Gene MAST3 (Mouse)

MAST3

Species: Mouse
Alias: MAST3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
MAST3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 274 Kinase domain by global Sugen HMM Fasta, JSON
MAST3.NA RNA Sugen 4149 None Fasta, JSON
MAST3.AA Protein Sugen 1321 None Fasta, JSON

Protein domain

Protein domains of MAST3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 MAST3.AA DUF1908 159-354 70 4.7e-147 499.64 Pfam 167-369 (369) Show / Hide 
Range on Protein: 159-354
Range on HMM: 167-369/369
Sequence Identity: 70% (144 aa)

SVVDED----GGRSPRLRPRSRSL-SPGRTSGTFDNEIVMMNHVYRERFPKATAQMEGRLQDFLAAFA--PGDRLALADGVLGFIHHQIVELARDCLAKS
|. |||    |.|||..||||||| ||.|...|||||||||||||.|||||||.|||.|||.|...|.  | |.|.|||.|..|||||.||.|||||.||
SCQDEDNNFCGCRSPHHRPRSRSLSSPSRSCITFDNEIVMMNHVYKERFPKATQQMEERLQHFIHHFKNIPCDSLRLADPVVRFIHHQVVEMARDCLHKS

GEALVTSRYFLEMQDKLERLLQDAHERSDSAEVGFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAREDQGVKTDLPRYIIRQLGLAKDPL
 ..|.|||||.|||.||||||..|||||.|.||.||.....||||||||||||||||||||||||||||||||||...||.|||.|||||.||||..||.
HAKLITSRYFYEMQEKLERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAKVMQGIKTDIPRYIIHQLGLNRDPI

EEI
||.
EEM
DUF1908 MAST3.AA DUF1908 80-158 64 2e-48 171.98 Pfam 1-92 (369) Show / Hide 
Range on Protein: 80-158
Range on HMM: 1-92/369
Sequence Identity: 64% (59 aa)

PLDSPRNFSAAAAISFPF--AR-------RADGRRWSLASLPSSGYGTNTPSSTVSSSSSSRERL----HQLPFQPTADELRFLSKHFRSSE
|.|||||||......|||  .|       ||||||||.|||||||||||.|||.|||..||.|||    ||||||||.|.|.||||||...|
PIDSPRNFSTSSMMNFPFVPIRRITNCRDRADGRRWSVASLPSSGYGTNPPSSNVSSQCSSQERLNQLPHQLPFQPTQDDLHFLSKHFCCTE
Kinase MAST3.AA MAST 389-662 54 9.5e-231 713.19 In-house 1-337 (337) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-337/337
Sequence Identity: 54% (182 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFET--RRHLCMVMEYVEGGDCATLLKNMG-PLP
||.||.||.|||||||||.|..|..|||.|.||.|..|..||..||||||.|||...||||| ||.||.|  ...|||||||.||||||.||...| ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEG---------------HIEKDAREFV------------
..||.||.|||||.|||||.||||||||||||.||.|.||||||||||||.|.|...||.|||               ||.|....|.            
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DKQVCGTPEYIAPEVIFRQG-YGKPVDWWAMGVILYEFLVGCVPFFGDTPEE-LFGQVVS--DEIMWPEG-----D
                        .||.||||.|||||||..|| ||||||||.||.|.|||||||.||.|||||| .|.....  .||.|||.     |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

EALPLDAQDLITRLLRQSPMDRLGTGGTHEVKQHPFF
.... .||||| .||.. | .|||..| .|.||||||
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase MAST3.AA MAST 389-662 51 3.3e-211 687.59 In-house 1-334 (334) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-334/334
Sequence Identity: 51% (172 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDM
||.||.||.||||.||||.|..|..|||.|.|.|...|..|...||.|||.||....||||| ||.||.|...|||||||.||||||.||...|.....|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEG---------------HIEKDAREFV---------------
|.||.|||||.|||||..|||||||||||.||.|.||||||||||||.|.|......|||               ....|...|.               
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DKQVCGTPEYIAPEVIFRQG-YGKPVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVVSDE---IMWPEG-----DEALP
                    .||.||||.||||||| .|| .|||||||.||.|.|||||||.||..|||||.|.......   |.||||     |||..
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

LDAQDLITRLLRQSPMDRLGTG-GTHEVKQHPFF
 .||||| .|| . | .|||.. | .||||||||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MAST3.AA AGC 389-662 29 1.1e-170 445.59 In-house 1-395 (395) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-395/395
Sequence Identity: 29% (117 aa)

FETIKLISNGAYGAVYLVRHR------DTRQRFAIKKINKQN-LILRN--QIQQVFVE------------RDILTFAE----------NPFVVG-MFCSF
|| .|.|. |..| |||||..      || . .|.|...|.   ....  ..... .|            |.||. .           .||.|  ...||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETRRH--LCMVMEYVE--------GGDCATLLKNMG-----PLPVDMARMYFAE-------TVLALEYLHN-YGIVHRD-LKPDNLLITSLGHIKLTDFG
.. .|  |..||||..        ||.| ..| ..|      .. ..|| |.||       .||||||||.  ||.||| |||.|.|... |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKIGLMSM-----------ATNLYEG---------------HIEKDA----------REFVDKQVCG--TPEYIAPEVIFRQGYGKPVDWWA--MGVIL
|.|.| ...            .. ...               .. ...           ..  .  ||  ||||.|||..    |||..|||.  .|...
LCKEGMNDGEKGQQSQSNMKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEFLVGCVPFFGDTPE----------ELFGQVV------SDEIMWP-------EGDEALPLDAQDLITRLLRQSPMDRLGTG-------GTHEVKQHPFF
||.|.|. ||.||.|.          |.| ..       .... .|       ..|. .  .|.|||..||   | .|||.|       |. |.|.||.|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAST3.AA S_TKc 389-662 32 1.7e-101 344.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-231/231
Sequence Identity: 32% (94 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEG--GDCATLLKNMGP---
.| ...|  ||.| ||..||..| ...|||.|.          ...  |..||     |..| .. .|..  ||.|||||..|  ||  ...|..|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVIFRQGYG
   .|  .|| |......||||.|. ||.||||||.|.|...  |||..||||...                       . .||||.|.||||.   |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

K-PVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPLDAQDLITRLLRQSPMDRLGTGGTHE----VKQHPFF
| ..|||. |.||||.|.|. ||   .....| ...             . .| |.| ..|.  | .|..     .    .|.||.|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAST3.AA RSK-Unclassified 389-662 37 8.6e-92 288.59 In-house 1-283 (283) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-283/283
Sequence Identity: 37% (107 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLK--NMGPLPV
|. ..||  |  | ||||| .|| | .|.|  .|. .| .| |. |  |..|.   . ||.| .. || |.  | ..|||  |||    |       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIG------LMS--MATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVIFRQG
| .|.| .|...||||||  ... ||||||| .    ||..||||.||. .       |       . .  |  .   |  .  ||| ||.|||.| | |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHG--FRTNSFCGTEEYLAPEMIRRCG

YGKPVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPLDAQDLITRLLRQSPMDRLGTG-G-THEVKQHPFF
 .| |||| .|...|| |.|| |. |.  .|.|  .   ..  |. |. .  ...||| .|| . |  ||| . |   ..|.||||
HTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPH-DSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase MAST3.AA AktR 389-662 36 9.4e-86 291.2 In-house 1-268 (268) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-268/268
Sequence Identity: 36% (103 aa)

FETIKLISNGAYGAVYLVRHR-DTRQRFAIKKINKQNLILRNQIQQVFVERDILT-FAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPV
|. .|.. .||.| ||||... |. . .|.| | |...| |||....  ||.|.   . .|| | .. .|.|...|  .|||..||.  . ||. . .  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DMARMYFAETVLALEYLHNY-GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDA-REFVDKQVCGTPEYIAPEVIFR-QGYGKPV
..|| |||. .|||||||.   |. |||||.|.|. . ||.|.|||||||              ....  .. . . .||||||.|||.|.. .|..|.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSV

DWWAMGVILYEFLVGCVPFFG-DTPEELFGQVVSDEIMWPEGDEALPLDAQDLIT-RLLRQSPMDRLG--TGGTHEVKQHPFF
|||| |. .|| ..|| ||.  .. .... .  .. .  ..  . .   ..|||. .|| . |  |||  . |. |.| ||.|
DWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MAST3.AA Pkinase 389-662 28 3.5e-82 284.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFV--ERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGG----DCATLLK--N
..... |  |..| ||. .|..|....|.|.|.|.  .  .. |. .   |  |.     |..| ....||...|..|||||.|||    | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

MGPL--PVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHI----KLTDFGLSKIGLMSMATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVI
 |..  . . ...|. ... .|||.|. ||.||||||.|.|| . |||    |..||||.|               .   . .  . .||||.|.|||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-M--TTFCGTPWYMAPEVI

F-RQGYGKPVDWWAMGVILYEFLVGCVPFFGD------TPEELFGQVVSDEIMWPEGDE------------------ALPLDAQDLITRLLRQSPMDRLG
  .|.||..||.|..|.||||.| |  || |.      .. ... .. . ......  .                  ... ...|.|...|.. | .|..
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

TGGTHEVKQHPFF
    ....|||.|
---AEQILQHPWF
Kinase MAST3.AA RSK 392-662 34 7.6e-81 274.9 In-house 1-278 (278) Show / Hide 
Range on Protein: 392-662
Range on HMM: 1-278/278
Sequence Identity: 34% (101 aa)

IKLISNGAYGAVYLVRHR---DTRQRFAIKKINKQNLILRNQ-IQQVFVERDILTFAE-NPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP---
.|.   |.||.|.|.|     ||.| .| | ..|  .. |.  .  .. ||.||   .  ||.|  . .|.|  .| ..|||..||.  | |.. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITS---LGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVIF----R
.  | |..|.|| |||.|.||  ||.||||||.| | ..    |||||||||..|..  ..   ..                |.| ||.|||..     .
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT--------------FCYTIEYMAPEMLKRANQQ

QGYGKPVDWWAMGVILYEFLVGCVPFFG---DTPEELFGQVVSDEIMWPEGD--EALPLDAQDLITRLLRQSPMDRLG--TGGTHEVKQHPFF
 |..| .|||  ||..|| |.||.|| |   ....|.. .. . .   ....  . |  .|.|||...|   | .|||   ... |.||||.|
GGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK-FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAST3.AA NDR 389-535 48 7.2e-79 242.74 In-house 1-152 (350) Show / Hide 
Range on Protein: 389-535
Range on HMM: 1-152/350
Sequence Identity: 48% (73 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAE--NPFVVGMFCSFETRRHLCMVMEYVEGGDCAT---LLKNMGP
|| ||.|. ||.| |.|||..||.. .|.|...|.  . .||. .|  ||||.. |   ||.|| ...||    .|. ||||. |||  |   ||..|. 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSK
.. |.|| | ||.|.|.|..|..|..|||.||||.|| . ||||||||||..
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCT
Kinase MAST3.AA PKA 389-535 42 2.2e-53 183.68 In-house 1-149 (263) Show / Hide 
Range on Protein: 389-535
Range on HMM: 1-149/263
Sequence Identity: 42% (64 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVG-MFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVD
||.|... .| .| |.|.||... . .|.| ..||  . ..|.. |  |. ||.  ..||.|  |  .| ..|.| ||||||.||.  . | . | .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MARMYFA-ETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSK
.|. | | . ||||||||.  |..||||| |.|| . ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase MAST3.AA Akt 389-540 39 1.2e-52 166.53 In-house 1-154 (264) Show / Hide 
Range on Protein: 389-540
Range on HMM: 1-154/264
Sequence Identity: 39% (61 aa)

FETIKLISNGAYGAVYLVRHRDTRQRF-AIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVD
|. .|..  |..| |.||.  || . . |.| . |. .| .||..... || ||    .||.|..  || |  .|..||.|. ||.  ..|.  .  . |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MARMYFAETVLALEYLHNYGIVHRD-LKPDNLLITSLGHIKLTDFGLSKIGLMS
 || | || .||.|.||. .|. || ||| |.|. . |||.||||||.| ....
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIK
Kinase MAST3.AA SGK 389-535 36 1.2e-51 157.52 In-house 1-173 (283) Show / Hide 
Range on Protein: 389-535
Range on HMM: 1-173/283
Sequence Identity: 36% (63 aa)

FETIKLISNGAYGAVYLVRHRDT------------------RQRFAIKKINKQNLI-------LRNQIQQVFVER-DILTFAENPFVVGMFCSFETRRHL
|. .|.|  | .| ||.|.| |.                   . .|.| ..||  |        ...   .  || .||     || |.   .| |   |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSK
 .||.||.||.    |.  . .| | || | || |.||||||   |..|||||.|.|  . ||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase MAST3.AA NDR 564-662 44 3.8e-44 133.63 In-house 243-350 (350) Show / Hide 
Range on Protein: 564-662
Range on HMM: 243-350/350
Sequence Identity: 44% (48 aa)

GTPEYIAPEVIFR-QGYGKPVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVVSDEIMW-----PEGDEA-LPLDAQDLITRLLRQSPMDRLG-TG-GTH
|||.|.||||. . .||.. .|||  |.|.||.|||  ||..|||.| .  . . ...|       . || |  .|.|||.||.   |. |||  | | .
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EVKQHPFF
|.|.||||
EIKSHPFF
Kinase MAST3.AA Akt 562-662 35 9.3e-39 121.47 In-house 162-264 (264) Show / Hide 
Range on Protein: 562-662
Range on HMM: 162-264/264
Sequence Identity: 35% (37 aa)

VCGTPEYIAPEVIFRQGYGKPVDWWA-MGVILYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPLDAQDLITRLLRQSPMDRLG--TGGTHEVKQ
.||||||.|||..  .|..|.||||.  |...||.. |  ||. .  ...| .  . ..  |.  ...  ...|||..||   |  |||   ....|.|.
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKR

HPFF
||.|
HPWF
Kinase MAST3.AA SGK 563-662 40 4e-38 114.99 In-house 186-283 (283) Show / Hide 
Range on Protein: 563-662
Range on HMM: 186-283/283
Sequence Identity: 40% (41 aa)

CGTPEYIAPEVIFRQGYGKPVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPLDAQDLITRLLRQSPMDRLGTG-GTHEVKQHPF
|||||| ||||.  |.... |||| .| .|||...|  ||.    .... .  . ..  | .      || |||. ||   | .||||  .  |.|.|||
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase MAST3.AA PKA 562-662 37 1.2e-32 114.76 In-house 158-263 (263) Show / Hide 
Range on Protein: 562-662
Range on HMM: 158-263/263
Sequence Identity: 37% (41 aa)

VCGTPEYIAPEVIFRQ-GYGKPVDWWAMGVILYEFLVGCVPFFGD--TPEELFGQVVSDEIMWPEGDEALPLDA---QDLITRLLRQSPMDRLGT--GGT
.||||||.|||.| .  |.||.||||| |.. ||.|.|  ||. .  .| ...   .. .| .|. .     ||    ||| .||   .  |.|.  .|.
LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFD---SDANYFKDLIKKLLQVDLTKRYGNMKNGV

HEVKQHPFF
  .| |..|
NDIKNHKWF
Kinase MAST3.AA TyrKc 389-648 19 2.7e-12 -23.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 389-648
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFA--ENPFVVGMFCSFETR-------RHLCMVMEYVEGGDCATLLK
 . .| . .||.| ||. . .   .  |.|....        ..    |  |..    ..| .| ..    .          |..||||...||.   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NMGP-LPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMS-MATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVIFRQ
. .| |...    .        ||||  ...||||   | |... ...| .|||||. .    ..    | .  ....|  ..         |||.|.  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYGKPVDWWAMGVILYEFLVGCVPFFGD------TPEELFGQVVSDEIMWPEGD-------EALPLDAQDLITRLLRQSPMDR---------L
 .    | |. || ..| .  . .   .      ...|.. .| . . | .  .       .. .   | ....  .  | ||         .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase MAST3.AA Pkinase_Tyr 461-535 30 1.2e-07 26.56 Pfam 81-159 (270) Show / Hide 
Range on Protein: 461-535
Range on HMM: 81-159/270
Sequence Identity: 30% (24 aa)

HLCMVMEYVEGGDCATLLKNM----GPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSK
....||||...||  . |..     .||.. .   . ..   ..|||.. ...||||   | |.|. ...| .||||..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase MAST3.AA S_TK_X 663-726 17 0.00087 8.22 SMART 1-79 (79) Show / Hide 
Range on Protein: 663-726
Range on HMM: 1-79/79
Sequence Identity: 17% (15 aa)

LALDWAGLLR----HKAEFVPQLE----AEDDTSYFD--TRSERYRHLGSEDDETNDEESSTEIPQ------------FSSCSHRF
  .|| .|..     .. |.|..      . |||.||    .|  .       .|.|.. .... .            |   . .|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
PDZ MAST3.AA PDZ 974-1054 25 2.1e-17 65.06 SMART 1-80 (80) Show / Hide 
Range on Protein: 974-1054
Range on HMM: 1-80/80
Sequence Identity: 25% (24 aa)

KKYGFSLRAIRVYMGDSDVYTVHHVVWSVEEGSPAQEAG------LRAGDLITHING-ESVLGLVHMDVVELLLKSGN-----KISLRTTALE
. .|||..              .... ||..|.||  ||      ||.|| |. .|| ..| .. | ..|..| ..|.     |..|     .
GGLGFSIVG-------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ MAST3.AA PDZ 1001-1051 25 3.8e-09 33.87 Pfam 33-86 (86) Show / Hide 
Range on Protein: 1001-1051
Range on HMM: 33-86/86
Sequence Identity: 25% (14 aa)

SVEEG-SPAQEAG-LRAGDLITHINGESVLGLVHMDVVELLLKSGN-KISLRTT
.| .| ..|. .| ...|| |. |||... .. |...|... .|.. ...|   
EVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ