Gene MarkmE3 (Mouse)

MarkmE3

Species: Mouse
Alias: MarkmE3
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmE3.AA Protein Sugen 232 None Fasta, JSON
MarkmE3.NA RNA Sugen 699 None Fasta, JSON
MarkmE3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 160 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MarkmE3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmE3.AA MARK 55-214 44 3e-93 305.14 In-house 1-184 (262) Show / Hide 
Range on Protein: 55-214
Range on HMM: 1-184/262
Sequence Identity: 44% (82 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILP---QSR-RN-PLVQSEIEIMKSLDHPHIIKVLHIID--TTRN-IFIVLEHAMGGELLSRIEKF--GY
||.|.|.|.||...|||| |..|..||||||..    ..  .   |..||||||.||||.||| .|.|.  |... |....|.| ||||...|...  |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

IAEKECHRLFSQIVYALKYCHKKGIDHR------------G--DVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDG
. |.|..|.|.|||.|..|||.|.| ||            |  ..|..|||....|..|||| .||||.||.|||..... |||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDG
Kinase MarkmE3.AA CAMKL 55-214 37 8.2e-82 260.84 In-house 1-214 (297) Show / Hide 
Range on Protein: 55-214
Range on HMM: 1-214/297
Sequence Identity: 37% (81 aa)

YKILTTLGQGSFGEVKLASH-LLTKIKVAIKILP--------QSRRNPL---------VQSEIEIMKSLD---HPHIIKVLHIIDTTRN------IFIVL
|.|. |||.||||.|||| | ..|..||||||.         ....|..         .. ||.|||.|.   ||.||| ...|.| ..      |..|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EHAMGGE--LLSRIEKFGY----IAEKECHRLFSQIVYALKYCHKKGIDHR------------GD--VKLADFGLGTKIIM-----GQKLVEFCGTLPYC
|.. |||  |. .|.| |.    . |.|..|.| ||| |..|||..|| ||            |.  .|..|||......      |||| .|||..||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEMLEG--RGYDG
|||...|  . |||
APEIFQGNNKPYDG
Kinase MarkmE3.AA CAMK 60-214 23 2.3e-63 202.73 In-house 1-312 (425) Show / Hide 
Range on Protein: 60-214
Range on HMM: 1-312/425
Sequence Identity: 23% (74 aa)

TLGQGSFGEVKLASHLLTK------------IKVAIKILPQSRRN------------------------------PLVQSEIEIMKS-------LDHPHI
|||.||||.|||. | .|.             ||||||.. ..                                  |..||||||.       ||||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKVLHIID------------TTRN--------IFIVL---EHAMGGEL----LSRIEKF---------------GYIAEKECHRLFSQIVYALKYCHKKG
|| .....            | ..        ...|.   |.. ||||    ...| .                |.. |.|..|.| ||. |..|||...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IDHR-----------------------------GDVKLADFGLGTKIIM------------------------GQKLVEFCGTLPYCA-PEMLEG-----
| ||                             ...|..|||. .|..                         |||. .||||..|.| ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------RGYDG
        . |.|
MQNATDEEKPYYG
Kinase MarkmE3.AA QIK 55-214 38 1.2e-49 171.28 In-house 1-196 (272) Show / Hide 
Range on Protein: 55-214
Range on HMM: 1-196/272
Sequence Identity: 38% (75 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILPQSRRNPL----VQSEIEIMKSLDHPHIIKVLHIIDTTRNIFIVLEHAMGGELLSRIEKFGY------
| |  |.| | |. |||| |  || ||||||.  |. .      .  |..|||.|.|||||| . .. | . ..|| | . .||.   . |.|       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------IAEKECHRLFSQIVYALKYCHKKGIDHR------------GDVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDG
              .||.|  | |.||. | .||||..| ||             ..|.||||..     || |  .||. || ||||.||. |||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDG
Kinase MarkmE3.AA AMPK 55-214 39 9.5e-48 139.87 In-house 1-178 (254) Show / Hide 
Range on Protein: 55-214
Range on HMM: 1-178/254
Sequence Identity: 39% (71 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILPQSRRNPL-----VQSEIEIMKSLDHPHIIKVLHII-DTTRNIFIVLEHAMGGELLSRIEKFGYIAEK
| |  |.| |.|| ||.. | ||. |||||||   .   .     .|.||.|.|.. |||||.   .| .|.. ||.|.|.. |||| . | | | . |.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

ECHRLFSQIVYALKYCHKKGIDHR------------GDVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDG
|  |.| ||. .. |||. .| ||              .|..||||      |..|   ||   | |||| .|. | |
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCG
Kinase MarkmE3.AA NuaK 55-214 38 1.1e-46 120.42 In-house 1-177 (252) Show / Hide 
Range on Protein: 55-214
Range on HMM: 1-177/252
Sequence Identity: 38% (68 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILPQSR---RNPLVQ--SEIEIMKSLDHPHIIKVLHIIDTTRNIFIVLEHAMGGELLSRIEKFGYIAEKE
|... |||.| .| ||||    |  .||||  . ..    . .|.   ||||| ||.|||||..  .      | ||.| | ||||   |.. . . |.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

CHRLFSQIVYALKYCHKKGIDHR------------GDVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDG
  ..| ||| |. |||| .| ||            ...| |||||      .. |  |||   |  ||  .|. | |
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHG
Kinase MarkmE3.AA NIM1 55-205 35 2.9e-39 113.0 In-house 1-173 (258) Show / Hide 
Range on Protein: 55-205
Range on HMM: 1-173/258
Sequence Identity: 35% (61 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILP------QSRRNPLVQSEIEIMKSLDHPHIIKVLHIIDTTRNIFIVLEHAMGGELLSRIEKFGYIAEK
| .   .| | |  |||. | ||| ||||||.             .  .||  |  . || |..   .. |   .. |.| | ||||  .| . | ..| 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

ECHRLFSQIVYALKYCHKKGIDHR------------GDVKLADFGLGTKIIM----GQKLVEFCGTLPYCAPE
.|  .|.||| | |  | ..| ||            . ||..|||  . ..|    .|.|  |||  || |||
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPE
Kinase MarkmE3.AA CAMK1 55-172 34 3e-37 105.78 In-house 1-132 (276) Show / Hide 
Range on Protein: 55-172
Range on HMM: 1-132/276
Sequence Identity: 34% (45 aa)

YKILTTLGQGSFGEVKLASHLLT---KIKVAIKILP--QSRRN------PLVQSEIEIMKS---LDHPHIIKVLHIIDTTRNIFIVLEHAMGGELLSRIE
|..  ..| |.|.||.|. |  |   . ..|||..   ..  .       ... ||||||.   .|||.|||   . .... . .|.|   ||||. || 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KFGYIAEKECHRLFSQIVYALKYCHKKGIDHR
. |.  ||.  ..  ||. |..|.|.||| ||
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHR
Kinase MarkmE3.AA Ciliate-E2 55-214 21 3.4e-37 125.23 In-house 1-266 (365) Show / Hide 
Range on Protein: 55-214
Range on HMM: 1-266/365
Sequence Identity: 21% (59 aa)

YKILTTLGQGSFGEVKLASHLLTKI------------------KVAIKILPQSRRNPL----VQSEIEIMK----------------SLDHPHIIKVLHI
||..  .|||.|| |..... ...                   ||.|||    . ..     . .|| ||.                .|.||.|||    
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

ID--TTRNIFIVLEHAMGGELLSRIEKF-----------GYIAEKECHRLFSQIVY---------------ALKYCHKKG-------------IDHRGDV
    .. ||..|.| . ||.|...|...           .|. |||. ... ||..               ||.|.|.|.             .     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLADFGLGTKII-----------MGQKLVEF----------------------CGTLPYCAPEMLEGRGYDG
|..|||| .|.            .. ..  .                      |||..| |||.|.| .||.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDN
Kinase MarkmE3.AA Pkinase 55-169 33 1.9e-34 122.89 Pfam 1-129 (293) Show / Hide 
Range on Protein: 55-169
Range on HMM: 1-129/293
Sequence Identity: 33% (43 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILPQSRRNPLVQ------SEIEIMKSLDHPHIIKVLHIIDTTRNIFIVLEHAMGG----ELLSRIE--KF
|.|. ..|.||||.|... |  | ..||.||.. ..... ..      |||.|||.|.||.|.. ...  . ..| .|.|...||    .| ..|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GYI--AEKECHRLFSQIVYALKYCHKKGI
| .   |.|| . . ||. .|.|||..||
GCFYFSEWECKFYMYQILRGLEYCHSMGI
Kinase MarkmE3.AA MELK 55-214 36 7.2e-34 112.92 In-house 1-178 (254) Show / Hide 
Range on Protein: 55-214
Range on HMM: 1-178/254
Sequence Identity: 36% (65 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILPQSRRN---PLVQSEIEIMKSLDHPHIIKVLHIIDTTRNIFIVLEHAMGGELLSRIEKFGYIAEKECH
|..  ..| | |. ||||.|.||  .|||||. . .     | |. |.. .|.| | || .. |.|.|   ||.|.|.  |||..  | .   . |.|  
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

RLFSQIVYALKYCHKKGIDHRG------------DVKLADFGLGTKIIMGQKLVE----FCGTLPYCAPEMLEGRGYDG
 .| ||| |. | | .|  ||              .|| ||||  |   |.|        || . | |||...|. | |
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT-KGRKDYHNLQTCCGSPAYAAPELIQGKQYIG
Kinase MarkmE3.AA S_TKc 55-231 23 7.4e-23 83.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-231
Range on HMM: 1-231/231
Sequence Identity: 23% (59 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILPQSRRNPLVQSEIEIMKSLDHPHIIKVLHIIDTTRNIFIVLEHAMG--GELLSRIEKFGY------IA
|.|| ..|.|.||.|... |  |. .|||||..       ...||.|.|. .||.|.| . ....  ....|.|.. |  |.|...|.| |.      . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EKECHRLFSQIVYALKYCHKKGI------------DHRGDVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDG--------------------
| .. ... ||. ||.|||..||            |.   .|..|||| ...        ||||. |.|||.|   ||..                    
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

-WATESPNT-----------------FFLN----------R-------HVEV
 .    ...                 .  .          .       |  .
PFP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase MarkmE3.AA Pkinase_Tyr 55-137 30 1.1e-17 60.56 Pfam 1-96 (270) Show / Hide 
Range on Protein: 55-137
Range on HMM: 1-96/270
Sequence Identity: 30% (29 aa)

YKILTTLGQGSFGEVKLASHL----LTKIKVAIKILPQSRRNPL-----VQSEIEIMKSL-DHPHIIKVLHIID-TTRN--IFIVLEHAMGGELLS
 ... .||.|.||||...        |||.||.|.|...   .        .|..|||.| .||.|.. . ..    .   |.||.|.. .| ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase MarkmE3.AA CAMK1 174-213 36 1.5e-11 29.76 In-house 149-194 (276) Show / Hide 
Range on Protein: 174-213
Range on HMM: 149-194/276
Sequence Identity: 36% (17 aa)

DVK--LADFGLGTKIIMGQ-KLVEFCGTLPYCAPEMLEG---RGYD
..|  .||||| ...  .  ..   |||. |.|||.||.    .||
KIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYD
Kinase MarkmE3.AA Pkinase 170-213 33 2e-09 34.41 Pfam 142-190 (293) Show / Hide 
Range on Protein: 170-213
Range on HMM: 142-190/293
Sequence Identity: 33% (17 aa)

DHRGDV----KLADFGLGTK--IIMGQKLVEFCGTLPYCAPEMLE-GRGYD
|..|..    |..||||  .  .  .. .  ||||..|.||| .  |..|.
DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG
Kinase MarkmE3.AA TyrKc 55-231 17 2.2e-09 -70.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-231
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

YKILTTLGQGSFGEVKLASHLLTKIKVAIKILPQSRRNPLVQSEIEIMKSL--DHPHIIKVLHIIDTT-------RNIFIVLEHAMGGELLSRIEKFGY-
 . . .|| | |||| ..      |.||.| |  .       .|..||..|  .||.|.. . .. .          ..||.|.. .| |.... | .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

IAEKECHRLFSQIVYALKYCHKKGIDHR-----------GD-VKLADFGLGTKIIMGQ-------KLVEF----CGT--LPY--CAPEMLEGR-------
.  |. .    ||     | |.|.. ||           .  || .|||| .. |          .        .|   ||.  .||| .  .       
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

--------------GYDGWAT---------------------ESPNT----------------------F-------FLNRHVEV
              |   .                       . |                        .       | . | . 
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF