Gene MAP2K1 (Mouse)

MAP2K1

Species: Mouse
Alias: MAP2K1, Map2k1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK1

Sequence

Name Sequence Type Origin Length Description Download
MAP2K1.AA Protein Sugen 393 None Fasta, JSON
MAP2K1.NA RNA Sugen 2119 None Fasta, JSON
MAP2K1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 294 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MAP2K1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP2K1.AA MEK1 68-361 82 3.7e-220 737.69 In-house 1-297 (297) Show / Hide 
Range on Protein: 68-361
Range on HMM: 1-297/297
Sequence Identity: 82% (246 aa)

FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG
||||.|||.||||||.|..|...|..|||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||.|||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD
|||.||..||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||.|||||||||
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPPPD

AKELELLFG----CHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
.||.| .||    |. ||..... ||.|....|.| .||||...|||||.|||||||||||||..||| ||||||.|||||||.|||||||||||.||
QKEYETMFGDNVYCEQEGEPHNIDPRERPNYHPIS-HGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K1.AA STE7 68-361 53 8.99999999999e-186 623.46 In-house 1-288 (288) Show / Hide 
Range on Protein: 68-361
Range on HMM: 1-288/288
Sequence Identity: 53% (172 aa)

FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKA-----
.|.|.|||.||.||| |. ||||| .||.|.|.|... |....||..||.|||.|| .||||.||||||..|.  |.||||.||||.||...|..     
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQG--THYSVQSDIWSMG
    ||||||||||...||||||.||.|||||.|||||||||||||||..||||||..|||.|||  |..|||...||.|||..|  .||.|.||.||.|
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LSL-VEMAVGRYPIP-----PPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNE-PPPKLPSGVFSLEFQDFVNKCLI
... .|||.||||.|     |||.|.... |.                            .. |||||.|..|||| |||.||   || ||||||||||.
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQ----------------------------PE-MAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQ

KNPAERADLKQLMV-HAFI
|.| ||....|||. | ||
KDPNERPKYHQLMKEHPFI
Kinase MAP2K1.AA STE7-Unclassified 68-361 39 5.8e-137 461.31 In-house 1-301 (301) Show / Hide 
Range on Protein: 68-361
Range on HMM: 1-301/301
Sequence Identity: 39% (135 aa)

FEKISELGAGNGGVVFKVSHKP------SGLVMARKLIHLEIK-PAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGE---ISICMEHMDGGSLD---Q
.| ...||.|..|.| |. ||.      .| .|| | | ...  .....||.|||..||.|. .||||..|||.|...    | |||| ||.||||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

VLKKA--------GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGT-----
..||.        |.|||..|||. ..||.|| || |||.| |||.||.||||||.|..|.|||||.|||....  |...||. .||||||.||      
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

HYSVQSDIWSMGLSLVEMAVGRYPIP-------------PPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL
 |||.||||| ||.. |.| |.||..             |                                          | ..|||..|||.| | |
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQP----------------------------------------ENMSFWELLSCIVNFPVPRL

PS-G---VFSLEFQDFVNKCLIKNPAERADLKQLMV-HAFI
|. .    .| ||.||..||..|.| ||.|  || . | .|
PDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase MAP2K1.AA STE 68-361 29 1.6e-114 386.81 In-house 1-359 (359) Show / Hide 
Range on Protein: 68-361
Range on HMM: 1-359/359
Sequence Identity: 29% (116 aa)

FEKISELGAGNGG-VVFKVSHKPS--------------GLVMARKLIHLEIK----------------PAIRNQIIRELQVLHECN--SPYIVGFYGAFY
.|.|...| |..| |. .. ||..              | .|| | ..|| .                . ...||..|......||  .|.|| .||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SDG-------EISICMEHMDGGSLDQVLKKA--------------GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG
 .|       |. ||||.|||||||...|.               .|.||......  ...||| |. ..|.|.|||.||.|||.     .|||||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLIDS------------------MANSFVGTRSYMSPERLQG------THYSVQSDIWSMGLSLVEMAVGRYPI---PPP-DAKELELLFGCHVEGDAAE
||.||                  . |.||||  .|.||..|.       .|....|||| |. ..||| |..|    .|.    .    ....   .   
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ--Q---

TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSG------------------VFSLEFQDFVNKCLIKNPAERADLKQLMV--HAFI
                         ||.| .|||.|||.||.                    .| ||.||.||||.|.| .|.. .||.   | ||
-------------------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP2K1.AA MEK5 69-264 53 3.6e-87 295.9 In-house 2-192 (254) Show / Hide 
Range on Protein: 69-264
Range on HMM: 2-192/254
Sequence Identity: 53% (105 aa)

EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGK
     || |||| |.|  | ||| ..| |.| |.|   .. ||. ||..|. | ||||.||||||. .  |||| | ||||||| . ..   |||.|||.
RYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLD-MYRC---IPEHILGR

VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIP
...|..|||.|| .  |||||||||||.||| .|.||||||||| ||..|..  ..||  || |||. | .| . ||.||.|....|||.||.| |
MTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYP
Kinase MAP2K1.AA S_TKc 68-361 26 2.8e-82 280.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 68-361
Range on HMM: 1-231/231
Sequence Identity: 26% (83 aa)

FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDG--GSLDQVLKKAGR-----
.|.. ..| |  |.|.|. || .| ..| | |.        ..|.||.|.|.. . |.|| .|..|.. ... ..||..||  |.| ...|| ||     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV-QSDIWSMGLSLVEMAV
 .||    ..   ....| |. .. .|.|||.||.|||...  .||.||||.. ||     ..|.||. ||.|| |   .|.   .|.|| |  | ||..
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV-
|. | |  ... ....                                                        | |. ||..||| |.|..|    ...  
GYPPFP-QMQMMFKKIG-------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------HAFI
      | ..
EWDIKCHPWF
Kinase MAP2K1.AA MEK4 68-262 41 7.4e-70 227.13 In-house 1-211 (275) Show / Hide 
Range on Protein: 68-262
Range on HMM: 1-211/275
Sequence Identity: 41% (88 aa)

FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIK-----PAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK----
 . ..|.|.|. |.| |  ||.|| .|| | |    .           .  .|. |     | |||| |||| .. |   |||| ||  |.|   |    
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMD-ISMDKFYKYVYM

-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQG----THYSVQSDIWSMG
 .  ||||.|.|.. ..... | || |.||| ||||||||||.. .| .||||||..||| ||.| .  .| | || |||..       | . ||.|| |
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLG

LSLVEMAVGRYP
  ..| | |..|
ITMYEVATGKFP
Kinase MAP2K1.AA MEK3 68-262 42 1.7e-68 232.1 In-house 1-205 (264) Show / Hide 
Range on Protein: 68-262
Range on HMM: 1-205/264
Sequence Identity: 42% (87 aa)

FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLK-KAGRI
 ..|.||| |  |.| |. |..|| .|| | |   .      ... .. .       || | |||| .  | . |||| ||  .||    .|.| .  .|
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGMHI

PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQG----THYSVQSDIWSMGLSLVEM
|| ||||... ....| |..|. |. ||||||||.|.|  | .|.||||.||.|.||||     | . || |||  .      |.| ||.||.|  ..||
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEM

AVGRYP
|.||||
AIGRYP
Kinase MAP2K1.AA MEK7 68-262 43 1.5e-66 224.8 In-house 1-206 (269) Show / Hide 
Range on Protein: 68-262
Range on HMM: 1-206/269
Sequence Identity: 43% (90 aa)

FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI-----
 . |...| |  | | |. || || .|| |             | . | |   |. .||||  .|.|  | .. |||| | .  .|  ||.         
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERLQG-----THYSVQSDIWSMGLSLVE
||||.||...|.|. | || ||| ||||||||||||   || |||||||.|| ..||.|..   |   || |||.         | . .|.||.| .|||
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

MAVGRYP
.| |.||
LATGQYP
Kinase MAP2K1.AA Pkinase 68-271 29 1.5e-64 225.58 Pfam 1-226 (293) Show / Hide 
Range on Protein: 68-271
Range on HMM: 1-226/293
Sequence Identity: 29% (68 aa)

FEKISELGAGNGGVVFKVSHKPSGL-VMARKLIHLEIKPAIRNQIIR--ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGG----SLDQVLK--KA
..... .|.|. |.|.|  || .|  |   ..   ..|.  . . .|  |.|.....|.|.|| .|..|.....| ..||...||    .|  ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRI--PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI----KLCDFGVSG---QLIDSMANSFVGTRSYMSPERLQ-GTHYSVQSDIWS
|..  .|. . ..   ...|| |. . ..|.|||.||.|||....|.|    |.||||..       .| ...|.||. ||.|| .. |..|.  .|.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

MGLSLVEMAVGRYPIPPP------DAKEL
.|. | ||. || | |        | ...
CGCILYEMLCGRPPFPGHCWHDNHDQMQM
Kinase MAP2K1.AA STE20 68-262 35 3.3e-57 196.39 In-house 1-226 (288) Show / Hide 
Range on Protein: 68-262
Range on HMM: 1-226/288
Sequence Identity: 35% (80 aa)

FEKISELGAGNGGVVFKVSHKPSGLV----MARKLIHLEIKP---AIRNQIIRELQVLHECNSPYIVGFYGAFYSD----GEISICMEHMDGGSLDQVLK
.|.. ..| |. |.|.|. |||.| .     | | . || .      .. |. | ... .|..|.|| .||... |     |. |.||...|||| ...|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---KAG------RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMA---NSFVGTRSYMSPERLQG---
   | |      .. |.    .   | .|| || ..|.| |||.|  |||....||.||.||||..||..    .|.   |.||||  .|.|| .|.   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHII-HRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--THYSVQSDIWSMGLSLVEMAVGRYP
    |   .|||| |  . ||| |. |
PDKGYDYKCDIWSLGITAIEMAEGEPP
Kinase MAP2K1.AA YSK 68-259 38 2.3e-50 149.65 In-house 1-197 (257) Show / Hide 
Range on Protein: 68-259
Range on HMM: 1-197/257
Sequence Identity: 38% (76 aa)

FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA--GRIPEQI
| | .  | |. |.|.|   .  . | | | | ||        | .| |.| .| ||||  .||..  |  . | ||.  |||. . .|.   | ..|. 
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQG--THYSVQSDIWSMGLSLVEMAVG
 . .   ..||| || .  || |||.|  |.|..  |..|||||||.||. |..   | ||||  .| ||  .   . |    ||||.|    ||| |
IAIILREILKGLDYLHSERKI-HRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKG
Kinase MAP2K1.AA MEK3 311-361 48 1.2e-20 66.9 In-house 213-264 (264) Show / Hide 
Range on Protein: 311-361
Range on HMM: 213-264/264
Sequence Identity: 48% (25 aa)

FELLDYIVNEPPPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
|. |  .| ||||.|| .  || ..|||.|.|| ||..||   ..|| | |.
FQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K1.AA MEK7 311-361 41 1.1e-15 49.74 In-house 214-269 (269) Show / Hide 
Range on Protein: 311-361
Range on HMM: 214-269/269
Sequence Identity: 41% (23 aa)

FELLDYIVNE--PPPKLPSGV---FSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
|| .  | |.  .|| || .    || .|..||.||| |.. .| . ..|| | ||
FEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K1.AA STE20 316-361 43 4.8e-15 51.69 In-house 238-288 (288) Show / Hide 
Range on Protein: 316-361
Range on HMM: 238-288/288
Sequence Identity: 43% (22 aa)

YIV--NEPPPKLP---SGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
.|   ..|||.|    .  .| ||.|||.||| |.|..|.  .||. | ||
MIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K1.AA MEK5 312-361 46 5.5e-15 51.27 In-house 205-254 (254) Show / Hide 
Range on Protein: 312-361
Range on HMM: 205-254/254
Sequence Identity: 46% (23 aa)

ELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
.||  ||.| ||.||.. ||  | .|.|.|. | | .|   ..|| | ||
QLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K1.AA TyrKc 68-360 18 1.4e-14 12.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 68-360
Range on HMM: 1-280/280
Sequence Identity: 18% (62 aa)

FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC--NSPYIVGFYGAFYSD-------GEISICMEHMDGGSLDQVLKKA
 ... .|| |. |.|.|   |   .  | | .. .     |  ..||......   . | || .||.  ..       . . | ||.|..|.|.. |.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM------ANSFV-----GTRS-----YMSPERLQGTHYS
.. .. . | . .. . .|  || .| .. |||    |.||.... .| .||| |   |..           .     |...      |.|| ..   ..
RPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VQSDIWSMGLSLVEMAVGRYPIPPPDA-----KELELLFGCHVEGDAAETPPR----PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL
 .||.|| |  . |.    |  .|.       .. . .. .  .|.  . ||                                          .   . 
TKSDVWSFGVCMWEIF--TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------FVCCPD

EFQDFVNKCLIKNPAERADLKQLMVHAF
|  .   .|   .|..|   ... .. |
EMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MAP2K1.AA YSK 317-361 42 1.2e-13 37.06 In-house 213-257 (257) Show / Hide 
Range on Protein: 317-361
Range on HMM: 213-257/257
Sequence Identity: 42% (19 aa)

IVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
|. ..||||    .|  | .||. || |.|..|   |.|  | ||
IPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MAP2K1.AA Pkinase_Tyr 107-248 26 7.9e-11 37.3 Pfam 46-199 (270) Show / Hide 
Range on Protein: 107-248
Range on HMM: 46-199/270
Sequence Identity: 26% (42 aa)

IRNQIIRELQVLHEC-NSPYIVGFYGAFY-SDGE--ISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV
.|   .||......  . | || .||. .  ..   | | ||.| .|.|.  |.|     .... . | . .. . ||. || .|. . |||.   |.||
CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLV

NSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPERLQGTHYSVQSDIWS
.. . .| |||| .  .  .  .  . .|.        |.|| ..   ....||.||
TENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS
Kinase MAP2K1.AA MEK4 308-361 23 8.7e-11 31.25 In-house 216-275 (275) Show / Hide 
Range on Protein: 308-361
Range on HMM: 216-275/275
Sequence Identity: 23% (14 aa)

M--AIFELLDYIVNEPPPKLPSGVF----SLEFQDFVNKCLIKNPAERADLKQLMVHAFI
.   .|. .  .|.  ||.| .  .    | .. .|.|.||.|.  .|.  ..|  . |.
NDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MAP2K1.AA Pkinase 310-361 20 2e-06 23.88 Pfam 227-293 (293) Show / Hide 
Range on Protein: 310-361
Range on HMM: 227-293/293
Sequence Identity: 20% (14 aa)

IFELLDYIVNEPPPKLPSGV---------------FSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
|.. .. .. .. |.. |.                 | |..||...|| |.|..|   .|.. | ..
ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF