.|....   .   ...|||    |||. ......
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

DSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASKN
                                                                      .     ..  .  .. ||........ |..
R---------------------------------------------------------------------HGLRFPFPE-HARFYMYQICCALEYCHSHG

CIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTF-ESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEG
 |||||   ||||..    ||||||||| .                 .|||| .    |.. ..|.|| |. |.|... |  |.|    . . .|.|.  
IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG--

FRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQ-----LIEKQI
         . |. | .. |.. || ||||  .. |      .   .
---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KIT.AA RTKB 592-691 35 1.7e-18 58.95 In-house 1-99 (264) Show / Hide 
Range on Protein: 592-691
Range on HMM: 1-99/264
Sequence Identity: 35% (35 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDS
.. |. || |||| |  |  . .  .. .  .|.| |||.| ..|| .  ||. |.  || | |.. ..| |    | ..  |.| .| |  .||  | |
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRAS