Gene MNK2 (Mouse)

MNK2

Species: Mouse
Alias: Mknk2, MNK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MNK

Sequence

Name Sequence Type Origin Length Description Download
MNK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
MNK2.AA Protein Sugen 459 None Fasta, JSON
MNK2.NA RNA Sugen 2681 None Fasta, JSON

Protein domain

Protein domains of MNK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MNK2.AA MNK 84-368 75 4.2e-235 787.34 In-house 1-292 (292) Show / Hide 
Range on Protein: 84-368
Range on HMM: 1-292/292
Sequence Identity: 75% (221 aa)

QLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQ-LGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNELEA
.|....|||||.|.||||||.....|||||||.||  ||.|.|||||||..|.||||||.|.|||.||..|||||||||||||..|.||..|.||.| ||
KLTDEHLGEGAYASVQTCVNIQSGKEYAVKIIDKQGPGHSRKRVFREVETFYHCQGHRNILQLIEWFEDDDRFYLVFEKMRGGPLLQHIQQRKHFTEHEA

SVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSG---IKLNGDC-SPISTPELLTPCGSAEYMAPEVVEAFS-EEASIYDKRCD
|.|..|.||||||.|||||||||||||||||||||.|.||||||||||||   |.||.|| .||.||||||||||||.||||||.||. .||..||||||
SQVIKDIASALDFMHNKGIAHRDLKPENILCEHPNHVCPVKICDFDLGSGRPPIHLNHDCSQPITTPELLTPCGSAEFMAPEVVDAFVYDEAHYYDKRCD

LWSLGVILYILLSGYPPFVGHCG-SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWV
||||||||||.|.|||||||||| .||||||||||..||||||..||||.||||.|.|.||| .||||||.||||||||||||||||.||||
LWSLGVILYIMLCGYPPFVGHCGDEDCGWDRGEACRDCQNMLFHCIQEGHYEFPEKEWHHISEEAKDLISNLLVRDAKQRLSAAQVLNHPWV
Kinase MNK2.AA MAPKAPK 84-368 58 1e-217 681.27 In-house 1-292 (292) Show / Hide 
Range on Protein: 84-368
Range on HMM: 1-292/292
Sequence Identity: 58% (171 aa)

QLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHIRSRVFREVEMLYQCQGHRNVLELIEFFEE----EDRFYLVFEKMRGGSILSHIHR--RRHF
.|...|||||....|||||.. |.|||||||.|.| ||.|....||||....||||.|....|..||.    ...||||.|.|.||....||..  ..||
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF

NELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDC-SPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRC
.| ||| ...|..||.||||...|||||||||||||...|...|||.|||.....|.||.|| .||.||||.|||....|||||||.||. ||..|||.|
TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK-EAHTYDKSC

DLWSLGVILYILLSGYPPFVGHCG-SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWV
|.||||||.||.|.|||||...|| .||.|||||||..||||.|..||||.|||||..||||| .|||||.|||.||..|||...||..|||.
DMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase MNK2.AA CAMK 89-368 26 2.1e-112 363.65 In-house 1-425 (425) Show / Hide 
Range on Protein: 89-368
Range on HMM: 1-425/425
Sequence Identity: 26% (113 aa)

VLGEGAHARVQTCVNLITN------------QEYAVKIIEKQ----------------------------LGHIRSRVFREVEMLYQCQG------HRNV
.||.|. . |  |..  |.            |..|.|||.|.                             .. | .|.||.|.. ..||      |.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LELIEFFEE-------------------EDRFYLVF---EKMRGG----SILSHIHRR---------------RHFNELEASVVVQDVASALDFLHNKGI
. |.|..|                    ....|.|.   | . ||     ....| ..               ..|.| ||. ... ..||....|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDLKPENILCEHPN--------------QVSPVKICDFDLGSGIKLNGDCS----------------PISTPELLTPCGSAEYMA-PEVVEAFS----
.||||||||||. . |              .. ..||.|| .   .. . ..                 |.... . |.||. |||| |||..  .    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-----EEASIYDKRCDLWSLGVILYILLSGYPPFVGHCG-SDCGWDRGEACPA---CQNMLFESIQEGKYEFPDKD------------WSHISFA-----
     ||   |.. || ||.||||||.|.||||| | |. ..|. |  |       ... ||| |..|||.||..             |..||       
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D--E---WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFV

---AKDLISKLLVRDAKQRLSAAQVLQHPWV
   .||||.|.|..| ..|....|.|.|||.
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
S_TKc MNK2.AA S_TKc 83-368 30 4.2e-90 306.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 83-368
Range on HMM: 1-231/231
Sequence Identity: 30% (93 aa)

YQLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRG--GSILSHIHRRRH----
|.. . ..|.|| ..|  |..  |....|.|||         .. ||...| .  .| |.  |...|.. |..|.|.| . |  |. ...|..|..    
YEILR-KIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDK
  |.| .|  ... ...||...|..|| ||||||||||. .      .||||| |   .               | ||. .||||||.         |.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------GYGK

-RCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQ-------HP
 .|| ||.|.|||..|.|||||                   ..|.|. |               |  |||.|.|.|..| ..|..| ..||       ||
CKCDWWSCGCILYEMLCGYPPFP-----------------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

WV
|.
WF
Kinase MNK2.AA RSK 85-368 32 2.1e-80 273.42 In-house 1-278 (278) Show / Hide 
Range on Protein: 85-368
Range on HMM: 1-278/278
Sequence Identity: 32% (96 aa)

LQED-VLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHIRSR----VFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRH---
|...  .| |..  .. |..  |.|.||.|...|     | .    ...|.. |  ||.| .. .| . |..|. .||. | .|||  . |. ...|   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQV-SPVKICDFDLGSGIKLNGDCSPIS-TPELLTPCGSAEYMAPEVVEAFSEEASIYDK
| | ||...   ...|...|| .|| |||||||||| .. .     .|..||..    |..    ... .  . |.|...||||||..       . .||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFC---KQF----RCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDK

RCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLS-----AAQVLQHPWV
 ||.|||||..| .|.|.||| |  ..           . .. ... ||.||. .. . |. .| .|||||.|.| || ..||.     |....|||| 
ACDWWSLGVLMYEMLTGCPPFQG-PND-----------NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Pkinase MNK2.AA Pkinase 83-368 30 9.7e-76 262.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 83-368
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YQLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHI--RSRVFR--EVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGG----SILSHIH--
|.. . ..|.|. ..|  |..  |....|||||.|.  .   . . .|  |....  . .| |...|...||..|. |.|.| ..||    .  ..|.  
YHIGR-KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

RRRHF--NELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQV-SPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEA
|.. |   | |.  ..  ....|...|..|| ||||||||||. . ... ..|||||| |   ..        . . . |.||. .||||||.     ..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR----GG

SIYDKRCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHIS-----------------FAAKDLISKLLVRD
. |....| ||.|.|||..|.|.||| ||       . ..   ..|. ... | .....|.   |. ||                  ..||.|...| .|
QYYGPKVDMWSCGCILYEMLCGRPPFPGH-------C-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

AKQRLSAAQVLQHPWV
 |.|..|.|.|||||.
PKKRPTAEQILQHPWF
Kinase MNK2.AA CAMK1 83-295 34 1.2e-73 213.48 In-house 1-216 (276) Show / Hide 
Range on Protein: 83-295
Range on HMM: 1-216/276
Sequence Identity: 34% (77 aa)

YQLQEDVLGEGAHARVQTCVNLIT---NQEYAVKIIE-KQ--LGHIR---SRVFREVEMLYQCQ--GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHI
|... ...|.|| . |  |..  |   ...||.|.|. |.   .. .    .. .|.|.. ..    | |.  ..|..|... |||| | . || ..  |
YEFG-KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

HRRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVK--ICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEA
  . ...| .|. ... ..||. ..| |||.||||||||.|.. .   |..|  |.|| |   .. . .        . |.||. .|.||||.|  .  .
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN-------LMKTACGTPGYVAPEVLECKK--D

SIYDKRCDLWSLGVILYILLSGYPPF
  ||| ||.|| |||.|||| |||||
KPYDKACDMWSIGVITYILLCGYPPF
Kinase MNK2.AA CAMKL 83-368 28 1.1e-71 228.04 In-house 1-297 (297) Show / Hide 
Range on Protein: 83-368
Range on HMM: 1-297/297
Sequence Identity: 28% (91 aa)

YQLQEDVLGEGAHARVQTCVN-LITNQEYAVKIIEKQ----LGHIRSR-----------VFREVEMLYQCQ--GHRNVLELIEFFEEEDR------FYLV
|.. . .||.|. . |. ... ..|....|.|||.|.      .....           ..||.. . . .  .| |.  | | .| ..       .|||
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

FEKMRGGS--ILSHIHRRRH----FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPN-QVSPVKICDFDLGSGIK-LNGDCSPISTPE--LL
 |   ||.   . .| ...|    . | ||    . . ||....|..||.|||.||||||  . . .   .||.|| ..  ..        | .|.  | 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPC------IFGPGQKLK

TPCGSAEYMAPEVVEAFSEEASI-YD-KRCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLIS
| ||| .|||||...     .   || .  | ||.||||| .. || || . . .        .   ..  |.. | .| |..|   |.|.|  ..|||.
TFCGSPPYMAPEIFQG----NNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K------QGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIR

KLLVRDAKQRLSAAQVLQHPWV
|.|... ..| .. |...|||.
KMLQVNPEKRPTIHQIMNHPWM
Kinase MNK2.AA MSK 85-368 32 7.8e-70 235.25 In-house 1-277 (277) Show / Hide 
Range on Protein: 85-368
Range on HMM: 1-277/277
Sequence Identity: 32% (95 aa)

LQED-VLGEGAHARVQTCVNLITNQEYAVKIIE----KQLGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNE
| .   .|.|.   .  ||.  |...||.||.      |     . . .|.  |  ||.| |. .| . | ..  .||| |  .||  . || .|.|| |
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

LEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLW
 |.....  . .|.|..| ||| |||||||||| .  .   .||. || . . .....   .  .     ||.. .|||||...   .. . ||. ||.|
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGF-ARLFPQDEEWRMKS-----PCFTLHYMAPEMLRRGYAQDGGYDEACDWW

SLGVILYILLSGYPPFV--GHCGS-DCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWV
||||||| .|.|  ||   .. ..  |         . .  .   |..|.  ||   |. .| .|||||..|| .| | ||..   ..| | 
SLGVILYTMLTGQVPFQQNEDDRQHSC---------NSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MNK2.AA MAPKAPK 84-295 35 1.9e-50 168.05 In-house 1-206 (268) Show / Hide 
Range on Protein: 84-295
Range on HMM: 1-206/268
Sequence Identity: 35% (79 aa)

QLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRF----------YLVFEKMRGGSILSHIHR
|. . ||| |   .|  |..  | | .| |.    .   . |  ||||.  .| ||... . |. .| .  |            | | | ||  .. |  
QIWKQVLGIGINGKVMQCYHKRTQQKFALKVL---RDSPKAR--REVELHWMCSGHPHIVQIIDVYENMYQFPHEPSPRKCLLIVMECMEGGELFHRIQE

R--RHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASI
|  .|| | ||. .......|....|   ||||||||||.|..  .. ...| .||  |   . ..      . .| |||    | |||| ..       
RGDQHFTEREAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDF--GFAKETTR------HNTLMTPCYTPYYVAPEVLGPEK-----

YDKRCDLWSLGVILYILLSGYPPF
||| ||.||||||.||.| |||||
YDKSCDMWSLGVIMYIMLCGYPPF
Kinase MNK2.AA CDPK 84-297 35 8.5e-48 144.8 In-house 1-215 (271) Show / Hide 
Range on Protein: 84-297
Range on HMM: 1-215/271
Sequence Identity: 35% (79 aa)

QLQEDVLGEGAHARVQTCVNL-ITNQEY-AVKIIEKQ-LGHIR--SRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFE--KMRGGSILSHIHRRRH
.  ..|||.|.   |  ...  .||||  |.|||.|  . .     ..|.|.| | |   | |.. . ||.. |. .|.|.|     ||  .  |  ..|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQL-DHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH

FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVS----PVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIY
|.| ||. ... . ||.   |...| |||||||||| .  .  |    ..|. |...    . | .        . . ||   |.|||| .        |
FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQN-QKI--EDKKMSQRCGTPYYIAPEVLQK------KY

DKRCDLWSLGVILYILLSGYPPFVG
.. ||.||.||||||||.||||| |
NEKCDIWSCGVILYILLCGYPPFYG
Kinase MNK2.AA RSK 83-227 34 1.8e-34 120.48 In-house 1-149 (271) Show / Hide 
Range on Protein: 83-227
Range on HMM: 1-149/271
Sequence Identity: 34% (51 aa)

YQLQEDVLGEGAHA---RVQTCVNLITNQEYAVKIIEKQLGHIRSRVF-REVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFN
| |.| ..|.|..     .. |.   |||.||.|||.|    ...||   |.. .     | ..  | . |. |   |.. . |||| .. .. . . | 
YELHE-CIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

ELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHP-NQVSPVKICDF
| |.. .   .|.|...|| .||.||||||||||      . . .|||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDF
Kinase MNK2.AA CDPK 319-368 54 4.2e-29 86.56 In-house 222-271 (271) Show / Hide 
Range on Protein: 319-368
Range on HMM: 222-271/271
Sequence Identity: 54% (27 aa)

FESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWV
.|....|||.| ...|.|||  |||||.|.|..| |.|.||.|.|||||.
MEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase MNK2.AA CAMK1 315-368 45 3.8e-27 75.9 In-house 222-276 (276) Show / Hide 
Range on Protein: 315-368
Range on HMM: 222-276/276
Sequence Identity: 45% (25 aa)

QNMLFESIQEGKYEFPDKDWSHISFA-AKDLISKLLVRDAKQRLSAAQVLQHPWV
.|.||| | ...|||| . | .||   |||.|...|. | |.|....|.|.|||.
DNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MNK2.AA MAPKAPK 322-368 48 6.5e-17 53.38 In-house 222-268 (268) Show / Hide 
Range on Protein: 322-368
Range on HMM: 222-268/268
Sequence Identity: 48% (23 aa)

IQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWV
|. |.||||.  || .| .||||| |||  |  .||.  ....|||.
IMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTERLTIEEFMNHPWI
Kinase MNK2.AA RSK 247-297 43 1.6e-15 52.04 In-house 162-207 (271) Show / Hide 
Range on Protein: 247-297
Range on HMM: 162-207/271
Sequence Identity: 43% (22 aa)

LLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVG
|.|.|..|.||||||.         .|. || ||.||..|. |.|..||..
LMTFCYTANYMAPEVL-----KRQGHDQACDWWSFGVLMYEMLTGCTPFQN
Kinase MNK2.AA RSK 322-368 38 1.2e-14 48.89 In-house 220-271 (271) Show / Hide 
Range on Protein: 322-368
Range on HMM: 220-271/271
Sequence Identity: 38% (20 aa)

IQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSA-----AQVLQHPWV
|..|.. .    |. ||  ||||....| ||  .||.|     .|..||||.
IKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MNK2.AA TyrKc 83-366 18 1e-10 -49.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 83-366
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

YQLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHIRSRVFREVEMLYQC-QGHRNVLELIEFFEEE-------DRFYLVFEKMRGGSILSHIHRR
 .| . .|||||  .|  ..     .. ||| . .     |    || ... .    | |.. |.    ..       .  ..|.| | .|. .......
ITLGK-KLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

RH-FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLN---GDCSPISTPELLTPCG--SAE------YMAPEVV
|. ..  .      ..|.  ..|| |.. ||||   |.|  ...    |||.|| |   |.     |        .  .. .  ..        ||||. 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIRWMAPECI

EAFSEEASIYDKRCDLWSLGVILY-ILLSGYPPFVG---HCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDW------SHISFAAKDLISKLLVRD
       ...    | || || .. |.  | .|  |   .                | ..    | .  . |. |        .       ....   .|
-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ------------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHED

AKQRLSAAQVLQHP
...| . ... .  
PEDRPTFSEIHECF
Kinase MNK2.AA Pkinase_Tyr 111-206 22 2.4e-07 25.49 Pfam 32-137 (270) Show / Hide 
Range on Protein: 111-206
Range on HMM: 32-137/270
Sequence Identity: 22% (24 aa)

AVKIIEKQLGHI---RSRVFREVEMLYQCQGHRNVLELIEFFE-EEDR--FYLVFEKMRGGSILSHIHR----RRHFNELEASVVVQDVASALDFLHNKG
|||..  .  |    |   .||.... |   | |.. |.     ...    |.|.| | .|. |.. ..    .....  .     ...|.....|..|.
AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN

IAHRDL
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CIHRDL