Gene MarkmA10 (Mouse)
MarkmA10
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| MarkmA10.AA | Protein | Sugen | 459 | None | Fasta, JSON |
| MarkmA10.NA | RNA | Sugen | 2215 | None | Fasta, JSON |
| MarkmA10.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 179 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of MarkmA10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MarkmA10.AA | MARK | 4-186 | 51 | 1e-112 | 369.71 | In-house | 73-262 (262) | Show / Hide |
Range on Protein: 4-186 Range on HMM: 73-262/262 Sequence Identity: 51% (98 aa) KTR-GYLIMELVEGQELYEYIKYS--GHIEEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNKG--NTKIIDFGLSTQVKPGDLLDEPCGAYAFG ... |||||...|.|||.||| |...|.|||.|| ||.|||.|||...|||| .||.|| || .| | ||||||.|....|| .|.. ||.... EQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYM APELFLWERYDGRKSDLWALGVILYYMVVGKVPFHLVT--IPELQRQTLAGVYPAPCGVSDELEDLLSLLMTVNPKYRPTVTEVMKHPWL |||.||...|||.| | |.|||.||.||.|..|| | . ||... |.|.|. || ||.|...|...|.||||..|||..|.|||||. APEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
|||||||||
| Kinase | MarkmA10.AA | CAMKL | 8-186 | 41 | 1.3e-94 | 302.33 | In-house | 97-297 (297) | Show / Hide |
Range on Protein: 8-186 Range on HMM: 97-297/297 Sequence Identity: 41% (85 aa) YLIMELVEGQE--LYEYIKYSGH----IEEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNKG--NTKIIDFGLSTQVKP-----GDLLDEPCGA ||.||...| | |..||. || ..|.|||..| ||.|||.|||.|||||| .||.|| .|..| | ||||||.|.. .| |..|.. || YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGS YAFGAPELFLW--ERYDGRKSDLWALGVILYYMVVGKVPFHLVTIP---------ELQRQTLAGVYPAPCGVSDELEDLLSLLMTVNPKYRPTVTEVMKH ... |||.|. ..|||.| | |..||||| ||.|..|| |.. ... .. . .| .. || ...||.. ...|||..|||. ..|.| PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH PWL ||. PWM |
|||||||||
| Kinase | MarkmA10.AA | CAMK | 4-186 | 26 | 2.3e-82 | 265.09 | In-house | 129-425 (425) | Show / Hide |
Range on Protein: 4-186
Range on HMM: 129-425/425
Sequence Identity: 26% (78 aa)
KTRGYLIM---ELVEGQEL----YEYIKYSGH---------------IEEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNK-------------
... |..| |...| || ..||. |. ..|.|||..| ||.||| ||| |.|||| |||.|| .|..
DKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIF
----GNTKIIDFGLSTQVKP------------------------GDLLDEPCGAYAFGA-PELFLW-------------ERYDGRKSDLWALGVILYYMV
.| ||||||......| |... ..|| .. | ||... ..|.|.|.| |..||||| |.
DWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIML
VGKVPFHLV-------------TIPELQRQTLAGVYP-APCG---------------VSDE--------LEDLLSLLMTVNPKYRPTVTEVMKHPWL
.|. || ...|| .. ..| | | .||| ||.. ...|.|. |.|......|||.
CGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
|
|||||||||
| Kinase | MarkmA10.AA | AMPK | 8-186 | 42 | 1.3e-67 | 199.77 | In-house | 76-254 (254) | Show / Hide |
Range on Protein: 8-186 Range on HMM: 76-254/254 Sequence Identity: 42% (76 aa) YLIMELVEGQELYEYIKYSGHIEEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNKGNTKIIDFGLSTQVKPGDLLDEPCGAYAFGAPELFLWER ...|| | | ||..|| | ..|.||. | ||.|.|.|||||.|||| ||| |. .| . | || ||||| | |..| || |||. . FMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKL YDGRKSDLWALGVILYYMVVGKVPFHLVTIPELQRQTLAGVYPAPCGVSDELEDLLSLLMTVNPKYRPTVTEVMKHPWL | |.. |.| ||||| |. |. || .|.| . ..|.|. | .|.| .||.. . .|.| | |. ....|||. YCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
|||||||||
| Kinase | MarkmA10.AA | NuaK | 9-186 | 41 | 1.2e-65 | 171.32 | In-house | 76-252 (252) | Show / Hide |
Range on Protein: 9-186 Range on HMM: 76-252/252 Sequence Identity: 41% (73 aa) LIMELVEGQELYEYIKYSGHIEEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNKGNTKIIDFGLSTQVKPGDLLDEPCGAYAFGAPELFLWERY ..|| | |||.|| . . | |||..| || ||| |||.|.|.|| || || |...| || ||||| . ...| || . || . | IVMEYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPY DGRKSDLWALGVILYYMVVGKVPFHLVTIPELQRQTLAGVYPAPCGVSDELEDLLSLLMTVNPKYRPTVTEVMKHPWL | | |.|||.|| || | || .| .| | | || || . | ...|||..| |. .. .|.|. HGPEVDCWSLGVLLYTMVYGTMPFDGHDFKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV |
|||||||||
| Kinase | MarkmA10.AA | QIK | 8-186 | 36 | 1.1e-62 | 214.6 | In-house | 74-272 (272) | Show / Hide |
Range on Protein: 8-186 Range on HMM: 74-272/272 Sequence Identity: 36% (73 aa) YLIMELVEGQELYEYIKYSGH--------------------IEEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNKGNTKIIDFGLSTQVKPGDL |...| .. |...|. |. ..|.|||..| ||.||| |||...|||| || || .|| | ||.|||.| |.| | YIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQL LDEPCGAYAFGAPELFLWERYDGRKSDLWALGVILYYMVVGKVPFHLVTIPELQRQTLAGVYPAPCGVSDELEDLLSLLMTVNPKYRPTVTEVMKHPWL | || .. |||.|. . ||| |.| | .||.|| .| |. || .|...|.. | | . | .| ..|.| ..|.|. | |. ...|.|. LMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
|||||||||
| Kinase | MarkmA10.AA | Pkinase | 8-186 | 29 | 2.4e-57 | 201.62 | Pfam | 76-293 (293) | Show / Hide |
Range on Protein: 8-186 Range on HMM: 76-293/293 Sequence Identity: 29% (65 aa) YLIMELVEGQ----ELYEYIK--YSGHI--EEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNKGNT----KIIDFGLSTQ--VKPGDLLDEPCG |..||..|| .|..||. ..| . .|.|.. ...|||... |||..||.|| |||.|| |||.|.. ||.||||. | .. .. .|| YMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG AYAFGAPELFLWERYDGRKSDLWALGVILYYMVVGKVPFHLV------TIPELQRQTLAGVYPAPCGVS---------------------DELEDLLSLL . . |||. . .|.|.|.| |..|.|||.|. |. || . .. .... . .. .. . .|. |... . TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC MTVNPKYRPTVTEVMKHPWL ...|| ||| .....|||. LCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | MarkmA10.AA | Ciliate-E2-Unclassified | 8-186 | 25 | 8.7e-55 | 188.33 | In-house | 97-352 (352) | Show / Hide |
Range on Protein: 8-186 Range on HMM: 97-352/352 Sequence Identity: 25% (66 aa) YLIMELVEGQELYEYIKYSGH-----------------IEEDEAR-----QIFLQILSAVSYCHRHG-IVHRGLKPDNIIIDNKG---NTKIIDFGLSTQ |..||..||..| .||| ... ..| .|. ..| |||.. .|.|. . |.|| .||.||..||.| . ||||||.| . YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK VK----------------PGDLLDEPCGAYAFG----APELFLWERYDGR---KSDLWALGVILYYMVVGKVPFHLVTIPE----------------LQR . . .... || . . |||.. . ||.. |.| |.||||||.|. |. || . . |.. YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ QTLAGVYP--------APCGVSDELEDLLS----LLMTVNPKYRPTVTEVMKHPWL . ... . .|...|.| .|... .. .||..|.| ....|||. NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| Kinase | MarkmA10.AA | Ciliate-E2 | 8-186 | 25 | 3.1e-54 | 184.56 | In-house | 110-365 (365) | Show / Hide |
Range on Protein: 8-186 Range on HMM: 110-365/365 Sequence Identity: 25% (68 aa) YLIMELVEGQELYEYIK------------YSGHIEEDEARQIFLQILS---------------AVSYCHRHG-IVHRGLKPDNIIIDNKGNTKIIDFGLS ||.||...|..|..||| . . . | |...|. |||. |. |.| . |.|| .||.||.. |||||||| YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLS TQVKP-----------GDLLDEP----------------------CGAYAFGAPELFLWERYDG--------RKSDLWALGVILYYMVVGKVPFHLVTIP ..... . ... || . . ||| . . ||. |.|.|.||||||.|. || || KKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------ ELQRQTLAGVYPAPCG------------------VSDELEDLLSL----LMTVNPKYRPT-VTEVMKHPWL |.| . . . || .|.| ||.. .. ..|. |.| ....|||. --QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | MarkmA10.AA | SNRK | 4-186 | 40 | 1.5e-51 | 166.95 | In-house | 70-254 (254) | Show / Hide |
Range on Protein: 4-186 Range on HMM: 70-254/254 Sequence Identity: 40% (75 aa) KTRGYLIMELVEGQELYEYI-KYSGHIEEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNK-GNTKIIDFGLSTQVKPGDLLDEPCGAYAFGAPE .|. |||.|| .| ..|.|| | ..|| ||. | ||. |..|||. .||| |||.|.. .| | |. ||| | . .||. |. ||. |. ||| QTKLYLILELGDGYDMYDYIMKHEKGLCEDLARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPE LFLWERYDGRKSDLWALGVILYYMVVGKVPFHLVTIPELQRQTLAGVYPAPCGVSDELEDLLSLLMTVNPKYRPTVTEVMKHPWL . | . || |.|.|||||| .| |..||. | . . | | |||| ||. .. .|| | .. |. |.|. ILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV |
|||||||||
| Kinase | MarkmA10.AA | RSK | 8-186 | 30 | 2e-47 | 163.89 | In-house | 77-278 (278) | Show / Hide |
Range on Protein: 8-186 Range on HMM: 77-278/278 Sequence Identity: 30% (61 aa) YLIMELVEGQELYEYIKYSGH---IEEDEARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDN---KGNTKIIDFGLSTQ--VKPGDLLDEPCGAYAFGA |||||...| ||.. .. .| . ||||.... .| .||.. | .||.|| |||.||. |. | |..|||.. | . . ... .|. .. | YLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMA PELFL---WER-YDGRKSDLWALGVILYYMVVGKVPFHL---VTIPELQRQTLAGV--YPAP--CGVSDELEDLLSLLMTVNPKYRPT-----VTEVMKH ||. .. .| . |.| |||..| | .|..||. . |. .. . | . | .|.| ||.. .....|. |.. . |. .| PEMLKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQH PWL ||. PWF |
|||||||||
| S_TKc | MarkmA10.AA | S_TKc | 1-186 | 26 | 5.8e-35 | 123.39 | SMART | 16-231 (231) | Show / Hide |
Range on Protein: 1-186 Range on HMM: 16-231/231 Sequence Identity: 26% (64 aa) MFAKTRG----------------------------------------YLIMELVEG--QELYEYIKYSGH------IEEDEARQIFLQILSAVSYCHRHG . .. .. |..||...| .|..||| |. . | .|| .. ||..|. |||.|| YKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG IVHRGLKPDNIIIDNKGNTKIIDFGLSTQVKPGDLLDEPCGAYAFGAPELFLWERYDGRKSDLWALGVILYYMVVGKVPFHLVTIPELQRQTLAGVYPAP |.|| |||.|| .|. . ||.||||..|. . || . |||.. |...|.| |..|.||| |..|. ||. .. .. .. . IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------- CGVSDELEDLLSLLMTVNPKYRPTVTEVMK-------HPWL |.|. |... .....|. |||. |... |||. ---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| TyrKc | MarkmA10.AA | TyrKc | 2-186 | 15 | 4e-06 | -124.28 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2-186 Range on HMM: 1-280/280 Sequence Identity: 15% (45 aa) FAKTR------------------------------------------G--------------------------YLIMELVEGQELYEYIKYSGH-IEED . . | ...||.... | .|...... . . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK EARQIFLQILSAVSYCHRHGIVHRGLKPDNIIIDNKGNTKIIDFGLSTQVKPG-------DLLDE----PC---GAYAFGAPELFLWERYD--GRKSDLW . .. .|| . .| |.....|| | |. ..... || ||||| .. . | . . . ||| . .| ||| | DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTTKSDVW ALGVILYYMV-VGKVPFHL-----VTIPELQRQTLAG-VYPAPCG--------VSDELEDLLSLLMTVNPKYRPTVTEVMKHPWL . || .. . |. | .. |. .. .| | | .||. .. . .|. ||| .|. | . SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
|||||||||
| UBA_CAMKL | MarkmA10.AA | UBA_CAMKL | 206-243 | 36 | 9.6e-13 | 43.86 | In-house | 1-41 (41) | Show / Hide |
Range on Protein: 206-243 Range on HMM: 1-41/41 Sequence Identity: 36% (15 aa) DPDIVDAMQYI--GFQAKDIRESLTKEKF-NEMSSAYYLLE |..|.. |. . ||. ..|.||| . |. |... .|||| DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL |
|||||||||