MLK2

Species: Mouse
Alias: MLK2, 2900074C18Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
MLK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
MLK2.NA RNA Sugen 3475 None Fasta, JSON
MLK2.AA Protein Sugen 940 None Fasta, JSON

Protein domain

Protein domains of MLK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MLK2.AA SH3 19-80 39 2.4e-22 81.49 SMART 1-58 (58) Show / Hide
Range on Protein: 19-80
Range on HMM: 1-58/58
Sequence Identity: 39% (25 aa)

PVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLP-SGRVGVFPSNYVAPAA
|.  |..||.| ...||....|| ..||..|     |.||| |..  .|..| ||||||..  
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID

SH3_1 MLK2.AA SH3_1 22-73 33 2.6e-14 51.28 Pfam 1-49 (49) Show / Hide
Range on Protein: 22-73
Range on HMM: 1-49/49
Sequence Identity: 33% (18 aa)

TAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDE-GWWTGQLPS-GRVGVFPS
.| .||.|....||....|| ..|....     |. .||.|.. . |..| |||
VALYDYQAQQPDELSFKKGDIIHVIEKS-----DDWDWWKGRCNNTGQEGWFPS

SH3_2 MLK2.AA SH3_2 20-79 22 1.5e-11 43.37 Pfam 1-68 (68) Show / Hide
Range on Protein: 20-79
Range on HMM: 1-68/68
Sequence Identity: 22% (16 aa)

VWTAVFDYEA-VGDEE-----LTLRRGDRVQVLSQDCAVS--GDEGWWTG-QL-PSGRV--GVFPSNYVAPA
.  ...||..  . .|     |....|| . |..    ..   ...|| .      ||.  |.|||..|.. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVID----NGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC

Kinase MLK2.AA MLK 98-357 72 1.1e-199 666.05 In-house 1-280 (280) Show / Hide
Range on Protein: 98-357
Range on HMM: 1-280/280
Sequence Identity: 72% (202 aa)

LQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVT---AEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPH
|...||||.|||||||||.|.||||||||.| |||.|...|   |||||||||||..|.|||||||||.||..|.|||||||.|||.|.||.||.|.|||
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGKRIPPH

VLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIE-----------------NHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRL
||||||||.|||||||||.||||||||||||.||||||.|.                 .|......||||||||||||||||.|||||||||||||||. 
VLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKE

SLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQL
|..||.|||||.|||||||||||||||.||.|||||||||||||||||||||||.|.|...||..||| ||.|..||.||
STWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL

Kinase MLK2.AA MLK 98-357 46 3e-161 541.98 In-house 1-291 (291) Show / Hide
Range on Protein: 98-357
Range on HMM: 1-291/291
Sequence Identity: 46% (138 aa)

LQLEEIIGVGGFGKVYRAVWRGEE-----VAVKAARLDPERDPAVT---AEQVRQEARLFGALQHPN----IIALRGACLSPPN-LCLVMEYARGGALSR
.|..|.||.|.||||....||...     ||||..| ... | ..|   ......|.|..  |.|||    ||...|.||.||. .|.||||..|| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLAGRR---------------VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT-T-KMSAAGTY
||.|.|               .......|||.|.||||.|||..||.||||||||| ||||.| |.. ......|||.|||..|.||.. | .||.||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

AWMAPEVI---RLSLFSKSSDVWSFGVLLWELLTGEVPYR-EIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQL
||||||||   | . .|...||||.||.|||.||.||||. ..|..|.|..||.|.|..||||||||....|...||..||| ||.| .|...|
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase MLK2.AA TKL 104-357 30 4.5e-107 362.03 In-house 1-364 (364) Show / Hide
Range on Protein: 104-357
Range on HMM: 1-364/364
Sequence Identity: 30% (113 aa)

IGVGGFGKVYRAVWRG----------EEVAVKAARLDP-----------------------ERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPN-
|| ||||.||...|||          ..||||  . .                        ....    .. ..|...   |.||||. . |.|..||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVMEYARGGA-LSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAP-----VPIIHRDLKSINILILEAIENHN------LADTVLK
            ||.||||. ||  |....      .|....|| ..||||||||.. |      ||||||||| |||. |  .|..       || ..|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ITDFGLAREWHKT---------------------TKMSAAGTYAWMAPEVIRLS----------------LFSKSSDVWSFGVLLWELLTGEVPYREIDA
|.||||.|.....                     |.|.  ||..||||||.| .                 .|...||.|||..|||.||...||.... 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

LAVA---------YGVAMNKLTLPIP------------STCPEPFARLLEECWDPDPHGRPDFGSILKQL
  .          ..|. ..| .|||            ..||.....|...|||.||. || |  |||.|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase MLK2.AA TyrKc 98-357 30 2.5e-82 280.71 SMART 1-280 (280) Show / Hide
Range on Protein: 98-357
Range on HMM: 1-280/280
Sequence Identity: 30% (90 aa)

LQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGAL--QHPNIIALRGACLSP-------PNLCLVMEYARGGALSRVLAG
..|....| | ||.||...|. ..||||  . |         |  ..|||.   |  .||||..| |.|...       . |..||||. .|.|   |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RR--VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT--------TKM-----SAA--GTYAWMA
.|  ...  |.....|.|.||.|||     ..|||||   |.|. |          . ||.||||.|...          ...     ..     . |||
HRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREI----DALAVAYGVAMNKLTLPIPST--------CPEPFARLLEECWDPDPHGRPDFGSILKQL
||.|. . |.  ||||||||..||..| |. || ..       . ..   ..   .|.|          ||.   .. ..||. ||. || |  | ...
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase MLK2.AA LZK 152-357 48 1.6e-80 271.2 In-house 44-241 (241) Show / Hide
Range on Protein: 152-357
Range on HMM: 44-241/241
Sequence Identity: 48% (101 aa)

LQHPNIIALRGACLSPPNLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFG
|.|||||...| |   |  | .|||   | |  || ..| ..|. .|.|  |.| ||.|||      |||||||| ||||         .. |.|| |||
LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGMHYLHQHK---IIHRDLKSPNILI--------SHNDVVKICDFG

LAREWHKT--TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRP
  ..| .   |||| .|| |||||||||    |   |.||||| |||.||.|.||...|  |. .||  | | ||.|||||| |  |.  ||   |  ||
TSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRP

DFGSILKQL
 |  ||  .
SFRQILMHW

Kinase MLK2.AA Pkinase 98-357 26 3.8e-78 270.73 Pfam 1-293 (293) Show / Hide
Range on Protein: 98-357
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

LQLEEIIGVGGFGKVYRAVWRGEE--VAVKAARLDPERDPAVTAEQVR-QEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGG----ALSRVLA---
......|| |.||.||.....|..  ||||  ... .... .  . .| .|...   |.||||. |.... .......||||..||     |....    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GRRV--PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWHKTTKMSAAGTYAWMAPEVIR-LSLFS
....  ..... ... |..||..|.|.     |||||||. |||| .  ..       .||.|||||.   . ...  .. .||. .|||||||  .  .
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KSSDVWSFGVLLWELLTGEVPYREI------DALAVAYGVAMNKLTLPIPSTCP-------------------EPFARLLEECWDPDPHGRPDFGSILKQ
...|.||.|..|.|.|.|. |...       | ... . . . .|  ..| .|.                   |..  ... |...||. || .  ||. 
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF

Kinase MLK2.AA Dicty4 98-359 35 3.2e-75 250.35 In-house 1-277 (277) Show / Hide
Range on Protein: 98-359
Range on HMM: 1-277/277
Sequence Identity: 35% (101 aa)

LQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACL----SPPNLCLVMEYARGGALSRVLAG-----
.. |..|| |.||.||.. ||| ||||| . .. . . . . .  |.|. . . ..||||. . |||.     |. .| |.||   | | ..|       
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-RRVPPH-VLVNW----AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR----EWHKTT-KMSAAGTYAWMAPEVIRL
  ....   |.      |  .|||||.||.  || |||||||| |.|. .        . . |..||||..    .  ...  |.|.|| .|||||| . 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK--------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH

SLFSKSSDVWSFGVLLWELLTGEVPYR--EIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQ--LEV
  .  ..|| ||| .|||.||.. ||    ..   .. .|.  || .|||. || ....|...|||.||  || |  |...  || 
QPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase MLK2.AA TKL-Unique 100-357 35 8.4e-73 248.17 In-house 1-290 (290) Show / Hide
Range on Protein: 100-357
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)

LEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQ-VRQEARLFGALQ-HPNIIALRGACL----SPPNLCLVMEYARGGALSRVLA------
  . || ||.|.||...|||..||.|   .  . |.  . .|  . | ..   |. ||||  . |.|     .|||.|.||||  || |  ||.      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----GRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAA-----------GTYAWMA
         .. . |. | ..|.||.|||.  |  |||||||| |.|. ..    | |    || ||||..   | .||..            |.. |||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNS---NIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PEVIRL--SLFSKSSDVWSFGVLLWELLTGEV------PYREIDALAVAYGVAM--NKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQL
|||.|   ...|..|||.|||. |||..|...      ||...|  ...  |.    .. .|||. ||. .  |...||..||  || | .|.. |
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase MLK2.AA LRRK 98-359 30 3e-72 246.32 In-house 1-351 (351) Show / Hide
Range on Protein: 98-359
Range on HMM: 1-351/351
Sequence Identity: 30% (109 aa)

LQLEEIIGVGGFG-KVYRAVWRG----------------------------EEVAVKAARLDP------------------------------ERDPAVT
|  || ||.|||| .|||| |||                            ..||.|   .||                              ..| .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

AEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRR---------V-PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINI
    |.|. .   |.||||. | | |..|  ||.|||||. |.|...|  ..         . .....   |.|.|.||.|||.  | ||||||||| ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LILEAIENH----NLADTVLKITDFGLAR--EWHKTT-KMSAAGTYAWMAPEVIR---LSLFSKSSDVWSFGVLLWELLTGE-VPYREIDALAVAYGVA-
|. .  .||      |... || |||. |     ...  .   |.  |||||..|    . ..  .|. |||..||||||..  |..|.|     ...  
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHD----FFDHMQ

-MNKLTL--------PIPST-CPE-----PFARLLEECWDPDPHGRPDFGSILKQLEV
 |... .        .||.. ||.      .  |...||. ||  || | .|.|.|. 
WMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase MLK2.AA ZAK 98-356 37 1.3e-68 234.25 In-house 1-257 (257) Show / Hide
Range on Protein: 98-356
Range on HMM: 1-257/257
Sequence Identity: 37% (105 aa)

LQLEEIIGVGGFGKVYRAVWRGEE-----VAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPN-LCLVMEYARGGAL--------S
.|. . .||| || |||| |         .|||                .  ||     . | |||   | |. |||    | |||  | |        |
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVF------------KIEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRS

RVLA----GRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR-EWHKTTKMSAAGTYAWMAPEVIRLS
  ..    |      . . || |.|.|| ||| |||. |||||||| |. |         .. |.|| |||  |   | .| ||  || .|||||.|  |
QEMDSSSGGNSM--DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVI--------DKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQS

L-FSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQ
.  .   ||||.|| |||.|| ||||.. . . ..  .     .| ||. || ||. |. .||  ||  || .  |   
EPVTETCDVWSYGVVLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI

Kinase MLK2.AA Pkinase_Tyr 98-357 33 1.7e-68 232.57 Pfam 1-270 (270) Show / Hide
Range on Protein: 98-357
Range on HMM: 1-270/270
Sequence Identity: 33% (94 aa)

LQLEEIIGVGGFGKVYRAVWR------GEEVAVKAARLDPERDPAVT--AEQVRQEARLFGAL-QHPNIIALRGACL--SPP-NLCLVMEYARGGALSRV
... . .| | ||.||...|.      . .||||  .   |         |   .||..   | .||||. | |.|.  . | ....||||. .| |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LAGR-----RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHK-----TTKMSAAGTYAWMAPEVI
|  .     ..... |.....|.|.||.||..    ..|||||   |.|. |        . | ||.||||||  ..     ... ..     |||||.|
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECI

RLSLFSKSSDVWSFGVLLWELLT-GEVP-YREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQL
. . |.  |||||||||.||..| || | | ...   |   .. .   .|.|  ||..  .|. .||..||  || |  |. ||
NYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase MLK2.AA S_TKc 98-360 26 5e-65 223.27 SMART 1-231 (231) Show / Hide
Range on Protein: 98-360
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

LQLEEIIGVGGFGKVYRAVWRG--EEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARG--GALSRVLAGRR---
 .. ..|| |.|||||......  ..||.|  .           |..|.| ..    .||||. | ... .  .|..||||. |  | | ...  |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSK-SSD
     |. .   .. |......|.|.     |||||||  |||. |          ..||.||||||.      ..  ||  .|||||.    ..| ..|
LRFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCD

VWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILK------QLEVI
.||.|..|.|.|.|. |..    ... . . .           ....  ... |.. ||  ||    .|.      . . .
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase MLK2.AA TK 98-357 19 8.5e-65 215.87 In-house 1-486 (486) Show / Hide
Range on Protein: 98-357
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

LQLEEIIGVGGFG---KVYRAVWRG---------------------------EEVAVKAARLDPERDPAVTAE-------------QVRQEARLFG--AL
..|.. .| | ||   .||.. |||                           ..||||  ... . ...   .             .  .|. ..   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNIIALRGACLSP------------PNLCLVMEYARGGA----LSRVLAGRR----------------------------------------------
.||||. | |.|. .            . ...||||. .|     |   |  .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPPHVLVNWAVQVARGMNYLHND--APV--PIIHRDLKSINILILEAIENH---NLADTVLKITDFG--
                               ...| |. ...|.|.|| |||          ..||||   |.|. |   ..        | ||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAREWHKTTKMSAAGTYA----------------------------WMAPEVIRLSL---------FSKSSDVWSFGVLLWELLT-G-EVPYRE
      |||. .. .   ....|                             |||||...            |.  |||||||||.||..| | | .| .
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IDA---------LAVAYGVAMN-------------KLTLPIPSTCP--------------EPFARLLEECWDPDPHGRPDFGSILKQL
..            |   . .              .. .| |  ||              | ...|. .||..||  ||.|  ...||
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase MLK2.AA DRK 98-359 33 3.1e-64 216.43 In-house 1-258 (258) Show / Hide
Range on Protein: 98-359
Range on HMM: 1-258/258
Sequence Identity: 33% (91 aa)

LQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPH--V
      || |..| |.|  ||| .|||| . .. . |     |  ..|. |   | ||||.   |.|. ||  | .|||   | | ..|    .      
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNE-FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL

LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR----EWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGV
.   .  .|.||.|||.  |. |||||||| | |. |            |. ||||.        ... | . ||  | |||| |   .    ||.||..
MKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVDEHWQ--------VKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAI

LLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEV
 |||..| . ||  .  . |   |   .. .|.|  || ....|. .||. ||  || .  .|. || 
VLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA