Gene MAP2K2 (Mouse)

MAP2K2

Species: Mouse
Alias: MAP2K2, Map2k2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK1

Sequence

Name Sequence Type Origin Length Description Download
MAP2K2.AA Protein Sugen 401 None Fasta, JSON
MAP2K2.NA RNA Sugen 1541 None Fasta, JSON
MAP2K2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 299 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MAP2K2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP2K2.AA MEK1 72-370 82 1e-221 742.89 In-house 1-297 (297) Show / Hide 
Range on Protein: 72-370
Range on HMM: 1-297/297
Sequence Identity: 82% (247 aa)

FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILG
||.|.|||.||||||.|.|||..|.||||||||||||||.|||||||||||||||||||||||||||||||||||||.|||||||||||.|.||||.|||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPD
|||.||||||.|||.||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||.|||||||||||
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPPPD

AKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFI
.||.|. ||..|.. ..||||...||.||...|||  |||||..||||||.|||||||||||||..|||..||.||.|||||||.|||||| ||.|.||
QKEYETMFGDNVYCEQEGEPHNIDPRERPNYHPIS--HGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K2.AA STE7 72-370 50 4.1e-185 621.26 In-house 1-288 (288) Show / Hide 
Range on Protein: 72-370
Range on HMM: 1-288/288
Sequence Identity: 50% (164 aa)

FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIK-PAVRNQIIRELQVLHECN-SPYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKEA-----
.|.|.|||.||.|||.|.||.||| |||.|.|.|... |. ..||..||.|||.|| .||||.||||||..|.  |.||||.||||.||...|..     
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----KRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQG--THYSVQSDIWSMG
    .||||.||||...||..|| ||.|||.|.|||||||||||||||..||||||..|||.|||  |..|||...||.|||..|  .||.|.||.||.|
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LSL-VELAIGRYPIP-----PPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNE-PPPKLPSGVFSSDFQEFV
... .|.|.||||.|     |||.|... .|.                                 .. |||||.|..|||| |||.||   || .||.||
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQ---------------------------------PE-MAIFEQLTCIVNENPPPRLP--KFSPEFQDFV

NKCLIKNPAERADLKLLMN-HAFI
||||.|.| ||.... ||. | ||
NKCLQKDPNERPKYHQLMKEHPFI
Kinase MAP2K2.AA STE7-Unclassified 72-370 37 6.00000000001e-137 461.26 In-house 1-301 (301) Show / Hide 
Range on Protein: 72-370
Range on HMM: 1-301/301
Sequence Identity: 37% (131 aa)

FERISELGAGNGGVVTKARHRP------SGLIMARKLIHLEIK-PAVRNQIIRELQVLHECN-SPYIVGFYGAFYSDGE---ISICMEHMDGGSLD---Q
.||...||.|..|.| |..| .      .| ||| | | ...  .. ..||.|||..||.|. .||||..|||.|...    | |||| ||.||||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

VLKEA--------KRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGT-----
..|..        ..||| .|||. ..|..|| || |||.| |||.||.||||||.|..|.|||||.|||....  |...||. .||||||.||      
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

HYSVQSDIWSMGLSLVELAIGRYPIP-------------PPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNE
 |||.||||| ||.. |.|.|.||..             |                                               | ..|||..|||.
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQP---------------------------------------------ENMSFWELLSCIVNF

PPPKLPS-G---VFSSDFQEFVNKCLIKNPAERADLKLLMN-HAFI
| | ||. .    .|..|. |..||..|.| ||.|   | | | .|
PVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase MAP2K2.AA STE 72-370 27 3e-114 385.87 In-house 1-359 (359) Show / Hide 
Range on Protein: 72-370
Range on HMM: 1-359/359
Sequence Identity: 27% (113 aa)

FERISELGAGNGG-VVTKARHRPS--------------GLIMARKLIHLEIK----------------PAVRNQIIRELQVLHECN--SPYIVGFYGAFY
.|.|...| |..| |.....| ..              | ||| | ..|| .                .  ..||..|......||  .|.|| .||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SDG-------EISICMEHMDGGSLDQVLKEA--------------KRIPEDILGKVSIAVLRG-LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS
 .|       |. ||||.|||||||...|.               .|.||......  ..|.| |.|| ..| |.|||.||.|||.     .|||||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GQLIDS------------------MANSFVGTRSYMSPERLQG------THYSVQSDIWSMGLSLVELAIGRYPI---PPP--------------DAKEL
|||.||                  . |.||||  .|.||..|.       .|....|||| |. ..|.| |..|    .|.              .    
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ----

EASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSG------------------VFSSDFQEFVNKCLIKNPAE
                                            ||.| .|||.|||.||.                    .|..|..|.||||.|.| .
--------------------------------------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNK

RADLKLLMN--HAFI
|.. . |..  | ||
RPTASQLLKSEHPFI
Kinase MAP2K2.AA MEK5 73-268 53 1.6e-84 287.11 In-house 2-192 (254) Show / Hide 
Range on Protein: 73-268
Range on HMM: 2-192/254
Sequence Identity: 53% (104 aa)

ERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGK
     || |||| | || | ||| |.| |.| |.|   .. ||. ||..|. | ||||.||||||. .  |||| | |||||||      ..||| |||.
RYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMY----RCIPEHILGR

VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIP
...|. .|| || .  .||||||||||.||| .|.||||||||| ||..|..  ..||  || |||. | .| . ||.||.|....|.|.||.| |
MTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYP
Kinase MAP2K2.AA S_TKc 72-370 25 7.3e-81 275.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 72-370
Range on HMM: 1-231/231
Sequence Identity: 25% (80 aa)

FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDG--GSLDQVLKEAKR-----
.| . ..| |  |.| |.||. .| |.| | |.        ..|.||.|.|.. . |.|| .|..|.. ... ..||..||  |.| ...|. .|     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV-QSDIWSMGLSLVELAI
 .||    ..   ....|.|. .. .|.|||.||.|||...  .||.||||.. ||     ..|.||. ||.|| |   .|.   .|.|| |  | |.. 
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLK
|. | |     .... | . .                                                        |... .|..||| |.|..|    
GYPPFP-----QMQMMFKKIG--------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

LLMN-------HAFI
 ...       | ..
EALQDEWDIKCHPWF
Kinase MAP2K2.AA Pkinase 72-370 23 3e-71 247.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 72-370
Range on HMM: 1-293/293
Sequence Identity: 23% (77 aa)

FERISELGAGNGGVVTKARHRPSGL-IMARKLIHLEIKPAVRNQIIR--ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGG----SLDQVLK--EA
..... .|.|. |.| |..|. .|      ..   ..|. .. . .|  |.|.....|.|.|| .|..|.....| ..||...||    .|  ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRI--PEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEI----KLCDFGVSG---QLIDSMANSFVGTRSYMSPERLQ-GTHYSVQSDIWS
...  .|. . ..   .||||.|. . . |.|||.||.|||....|.|    |.||||..       .| ...|.||. ||.|| .. |..|.  .|.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

MGLSLVELAIGRYPIPPP------DAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEF
.|. | |.. || | |        | ... .  ..| ..    ...|.|...... .                          . ...     |.....|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H------------------------F-HWTF-HNWSEECKDF

VNKCLIKNPAERADLKLLMNHAFI
...|| |.|..|   . ...| ..
IKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP2K2.AA MEK3 72-266 43 3.4e-69 234.45 In-house 1-205 (264) Show / Hide 
Range on Protein: 72-266
Range on HMM: 1-205/264
Sequence Identity: 43% (90 aa)

FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNS-PYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLK-EAKRI
 . |.||| |  |.| | |||.|| ||| | |   .      ... .. .       || | |||| .  | . |||| ||  .||    .|.|   ..|
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGMHI

PEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQG----THYSVQSDIWSMGLSLVEL
|||||||... . ..| |..|. .. ||||||||.|.|  | .|.||||.||.|.||||     | . || |||  .      |.| ||.||.|  ..|.
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEM

AIGRYP
||||||
AIGRYP
Kinase MAP2K2.AA MEK4 72-266 41 5.2e-68 221.02 In-house 1-211 (275) Show / Hide 
Range on Protein: 72-266
Range on HMM: 1-211/275
Sequence Identity: 41% (87 aa)

FERISELGAGNGGVVTKARHRPSGLIMARKLIH-LEIK-----PAVRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEA--
 . ..|.|.|. |.| | .|..|| ||| | |    .           .  .|. |     | |||| |||| .. |   |||| ||  |.|   | .  
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMD-ISMDKFYKYVYM

---KRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQG----THYSVQSDIWSMG
   .||||.|.|.. ... . | || |.|.| ||||||||||.. .| .||||||..||| ||.| .  .| | || |||..       | . ||.|| |
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLG

LSLVELAIGRYP
  ..|.| |..|
ITMYEVATGKFP
Kinase MAP2K2.AA MEK7 72-266 43 1.7e-67 228.03 In-house 1-206 (269) Show / Hide 
Range on Protein: 72-266
Range on HMM: 1-206/269
Sequence Identity: 43% (91 aa)

FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRI-----
 . |...| |  | |.| ||. || ||| |             | . | |   |. .||||  .|.|  | .. |||| | .  .|  ||  |       
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

PEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERLQG-----THYSVQSDIWSMGLSLVE
|| |.||...|.   | || |||.||||||||||||   || |||||||.|| ..||.|..   |   || |||.         | . .|.||.| .|||
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

LAIGRYP
|| |.||
LATGQYP
Kinase MAP2K2.AA STE20 72-261 34 3.3e-55 189.72 In-house 1-221 (288) Show / Hide 
Range on Protein: 72-261
Range on HMM: 1-221/288
Sequence Identity: 34% (76 aa)

FERISELGAGNGGVVTKARHRPSGLI----MARKLIHLEIKP---AVRNQIIRELQVLHECNSPYIVGFYGAFYSD----GEISICMEHMDGGSLDQVLK
.| . ..| |. |.| ||.|.|.| .     | | . || .      .. |. | ... .|..|.|| .||... |     |. |.||...|||| ...|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---EAK------RIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMA---NSFVGTRSYMSPERLQG---
   . .      .. |.    .   ||.||.|| ..|.| |||.|  |||....||.||.||||..||..    .|.   |.||||  .|.|| .|.   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHII-HRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--THYSVQSDIWSMGLSLVELA
    |   .|||| |  . |.|
PDKGYDYKCDIWSLGITAIEMA
Kinase MAP2K2.AA MST 72-261 37 4.6e-45 141.14 In-house 1-191 (254) Show / Hide 
Range on Protein: 72-261
Range on HMM: 1-191/254
Sequence Identity: 37% (73 aa)

FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFY--SDGEISICMEHMDGGSLDQVLKEAKR-IPED
|. .  || |. |.| || |. .| | | |..  .      ..|| |   . .|.|.|||..|| ..   . .. |.||. ..||.  . |  .|   |.
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN---EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQ

ILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELA
    ..  .|.||.||   . ..||| |. |||.| .|| || ||||||||.| |  .|...||  .|.|| .|   |    |||| | . .|.|
QIACILYDTLQGLQYLHDNK-KIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMA
Kinase MAP2K2.AA MEK3 320-370 48 2.8e-19 62.19 In-house 213-264 (264) Show / Hide 
Range on Protein: 320-370
Range on HMM: 213-264/264
Sequence Identity: 48% (25 aa)

FELLDYIVNEPPPKLPSGV-FSSDFQEFVNKCLIKNPAERADLKLLMNHAFI
|. |  .| ||||.|| .  || |.| |.|.|| ||..||   . || | |.
FQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K2.AA MEK7 320-370 42 3.4e-16 51.44 In-house 214-269 (269) Show / Hide 
Range on Protein: 320-370
Range on HMM: 214-269/269
Sequence Identity: 42% (24 aa)

FELLDYIVNE--PPPKLPSGV---FSSDFQEFVNKCLIKNPAERADLKLLMNHAFI
|| .  | |.  .|| || .    || ||..||.||| |.. .| . . || | ||
FEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K2.AA MEK5 321-370 46 1.2e-14 50.02 In-house 205-254 (254) Show / Hide 
Range on Protein: 321-370
Range on HMM: 205-254/254
Sequence Identity: 46% (23 aa)

ELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFI
.||  ||.| ||.||.. ||  | .|.|.|. | | .|   . ||.| ||
QLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K2.AA TyrKc 72-370 17 5.8e-14 3.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 72-370
Range on HMM: 1-280/280
Sequence Identity: 17% (59 aa)

FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHEC--NSPYIVGFYGAFYSD-------GEISICMEHMDGGSLDQVLKEA
 . . .|| |. |.| |.. .   .  | | .. .     |  ..||......   . | || .||.  ..       . . | ||.|..|.|.. |.. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KR-IPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM------ANSFV-----GTRS-----YMSPERLQGTHYS
.. .. . | . .. . .| .|| .| .. |||    |.||.... .| .||| |   |..           .     |...      |.|| ..   ..
RPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VQSDIWSMGLSL---VELAIGRYP------IPPPDAKELEASFGRPVVDGADGEPH----SVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPP
 .||.|| |  .     .    ||      ... .. |.  . .|.     .  |.    |                                       
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM-----PQPPNDYPMS---------------------------------------

KLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFI
   .   ...  .   .|   .|..|   . .  | ..
---FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MAP2K2.AA STE20 325-370 37 1e-13 46.74 In-house 238-288 (288) Show / Hide 
Range on Protein: 325-370
Range on HMM: 238-288/288
Sequence Identity: 37% (19 aa)

YIV--NEPPPKLP---SGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFI
.|   ..|||.|    .  .|..|..||.||| |.|..|.  . |..| ||
MIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K2.AA Pkinase_Tyr 72-252 24 2.9e-11 38.78 Pfam 1-199 (270) Show / Hide 
Range on Protein: 72-252
Range on HMM: 1-199/270
Sequence Identity: 24% (49 aa)

FERISELGAGNGGVVTKARHR----PSGLIMARKLIHLEIKPAV---RNQIIRELQVLHEC-NSPYIVGFYGAFY-SDGE--ISICMEHMDGGSLDQVLK
 . . .||.|. |.| |.. .      ..  | | .  |        |   .||......  . | || .||. .  ..   | | ||.| .|.|.  |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

E----AKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPERLQGTHYSVQSD
.     ....   | . .. . .|..|| .|. . |||.   |.||.. . .| |||| .  .  .  .  . .|.        |.|| ..   ....||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

IWS
.||
VWS
Kinase MAP2K2.AA MEK4 317-370 23 2.5e-10 29.73 In-house 216-275 (275) Show / Hide 
Range on Protein: 317-370
Range on HMM: 216-275/275
Sequence Identity: 23% (14 aa)

M--AIFELLDYIVNEPPPKLPSGVF----SSDFQEFVNKCLIKNPAERADLKLLMNHAFI
.   .|. .  .|.  ||.| .  .    | .. .|.|.||.|.  .|.  . |  . |.
NDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MAP2K2.AA MST 339-370 46 4.2e-10 28.23 In-house 223-254 (254) Show / Hide 
Range on Protein: 339-370
Range on HMM: 223-254/254
Sequence Identity: 46% (15 aa)

FSSDFQEFVNKCLIKNPAERADLKLLMNHAFI
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WSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI