Gene MarkmD4 (Mouse)

MarkmD4

Species: Mouse
Alias: MarkmD4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmD4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
MarkmD4.AA Protein Sugen 520 None Fasta, JSON
MarkmD4.NA RNA Sugen 1563 None Fasta, JSON

Protein domain

Protein domains of MarkmD4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmD4.AA MARK 25-273 43 4.5e-151 496.92 In-house 1-262 (262) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-262/262
Sequence Identity: 43% (114 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLE---KNI-NSMAEITSEVELLQSLEHRNIVRFFHMID--TLTT-TYMIMEYVAGEDLEKCLRAL--GC
..||. .|.||...||||||..|...||.|..|   .|  ..| .. .|.|....|.| ||...||.|.  | .. .|.||||. | .|  ...|   |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LKEEEARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAG--NAKLCDFGMAIKTTEGQMLEETCGSVFYWAPEILARKPYDGLAVDMWSLGIVLYVLV
|.|||||  |.||||||...|...|.|||||.||||.|. |  |.|..|||..|. ..||.|.. ||.  |.||||. .||||| .||.||||.|||..|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGHFPYVEAT--IEDMHRVITTTMCPIPYHLSFPCHIIIARLLMVPTWYRMTIHQLVERPWL
.|.||. ..|  ...... |.. ...||.|.|  |. .| |||.|. ..|.||......||.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MarkmD4.AA CAMKL 25-273 34 7.2e-127 406.96 In-house 1-297 (297) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-297/297
Sequence Identity: 34% (103 aa)

FRMLTSLGCGSFGEVKLACH-LPTRIRVAVKVLEKNINSMAEITS----------------EVELLQSLE---HRNIVRFFHMIDTLTT------TYMIM
.|..  ||.||||.||||.| . |...||.|...|.  .. ....                |......|    | ||......|.| ..       |..|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYVAGED--LEKCLRALGC----LKEEEARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAG--NAKLCDFGMAIKTTE-----GQMLEETCGSVFYW
||. | .  |   ... |.    ..|.|||  |.||||||...|...|.|||||.||||.|  |  |.|..|||.... ..     ||.|.. |||  |.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILAR--KPYDGLAVDMWSLGIVLYVLVTGHFPYVEATI--------EDMHRVITTTMCP-IPYHLSFPCHIIIARLLMVPTWYRMTIHQLVERPWL
||||...  ||||| .||.||.|..||..|.|..|  ..|.        . .......  .| |.||.| .|. .| ..|.|  ..|.||||... ||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MarkmD4.AA CAMK 30-273 22 1.2e-101 328.32 In-house 1-425 (425) Show / Hide 
Range on Protein: 30-273
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

SLGCGSFGEVKLACHLPTR------------IRVAVKVLEKN-----------------------------INSMAEITSEVELLQS-------LEHRNI
 || ||||.|||..|  |              .||.|...|.                              ...... .|.|....       | |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFFHMID------------TLTT--------TYMIM---EYVAGE----DLEKCLRALGC---------------LKEEEARPVFQQIVSAVHFLHQRR
........            | ..         ||.|   ||. |     ||   ... ||               ..|.||| .|.||.||||..|.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IAHRDIKLENILVDAA-----------------GNAKLCDFGMAIKTTE------------------------GQMLEETCGSVFYWA-PEILAR-----
|.|||.|.||||.|                   .| |..|||.|.| ..                        ||.... ||.  | | ||.| .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KPYDGLAVDMWSLGIVLYVLVTGHFPYVEA-------------TIEDMHRVITTTMCP-IPYH-----------------------LSFPCH
        |||.| ..||||.|..||....|..|. .              ....... |..  .  .|..                       .|  | 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

IIIARLLMVPTWYRMTIHQLVERPWL
  | ..| |  . ||||.|  . ||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MarkmD4.AA AMPK 25-273 35 4.2e-82 243.55 In-house 1-254 (254) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-254/254
Sequence Identity: 35% (89 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEK----NINSMAEITSEVELLQSLEHRNIVRFFHMI-DTLTTTYMIMEYVAGEDLEKCLRALGCLKEE
. .   .|.|.|| ||.. |  |.  ||.|.|.|    .   .  | .|...|... | .|.. .  | .| |  .|.||||.| .|       | |.|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAGNAKLCDFGMAIKTTEGQMLEETCGSVFYWAPEILARKPYDGLAVDMWSLGIVLYVLVTGHFPY
||. .||||.|.|  .|.  |.||| |.||.| |.  | |. |||     ..|..|   |||  | |||. . |.| |. || || |..||... |  | 
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

VEATIEDMHRVITTTMCPIPYHLSFPCHIIIARLLMVPTWYRMTIHQLVERPWL
 .  . .  . |.    .||..||  .. .| ..| |    |.|||.... ||.
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MarkmD4.AA S_TKc 25-273 28 4.9e-80 273.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-231/231
Sequence Identity: 28% (75 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEKNINSMAEITSEVELLQSLEHRNIVRFFHMIDTLTTTYMIMEYVAG--EDLEKCLRALGC------L
...|  .| |.||.|... |  |  .||.|..         | .|...|..  | |||... .... .  ||.|||. |   || . ..  |.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KEEEARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAGNAKLCDFGMAIKTTEGQMLEETCGSVFYWAPEILARKPYDGLAVDMWSLGIVLYVLVTGH
 | .|| ...||..|. ..|...| |||.| ||||.|   . |.||||.| .          ||. .| |||.|   .|.. ..|.||.|..|| ...| 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

FPYVEATIEDMHRVITTTMCPIPYHLSFPCHIIIARLLMVPTWYRMTIHQLVE-------RPWL
 |.   ... | ..|           | ..  .| ..| .    |.|. .. .        ||.
PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmD4.AA NuaK 25-273 36 2.7e-72 189.21 In-house 1-252 (252) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-252/252
Sequence Identity: 36% (93 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEKN-INS---MAEITSEVELLQSLEHRNIVRFFHMIDTLTTTYMIMEYVAGEDLEKCLRALGCLKEEE
....  || | .| ||||    |   ||.|   |. | .   |  |  |.|.. ||.| .|.  .          ..||| .| .|   .   . | |.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAGNAKLCDFGMAIKTTEGQMLEETCGSVFYWAPEILARKPYDGLAVDMWSLGIVLYVLVTGHFPYV
|| .| |||||||. |. ||.||| |||||| |. .|||  |||.     ....|.  |||  |  |||   .|| |  || ||||..||..| |  |. 
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

EATIEDMHRVITTTMCPIPYHLSFPCHIIIARLLMVPTWYRMTIHQLVERPWL
      . . |.      | . |  |   |  .|||   .| || .  . .|.
GHDFKHLVKQISQGAYYEPCKPSDAC-MLIRWMLMVNPRRRATIYDICHHWWV
Kinase MarkmD4.AA Pkinase 25-273 29 4e-69 240.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEK-NINSMAEIT----SEVELLQSLEHRNIVRFFHMIDTLTTTYMIMEYVAGE----DLEKCLR--AL
.. .  .| ||||.|....|  |...||||...| ...|  ..|    ||......| | ||||....  . .  ||.|||. |     ||   ..  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GCL--KEEEARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAGNA----KLCDFGMAIK--TTEGQMLEETCGSVFYWAPEILARKPYDGLAVDMWSL
||.   |.|.. .. ||.... ..|...| |||.|.||||.|  |.     |.|||| | .  .  .. .   ||. .| |||..   .|.| .|||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIVLYVLVTGHFPYVEA----TIEDMHRVITTTMC-----PIPYHLS-------------------FPCHIIIARLLMVPTWYRMTIHQLVERPWL
|..|| ...|..|. ..    .  |.  .|  .|.     ..|.  |                    .|  .| ..| .    | |..|... ||.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MarkmD4.AA QIK 25-273 33 6.6e-64 218.62 In-house 1-272 (272) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-272/272
Sequence Identity: 33% (92 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEK---NINSMAEITSEVELLQSLEHRNIVRFFHMIDTLTTTYMIMEYVAGEDLEKCLRALGC------
. .   .| | |. |||| |  |  .||.|.. |   .   .  .  ||... .|.| .|.. .  . |    |...||  . ..   | . |       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LKEEEARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAGNAKLCDFGMAIKTTEGQMLEETCGSVFYWAPEILARKPYDGLAVD
              ..|.||| .|.||.||||..|.| |.|||.| |||| |.  | |. |||.    ..||.|.  |||  | |||..  | |||  ||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

MWSLGIVLYVLVTGHFPYVEATIEDMHRVITTTMCPIPYHLSFPCHIIIARLLMVPTWYRMTIHQLVERPWL
 ||.|.||||||.| .|.   |.. . . .      ||. .|  |  .| . | |    |.|| | .. .|.
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MarkmD4.AA MELK 25-273 35 8.5e-61 206.41 In-house 1-254 (254) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-254/254
Sequence Identity: 35% (90 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEKNI--NSMAEITSEVELLQSLEHRNIVRFFHMIDTLTTTYMIMEYVAGEDLEKCLRALGCLKEEEAR
. .   .| | |. ||||||. |  .||.|...||   . .  .  |.. |..|.|..| ...|.|.|    .|.||| .| ..   .     |.|||.|
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

PVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAGNAKLCDFGMAIKTTEGQM----LEETCGSVFYWAPEILARKPYDGLAVDMWSLGIVLYVLVTGHFP
 .|.|||||. ..| .  ||||.| ||.|.|   . || |||.  ||  |..    |.  |||  | |||..  | | |   |.||.||.||||. |  |
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT-KGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLP

YVEATIEDMHRVITTTMCPIPYHLSFPCHIIIARLLMVPTWYRMTIHQLVERPWL
. .  .. | . |   .   | .||     .. ..| |    |. ...|.. ||.
FDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase MarkmD4.AA SNRK 25-273 37 8.5e-58 187.71 In-house 1-254 (254) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-254/254
Sequence Identity: 37% (96 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEK---NINSMAEITSEVELLQSLEHRNIVRFFHMIDTLTTTYMIMEYVAGEDL-EKCLRALGCLKEEE
. .   || | |  |||| |. |  .|||||..|      | |..  ||  ..   | |||| . .||| |  |.|.|   | |. .  ..    |.|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARPVFQQIVSAVHFLHQRRIAHRDIKLEN-ILVDAAGNAKLCDFGMAIKTTEGQMLEETCGSVFYWAPEILARKPYDGLAVDMWSLGIVLYVLVTGHFPY
||  | ||. |. . ||... |||.| || .  .  |  || ||| . |   |. ||  |||. | |||||    ||  |||.||||..||.|| |. |.
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

VEATIEDMHRVITTTMCPIPYHLSFPCHIIIARLLMVPTWYRMTIHQLVERPWL
 ||   .    |      .| |.|  |. .|...|.     | .. ..|. .|.
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MarkmD4.AA ULK 25-273 25 3.6e-57 196.26 In-house 1-329 (329) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-329/329
Sequence Identity: 25% (83 aa)

FRMLTSLGCGSFGEVKLACHLPTR----IRVAVKVLE----KNINSMAE-------ITSEVELLQSLE--------HRNIVRFFHMIDTL--TTTYMIME
. .   || |||| |  . .  |     . ||.|...    ...| ..|       ...|..... |         | |||.....  |   . .|.|||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YVAGEDLEKCLRALGC----------LKEEEARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAA------------GNAKLCDFGMAIKTTEG----Q
|  | |||. .   .           | |.||. .|.||...  .||...| |||||..|||..              | .|..||| | . ...    |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

MLEETC------GSVFYWAPEILA----RKPYDGLAVDMWSLGIVLYVLVTGHFP---YVEATIE-----DMHRV-------ITTTMCPIP-----YHLS
|.  .       |.  | ||.||     .|||.   .|.||||...| ...|  |   .   .       .  .        | ..   .|     ...|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

FPCHIIIARLLMVPTWYRMTIHQLVERPWL
  |. .| |.| .    |.....| . ||.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase MarkmD4.AA Ciliate-E2-Unclassified 25-273 22 2.4e-53 183.39 In-house 1-352 (352) Show / Hide 
Range on Protein: 25-273
Range on HMM: 1-352/352
Sequence Identity: 22% (78 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEKNINSM-------------AEITSEVE-------------LLQSLEHRNIVRFFHMIDTLTTTYMIM
....  .| |.||.|... |  .    | | . |... .             ...  . .             .|... | .||..|..  .  . |..|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYVAGEDLEKCLRAL-----------------GCLKEEEAR-----PVFQQIVSAVHFLHQR-RIAHRDIKLENILVDAAG---NAKLCDFGMAI-----
||. | ||.....                    .. |..|.       | ||...  .||.   | |||||.||||.|  |   . |..||| ..     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---KTTEG---------QMLEETCGSVFYW----APEILARKPYDG---LAVDMWSLGIVLYVLVTGHFPYVEATIED----------------MHRVIT
   . |..         ||.  .||.  |     |||.| .. ||.    ..|.||||..|| ...| .|.   . |.                ... | 
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

TTMCP--------IPYHLSFPCHIIIA----RLLMVPTWYRMTIHQLVERPWL
   .         ||.|.|. .  .|     ..| .   .|.|. |. . ||.
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MarkmD4.AA Pkinase_Tyr 25-219 25 6.9e-21 71.36 Pfam 1-216 (270) Show / Hide 
Range on Protein: 25-219
Range on HMM: 1-216/270
Sequence Identity: 25% (56 aa)

FRMLTSLGCGSFGEVKLACHL----PTRIRVAVKVLEKNINSM----AEITSEVELLQSL-EHRNIVRFFHMID-TLTT--TYMIMEYVAGEDLEKCLRA
 ...  || |.||||...        |.| ||||.|  .  .     ..  .|.... .|  | ||||.   .         |..|||... || . ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----LGCLKEEEARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAGNAKLCDFGMAIKT-----TEGQMLEETCGSVFYWAPEILARKPYDGLAVDMW
     . |. ..     .|| ..  .|..... |||.   |.||.  . .| ||||.|           .. ...   ..  ||| .. . .   . | |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFT-TKSDVW

SLGIVLYVLVT-GHFP-Y
| |.... ..| |  | |
SFGVLMWEIFTYGEQPTY
Kinase MarkmD4.AA TyrKc 25-268 21 1e-16 47.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-268
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

FRMLTSLGCGSFGEVKLACHLPTRIRVAVKVLEKNINSMAEITSEVELLQSL--EHRNIVRFFHMIDTL-------TTTYMIMEYVAGEDLEKCLRALGC
 ...  ||.| |||| ..      | ||||.| ..   .... .| ... .|  .| ||||..  . .           ...|||... || . ||. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LKEEEARPVFQQIVSAVHFLHQRRIAHRDIKLENILVDAAGNAKLCDFGMAIKTTEG-------QMLEET---CGS----VFYWAPEILARKPYDGLAV
 |. ..      || .   .||.... |||.   |.||.. . .| .|||.. . ...       ..   .   .|     .   ||| .  . .   . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS

DMWSLGIVLY-VLVTGHFPYVE-----ATIEDMHRVITTT--MCPIPYHLSFP-----CHIIIARLLMVPTWYR--------MTIHQLV
| || |.... ..  |  || .      . ..... . .   | . |...  |     |.  . . .|   | .         .||.. 
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
UBA_CAMKL MarkmD4.AA UBA_CAMKL 289-326 32 2.2e-05 17.71 In-house 2-41 (41) Show / Hide 
Range on Protein: 289-326
Range on HMM: 2-41/41
Sequence Identity: 32% (13 aa)

PRIVNTMCTI--GYTCEEIVSSLTNRRLKDEVMATFNILK
..|.. ||..  |.. |||..|| |..  ....||  .| 
EEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL