Gene MarkmA4 (Mouse)
MarkmA4
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| MarkmA4.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 249 | Kinase domain by global Sugen HMM | Fasta, JSON |
| MarkmA4.NA | RNA | Sugen | 2734 | None | Fasta, JSON |
| MarkmA4.AA | Protein | Sugen | 504 | None | Fasta, JSON |
Protein domains of MarkmA4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MarkmA4.AA | MARK | 28-276 | 51 | 7.1e-166 | 546.01 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-262/262 Sequence Identity: 51% (134 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIQ---KRG-YWCILIMSEVDLLMMADHPNVISLLQVIE--TKKK-VYLIMELCEGKSLYQHIRKA--GY | || |||||..|.||||.|..||..||.|... . |. .|.|...... ||||.|.|..||| |... .|||||...|..||..|... |. YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDG--KVKIIDFGLSTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMV |.| |||..|.|..||.||||...|||||.||.||.. ..| ..||||||.|....|||||| ||||.|. |||..|. ||||||.|.|.||||||||| LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV TGKIPFDACS--IKRLVKRILAGKYSIPSRLSAELRDLLSLLMTANPKLRPTVAEVMVHPWV .|. |||... .| | |.||.|||.||...|.|.|.|...|.|.||. |||. |.| |||. CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | MarkmA4.AA | CAMKL | 28-276 | 39 | 3.5e-139 | 446.9 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-297/297 Sequence Identity: 39% (119 aa) YVMLETIGHGGCATVKLAQH-RLTGTHVAVKTIQKRGYWCILIMS----------------EVDLLMMAD---HPNVISLLQVIETKKK------VYLIM | ...|.|.|....||||.| |.||..||.| | |.. |.. .|. |. ...| . |||.|.|..||||... .||.| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM ELCEGKS--LYQHIRKAGY----LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDG--KVKIIDFGLSTKVKP-----GQKLNLFCGTYPFS |.|.| . |...|.| |. ..||||| .|.|..||.||||..||||||.||.||.. ..| ..||||||.|.. .| ||||. |||..|. EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM APEVLLS--TPYDGPKIDVWTLGVVLYFMVTGKIPFDACSIK-------RLVKRILAGKYSIP--SRLSAELRDLLSLLMTANPKLRPTVAEVMVHPWV |||.... .||||||.|.| .||.||.||.|. |||. ... .| ..| | | .| ...| ..|||.. ... ||. |||. ..| |||. APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | MarkmA4.AA | CAMK | 33-276 | 24 | 1.9e-122 | 396.6 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 33-276
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)
TIGHGGCATVKLAQHRLTG------------THVAVKTIQKR-----------------------------GYWCILIMSEVDLLMM-------ADHPNV
|.|.|. ..|||..|..|. ..||.| | |. .... ...|...... ||||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
ISLLQVIE------------TKKK--------VYLIM---ELCEGK----SLYQHIRKA---------------GYLQEHEARALFKQLLSAMNYCHNQG
|.|..|.| | .| .|..| |.|.| |...|.. |...|.||| .|.|..||..|||...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IVHRDLKPDNIMVEKD-----------------GKVKIIDFGLSTKVKP------------------------GQKLNLFCGTYPFSA-PEVLLS-----
||||||||.||.. .. ...||||||...|..| |||.. |||| .. | ||||..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------TPYDGPKIDVWTLGVVLYFMVTGKIPFDAC-------------SIKRLVKRILAGKYS-IPSR-----------------------LSAELR
||.|||.|.| .||.||.|..|. ||.. ....| ..|..|||. .|. .|.| .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DLLSLLMTANPKLRPTVAEVMVHPWV
||.. ... .|. |.|..... |||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | MarkmA4.AA | S_TKc | 28-276 | 32 | 1.7e-99 | 337.76 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-231/231 Sequence Identity: 32% (87 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIQKRGYWCILIMSEVDLLMMADHPNVISLLQVIETKKKVYLIMELCEG--KSLYQHIRKAGY------L | .|..||.|. ..|....|. || .||.| | . |..|...|.. .|||.. |. |... ...|..||.|.| .|...|.| |. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF QEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLSTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTGK | .|| ...|...|..|||..||.||||||.||.. . .||.||||.... . |||| . ||||| .|...|.|.| .|..|| |..|. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY IPFDACSIKRLVKRILAGKYSIPSRLSAELRDLLSLLMTANPKLRPTVAEVMV-------HPWV ||. .... |.|. | |..|... ... .|. |||. |.. |||. PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | MarkmA4.AA | AGC | 28-276 | 20 | 1.1e-91 | 236.61 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-395/395 Sequence Identity: 20% (82 aa) YVMLETIGHGGCATVKLAQHR------LTGTHVAVKTIQKRG---------YWCILIM----------SEVDLLMMAD----------HPNVIS-LLQVI . .| .|| |. .| |.... || |.| ..|. .... .| . |.... ||.... | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF ETKKK--VYLIMELCE---------GK-SLYQHIR---KAGYLQEHEARALFKQ-------LLSAMNYCHN-QGIVHRD-LKPDNIMVEKDGKVKIIDFG ..|.. .|..||... | |..|.. | |.. | .|| . . ...|. | |. .||.||| |||.||. .|| .|. ||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG LSTKVKPG---------------------------------------------------QKLNLFCG--TYPFSAPEVLLSTPYDGPKIDVWT--LGVVL |..... . .. . ||| | . |||.| |. | |. ||... LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM YFMVTGKIPFDACS----------IKRLVKRILAG------KYSIP----------SRLSAELRDLLSLLMTANPKLRPT----------VAEVMVHPWV | |.||. || . . . . ..|. | | .| . .| |..||.. |.. .|. |.. . |.. ||| YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | MarkmA4.AA | Pkinase | 28-276 | 29 | 2.9e-91 | 314.29 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-293/293 Sequence Identity: 29% (88 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIQKRGYWCILIMS-----EVDLLMMADHPNVISLLQVIETKKKVYLIMELCEGK----SLYQHIR--KA |. ...|| |. ..|....|. || ||||.| ||. . .. |. .. . .|||.. |. . |.|...|..||.||| .|. .|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GYL--QEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKV----KIIDFGLSTK--VKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTL | . .|.|.. ..|.|....|||..||.||||||.||.. ..| . ||.||||. . ... .. ||||... ||||... .|.|||.|.| . GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVVLYFMVTGKIPFDAC------SIKRLVKRILAGKYSIPSRLS---------------------AELRDLLSLLMTANPKLRPTVAEVMVHPWV |..|| |..|. ||. . . . ...||. .... .. . |..|... . . .|| ||| .... |||. GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | MarkmA4.AA | AMPK | 28-276 | 39 | 2.6e-90 | 268.34 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-254/254 Sequence Identity: 39% (100 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIQKR----GYWCILIMSEVDLLMMADHPNVISLLQVI-ETKKKVYLIMELCEGKSLYQHIRKAGYLQEH |.. .||| | ||.. | |||. ||.| . |. | .|...| . ||..| | .|| ||.. ...|| | |. | | | |||. YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER EARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLSTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTGKIPF ||. .|.| .|. |||. .|||||||| |. .. ..|| ||||| | |..| || |||. . .| ||..|.| ||.|| |. |. || EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF DACSIKRLVKRILAGKYSIPSRLSAELRDLLSLLMTANPKLRPTVAEVMVHPWV | .. | |.|..|.|.||. || | .||.. . . .| | |. ... ||| DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | MarkmA4.AA | QIK | 28-276 | 37 | 8.8e-87 | 294.61 | In-house | 1-272 (272) | Show / Hide |
Range on Protein: 28-276
Range on HMM: 1-272/272
Sequence Identity: 37% (102 aa)
YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIQKR---GYWCILIMSEVDLLMMADHPNVISLLQVIETKKKVYLIMELCEGKSLYQHIRKAGY------
| . ||| | |.||||.|| | | ||.| | | . . || .. | .||..| |.||.||.. |...| |.. .. .. | |
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV
--------------LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLSTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKID
..| ||| |.|..|| |||...||||||| ||. .. .||.|||.| |.|| |. .||. |. |||... |||||.|
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD
VWTLGVVLYFMVTGKIPFDACSIKRLVKRILAGKYSIPSRLSAELRDLLSLLMTANPKLRPTVAEVMVHPWV
.| .||||| .|.|..||| ... | .|.| ||. || .| .. .| .. .|. | |.. .. |.|
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
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| Kinase | MarkmA4.AA | SNRK | 28-276 | 42 | 2.5e-82 | 269.36 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-254/254 Sequence Identity: 42% (107 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIQKRGYWCI---LIMSEVDLLMMADHPNVISLLQVIETKKKVYLIMELCEGKSLYQHIRKAGY-LQEHE | . .|.|.| | ||||.| || .|||| | | . .. || . . |||.. | ||.|. |.|||.|| .| .| .| | |.| YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL ARALFKQLLSAMNYCHNQGIVHRDLKPDN-IMVEKDGKVKIIDFGLSTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTGKIPF || |.|.. |..||| .|||||||.| . || | ||. ||| | | .||.||. .|| .||||.|| || | .|.| |||.|| .| |. || ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF DACSIKRLVKRILAGKYSIPSRLSAELRDLLSLLMTANPKLRPTVAEVMVHPWV . . .|. ||..|...|.| |||. .. .|| | .. |. |.|| QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV |
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| Kinase | MarkmA4.AA | Ciliate-E2 | 28-276 | 22 | 3.7e-80 | 272.61 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-365/365 Sequence Identity: 22% (86 aa) YVMLETIGHGGCATVKLAQHRLTGTH-----------------------VAVKTIQKRGYWCIL----IMSEVD----------LLMMADHPNVISLLQV | .. || |. ..|......... .|.|...|.. |. || |.. .| .|||.| . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IE--TKKKVYLIMELCEGKSLYQHIR------------KAGYLQEHEARALFKQLLS---------------AMNYCHNQG-IVHRDLKPDNIMVEKDGK . .....||.||.|.|..|...|. . .|. | |.. ..||.|. |..|.|... |.|||.||.||.. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- VKIIDFGLSTKVKPGQKLNL--------------------------------FCGTYPFSAPEVLLSTPYDG--------PKIDVWTLGVVLYFMVTGKI .||||||||.|... .. .. .|||... |||.| . .||. |.|.| |||.||.|..|| IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PFDACSIKRLVKRILAGKYSIP------------------SRLSAELRDLLSL----LMTANPKLRPT-VAEVMVHPWV || . |. .|...| .| | ||.. .. .|. |.| ... ||| PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | MarkmA4.AA | Ciliate-E2-Unclassified | 28-276 | 24 | 1.3e-71 | 244.2 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 28-276
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)
YVMLETIGHGGCATVKLAQHRLTGTHV------------AVKTIQKRGYWCILIMSEVD----------------LLMMADHPNVISLLQVIETKKKVYL
| ....||.|| ..|...||. .. . ..| |.. ...| |. .| . .||... .. . ..|...|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI
IMELCEGKSLYQHIRK-----------------AGYLQEHEAR-----ALFKQLLSAMNYCHNQG-IVHRDLKPDNIMVEKDG---KVKIIDFGLSTKVK
.||.|||..| |.|.| ..| .|. .|.|.|.. .|.| .. |.|||.||.||.. ..| ..||||||.| | .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ
----------------PGQKLNLFCGTYPFS----APEVLLSTPYDGP---KIDVWTLGVVLYFMVTGKIPFDACSIKR----------------LVKRI
. |... ||||. . ||||| . ||.. |.|.|.|||.||.|..|. ||.. . . | . |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
LAGKYSIPS--------RLSAELRDLLS----LLMTANPKLRPTVAEVMVHPWV
.......|. ..| | |... .. ||. |.| ... |||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | MarkmA4.AA | TSSK | 28-276 | 30 | 2.9e-71 | 233.15 | In-house | 1-289 (289) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-289/289 Sequence Identity: 30% (87 aa) YVMLETIGHGGCATVKLAQHRLTGTH----------------VAVKTIQK----RGYWCILIMSEVDLLMM-ADHPNVISLLQVIETKK-KVYLIMELCE | . ..|||| |.|..|... . . ||.| | . . | . | . . . .|||.| ... .|| |.|..||..| YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE GKSLYQHIRKA------GYLQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLSTKVKPGQ------KLNLFCGTYPFSAPEVL . | ..|.. | |.| .||..|.|. ||. |||. ..|||||| || |.. .|..||| . ...... .. ||| | .|||.| HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEIL LSTPYDGPKIDVWTLGVVLYFMVTGKIPFDA--CSIKRLVKRIL--AGKYSI--PSRLSAELRDLLSLLMTANPKLRPTVAEVMVHPWV .. |||. . ||| .||.|| ||.|. ||| |... ... .. . .|.| .||.. ... .|..||.. |.. |.|. RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM |
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| Kinase | MarkmA4.AA | Pkinase_Tyr | 28-169 | 25 | 1.3e-17 | 60.32 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 28-169 Range on HMM: 1-158/270 Sequence Identity: 25% (40 aa) YVMLETIGHGGCATVKLAQHR----LTGTHVAVKTIQKRGYWCIL-----IMSEVDLLMMA-DHPNVISLLQVIE-TKKK--VYLIMELCEGKSLYQHIR ......|.| .|... . |...||||.. | |. |.|. ... .|||...|. |. .. .|..||.... .|. . | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR K----AGYLQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLS | . | .. | ..|.| ......|||| |..|.....||| ||||. KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA |
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| Kinase | MarkmA4.AA | TyrKc | 28-275 | 20 | 2.1e-17 | 58.62 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 28-275 Range on HMM: 1-280/280 Sequence Identity: 20% (60 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIQKRGYWCILIMSEVDLLMMA--DHPNVISLLQVIETK-------KKVYLIMELCEGKSLYQHIRKAGY ......|.| .| ... . . ||||.... .|.| .... .|||.. |. |. .. . ....||.... .| ...|| . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLSTKVKPG------QKLNLF----CGT--YPF--SAPEVLLSTPYDGPKI |. . | . |.| | ....|||| |..| ... ||| ||||| ... . .. .| | |||.. . .| KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS DVWTLGVVLYFMVT-GKIPFDA-----CSIKRLVKRILAGKYSIPSRL---------SAELRDLLSLLMTANPKLRPTVAEVMVHPW ||| ||... . | |. | .| ....... .|.. . ..|. .. . ..|. ||| .|. .. . DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
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| Kinase | MarkmA4.AA | APH | 114-170 | 13 | 6.4e-05 | 17.66 | Pfam | 142-203 (248) | Show / Hide |
Range on Protein: 114-170 Range on HMM: 142-203/248 Sequence Identity: 13% (9 aa) RKAGYLQ---EHEARA-LFKQLLSAMNYCHNQGIVHRDLKPDNIMVE-KDGKVK---IIDFGLST ....... ..... |. .|.... ...|.|..|.|.|. ... . .||.. .. VDPEWFDEDRQWWLWQRLWAWLEAHWP---PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDAC |
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| Kinase | MarkmA4.AA | Pkinase_Tyr | 204-237 | 29 | 2.459458 | 1.76 | Pfam | 196-232 (270) | Show / Hide |
Range on Protein: 204-237 Range on HMM: 196-232/270 Sequence Identity: 29% (11 aa) DVWTLGVVLYFMVT-GKIP-FDACSIKRLVKRI-LAG ||| ||... ..| |..| . .| .....| | DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG |
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| UBA_CAMKL | MarkmA4.AA | UBA_CAMKL | 296-333 | 36 | 3.4e-13 | 45.45 | In-house | 1-41 (41) | Show / Hide |
Range on Protein: 296-333 Range on HMM: 1-41/41 Sequence Identity: 36% (15 aa) DPAIVKAMGHI--GFQAQDIEDSLRQRKF-NQTMASYCLLK |. |.. | .. ||. ..|..|||..|. |. .| |.|| DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL |
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