Gene MER (Mouse)

MER

Species: Mouse
Alias: Mertk, MER
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Axl

Sequence

Name Sequence Type Origin Length Description Download
MER.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON
MER.AA Protein Sugen 994 None Fasta, JSON
MER.NA RNA Sugen 3555 None Fasta, JSON

Protein domain

Protein domains of MER.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG MER.AA IG 94-189 15 2.3e-08 35.05 SMART 1-58 (58) Show / Hide 
Range on Protein: 94-189
Range on HMM: 1-58/58
Sequence Identity: 15% (15 aa)

IGHIVLSEHKNVKFNCSINIPNTYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSIASVQRSDN---GSYFCKMKVNNREIVS-DPIYVEVQ
 . .. .|  .|...| ..          |.|.                            . | .||..|    | |.|  .  . .. | ......||
PP-VTVKEGETVTLTC-VS---------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set MER.AA I-set 123-171 29 0.186765 7.45 Pfam 32-76 (92) Show / Hide 
Range on Protein: 123-171
Range on HMM: 32-76/92
Sequence Identity: 29% (15 aa)

ISWWKDGKELL--GAHHSITQFYPDEEGVSIIALFSIASVQRSDNGSYFCK
.|| |||..|   . .|..|.        . .. . |  ||..| |.| |.
VSWFKDGQPLRPDSDRHQMTYDG------DGTYTLTISNVQPDDEGKYTCV
IG MER.AA IG 198-276 17 4.2e-07 30.85 SMART 1-58 (58) Show / Hide 
Range on Protein: 198-276
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

PESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEKPERSPSVLTVPGLTET-----AVFSCEAHNDKGLTVS-KGVHINIK
|. | | .    .||| .       .|.|                 ||. ....      ... |.|.  .| . | .|... ..
PP-VTVKEGETVTLTC-VS------QIWWY----------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set MER.AA I-set 192-222 32 0.000342 16.74 Pfam 1-31 (92) Show / Hide 
Range on Protein: 192-222
Range on HMM: 1-31/92
Sequence Identity: 32% (10 aa)

PYFIKQPESVNVTRNTAFNLTCQAVGPPEPV
|.|...| .| |.   . ...||. | |.|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQ
FN3 MER.AA FN3 279-363 15 3.8e-10 40.97 SMART 1-69 (69) Show / Hide 
Range on Protein: 279-363
Range on HMM: 1-69/69
Sequence Identity: 15% (16 aa)

PSPPTE---VHILNSTAH------SILVSWV-PGFDGYSPLQNCSIQVKEADRLSNGSVMVFNTSASPHLYEIQQLQAL----ANYSIAVSCRNE--IGW
|.||.    ... . |..      |. .||  |   ||.                               | .  |..      .|.. |...|.   |.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-IVGYR-------------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

S
.
G
FN3 MER.AA FN3 379-465 13 0.000345 21.16 SMART 1-69 (69) Show / Hide 
Range on Protein: 379-465
Range on HMM: 1-69/69
Sequence Identity: 13% (14 aa)

SVAPLN---ITVFLNESN-----NILDIRWTKPPIKRQDGELVGYRISHVWESAGTYKELSEEVSQNGSWAQIPVQIHN----ATCTVRIAAITK--GGI
  .| |   ..|    |.     . . ..|..|         ||||                        . ..    .     . ..|..|...  .|.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

G
|
G
Kinase MER.AA Axl 582-847 82 2.1e-213 715.23 In-house 1-267 (267) Show / Hide 
Range on Protein: 582-847
Range on HMM: 1-267/267
Sequence Identity: 82% (221 aa)

LVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSS-QGIPKPMVILPFMKYGDLHTFLLY
.||||.||||||||||||.||||||...|||||.||.|...|.|||||||||||||.|.||||.||.||||..|. |.||||||||||||.|||||||||
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

SRLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWA
|||...|.|..||.|.|||.|||.||||||||||.||||||||||||.||||||||||||||||||||||||.|||||||||||||||||||||||||||
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVWA

FGVTMWEITTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRL
||||||||.|||.||||||.||||||||.|||||||||||.|||||.||.||.|||.|||.|||||.
FGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase MER.AA Pkinase_Tyr 582-849 42 2.3e-138 469.24 Pfam 1-270 (270) Show / Hide 
Range on Protein: 582-849
Range on HMM: 1-270/270
Sequence Identity: 42% (118 aa)

LVLGKVLGEGEFGSVMEGNLK-QEDGTSQKVAVKTMKLDNFSQRE--IEEFLSEAACMKDF-NHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTF
...||.||||.||.|..| .| ..|.| ..||||..  .. ....  .|.|..||. || . .|||..||.|||.. . ..  ........|..|||...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDY

LLYSRLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYY-RQGRIAKMPVKWIAIESLADRVYTSKS
|   |  .... . ...||.. ..||.|||||...|. |||||||||.. ....| ..||||.. ||. ||| |..  .|.|.|| | |.......|.||
LRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVWAFGVTMWEITTRGMTP-YPGVQNHEMYDYL-LHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRLQL
|||.|||.|||| |.|..| |||. |.|.|.|.  .|.|...||.| ||.||.| .|| .|| |||||| .. ||
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MER.AA TyrKc 582-849 39 8.60000000001e-132 445.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 582-849
Range on HMM: 1-280/280
Sequence Identity: 39% (118 aa)

LVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDF--NHPNVIRLLGVCIELSSQGI---PKPMVILPFMKYGDLHT
..|||.||||.|| |..| .|      ..||||..| |      .|.|..||  |. .  .|||..||.|||.. . .     . .|... .|..|||. 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKD

FLLYSRLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG-------DYYRQGR--IAK--MPVKWIAIE
.| ..| .     . ...||.|. .||.|||||. .|. |||||||||.. .. || ..|||||..||..       ||||.     .|  .|..| |.|
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

SLADRVYTSKSDVWAFGVTMWEITTRGMTPYPG-----VQNHEMYDYLLHGHRLKQPED--------CLDELYDIMYSCWSADPLDRPTFSVLRLQL
.. ....|.|||||.|||.|||| |.|..||||     . | |.. |. .|.|..||..        | ||.|.|| .|| .|| |||||| .. ..
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MER.AA TK 582-849 25 6.9e-115 386.76 In-house 1-486 (486) Show / Hide 
Range on Protein: 582-849
Range on HMM: 1-486/486
Sequence Identity: 25% (126 aa)

LVLGKVLGEGEFG---SVMEGNLKQED----------------------GTSQKVAVKTMKLD-NFSQREIEE-----------FLSEAACMKDFN----
..|||.||||.||    |..| .....                      |. ..||||..|.. . ||.| ..           ||.||. || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVIRLLGVCIELSSQ-------GIPKPMVILPFMKYGD----LHTFLLYSRLNTGPKY---------------------------------------
 |||..||.||| .  ..       . . .|... .|..||    |...|  .| .. .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IHLQTLLKFMMDIAQGMEYLSNR------NFLHRDLAARNCMLRDDMT-----------VCVADFG---
                               .....|| ....||.|||||. .      || |||||||||.. ....           . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKKIYS------------------------GDYYRQGRIAKMPVKWIAIESLADRV---------YTSKSDVWAFGVTMWEITTRG-MTPYPGV
     |...|||                         |||||   .|.|..| | |.|.|||         .|.|||||.|||.|||| |.| ...|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

QN---------HEMYDYLLHG--------------HRLKQPEDCL--------------DELYDIMYSCWSADPLDRPTFSVLRLQL
 |         .|...||  |              .|..||..|               .|.||.| .||..|| |||||| |. ||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MER.AA Met 583-843 41 7.2e-109 358.13 In-house 1-271 (271) Show / Hide 
Range on Protein: 583-843
Range on HMM: 1-271/271
Sequence Identity: 41% (115 aa)

VLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMK-LDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYS
....|.| | || |  | . ..||   ..|.|. .        .|..|| |.  ||.|.||||  |.|.|.. ..     |.|.||.|| ||| ||    
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGH---MPWVVLPYMKHGDLKTFIRNP

RLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKI-YSGDYY--RQGRI-AKMPVKWIAIESLA--------D
  |     .    |. |  ..|.||.|.  . | |||||.|||||  ..|| ||||||. .. |   ||  .. .  |. |||| | |.|         .
QNN-----PCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPT

RV-YTSKSDVWAFGVTMWEITTRGMTPYPGVQN-HEMYDYLLHG--HRLKQPEDCLDELY-DIMYSCWSADPLDRPTFS
.  .|.||||| ||| |||  ||| .||| | |      .|  |   || ||| | | || |.| .||.|.| |||.||
YRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase MER.AA UTK 582-849 35 1.9e-96 326.76 In-house 1-296 (296) Show / Hide 
Range on Protein: 582-849
Range on HMM: 1-296/296
Sequence Identity: 35% (106 aa)

LVLGKVLGEGEFGSVMEGNLKQED--GTSQKVAVKTMKLDNFSQREIE---EFLSEAA---CMKDFN-HPNVIRLLGVCIELSSQGIPKPMVILPFMKYG
. ||. ||.|.|| | .. ..|..  .. ..||||. . . ..|.| |   .|. ||.    || |. ||||.||.|||   .      .|... .|. |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-----WMIVTEYMENG

DLHTFLLYSRLNTG--PKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDD-------MTVCVADFG---LSKKIY---------SGDYYRQ
|| ..| ..| ...  | .  | ..|....||| ||.||....| ||||||||| . ..       |.. .||||   .|. ..         . .||..
DLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

GRIAKMPVKWIAIESLADR-VYTSKSDVWAFGVTMWEITTRGMTPYPGVQNHEMYDYLLHG--HRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRLQ
    ..|..| | |.|...  .|.|||||.|||..||| |.| .||||  |..    .. |  .|...|.|| ...|..| .|| .|| .||.|  |. |
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

L
.
M
Kinase MER.AA TK-Unique 582-849 34 4.4e-91 308.91 In-house 1-294 (294) Show / Hide 
Range on Protein: 582-849
Range on HMM: 1-294/294
Sequence Identity: 34% (102 aa)

LVLGKVLGEGEFGSVMEGNLKQ---EDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFN-HPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTF
|..|.|.|||.|| |  | ...   ...  ..||||. | ||... .  .||.|.. ||    |||....||.|.. .      .| |.... .|.| ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK-DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD----EPWMIIMEYCPCGNLQHY

LLYSRLN-------------------TGPKY-IHLQTLLKFMMDIAQGMEYLSN--RNFLHRDLAARNCMLRDDMTVCVADFGLSKKIY-SGDYYRQGRI
| ..| .                   . ... | ...|. |. .||.|||||.   ... ||||.|||..| .| .. ..|||.....|  |.| .... 
LRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQ

AKMPVKWIAIESLA--DRVY-TSKSDVWAFGVTMWEITTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC-LDELYDIMYSCWSADPLDRPTFSVLRLQL
 ..|..| | |||   ...| |.|||||.|||.|||| | | .||||. . .. . .  |.|..||| |  .|.| .|.|||. .| .||.|. .. .|
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MER.AA InsR 582-851 40 2e-89 300.56 In-house 1-278 (278) Show / Hide 
Range on Protein: 582-851
Range on HMM: 1-278/278
Sequence Identity: 40% (115 aa)

LVLGKVLGEGEFGSVMEGNLKQ--EDGTSQ--KVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTF
.||.. .|.| || | ||..|   .|. .   ..|.|| . .| | ||  |||.||  || ||. .|.||||||    |.| |  .|.  .|.|||| ..
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVN-ENASMRERIEFLNEASVMKEFNCHHVVRLLGVC----SRGQPM-YVVMEMMTYGDLKSY

LLYSRLNTG---PKYI------HLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLA
|.  |   .   | ..       |. ..    .|. || ||  ..| |||||.||||  .| || ..|||.   ||  |||| |.  ..|| | | ||| 
LRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLK

DRVYTSKSDVWAFGVTMWEITTRGMTPYPGVQNHEMYDYL-LHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRLQLEK
| |.|..|||| ||| .||..| |  || |  | .  .|    |  |..|| | . ....|  ||   | .||||  .   |  
DGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase MER.AA Abl 582-849 42 7.9e-81 269.32 In-house 1-252 (252) Show / Hide 
Range on Protein: 582-849
Range on HMM: 1-252/252
Sequence Identity: 42% (115 aa)

LVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYS
... . || | .| | ||  |. | |   |||||.| |.    |..||| ||| ||.  |||...|||||        |   .|  || || |  .|   
IMMKHKLGGGQYGEVYEGVWKRHDCT---VAVKTLKEDTM---EVHEFLKEAAIMKEMKHPNLVQLLGVCTR-----EPPFYIITEFMCYGNLLDYL---

RLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAF
  ... . ..  .||     || ||.|| .|.|.|||||||||.. ..  | ||||||. ..  .| |     || |.|| | ||||   . ||||||||
-RECDREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLA-RMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAF

GVTMWEITTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRLQL
|| .||| | ||.||||..  ..|. | .|.|. .|| | .. |..|  ||  .. |||.|  .  ..
GVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase MER.AA Src 582-849 38 2.7e-79 269.06 In-house 1-255 (255) Show / Hide 
Range on Protein: 582-849
Range on HMM: 1-255/255
Sequence Identity: 38% (105 aa)

LVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILP-FMKYGDLHTFLLY
. | . ||.| || | .|  ..    . ||||||.| .. |.   | || ||  || . |.....|. || .        |  |   .|. | | ..|  
IKLCRKLGQGQFGEVWMGYWNG----NTKVAVKTLKPGTMSP---EAFLQEAQIMKKLRHEKLVQLYAVCSQEE------PIYIVTEYMSHGSLLDYLKK

SRLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG-DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVW
   ..  ...||..|. .   .|.||.||. .|. ||||||||    ..  . |||||| . |  . | |     ||.|.|| | | .  ...| |||||
---DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVW

AFGVTMWEITTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYD-IMYSCWSADPLDRPTFSVLRLQL
 ||. ..|| |.| .|||| .|||  . . .| |. .|. | ||||. ||  || .|| .||||  |.  |
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase MER.AA HMTK 582-848 34 4.8e-77 262.28 In-house 1-291 (291) Show / Hide 
Range on Protein: 582-848
Range on HMM: 1-291/291
Sequence Identity: 34% (105 aa)

LVLGKVLGEGEFG-----------------SVMEGNLK------QEDGTSQK-VAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQ
|  .||.| | ||                  |  . ..      ..|. . . .|||... |. |   .||||.||  |  ..|||...| ||| .    
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDA-SHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQ---

GIPKP-MVILPFMKYGDLHTFLLYSRLNTGPKYIHLQTL--LKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIY-SGDYYRQGR
   .| .. | .|.||||  .|   |     | |.|...  |.|.  .|.||.|..   ..|.|||||||.. .   | .|||||. ..    ||...  
---RPWLCVLEYMQYGDLRNVLKTCRE----KNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRK

IA-KMPVKWIAIESLA--DRVYTSKSDVWAFGVTMWEITTRGMTPYP--GVQNHEMYDYLLHGHRLKQPED--CLDELYDIMYSCWSADPLDRPTFSVLR
 . |.|.|| |.| ..  ...   |||||||||||||| . |..||.  .. | |. ...  | || ||..  | |...| |..|| .||  ||||. |.
HMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQ

LQ
  
KM
Kinase MER.AA Fer 694-850 34 7.4e-56 188.72 In-house 112-283 (283) Show / Hide 
Range on Protein: 694-850
Range on HMM: 112-283/283
Sequence Identity: 34% (59 aa)

TLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVC---VADFGLSKK--IYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEI
..... ...|.|||||  .| .|||.||||| . .| ...   ..|||.|..   |  ||.      |.|..| | |.. ...|..|.|||.|||..|||
EKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEI

TTRGMTPYPG----VQNHEM-----YDYLLHGHRLKQPEDCLDELYDIMY-SCWSADPLDRPTFSVLRLQLE
 |.| .||||    ... ..       .   |.... |. . .|.. ||  .|| .|| ||||.. .. .|.
FTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase MER.AA S_TKc 582-856 21 2.8e-44 154.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 582-856
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

LVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKY--GDLHTFLL
  .....|.| ||.|. .  |    | ..||.| .|         | ...| ...|  .|||...|..|. .       .  ... ..    |||.... 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIK

YSRLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTS-KSDV
  . . ......  .  ..|  |....||. .....||||   | .| .  .. ..||||....         .       ..| | |    |.  |.|.
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WAFGVTMWEITTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRL--QLEKLSESL
|..|....|  . | .|.|  | ..|.. ..            .|. |..  |.  || .|||   .    .. |. . .
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MER.AA Pkinase 582-849 20 9.9e-38 134.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 582-849
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

LVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLS--EAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYG----DLH
...|...|.| ||.|    . .. ||...||||..|... .  . .. .   |.. || .||||..||.... .      ... ......  |    ||.
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLF

TFLLYSRLNTGPKYIHL----QTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTV----CVADFGLSKKIYSGDYYRQGRIAKMPV---KWIAI
...         ..  .    ... ..|  |..|.||. .....||||   |... .....    ...||||.|...    |  .. .. ..    ..| 
DYIST------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAP

ESLA-DRVYTSKSDVWAFGVTMWEITTRGMTPYPGV------QNHEMYDYLLH-GHRLKQPEDCL-------------------DELYDIMYSCWSADPL
| .  .. |..|.|.|..|....|  . | .|.||          .|..  ..   .   |..|                    .|. |....|.  || 
EVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

DRPTFSVLRLQ--L
.|||.  .     .
KRPTAEQILQHPWF
Kinase MER.AA Fer 582-651 41 2.7e-21 69.35 In-house 1-78 (283) Show / Hide 
Range on Protein: 582-651
Range on HMM: 1-78/283
Sequence Identity: 41% (32 aa)

LVLGKVLGEGEFGSVMEG--NLKQ-EDGTSQK--VAVKTMKL-DNFSQRE-IEEFLSEAACMKD-FNHPNVIRLLGVC
 .|||.|||| || |  |   ||   ......  ||||..|.  .....| |.||. ||  |.  ..||||... |||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVC